JP2001509679A - レセプターをコードするポリヌクレオチドとポリペプチド - Google Patents
レセプターをコードするポリヌクレオチドとポリペプチドInfo
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- JP2001509679A JP2001509679A JP53460298A JP53460298A JP2001509679A JP 2001509679 A JP2001509679 A JP 2001509679A JP 53460298 A JP53460298 A JP 53460298A JP 53460298 A JP53460298 A JP 53460298A JP 2001509679 A JP2001509679 A JP 2001509679A
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- polypeptide
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US60/034,205 | 1997-08-05 | ||
| PCT/US1998/000959 WO1998031799A2 (en) | 1997-01-21 | 1998-01-21 | Polynucleotides and polypeptides encoding receptors |
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| JP2001509679A true JP2001509679A (ja) | 2001-07-24 |
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Cited By (1)
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| JP2014114292A (ja) * | 2007-04-11 | 2014-06-26 | Gene Signal Int Sa | 抗腫瘍薬、医薬品、組成物、及びその使用 |
Families Citing this family (61)
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| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| CA2278118A1 (en) * | 1997-01-21 | 1998-07-23 | Human Genome Sciences, Inc. | Polynucleotides and polypeptides encoding receptors |
| US6605699B1 (en) | 1997-01-21 | 2003-08-12 | Human Genome Sciences, Inc. | Galectin-11 polypeptides |
| US20030185830A1 (en) | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6818751B1 (en) | 1997-08-01 | 2004-11-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6759515B1 (en) | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7033827B2 (en) | 1997-02-25 | 2006-04-25 | Corixa Corporation | Prostate-specific polynucleotide compositions |
| US6894146B1 (en) | 1997-02-25 | 2005-05-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7202342B1 (en) | 1999-11-12 | 2007-04-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6329505B1 (en) | 1997-02-25 | 2001-12-11 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| US6613872B1 (en) | 1997-02-25 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6395278B1 (en) | 1997-02-25 | 2002-05-28 | Corixa Corporation | Prostate specific fusion protein compositions |
| US6800746B2 (en) | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6261562B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6630305B1 (en) | 1999-11-12 | 2003-10-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6620922B1 (en) | 1997-02-25 | 2003-09-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6943236B2 (en) | 1997-02-25 | 2005-09-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| EP1005546A2 (en) | 1997-02-25 | 2000-06-07 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US7517952B1 (en) | 1997-02-25 | 2009-04-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6146845A (en) * | 1997-04-02 | 2000-11-14 | Smithkline Beecham Corporation | Polynucleotides encoding a sialoadhesin family member-2 (SAF-2) |
| US6485933B1 (en) | 1997-05-07 | 2002-11-26 | Incyte Genomics, Inc. | B cell receptor associated proteins |
| EP0879880A1 (en) * | 1997-05-22 | 1998-11-25 | Smithkline Beecham Corporation | ATG-1117 (AIF-3), a homolog of allograft inflammatory factor-1/RC-9 |
| US5849528A (en) * | 1997-08-21 | 1998-12-15 | Incyte Pharmaceuticals, Inc.. | Polynucleotides encoding a human S100 protein |
| CA2218199A1 (en) * | 1997-12-09 | 1999-06-09 | Mcgill University | Short gcg expansions in the pab ii gene for oculopharyngeal muscular dystrophy and diagnostic thereof |
| AU4969599A (en) * | 1998-07-06 | 2000-01-24 | Human Genome Sciences, Inc. | Galectin 11 |
| US6168920B1 (en) | 1998-08-10 | 2001-01-02 | Incyte Genomics, Inc. | Extracellular adhesive proteins |
| US7538086B2 (en) * | 1998-09-01 | 2009-05-26 | Genentech, Inc. | PRO1303 polypeptides |
| NZ510464A (en) * | 1998-09-01 | 2004-05-28 | Genentech Inc | Further pro polypeptides and sequences thereof |
| AU2985200A (en) * | 1999-02-03 | 2000-08-25 | Immunex Corporation | Novel sialoadhesins |
