IL128912A - Complexes of nucleic acids with polymers substituted by residues which enable transfection of cells - Google Patents
Complexes of nucleic acids with polymers substituted by residues which enable transfection of cellsInfo
- Publication number
- IL128912A IL128912A IL128912A IL12891297A IL128912A IL 128912 A IL128912 A IL 128912A IL 128912 A IL128912 A IL 128912A IL 12891297 A IL12891297 A IL 12891297A IL 128912 A IL128912 A IL 128912A
- Authority
- IL
- Israel
- Prior art keywords
- residues
- cells
- free
- substituted
- polylysine
- Prior art date
Links
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Substances O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
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- 230000028993 immune response Effects 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
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- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
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- 150000002772 monosaccharides Chemical group 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
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- 210000000822 natural killer cell Anatomy 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 229920002851 polycationic polymer Polymers 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 238000002165 resonance energy transfer Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9613990A FR2755976B1 (fr) | 1996-11-15 | 1996-11-15 | Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires |
| PCT/FR1997/002022 WO1998022610A1 (fr) | 1996-11-15 | 1997-11-10 | Nouveaux complexes polymeriques pour la transfection d'acides nucleiques, avec des residus destabilisant des membranes cellulaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL128912A0 IL128912A0 (en) | 2000-02-17 |
| IL128912A true IL128912A (en) | 2006-06-11 |
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ID=9497684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL128912A IL128912A (en) | 1996-11-15 | 1997-11-10 | Complexes of nucleic acids with polymers substituted by residues which enable transfection of cells |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6372499B1 (enExample) |
| EP (1) | EP0946744B1 (enExample) |
| JP (1) | JP2001504344A (enExample) |
| AT (1) | ATE274066T1 (enExample) |
| AU (1) | AU742818B2 (enExample) |
| CA (1) | CA2267833A1 (enExample) |
| DE (1) | DE69730348T2 (enExample) |
| ES (1) | ES2225992T3 (enExample) |
| FR (1) | FR2755976B1 (enExample) |
| IL (1) | IL128912A (enExample) |
| WO (1) | WO1998022610A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| ES2213397T3 (es) * | 1998-12-02 | 2004-08-16 | I.D.M. Immuno-Designed Molecules | Nuevos conjugados oligomericos capaces de transferir moleculas biologicas a las celulas. |
| WO2001016295A1 (en) * | 1999-09-01 | 2001-03-08 | The Regents Of The University Of California | Novel natriuretic peptide receptors, interacting compounds and methods of regulating proliferation and/or survival of neurons |
| US7070807B2 (en) * | 1999-12-29 | 2006-07-04 | Mixson A James | Branched histidine copolymers and methods for using same |
| CA2394758A1 (en) * | 1999-12-29 | 2001-07-05 | A. James Mixson | Histidine-containing copolymers enhance pharmaceutical agent delivery |
| DK1301213T3 (en) * | 2000-07-21 | 2017-03-27 | Revance Therapeutics Inc | MULTI-COMPONENT SYSTEMS FOR BIOLOGICAL TRANSPORT |
| FR2812658B1 (fr) * | 2000-08-01 | 2005-04-15 | De Bruno Vandiere | Procede d'analyse d'acides nucleiques |
| US7465708B2 (en) | 2002-11-25 | 2008-12-16 | Mixson A James | Branched cationic copolymers and methods for antimicrobial use |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| BRPI0508440A (pt) | 2004-03-03 | 2007-07-24 | Revance Therapeutics Inc | composições e métodos para diagnóstico tópico e transporte terapêutico |
| US7740861B2 (en) * | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| US20060040879A1 (en) * | 2004-08-21 | 2006-02-23 | Kosak Kenneth M | Chloroquine coupled nucleic acids and methods for their synthesis |
| AU2005284727A1 (en) * | 2004-09-17 | 2006-03-23 | University Of Massachusetts | Compositions and their uses for lysosomal enzyme deficiencies |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| US20060211004A1 (en) | 2005-02-15 | 2006-09-21 | Ilsley Diane D | Methods and compositions for determining non-specific cytotoxicity of a transfection agent |
