JP2001511142A - ベクターとして鳥類の感染性喉頭気管炎ウイルスを用いた鳥類用組換え生ワクチン - Google Patents
ベクターとして鳥類の感染性喉頭気管炎ウイルスを用いた鳥類用組換え生ワクチンInfo
- Publication number
- JP2001511142A JP2001511142A JP53258198A JP53258198A JP2001511142A JP 2001511142 A JP2001511142 A JP 2001511142A JP 53258198 A JP53258198 A JP 53258198A JP 53258198 A JP53258198 A JP 53258198A JP 2001511142 A JP2001511142 A JP 2001511142A
- Authority
- JP
- Japan
- Prior art keywords
- virus
- recombinant
- iltv
- sequence
- plasmid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16041—Use of virus, viral particle or viral elements as a vector
- C12N2710/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/816—Viral vaccine for avian species, e.g. poultry or other birds
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 特定のILTV株において配列NO.1のヌクレオチド3873〜4260の間に規定され 且つILTVのORF D終止コドンとORF E終止コドンとの間の遺伝子間領域で形成され る挿入部位に挿入された少なくとも1つの異種塩基配列を含み且つ発現するILTV ウイルスをベクターとして有する鳥類用組換え生ワクチン。 2. 上記の塩基配列が単純に挿入されるか、挿入部位を完全または部分的に欠 失させて挿入されたものである請求項1に記載の組換え生ワクチン。 3. 挿入される塩基配列を発現するためにベクターが強い真核生物プロモータ を有する請求項1または2に記載の組換え生ワクチン。 4. 強いプロモータがCMV即時初期プロモータ、好ましくはネズミまたはヒト のCWV即時初期プロモータ、ラウス肉腫ウイルス(RSV)LTRプロモータ、SV40ウ イルス初期プロモータからなる群の中から選択される請求項3に記載の組換え生 ワクチン。 5. 異なる真核生物のプロモータの制御下で挿入部位に挿入される少なくとも 2つの塩基配列を含む請求項1〜4のいずれか一項に記載の組換え生ワクチン。 6. 真核生物のプロモータが由来の異なる動物のCMV即時初期プロモータであ る請求項5に記載の組換え生ワクチン。 7. CMV即時初期プロモータと他の塩基配列を有する他のプロモータと組み合 された第1の塩基配列を有し、これら2つのプロモータの5'末端が隣接するよう に配置された請求項5に記載の組換え生ワクチン。 8. 一連のプロモータと、IRESによって対になって分離された2つまたはそれ 以上の遺伝子と、ポリアデニレーションシグナルとを有する発現カセットが挿入 部位に挿入された請求項1〜7のいずれか一項に記載の組換え生ワクチン。 9. 鳥類の病原物質の抗原ポリペプチドをコードする塩基配列が挿入部位に挿 入された請求項1〜8のいずれか一項に記載の組換え生ワクチン。 10. ニューカッスル病ウイルス(NDV)、ガンボロ病ウイルス(IBDV)、マレック 病ウイルス(MDV)、感染性気管支炎ウイルス(IBV)、ニワトリの貧血症ウイルス(C AV)、ニワトリの肺炎ウイルスより成る群の中から選択される鳥類の病原物質の 抗原をコードする塩基配列を有する請求項9に記載の組換え生ワクチン。 11. NDVウイルスのポリペプチドFおよびHNをコードする塩基配列から選択さ れる塩基配列を有する請求項10に記載の組換え生ワクチン。 12. MDVウイルスのポリペプチドgB,gC,gDおよびgH+gLをコードする塩基配列 から選択される塩基配列を有する請求項10に記載の組換え生ワクチン。 13. IBDVのVP2抗原、IBVウイルスのSまたはSの一部、MおよびNの抗原、CA VのVP1およびVP2抗原、ニワトリの肺炎ウイルスのGおよびF抗原に対応する配 列より成る群の中から選択される少なくとも1つの塩基配列を有する請求項10に 記載の組換え生ワクチン。 14. 免疫調節性ポリペプチドをコードする塩基配列が挿入部位に挿入された請 求項1〜13に記載の組換え生ワクチン。 15. この塩基配列がサイトカインをコードする配列の群の中から選択される請 求項14に記載の組換え生ワクチン。 16. 互いに異なる配列が挿入された請求項1〜15のいずれか一項に記載の組換 え生ワクチンを混合状態または混合が可能な状態で少なくとも2種類含む多価ワ クチン製剤。 17. 特定のILTV株の配列NO.1のヌクレオチド3873〜4260で規定され且つILTV のORF D終止コドンとORF E終止コドンとの間の遺伝子間領域で形成される挿入部 位に挿入された少なくとも1つの異種塩基配列を有するILTVウイルス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9701317A FR2758986B1 (fr) | 1997-01-31 | 1997-01-31 | Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire |
FR97/01317 | 1997-01-31 | ||
PCT/FR1998/000122 WO1998033928A1 (fr) | 1997-01-31 | 1998-01-23 | Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001511142A true JP2001511142A (ja) | 2001-08-07 |
Family
ID=9503369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53258198A Pending JP2001511142A (ja) | 1997-01-31 | 1998-01-23 | ベクターとして鳥類の感染性喉頭気管炎ウイルスを用いた鳥類用組換え生ワクチン |
Country Status (10)
Country | Link |
---|---|
US (1) | US6306400B1 (ja) |
EP (1) | EP0968297B1 (ja) |
JP (1) | JP2001511142A (ja) |
AR (1) | AR010102A1 (ja) |
AU (1) | AU735265B2 (ja) |
CO (1) | CO4650230A1 (ja) |
FR (1) | FR2758986B1 (ja) |
MA (1) | MA24458A1 (ja) |
TN (1) | TNSN98015A1 (ja) |
WO (1) | WO1998033928A1 (ja) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1026246B1 (en) * | 1997-10-03 | 2006-11-29 | Zeon Corporation | Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same |
AR031405A1 (es) * | 2000-11-21 | 2003-09-24 | Wyeth Corp | Metodos y vacunas para conferir proteccion in ovo contra la rinotraqueitis del pavo |
EP1241177A1 (en) * | 2001-03-15 | 2002-09-18 | Akzo Nobel N.V. | Recombinant infectious laryngotracheitis virus vaccine |
EP2390352A1 (en) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
EP1663302B1 (en) * | 2003-09-03 | 2012-06-13 | Alpharma, LLC | Method for vaccination of poultry by bacteriophage lysate |
