JP2001511463A5 - - Google Patents
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- Publication number
- JP2001511463A5 JP2001511463A5 JP2000504921A JP2000504921A JP2001511463A5 JP 2001511463 A5 JP2001511463 A5 JP 2001511463A5 JP 2000504921 A JP2000504921 A JP 2000504921A JP 2000504921 A JP2000504921 A JP 2000504921A JP 2001511463 A5 JP2001511463 A5 JP 2001511463A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- preventing
- metastatic growth
- reducing metastatic
- surgery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010061289 Metastatic neoplasm Diseases 0.000 description 4
- 230000001394 metastastic Effects 0.000 description 4
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N Taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 description 2
- 229960004267 Taurolidine Drugs 0.000 description 2
- 229950007343 Taurultam Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960002897 Heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000002628 heparin derivative Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 転移性増殖を予防または低減する方法に使用するための医薬の製造におけるタウロリジン、タウルルタムまたはこれらの混合物を包含する溶液の使用。
【請求項２】 外科手術後の転移性増殖を予防または低減するための請求項１記載の使用。
【請求項３】 最小侵襲外科手術後の転移性増殖を予防または低減するための請求項２記載の使用。
【請求項４】 腹腔鏡外科手術中トロカールの使用後の転移性増殖を予防または低減するための請求項２または３記載の使用。
【請求項５】 溶液がタウロリジン０.５〜３重量％またはタウルルタム２〜３重量％を含有している請求項１〜４のいずれか一項記載の使用。
【請求項６】 前記方法が前記医薬をヘパリン、ヘパリン誘導体またはヒアルロン酸と別個にまたは引き続いて投与することからなる請求項１〜５のいずれか一項記載の使用。
【請求項１】 転移性増殖を予防または低減する方法に使用するための医薬の製造におけるタウロリジン、タウルルタムまたはこれらの混合物を包含する溶液の使用。
【請求項２】 外科手術後の転移性増殖を予防または低減するための請求項１記載の使用。
【請求項３】 最小侵襲外科手術後の転移性増殖を予防または低減するための請求項２記載の使用。
【請求項４】 腹腔鏡外科手術中トロカールの使用後の転移性増殖を予防または低減するための請求項２または３記載の使用。
【請求項５】 溶液がタウロリジン０.５〜３重量％またはタウルルタム２〜３重量％を含有している請求項１〜４のいずれか一項記載の使用。
【請求項６】 前記方法が前記医薬をヘパリン、ヘパリン誘導体またはヒアルロン酸と別個にまたは引き続いて投与することからなる請求項１〜５のいずれか一項記載の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9716219.2 | 1997-07-31 | ||
| GBGB9716219.2A GB9716219D0 (en) | 1997-07-31 | 1997-07-31 | Prevention of metastases |
| PCT/GB1998/002311 WO1999006114A2 (en) | 1997-07-31 | 1998-07-31 | Use of taurolidine or taurultam for the manufacture of a medicament for the prevention of metastases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010029152A Division JP2010215615A (ja) | 1997-07-31 | 2010-02-12 | 転移予防のための医薬の製造のためのタウロリジンまたはタウルルタムの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001511463A JP2001511463A (ja) | 2001-08-14 |
| JP2001511463A5 true JP2001511463A5 (ja) | 2006-01-05 |
Family
ID=10816777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000504921A Pending JP2001511463A (ja) | 1997-07-31 | 1998-07-31 | 転移予防のための医薬の製造のためのタウロリジンまたはタウルルタムの使用 |
| JP2010029152A Pending JP2010215615A (ja) | 1997-07-31 | 2010-02-12 | 転移予防のための医薬の製造のためのタウロリジンまたはタウルルタムの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010029152A Pending JP2010215615A (ja) | 1997-07-31 | 2010-02-12 | 転移予防のための医薬の製造のためのタウロリジンまたはタウルルタムの使用 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1001781B1 (ja) |
| JP (2) | JP2001511463A (ja) |
| AT (1) | ATE318141T1 (ja) |
| DE (1) | DE69833554T2 (ja) |
| ES (1) | ES2255172T3 (ja) |
| GB (1) | GB9716219D0 (ja) |
| WO (1) | WO1999006114A2 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9626795D0 (en) | 1996-12-23 | 1997-02-12 | Geistlich Soehne Ag | Combating infection in delivery systems |
| US6479481B1 (en) * | 1999-06-04 | 2002-11-12 | Ed. Geistlich Soehne Ag Fur Chemische Industrie | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) |