| KR20070110402A (ko) | 2005-03-03 | 2007-11-16 | 레반스 테라퓨틱스 | 보툴리눔 독소의 국소 적용 및 경피 전달을 위한 조성물 및방법 |
| AU2006306228A1 (en) * | 2005-10-24 | 2007-05-03 | University Of Massachusetts | Compositions and their uses for gene therapy of bone conditions |
| US8389485B2 (en) * | 2007-10-29 | 2013-03-05 | University Of Massachusetts | Encapsulated nanoparticles for nucleic acid delivery |
| FR2928373B1 (fr) * | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
| US8815818B2 (en) | 2008-07-18 | 2014-08-26 | Rxi Pharmaceuticals Corporation | Phagocytic cell delivery of RNAI |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
| EP2678002A2 (en) | 2011-02-25 | 2014-01-01 | Medtronic, Inc. | Therapy for kidney disease and/or heart failure |
| EP2750697A4 (en) | 2011-09-02 | 2015-03-25 | Medtronic Inc | CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| US9162191B2 (en) * | 2012-11-15 | 2015-10-20 | Board Of Trustees Of The University Of Alabama | Imidazole-containing polymer membranes and methods of use |
| CN102949729B (zh) * | 2012-11-20 | 2014-06-18 | 中国科学院宁波材料技术与工程研究所 | 主动靶向型小干扰核糖核酸输送载体及其制备方法 |
| JP7167059B2 (ja) | 2017-04-19 | 2022-11-08 | フィオ ファーマシューティカルズ コーポレーション | 核酸化合物の局所送達 |
| AR122446A1 (es) * | 2020-04-29 | 2022-09-14 | Medimmune Llc | Composiciones y métodos para suministrar agentes farmacéuticamente activos |
| WO2022189361A1 (en) * | 2021-03-08 | 2022-09-15 | Universiteit Gent | Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1316990A (en) * | 1970-09-17 | 1973-05-16 | Roche Products Ltd | Imidazolyl derivatives |
| US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
| US5354844A (en) * | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| ES2090049T3 (es) * | 1989-03-16 | 1996-10-16 | Boehringer Ingelheim Int | Unidades geneticas para la inhibicion de la funcion de arn. |
| CA2097589C (en) * | 1990-12-19 | 1998-05-05 | Lee Josephson | Targeting of therapeutic agents using polysaccharides |
| DE4104186A1 (de) * | 1991-02-12 | 1992-08-13 | Genentech Inc | Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe |
| WO1993009176A2 (en) * | 1991-10-29 | 1993-05-13 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| AU682308C (en) * | 1992-04-03 | 2006-08-17 | Regents Of The University Of California, The | Self-assembling polynucleotide delivery system |
| FR2719316B1 (fr) * | 1994-04-28 | 1996-05-31 | Idm | Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules. |
| US5733762A (en) * | 1994-04-28 | 1998-03-31 | I.D.M. Immuno-Designed Molecules | Complexes of nucleic acid and polymer, their process of preparation and their use for the transfection of cells |
| US6030941A (en) * | 1996-05-01 | 2000-02-29 | Avi Biopharma, Inc. | Polymer composition for delivering substances in living organisms |
-
1996
- 1996-11-15 FR FR9613990A patent/FR2755976B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-10 WO PCT/FR1997/002022 patent/WO1998022610A1/fr not_active Ceased
- 1997-11-10 DE DE69730348T patent/DE69730348T2/de not_active Expired - Fee Related
- 1997-11-10 AT AT97945903T patent/ATE274066T1/de not_active IP Right Cessation
- 1997-11-10 EP EP97945903A patent/EP0946744B1/fr not_active Expired - Lifetime
- 1997-11-10 CA CA002267833A patent/CA2267833A1/fr not_active Abandoned
- 1997-11-10 US US09/297,519 patent/US6372499B1/en not_active Expired - Fee Related
- 1997-11-10 IL IL128912A patent/IL128912A/en not_active IP Right Cessation
- 1997-11-10 ES ES97945903T patent/ES2225992T3/es not_active Expired - Lifetime
- 1997-11-10 JP JP52325798A patent/JP2001504344A/ja not_active Ceased
- 1997-11-10 AU AU51239/98A patent/AU742818B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU742818B2 (en) | 2002-01-10 |
| AU5123998A (en) | 1998-06-10 |
| EP0946744A1 (fr) | 1999-10-06 |
| ATE274066T1 (de) | 2004-09-15 |
| US6372499B1 (en) | 2002-04-16 |
| DE69730348T2 (de) | 2005-09-01 |
| ES2225992T3 (es) | 2005-03-16 |
| IL128912A0 (en) | 2000-02-17 |
| WO1998022610A1 (fr) | 1998-05-28 |
| JP2001504344A (ja) | 2001-04-03 |
| FR2755976B1 (fr) | 1999-01-15 |
| DE69730348D1 (de) | 2004-09-23 |
| FR2755976A1 (fr) | 1998-05-22 |
| EP0946744B1 (fr) | 2004-08-18 |
| CA2267833A1 (fr) | 1998-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |