CA2270056A1 - Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes - Google Patents
Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes Download PDFInfo
- Publication number
- CA2270056A1 CA2270056A1 CA002270056A CA2270056A CA2270056A1 CA 2270056 A1 CA2270056 A1 CA 2270056A1 CA 002270056 A CA002270056 A CA 002270056A CA 2270056 A CA2270056 A CA 2270056A CA 2270056 A1 CA2270056 A1 CA 2270056A1
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- Prior art keywords
- phenyl
- cis
- formula
- compound
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 16
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- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 14
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- 150000003624 transition metals Chemical class 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 101150025395 trkA gene Proteins 0.000 description 1
- 101150113435 trkA1 gene Proteins 0.000 description 1
- 230000007497 verbal memory Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK119996 | 1996-10-28 | ||
| DK1199/96 | 1996-10-28 | ||
| PCT/DK1997/000485 WO1998018778A1 (en) | 1996-10-28 | 1997-10-28 | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2270056A1 true CA2270056A1 (en) | 1998-05-07 |
Family
ID=8102089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002270056A Abandoned CA2270056A1 (en) | 1996-10-28 | 1997-10-28 | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0934299A1 (xx) |
| JP (1) | JP2001502710A (xx) |
| AU (1) | AU4772297A (xx) |
| CA (1) | CA2270056A1 (xx) |
| IL (1) | IL129618A0 (xx) |
| NO (1) | NO992005L (xx) |
| WO (1) | WO1998018778A1 (xx) |
| ZA (1) | ZA979649B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU722089B2 (en) * | 1996-12-13 | 2000-07-20 | Chugai Seiyaku Kabushiki Kaisha | Novel benzopyran derivatives |
| JP2000119187A (ja) * | 1998-10-15 | 2000-04-25 | Taisho Pharmaceut Co Ltd | 抑うつ気分の予防または改善用組成物 |
| US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| CN101056868B (zh) | 2004-09-21 | 2012-05-02 | 马休爱德华兹股份有限公司 | 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用 |
| JP6013349B2 (ja) | 2010-11-01 | 2016-10-25 | メイ ファーマ, インク.Mei Pharma, Inc. | 癌の処置のためのイソフラボノイド化合物および方法 |
| HUE054998T2 (hu) | 2015-02-02 | 2021-10-28 | Mei Pharma Inc | Kombinációs terápiák emlõrák kezelésében való alkalmazásra |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3340276A (en) * | 1964-04-01 | 1967-09-05 | Ciba Geigy Corp | 3, 4-diphenyl-chromans |
| DE1543749A1 (de) * | 1966-02-16 | 1969-12-11 | Merck Ag E | Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen |
| US5280040A (en) * | 1993-03-11 | 1994-01-18 | Zymogenetics, Inc. | Methods for reducing bone loss using centchroman derivatives |
| HUP9702244A3 (en) * | 1995-01-13 | 1999-12-28 | Novo Nordisk As | Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders |
-
1997
- 1997-10-28 IL IL12961897A patent/IL129618A0/xx unknown
- 1997-10-28 AU AU47722/97A patent/AU4772297A/en not_active Abandoned
- 1997-10-28 WO PCT/DK1997/000485 patent/WO1998018778A1/en not_active Application Discontinuation
- 1997-10-28 EP EP97910266A patent/EP0934299A1/en not_active Withdrawn
- 1997-10-28 JP JP10519944A patent/JP2001502710A/ja active Pending
- 1997-10-28 CA CA002270056A patent/CA2270056A1/en not_active Abandoned
- 1997-10-28 ZA ZA9709649A patent/ZA979649B/xx unknown
-
1999
- 1999-04-27 NO NO992005A patent/NO992005L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934299A1 (en) | 1999-08-11 |
| WO1998018778A1 (en) | 1998-05-07 |
| NO992005L (no) | 1999-06-25 |
| IL129618A0 (en) | 2000-02-29 |
| NO992005D0 (no) | 1999-04-27 |
| JP2001502710A (ja) | 2001-02-27 |
| AU4772297A (en) | 1998-05-22 |
| ZA979649B (en) | 1998-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |