CA2280736C - Methods for modulating hematopoiesis and vascular growth - Google Patents

Methods for modulating hematopoiesis and vascular growth Download PDF

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Publication number
CA2280736C
CA2280736C CA2280736A CA2280736A CA2280736C CA 2280736 C CA2280736 C CA 2280736C CA 2280736 A CA2280736 A CA 2280736A CA 2280736 A CA2280736 A CA 2280736A CA 2280736 C CA2280736 C CA 2280736C
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hedgehog
compound
protein
cells
use according
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French (fr)
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CA2280736A1 (en
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Margaret H. Baron
Sarah M. Farrington
Maria Belaoussoff
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Harvard University
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Harvard University
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  • Immunology (AREA)
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  • Physics & Mathematics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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CA2280736A 1997-02-10 1998-02-10 Methods for modulating hematopoiesis and vascular growth Expired - Fee Related CA2280736C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3751397P 1997-02-10 1997-02-10
US60/037,513 1997-02-10
US4976397P 1997-06-16 1997-06-16
US60/049,763 1997-06-16
US09/021,660 US6713065B2 (en) 1997-02-10 1998-02-10 Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
PCT/US1998/002633 WO1998035020A2 (en) 1997-02-10 1998-02-10 Methods for modulating hematopoiesis and vascular growth

Publications (2)

Publication Number Publication Date
CA2280736A1 CA2280736A1 (en) 1998-08-13
CA2280736C true CA2280736C (en) 2012-05-29

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CA2280736A Expired - Fee Related CA2280736C (en) 1997-02-10 1998-02-10 Methods for modulating hematopoiesis and vascular growth

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US (3) US6713065B2 (enExample)
EP (1) EP1019490B1 (enExample)
JP (2) JP4669968B2 (enExample)
AT (1) ATE449836T1 (enExample)
CA (1) CA2280736C (enExample)
DE (1) DE69841320D1 (enExample)
DK (1) DK1019490T3 (enExample)
ES (1) ES2339724T3 (enExample)
WO (1) WO1998035020A2 (enExample)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
CA2280736C (en) * 1997-02-10 2012-05-29 The President And Fellows Of Harvard College Methods for modulating hematopoiesis and vascular growth
AU8173098A (en) 1997-06-27 1999-01-19 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP2002524528A (ja) 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
GB9910664D0 (en) * 1999-05-07 1999-07-07 Zeneca Ltd Cells and assay
EP1728797A3 (en) 1999-10-13 2011-03-02 Johns Hopkins University School of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
US6903073B2 (en) * 1999-12-10 2005-06-07 The General Hospital Corporation Methods to stimulate insulin production by pancreatic beta-cells
WO2001063281A1 (en) * 2000-02-23 2001-08-30 Musc Foundation For Research Development Methods of screening for compounds that modulate blood vessel formation
CA2412215A1 (en) * 2000-06-16 2001-12-27 Curis, Inc. Angiogenesis-modulating compositions and uses
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
JP5196700B2 (ja) 2000-10-13 2013-05-15 キュリス，インコーポレイテッド ヘッジホッグアンタゴニスト、それらに関する方法及び利用
EP1411938B1 (en) 2001-07-02 2005-07-06 Tas, Sinan Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
US7828101B2 (en) * 2002-12-03 2010-11-09 Radtke Jeffrey L Self-propelled wheel for bicycles and similar vehicles
ES2433493T3 (es) * 2003-06-25 2013-12-11 Ottawa Hospital Research Institute Métodos y composiciones para modular el crecimiento de células pluripotenciales y la diferenciación
AU2005231692B2 (en) 2004-03-26 2011-01-27 Curis, Inc. RNA interference modulators of Hedgehog signaling and uses thereof
JP2007217283A (ja) * 2004-03-30 2007-08-30 Niigata Tlo:Kk 血管新生促進剤および血管新生療法
EP1756267A2 (en) 2004-05-14 2007-02-28 Becton, Dickinson and Company Stem cell populations and methods of use
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
CA3019967A1 (en) * 2008-11-13 2010-05-20 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation of bmp-6
GB201204201D0 (en) * 2012-03-09 2012-04-25 Ucl Business Plc Erythropoiesis

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4811522A (en) * 1987-03-23 1989-03-14 Gill Jr Gerald L Counterbalanced polishing apparatus
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6384192B1 (en) * 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
WO1995018856A1 (en) * 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
CA2184092A1 (en) * 1994-02-25 1995-08-31 Thomas M. Jessell Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
US5681278A (en) * 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US6027882A (en) * 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
DE69534310T2 (de) * 1994-10-07 2006-04-27 The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto Ptc gene und ihre verwendung
US6946257B1 (en) * 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto
US6429354B1 (en) * 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5759811A (en) 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
CA2280736C (en) 1997-02-10 2012-05-29 The President And Fellows Of Harvard College Methods for modulating hematopoiesis and vascular growth
US6867216B1 (en) * 1998-04-09 2005-03-15 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signal pathways, compositions and uses related thereto
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP2002524528A (ja) 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
CA2343335C (en) * 1998-09-11 2014-05-27 Biogen, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
IL142905A0 (en) 1998-11-02 2002-04-21 Biogen Inc Functional antagonists of hedgehog activity
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
JP2003501395A (ja) 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
US20050080138A1 (en) * 1999-09-16 2005-04-14 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE60017157T2 (de) 1999-09-16 2005-12-22 Curis, Inc., Cambridge Vermittler von igel signalwegen, deren zusammenstellungen und verwendungen
US6552016B1 (en) * 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
EP1227805B2 (en) 1999-10-14 2011-02-23 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE20022471U1 (de) * 2000-01-08 2001-12-06 SensoPart Industriesensorik GmbH, 79695 Wieden Nachrüstgerät für ein Zielfernrohr
US6613798B1 (en) * 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
AU4966401A (en) 2000-03-30 2001-10-15 Curis Inc Small organic molecule regulators of cell proliferation
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
CA2412215A1 (en) 2000-06-16 2001-12-27 Curis, Inc. Angiogenesis-modulating compositions and uses
JP2002100593A (ja) * 2000-09-21 2002-04-05 Nikon Corp 研磨装置、これを用いた半導体デバイスの製造方法及びこの製造方法により製造された半導体デバイス
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
JP5196700B2 (ja) 2000-10-13 2013-05-15 キュリス，インコーポレイテッド ヘッジホッグアンタゴニスト、それらに関する方法及び利用
EP1401469A2 (en) 2001-04-09 2004-03-31 Lorantis Limited Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways
NZ530580A (en) 2001-07-27 2007-02-23 Curis Inc Mediators of hedgehog signaling pathways, compositions and uses related thereto

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