JP2001505917A - 脊椎動物肝臓組織由来の生物材料 - Google Patents
脊椎動物肝臓組織由来の生物材料Info
- Publication number
- JP2001505917A JP2001505917A JP52694998A JP52694998A JP2001505917A JP 2001505917 A JP2001505917 A JP 2001505917A JP 52694998 A JP52694998 A JP 52694998A JP 52694998 A JP52694998 A JP 52694998A JP 2001505917 A JP2001505917 A JP 2001505917A
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- Prior art keywords
- tissue
- liver
- composition
- basement membrane
- warm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.温血脊椎動物の肝臓基底膜から成り、前記肝臓基底膜が前記温血脊椎動物の 細胞を実質的に含まない組成物。 2.前記肝臓基底膜が流動状である請求項1記載の組成物。 3.前記肝臓基底膜が乾燥していて粉体状である請求項1記載の組成物。 4.温血脊椎動物の肝臓組織から調製された組成物であって、温血脊椎動物に移 植されたときに内因性組織の増殖を誘発することができる非免疫原性組織移植片 として有用であり、前記肝臓組織と共生する内因性細胞を欠く肝臓基底膜から本 質的に成る細胞外基質を含んで成る組成物。 5.損傷または病変組織の修復に利用するための非免疫原生組織移植片組成物を 調製するための肝臓基底膜の利用。 6.温血脊椎動物における内因性組織の増殖が必要な部位で内因性組織の形成を 誘発させる方法であって、移植片組成物が施される部位の内因性組織の増殖を効 果的に誘発する量の温血脊椎動物の肝臓組織基底膜から本質的に成る細胞外基質 を含む移植片組成物を移植することから成る方法。 7.前記移植片組成物が流動化されていて、かつ注入によって前記温血脊椎動物 内に施される請求項6記載の方法。 8.前記組成物を前記温血脊椎動物内に外科的に移植することによって前記移植 片組成物が施される請求項6記載の方法。 9.細胞および細胞外要素の両方を有する温血脊椎動物肝組織由来組織移植片組 成物を調製する方法であって、細胞外組織を実質的に崩壊させることなく前記細 胞外要素から前記肝臓組織の細胞要素を解離させるのに十分な時間細胞解離溶液 で前記肝臓組織を処理する段階と、前記細胞要素を前記細胞外要素から分離する 段階、とから成る方法。 10.前記細胞解離溶液がカオトロピック剤を含む請求項9記載の方法。 11.前記細胞解離溶液がプロテアーゼを含む請求項9記載の方法。 12.前記細胞解離溶液がEDTAおよびトリプシンを含む請求項9記載の方法。 13.前記肝臓組織が前記細胞解離溶液で処理される前にシート状またはストリ ップ状にスライスされる請求項9記載の方法。 14.前記肝臓組織が約500μまでの厚さを有するシート状またはストリップ状 にスライスされる請求項13記載の方法。 15.細胞集団の増殖を支持するための肝臓組織由来組成物であって、供給源肝 臓組織の内因性細胞を欠く分離肝臓基底膜と、前記細胞集団の増殖をインビトロ で支持するための添加栄養素、とから成る組成物。 16.細胞集団の増殖を支持するための肝臓組織由来組成物であって、供給源肝 臓組織内因性細胞を欠く肝臓基底膜を含む基質で被覆された培養物から成る組成 物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3268096P | 1996-12-10 | 1996-12-10 | |
US60/032,680 | 1996-12-10 | ||
PCT/US1997/022727 WO1998025637A1 (en) | 1996-12-10 | 1997-12-10 | Biomaterial derived from vertebrate liver tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001505917A true JP2001505917A (ja) | 2001-05-08 |
JP4638562B2 JP4638562B2 (ja) | 2011-02-23 |
Family
ID=21866250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52694998A Expired - Fee Related JP4638562B2 (ja) | 1996-12-10 | 1997-12-10 | 脊椎動物肝臓組織由来の生物材料 |
Country Status (8)
Country | Link |
---|---|
US (4) | US6379710B1 (ja) |
EP (1) | EP0942739B1 (ja) |
JP (1) | JP4638562B2 (ja) |
AU (1) | AU732726B2 (ja) |
CA (1) | CA2274033C (ja) |
DK (1) | DK0942739T3 (ja) |
ES (1) | ES2263185T3 (ja) |
WO (1) | WO1998025637A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016508369A (ja) * | 2013-02-08 | 2016-03-22 | シャンハイ インスティチューツ フォー バイオロジカル サイエンシーズ、 チャイニーズ アカデミー オブ サイエンシーズ | ヒト肝細胞様細胞およびその使用 |
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