ES2417019T3 (es) | 2003-11-13 | 2013-08-05 | University Of Georgia Research Foundation, Inc. | Procedimiento de caracterización del virus de la enfermedad de la bursitis infecciosa |
WO2005112544A2 (en) | 2004-02-19 | 2005-12-01 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
DE602006013117D1 (de) | 2005-04-25 | 2010-05-06 | Merial Ltd | Nipah-virus-impfstoffe |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
US7794714B2 (en) * | 2008-03-14 | 2010-09-14 | The United States Of America As Represented By The Secretary Of Agriculture | Newcastle disease virus monoclonal antibodies |
MX2011010406A (es) | 2009-04-03 | 2012-01-20 | Merial Ltd | Vacunas aviares vectorizadas con el virus de la emfermedad de newcastle. |
PE20121685A1 (es) | 2009-12-28 | 2012-12-28 | Merial Ltd | Antigeno ndv recombinante y usos del mismo |
EP3156070A3 (en) | 2010-08-31 | 2017-06-14 | Merial Inc. | Newcastle disease virus vectored herpesvirus vaccines |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
EP2694678A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
US20140296248A1 (en) | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
WO2012145577A1 (en) | 2011-04-20 | 2012-10-26 | Merial Limited | Adjuvanted rabies vaccine with improved viscosity profile |
EP2701736A1 (en) | 2011-04-25 | 2014-03-05 | Advanced Bioscience Laboratories, Inc. | Truncated hiv envelope proteins (env), methods and compositions related thereto |
ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
LT2741740T (lt) | 2011-08-12 | 2017-08-10 | Merial, Inc. | Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
US9556419B2 (en) | 2013-03-12 | 2017-01-31 | Merial Inc. | Reverse genetics Schmallenberg virus vaccine compositions, and methods of use thereof |
CN104164408B (zh) * | 2013-05-15 | 2016-12-28 | 普莱柯生物工程股份有限公司 | 抗鸡新城疫、传染性支气管炎和禽流感疫苗组合物及制备 |
AU2015343369B2 (en) | 2014-11-03 | 2018-11-22 | Georgia Tech Research Corporation | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
BR112017027895A2 (pt) | 2015-06-23 | 2018-11-06 | Merial Inc | vetores virais recombinantes contendo proteínas menores de prrsv e métodos de fabricação e utilização destes |
PL3554536T3 (pl) | 2016-12-14 | 2023-03-06 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory hvt wyrażające wiele antygenów patogenów ptasich oraz szczepionki je zawierające |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992003554A1 (en) * | 1990-08-24 | 1992-03-05 | Arthur Webster Pty. Ltd. | Infectious laryngotracheitis virus vaccine |
AU2946395A (en) * | 1994-06-30 | 1996-01-25 | Board of Regents of the University of Illinois, The | Recombinant infectious laryngotracheitis virus and vaccine |
FR2728795B1 (fr) * | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
-
1997
- 1997-01-31 FR FR9701317A patent/FR2758986B1/fr not_active Expired - Lifetime
-
1998
- 1998-01-13 AR ARP980100145A patent/AR010102A1/es unknown
- 1998-01-19 CO CO98001954A patent/CO4650230A1/es unknown
- 1998-01-23 EP EP98904207A patent/EP0968297B1/fr not_active Expired - Lifetime
- 1998-01-23 AU AU62177/98A patent/AU735265B2/en not_active Expired
- 1998-01-23 JP JP53258198A patent/JP2001511142A/ja active Pending
- 1998-01-23 MA MA24942A patent/MA24458A1/fr unknown
- 1998-01-23 WO PCT/FR1998/000122 patent/WO1998033928A1/fr active IP Right Grant
- 1998-01-27 TN TNTNSN98015A patent/TNSN98015A1/fr unknown
-
1999
- 1999-07-28 US US09/362,831 patent/US6306400B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0968297B1 (fr) | 2005-03-23 |
AU735265B2 (en) | 2001-07-05 |
CO4650230A1 (es) | 1998-09-03 |
FR2758986A1 (fr) | 1998-08-07 |
EP0968297A1 (fr) | 2000-01-05 |
AR010102A1 (es) | 2000-05-17 |
MA24458A1 (fr) | 1998-10-01 |
TNSN98015A1 (fr) | 2005-03-15 |
WO1998033928A1 (fr) | 1998-08-06 |
FR2758986B1 (fr) | 1999-04-30 |
US6306400B1 (en) | 2001-10-23 |
AU6217798A (en) | 1998-08-25 |
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