| US7132413B1 (en) | 1997-07-31 | 2006-11-07 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Anticoagulant/sterilizing compositions and methods |
| US20030027818A1 (en) * | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
| US8304390B2 (en) | 1997-07-31 | 2012-11-06 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method of treatment for preventing or reducing tumor growth in the liver of patient |
| CA2302720C (en) * | 1999-03-29 | 2009-07-14 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Anticoagulant/sterilizing compositions and methods |
| US7345039B2 (en) | 1999-06-04 | 2008-03-18 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
| US8030301B2 (en) | 1999-06-04 | 2011-10-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
| US7892530B2 (en) | 1999-06-04 | 2011-02-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
| CN100519525C (zh) | 1999-12-06 | 2009-07-29 | 葛兰素集团有限公司 | 芳香砜类及其医疗用途 |
| CA2393159C (en) | 1999-12-06 | 2010-04-20 | Paul Calabresi | Methods of treating tumors |
| US6641571B2 (en) | 2000-01-05 | 2003-11-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Reduction of postoperative complications of cardiopulmonary bypass (CPB) surgery |
| AU779362B2 (en) * | 2000-10-27 | 2005-01-20 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
| CA2363973C (en) * | 2000-11-28 | 2009-03-10 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
| US20030092707A1 (en) * | 2001-10-19 | 2003-05-15 | Redmond H. Paul | Treatment of breast cancer |
| EP1450814B1 (en) * | 2001-10-01 | 2016-11-30 | Geistlich Pharma AG | Methods of inhibiting metastases |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| JP5043294B2 (ja) | 2003-09-29 | 2012-10-10 | エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー | 中皮腫を治療する方法 |
| DE07825069T1 (de) * | 2006-09-07 | 2010-04-08 | Ed Geistlich Söhne Ag Für Chemische Industrie | Verfahren zur behandlung von knochenkrebs |
| CN113226325A (zh) * | 2018-08-31 | 2021-08-06 | 科医公司 | 牛磺罗定对哺乳动物体内表达myc的肿瘤的治疗 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6117A (ja) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | ムコ多糖系癌転移抑制剤 |
| GB9015108D0 (en) * | 1990-07-09 | 1990-08-29 | Geistlich Soehne Ag | Chemical compositions |
| CA2122519C (en) * | 1994-04-29 | 2001-02-20 | Rudolf Edgar Dr. Falk | Cancer treatment and metastasis prevention |
| GB9400163D0 (en) * | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
| DE19606897C2 (de) * | 1996-02-13 | 2002-08-29 | Geistlich Soehne Ag | Mittel zur Verhinderung der Tumorzellverschleppung und der Entstehung von Trokarmetastasen in der offenen und laparoskopischen Chirurgie maligner Tumoren |
-
1997
- 1997-07-31 GB GBGB9716219.2A patent/GB9716219D0/en active Pending
-
1998
- 1998-07-31 ES ES98937635T patent/ES2255172T3/es not_active Expired - Lifetime
- 1998-07-31 WO PCT/GB1998/002311 patent/WO1999006114A2/en active IP Right Grant
- 1998-07-31 JP JP2000504921A patent/JP2001511463A/ja active Pending
- 1998-07-31 AT AT98937635T patent/ATE318141T1/de active
- 1998-07-31 EP EP98937635A patent/EP1001781B1/en not_active Expired - Lifetime
- 1998-07-31 DE DE69833554T patent/DE69833554T2/de not_active Expired - Lifetime
-
2010
- 2010-02-12 JP JP2010029152A patent/JP2010215615A/ja active Pending
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