JP2001504344A5 - - Google Patents

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Publication number
JP2001504344A5
JP2001504344A5 JP1998523257A JP52325798A JP2001504344A5 JP 2001504344 A5 JP2001504344 A5 JP 2001504344A5 JP 1998523257 A JP1998523257 A JP 1998523257A JP 52325798 A JP52325798 A JP 52325798A JP 2001504344 A5 JP2001504344 A5 JP 2001504344A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998523257A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001504344A (ja
Filing date
Publication date
Priority claimed from FR9613990A external-priority patent/FR2755976B1/fr
Application filed filed Critical
Publication of JP2001504344A publication Critical patent/JP2001504344A/ja
Publication of JP2001504344A5 publication Critical patent/JP2001504344A5/ja
Ceased legal-status Critical Current

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JP52325798A 1996-11-15 1997-11-10 核酸のトランスフェクションのための、細胞膜の脱安定化を引き起こす残基を有する新規なポリマー性複合体 Ceased JP2001504344A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9613990A FR2755976B1 (fr) 1996-11-15 1996-11-15 Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
FR96/13990 1996-11-15
PCT/FR1997/002022 WO1998022610A1 (fr) 1996-11-15 1997-11-10 Nouveaux complexes polymeriques pour la transfection d'acides nucleiques, avec des residus destabilisant des membranes cellulaires

Publications (2)

Publication Number Publication Date
JP2001504344A JP2001504344A (ja) 2001-04-03
JP2001504344A5 true JP2001504344A5 (enExample) 2005-03-10

Family

ID=9497684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52325798A Ceased JP2001504344A (ja) 1996-11-15 1997-11-10 核酸のトランスフェクションのための、細胞膜の脱安定化を引き起こす残基を有する新規なポリマー性複合体

Country Status (11)

Country Link
US (1) US6372499B1 (enExample)
EP (1) EP0946744B1 (enExample)
JP (1) JP2001504344A (enExample)
AT (1) ATE274066T1 (enExample)
AU (1) AU742818B2 (enExample)
CA (1) CA2267833A1 (enExample)
DE (1) DE69730348T2 (enExample)
ES (1) ES2225992T3 (enExample)
FR (1) FR2755976B1 (enExample)
IL (1) IL128912A (enExample)
WO (1) WO1998022610A1 (enExample)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
CA2348823A1 (en) * 1998-12-02 2000-06-08 I.D.M. Immuno-Designed Molecules New oligomeric conjugates liable to transfer biological molecules into cells
AU7352200A (en) * 1999-09-01 2001-03-26 Regents Of The University Of California, The Novel natriuretic peptide receptors, interacting compounds and methods of regulating proliferation and/or survival of neurons
US7070807B2 (en) 1999-12-29 2006-07-04 Mixson A James Branched histidine copolymers and methods for using same
EP1242052A4 (en) * 1999-12-29 2003-07-02 A James Mixson HISTIDIN COPOLYMER AND METHODS OF USE THEREOF
CA2797652C (en) * 2000-07-21 2016-03-08 Revance Therapeutics, Inc. Multi-component biological transport systems
FR2812658B1 (fr) * 2000-08-01 2005-04-15 De Bruno Vandiere Procede d'analyse d'acides nucleiques
US7465708B2 (en) 2002-11-25 2008-12-16 Mixson A James Branched cationic copolymers and methods for antimicrobial use
AU2005251676B2 (en) 2004-03-03 2011-09-29 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
US20060040879A1 (en) * 2004-08-21 2006-02-23 Kosak Kenneth M Chloroquine coupled nucleic acids and methods for their synthesis
CN101052383B (zh) 2004-09-17 2013-01-30 马萨诸塞大学 用于溶酶体酶缺乏症的组合物和其用途
US20060094104A1 (en) * 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
US20060211004A1 (en) 2005-02-15 2006-09-21 Ilsley Diane D Methods and compositions for determining non-specific cytotoxicity of a transfection agent
BRPI0608249A2 (pt) 2005-03-03 2009-12-08 Revance Therapeutics Inc formulação, método para aplicação tópica e kit para distribuição transdérmica de toxina botulìnica
WO2007050643A2 (en) * 2005-10-24 2007-05-03 University Of Massachusetts Compositions and their uses for gene therapy of bone conditions
JP2011517279A (ja) * 2007-10-29 2011-06-02 ユニバーシティ オブ マサチューセッツ 核酸(siRNA)送達用の酵母細胞壁粒子(YCWP)多層状ナノ粒子
FR2928373B1 (fr) * 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
CN108165548B (zh) 2008-09-22 2022-10-14 菲奥医药公司 减小大小的自递送RNAi化合物
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
WO2012115772A2 (en) 2011-02-25 2012-08-30 Medtronic, Inc. Therapy for kidney disease and/or heart failure
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US9162191B2 (en) * 2012-11-15 2015-10-20 Board Of Trustees Of The University Of Alabama Imidazole-containing polymer membranes and methods of use
CN102949729B (zh) * 2012-11-20 2014-06-18 中国科学院宁波材料技术与工程研究所 主动靶向型小干扰核糖核酸输送载体及其制备方法
AR122446A1 (es) * 2020-04-29 2022-09-14 Medimmune Llc Composiciones y métodos para suministrar agentes farmacéuticamente activos
WO2022189361A1 (en) * 2021-03-08 2022-09-15 Universiteit Gent Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1316990A (en) * 1970-09-17 1973-05-16 Roche Products Ltd Imidazolyl derivatives
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
ES2090049T3 (es) * 1989-03-16 1996-10-16 Boehringer Ingelheim Int Unidades geneticas para la inhibicion de la funcion de arn.
WO1992011037A2 (en) * 1990-12-19 1992-07-09 Advanced Magnetics Inc. Targeting of therapeutic agents using polysaccharides
DE4104186A1 (de) * 1991-02-12 1992-08-13 Genentech Inc Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
WO1993009176A2 (en) * 1991-10-29 1993-05-13 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
DK0636028T3 (da) * 1992-04-03 2004-07-12 Univ California Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid
FR2719316B1 (fr) * 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
US5733762A (en) * 1994-04-28 1998-03-31 I.D.M. Immuno-Designed Molecules Complexes of nucleic acid and polymer, their process of preparation and their use for the transfection of cells
US6030941A (en) * 1996-05-01 2000-02-29 Avi Biopharma, Inc. Polymer composition for delivering substances in living organisms

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