| CA2371611A1 (en) * | 1999-04-21 | 2000-10-26 | Jian Ni | Galectin 11 |
| DE60042799D1 (de) * | 1999-06-09 | 2009-10-01 | Genentech Inc | Methoden zur Diagnose von Tumoren |
| AU2883700A (en) * | 1999-06-23 | 2001-01-09 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6960651B2 (en) | 1999-06-29 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | TANGO 332 polypeptides |
| EP1194534A4 (en) * | 1999-06-29 | 2004-03-24 | Millennium Pharm Inc | NOVEL GENES ENCODING PROTEINS THAT CAN BE USED IN DIAGNOSTIC, PREVENTIVE, THERAPEUTIC OR OTHER AREAS |
| US6914132B1 (en) | 1999-06-30 | 2005-07-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6509448B2 (en) | 1999-06-30 | 2003-01-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6686447B1 (en) | 1999-06-30 | 2004-02-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6667154B1 (en) * | 1999-06-30 | 2003-12-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6858204B2 (en) | 1999-06-30 | 2005-02-22 | Corxia Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030125245A1 (en) | 1999-06-30 | 2003-07-03 | Tongtong Wang | Compositions and methods for therapy and diagnosis of lung cancer |
| NZ516381A (en) | 1999-06-30 | 2004-03-26 | Corixa Corp | Lung tumor proteins in the therapy and diagnosis of lung cancer |
| US6504010B1 (en) | 1999-06-30 | 2003-01-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| WO2001002564A1 (fr) * | 1999-06-30 | 2001-01-11 | Takeda Chemical Industries, Ltd. | Nouveau polypeptide et adn de ce polypeptide |
| US6746846B1 (en) | 1999-06-30 | 2004-06-08 | Corixa Corporation | Methods for diagnosing lung cancer |
| US20030211510A1 (en) | 1999-06-30 | 2003-11-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| DE60129210T2 (de) | 2000-02-29 | 2008-03-20 | Mitsubishi Pharma Corp. | Zyklische amid-derivate |
| EP1267907A1 (en) * | 2000-03-23 | 2003-01-02 | Akzo Nobel N.V. | Use of mia in immunotherapy |
| WO2001096399A2 (en) * | 2000-06-15 | 2001-12-20 | Curagen Corporation | Novel interferon-induced tetraspan protein and nucleic acids encoding same |
| US20040081972A1 (en) * | 2000-08-01 | 2004-04-29 | Mitsuo Satoh | Novel physiologically active peptide and use thereof |
| US7048931B1 (en) | 2000-11-09 | 2006-05-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| CN1373218A (zh) * | 2001-02-28 | 2002-10-09 | 中国医学科学院阜外心血管病医院 | 炎性抑制因子Fwa116 |
| WO2006007202A2 (en) * | 2004-05-28 | 2006-01-19 | Idexx Laboratories, Inc | Canine cd20 compositions |
| US7495073B2 (en) * | 2005-03-24 | 2009-02-24 | Asia Hepato Gene Company | Short isoform of Annexin A10 at chromosome 4q, termed Annexin 10s (ANXA10s) and methods of use |
| EP1980571B1 (en) * | 2007-04-11 | 2010-10-13 | Gene Signal International Sa | Anti-tumor drug, medicament, composition, and use thereof |
| US8372810B2 (en) * | 2007-04-11 | 2013-02-12 | Gene Signal International Sa | Anti-tumor drug, medicament, composition, and use thereof |
| TWI387750B (zh) * | 2009-02-10 | 2013-03-01 | Nat Defense Medical Ct | Biomarker and detection method for detecting kidney disease |
| EP2496604B1 (en) * | 2009-11-06 | 2017-08-23 | IDEXX Laboratories, Inc. | Canine anti-cd20 antibodies |
| US8637642B2 (en) | 2010-09-29 | 2014-01-28 | Seattle Genetics, Inc. | Antibody drug conjugates (ADC) that bind to 191P4D12 proteins |
| US20150301068A1 (en) * | 2012-01-30 | 2015-10-22 | Vib Vzw | Means and method for diagnosis and treatment of alzheimer's disease |
| AU2019392090A1 (en) | 2018-12-03 | 2021-06-17 | Agensys, Inc. | Pharmaceutical compositions comprising anti-191P4D12 antibody drug conjugates and methods of use thereof |
Family Cites Families (16)
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|---|---|---|---|---|
| DE3789413T2 (de) * | 1986-10-03 | 1994-07-28 | Ciba Geigy Ag | Lymphokin-ähnliche Peptide. |
