JP2001511650A5 - - Google Patents

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Publication number
JP2001511650A5
JP2001511650A5 JP1998535042A JP53504298A JP2001511650A5 JP 2001511650 A5 JP2001511650 A5 JP 2001511650A5 JP 1998535042 A JP1998535042 A JP 1998535042A JP 53504298 A JP53504298 A JP 53504298A JP 2001511650 A5 JP2001511650 A5 JP 2001511650A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP1998535042A
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English (en)
Japanese (ja)
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JP4669968B2 (ja
JP2001511650A (ja
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Priority claimed from US09/021,660 external-priority patent/US6713065B2/en
Publication of JP2001511650A publication Critical patent/JP2001511650A/ja
Publication of JP2001511650A5 publication Critical patent/JP2001511650A5/ja
Application granted granted Critical
Publication of JP4669968B2 publication Critical patent/JP4669968B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53504298A 1997-02-10 1998-02-10 造血及び血管生成の調節方法 Expired - Fee Related JP4669968B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3751397P 1997-02-10 1997-02-10
US60/037,513 1997-02-10
US4976397P 1997-06-16 1997-06-16
US60/049,763 1997-06-16
US09/021,660 US6713065B2 (en) 1997-02-10 1998-02-10 Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
PCT/US1998/002633 WO1998035020A2 (en) 1997-02-10 1998-02-10 Methods for modulating hematopoiesis and vascular growth

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009136272A Division JP2009261956A (ja) 1997-02-10 2009-06-05 造血及び血管生成の調節方法

Publications (3)

Publication Number Publication Date
JP2001511650A JP2001511650A (ja) 2001-08-14
JP2001511650A5 true JP2001511650A5 (enExample) 2005-10-06
JP4669968B2 JP4669968B2 (ja) 2011-04-13

Family

ID=27361699

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53504298A Expired - Fee Related JP4669968B2 (ja) 1997-02-10 1998-02-10 造血及び血管生成の調節方法
JP2009136272A Pending JP2009261956A (ja) 1997-02-10 2009-06-05 造血及び血管生成の調節方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009136272A Pending JP2009261956A (ja) 1997-02-10 2009-06-05 造血及び血管生成の調節方法

Country Status (9)

Country Link
US (3) US6713065B2 (enExample)
EP (1) EP1019490B1 (enExample)
JP (2) JP4669968B2 (enExample)
AT (1) ATE449836T1 (enExample)
CA (1) CA2280736C (enExample)
DE (1) DE69841320D1 (enExample)
DK (1) DK1019490T3 (enExample)
ES (1) ES2339724T3 (enExample)
WO (1) WO1998035020A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841320D1 (de) 1997-02-10 2010-01-07 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
AU8173098A (en) 1997-06-27 1999-01-19 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US7098196B1 (en) 1999-10-13 2006-08-29 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
JP2002524528A (ja) 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
GB9910664D0 (en) * 1999-05-07 1999-07-07 Zeneca Ltd Cells and assay
US6903073B2 (en) * 1999-12-10 2005-06-07 The General Hospital Corporation Methods to stimulate insulin production by pancreatic beta-cells
AU2001243220A1 (en) * 2000-02-23 2001-09-03 Musc Foundation For Research Development Methods of screening for compounds that modulate blood vessel formation
EP1294752A2 (en) * 2000-06-16 2003-03-26 Curis, Inc. Angiogenesis-modulating compositions and uses
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
DK1387674T3 (en) 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
CA2452152A1 (en) 2001-07-02 2002-10-10 Sinan Tas Use of cyclopamine in the treatment of psoriasis
US7828101B2 (en) * 2002-12-03 2010-11-09 Radtke Jeffrey L Self-propelled wheel for bicycles and similar vehicles
EP1639097B1 (en) * 2003-06-25 2013-08-07 Ottawa Health Research Institute Methods and compositions for modulating stem cell growth and differentiation
EP1730280B1 (en) 2004-03-26 2018-10-24 Curis, Inc. Rna interference modulators of hedgehog signaling and uses thereof
JP2007217283A (ja) * 2004-03-30 2007-08-30 Niigata Tlo:Kk 血管新生促進剤および血管新生療法
WO2005113751A1 (en) 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2349332B1 (en) * 2008-11-13 2019-10-23 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation bmp-6
GB201204201D0 (en) * 2012-03-09 2012-04-25 Ucl Business Plc Erythropoiesis

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4811522A (en) * 1987-03-23 1989-03-14 Gill Jr Gerald L Counterbalanced polishing apparatus
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US6271363B1 (en) * 1993-12-30 2001-08-07 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
CA2179029C (en) * 1993-12-30 2009-02-24 Philip W. Ingham Vertebrate embryonic pattern-inducing hedgehog-like proteins
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6566092B1 (en) * 1994-02-25 2003-05-20 The Trustees Of Columbia University In The City Of New York DNA encoding a vertebrate homolog of hedgehog, Vhh-1, expressed by the notochord, and uses thereof
US5681278A (en) * 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US6429354B1 (en) * 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
US6946257B1 (en) * 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto
US6027882A (en) * 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
JP3776454B2 (ja) * 1994-10-07 2006-05-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ パッチド遺伝子及びそれらの使用
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5759811A (en) 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
DE69841320D1 (de) * 1997-02-10 2010-01-07 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US6867216B1 (en) * 1998-04-09 2005-03-15 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signal pathways, compositions and uses related thereto
JP2002524528A (ja) * 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
EP1112087B1 (en) 1998-09-11 2010-02-24 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
DE69939327D1 (de) 1998-11-02 2008-09-25 Curis Inc Funktionelle antagonisten von hedgehog-aktivität
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
AU780358B2 (en) 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
US20050080138A1 (en) * 1999-09-16 2005-04-14 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
WO2001019800A2 (en) 1999-09-16 2001-03-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6552016B1 (en) * 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
AU780612C (en) 1999-10-14 2005-10-20 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE20022471U1 (de) * 2000-01-08 2001-12-06 SensoPart Industriesensorik GmbH, 79695 Wieden Nachrüstgerät für ein Zielfernrohr
DE60113823T3 (de) 2000-03-30 2010-07-01 Curis, Inc., Cambridge Kleine organische moleküle als regulatoren der zellproliferation
US6613798B1 (en) * 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
EP1294752A2 (en) 2000-06-16 2003-03-26 Curis, Inc. Angiogenesis-modulating compositions and uses
JP2002100593A (ja) * 2000-09-21 2002-04-05 Nikon Corp 研磨装置、これを用いた半導体デバイスの製造方法及びこの製造方法により製造された半導体デバイス
DK1387674T3 (en) 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
JP2004534743A (ja) 2001-04-09 2004-11-18 ロランティス リミテッド ヘッジホッグ
EA007339B1 (ru) 2001-07-27 2006-08-25 Кьюэрис, Инк. Медиаторы путей передачи сигналов генами hedgehog, содержащие их композиции и способы применения указанных веществ

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