JP2001502710A - エストロゲン関連疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体 - Google Patents
エストロゲン関連疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体Info
- Publication number
- JP2001502710A JP2001502710A JP10519944A JP51994498A JP2001502710A JP 2001502710 A JP2001502710 A JP 2001502710A JP 10519944 A JP10519944 A JP 10519944A JP 51994498 A JP51994498 A JP 51994498A JP 2001502710 A JP2001502710 A JP 2001502710A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- compound
- cis
- formula
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 101150025395 trkA gene Proteins 0.000 description 1
- 101150113435 trkA1 gene Proteins 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000007497 verbal memory Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK119996 | 1996-10-28 | ||
| DK1199/96 | 1996-10-28 | ||
| PCT/DK1997/000485 WO1998018778A1 (en) | 1996-10-28 | 1997-10-28 | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001502710A true JP2001502710A (ja) | 2001-02-27 |
Family
ID=8102089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10519944A Pending JP2001502710A (ja) | 1996-10-28 | 1997-10-28 | エストロゲン関連疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0934299A1 (xx) |
| JP (1) | JP2001502710A (xx) |
| AU (1) | AU4772297A (xx) |
| CA (1) | CA2270056A1 (xx) |
| IL (1) | IL129618A0 (xx) |
| NO (1) | NO992005L (xx) |
| WO (1) | WO1998018778A1 (xx) |
| ZA (1) | ZA979649B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0944613B1 (en) * | 1996-12-13 | 2002-10-09 | Chugai Seiyaku Kabushiki Kaisha | Benzopyran derivatives |
| JP2000119187A (ja) * | 1998-10-15 | 2000-04-25 | Taisho Pharmaceut Co Ltd | 抑うつ気分の予防または改善用組成物 |
| ATE532777T1 (de) | 2004-09-21 | 2011-11-15 | Marshall Edwards Inc | Substituierte chromanderivate, medikamente und anwendungen in der therapie |
| US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| EP2635121B1 (en) | 2010-11-01 | 2020-01-08 | MEI Pharma, Inc. | Isoflavonoid compounds and methods for the treatment of cancer |
| PL3253208T3 (pl) | 2015-02-02 | 2021-11-08 | Mei Pharma, Inc. | Terapie kombinowane do zastosowania w leczeniu nowotworu piersi |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3340276A (en) * | 1964-04-01 | 1967-09-05 | Ciba Geigy Corp | 3, 4-diphenyl-chromans |
| DE1543749A1 (de) * | 1966-02-16 | 1969-12-11 | Merck Ag E | Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen |
| US5280040A (en) * | 1993-03-11 | 1994-01-18 | Zymogenetics, Inc. | Methods for reducing bone loss using centchroman derivatives |
| HUP9702244A3 (en) * | 1995-01-13 | 1999-12-28 | Novo Nordisk As | Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders |
-
1997
- 1997-10-28 AU AU47722/97A patent/AU4772297A/en not_active Abandoned
- 1997-10-28 JP JP10519944A patent/JP2001502710A/ja active Pending
- 1997-10-28 EP EP97910266A patent/EP0934299A1/en not_active Withdrawn
- 1997-10-28 CA CA002270056A patent/CA2270056A1/en not_active Abandoned
- 1997-10-28 ZA ZA9709649A patent/ZA979649B/xx unknown
- 1997-10-28 WO PCT/DK1997/000485 patent/WO1998018778A1/en not_active Application Discontinuation
- 1997-10-28 IL IL12961897A patent/IL129618A0/xx unknown
-
1999
- 1999-04-27 NO NO992005A patent/NO992005L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2270056A1 (en) | 1998-05-07 |
| ZA979649B (en) | 1998-04-28 |
| NO992005D0 (no) | 1999-04-27 |
| EP0934299A1 (en) | 1999-08-11 |
| NO992005L (no) | 1999-06-25 |
| IL129618A0 (en) | 2000-02-29 |
| AU4772297A (en) | 1998-05-22 |
| WO1998018778A1 (en) | 1998-05-07 |
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