JP2001517081A - 機能性タンパク質の産生：剪断応力と重力との釣合い - Google Patents
機能性タンパク質の産生：剪断応力と重力との釣合いInfo
- Publication number
- JP2001517081A JP2001517081A JP54098398A JP54098398A JP2001517081A JP 2001517081 A JP2001517081 A JP 2001517081A JP 54098398 A JP54098398 A JP 54098398A JP 54098398 A JP54098398 A JP 54098398A JP 2001517081 A JP2001517081 A JP 2001517081A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- shear stress
- culture
- rotating wall
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4320597P | 1997-04-08 | 1997-04-08 | |
| US60/043,205 | 1997-04-08 | ||
| PCT/US1998/006826 WO1998045468A1 (fr) | 1997-04-08 | 1998-04-07 | Elaboration de proteines fonctionnelles : equilibre entre contrainte tangentielle et gravite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001517081A true JP2001517081A (ja) | 2001-10-02 |
Family
ID=21926026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54098398A Ceased JP2001517081A (ja) | 1997-04-08 | 1998-04-07 | 機能性タンパク質の産生：剪断応力と重力との釣合い |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0972069A1 (fr) |
| JP (1) | JP2001517081A (fr) |
| AU (1) | AU6953498A (fr) |
| BR (1) | BR9808510A (fr) |
| CA (1) | CA2286349A1 (fr) |
| IL (1) | IL132264A0 (fr) |
| WO (1) | WO1998045468A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010524495A (ja) * | 2007-04-28 | 2010-07-22 | ヒョンジン ヤン， | 粉末状の足場を用いた細胞間の信号調節による細胞培養方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002533113A (ja) * | 1998-12-24 | 2002-10-08 | フローレンス・メディカル・リミテッド | 複数の剪断応力応答配列（ｓｓｒｅ）および目的の遺伝子を含む発現ベクター、およびその使用法 |
| AU2005270968A1 (en) * | 2004-08-04 | 2006-02-16 | Merck Serono Sa | Capsules containing transfected cells, method for preparing the same and uses thereof for immunization and vaccination |
| EP2454373B1 (fr) * | 2009-07-15 | 2014-11-19 | AbbVie Inc. | Augmentation de la production cellulaire par transduction mecanique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988623A (en) * | 1988-06-30 | 1991-01-29 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Rotating bio-reactor cell culture apparatus |
| WO1991011535A1 (fr) * | 1990-01-30 | 1991-08-08 | Childrens Hospital Of Los Angeles | Inhibition de transcription a l'aide d'oligonucleotides bicatenaires |
-
1998
- 1998-04-07 JP JP54098398A patent/JP2001517081A/ja not_active Ceased
- 1998-04-07 IL IL13226498A patent/IL132264A0/xx unknown
- 1998-04-07 AU AU69534/98A patent/AU6953498A/en not_active Abandoned
- 1998-04-07 CA CA002286349A patent/CA2286349A1/fr not_active Abandoned
- 1998-04-07 EP EP98915320A patent/EP0972069A1/fr not_active Withdrawn
- 1998-04-07 WO PCT/US1998/006826 patent/WO1998045468A1/fr not_active Application Discontinuation
- 1998-04-07 BR BR9808510-7A patent/BR9808510A/pt not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010524495A (ja) * | 2007-04-28 | 2010-07-22 | ヒョンジン ヤン， | 粉末状の足場を用いた細胞間の信号調節による細胞培養方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0972069A1 (fr) | 2000-01-19 |
| BR9808510A (pt) | 2000-05-23 |
| WO1998045468A1 (fr) | 1998-10-15 |
| CA2286349A1 (fr) | 1998-10-15 |
| AU6953498A (en) | 1998-10-30 |
| IL132264A0 (en) | 2001-03-19 |
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