| US5011912A (en) * | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| FR2636953B1 (fr) * | 1988-09-26 | 1990-12-14 | Roussy Inst Gustave | Nouveaux polypeptides produits par des lymphocytes humains, genes codant pour ces polypeptides et applications pharmaceutiques et biologiques |
| US5580753A (en) * | 1989-05-23 | 1996-12-03 | Ludwig Institute For Cancer Research | DNA encoding the human cytokine, interleukin-9 |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| SG66214A1 (en) * | 1990-09-05 | 1999-07-20 | Heart Research Inst Ltd | Novel chemotactic factor |
| US5536637A (en) * | 1993-04-07 | 1996-07-16 | Genetics Institute, Inc. | Method of screening for cDNA encoding novel secreted mammalian proteins in yeast |
| US5770366A (en) * | 1993-07-20 | 1998-06-23 | Boehringer Mannheim Gmbh | Melanoma-inhibiting protein |
| US5527884A (en) * | 1993-12-21 | 1996-06-18 | President And Fellows Of Harvard College | Mediators of chronic allograft rejection and DNA molecules encoding them |
| NZ301067A (en) * | 1994-12-06 | 1998-03-25 | Immunex Corp | Cytokine designated lerk-7 for activating tyrosine kinases |
| WO1997004122A1 (en) * | 1995-07-20 | 1997-02-06 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
| CA2278118A1 (en) * | 1997-01-21 | 1998-07-23 | Human Genome Sciences, Inc. | Polynucleotides and polypeptides encoding receptors |
| US6020478A (en) * | 1997-02-28 | 2000-02-01 | Incyte Pharmaceuticals, Inc. | Human tumor-associated antigen |
| US5849528A (en) | 1997-08-21 | 1998-12-15 | Incyte Pharmaceuticals, Inc.. | Polynucleotides encoding a human S100 protein |
| US6168920B1 (en) * | 1998-08-10 | 2001-01-02 | Incyte Genomics, Inc. | Extracellular adhesive proteins |
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1998
- 1998-01-21 CA CA002278118A patent/CA2278118A1/en not_active Abandoned
- 1998-01-21 US US09/010,147 patent/US6653445B1/en not_active Expired - Fee Related
- 1998-01-21 EP EP98902623A patent/EP0972022A2/en not_active Withdrawn
- 1998-01-21 JP JP53460298A patent/JP2001509679A/ja not_active Withdrawn
- 1998-01-21 EP EP98903557A patent/EP1007663A2/en not_active Withdrawn
- 1998-01-21 CA CA002278248A patent/CA2278248A1/en not_active Abandoned
- 1998-01-21 WO PCT/US1998/000959 patent/WO1998031799A2/en not_active Ceased
- 1998-01-21 WO PCT/US1998/000960 patent/WO1998031800A2/en not_active Ceased
- 1998-01-21 AU AU60303/98A patent/AU6030398A/en not_active Abandoned
- 1998-01-21 AU AU59233/98A patent/AU5923398A/en not_active Abandoned
- 1998-01-21 JP JP53460398A patent/JP2001509029A/ja not_active Withdrawn
-
2002
- 2002-05-29 US US10/156,136 patent/US20030129696A1/en not_active Abandoned
- 2002-12-10 US US10/314,942 patent/US7098316B2/en not_active Expired - Fee Related
-
2005
- 2005-01-25 US US11/041,419 patent/US20050176044A1/en not_active Abandoned
-
2006
- 2006-07-25 US US11/459,845 patent/US20070004008A1/en not_active Abandoned
-
2007
- 2007-08-01 US US11/832,019 patent/US20080058247A1/en not_active Abandoned
-
2009
- 2009-04-29 US US12/431,986 patent/US20090208969A1/en not_active Abandoned
-
2010
- 2010-11-23 US US12/952,967 patent/US20110151473A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014114292A (ja) * | 2007-04-11 | 2014-06-26 | Gene Signal Int Sa | 抗腫瘍薬、医薬品、組成物、及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001509029A (ja) | 2001-07-10 |
| EP1007663A2 (en) | 2000-06-14 |
| US20070004008A1 (en) | 2007-01-04 |
| US20050119457A1 (en) | 2005-06-02 |
| AU6030398A (en) | 1998-08-07 |
| US20050176044A1 (en) | 2005-08-11 |
| CA2278118A1 (en) | 1998-07-23 |
| US6653445B1 (en) | 2003-11-25 |
| WO1998031799A2 (en) | 1998-07-23 |
| US20030129696A1 (en) | 2003-07-10 |
| US20080058247A1 (en) | 2008-03-06 |
| WO1998031800A2 (en) | 1998-07-23 |
| US20110151473A1 (en) | 2011-06-23 |
| AU5923398A (en) | 1998-08-07 |
| EP0972022A2 (en) | 2000-01-19 |
| CA2278248A1 (en) | 1998-07-23 |
| US20090208969A1 (en) | 2009-08-20 |
| US7098316B2 (en) | 2006-08-29 |
| WO1998031800A3 (en) | 1998-11-26 |
| WO1998031799A3 (en) | 1998-11-05 |
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