JP2001502673A - キラルペプチド核酸 - Google Patents

キラルペプチド核酸

Info

Publication number
JP2001502673A
JP2001502673A JP10518106A JP51810698A JP2001502673A JP 2001502673 A JP2001502673 A JP 2001502673A JP 10518106 A JP10518106 A JP 10518106A JP 51810698 A JP51810698 A JP 51810698A JP 2001502673 A JP2001502673 A JP 2001502673A
Authority
JP
Japan
Prior art keywords
protected
group
cis
ester
proline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP10518106A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001502673A5 (enExample
Inventor
ロウエ，ゴードン
Original Assignee
アイシス イノヴェイション リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アイシス イノヴェイション リミテッド filed Critical アイシス イノヴェイション リミテッド
Publication of JP2001502673A publication Critical patent/JP2001502673A/ja
Publication of JP2001502673A5 publication Critical patent/JP2001502673A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP10518106A 1996-10-14 1997-10-13 キラルペプチド核酸 Ceased JP2001502673A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9621367.3A GB9621367D0 (en) 1996-10-14 1996-10-14 Chiral peptide nucleic acids
GB9621367.3 1996-10-14
PCT/GB1997/002820 WO1998016550A1 (en) 1996-10-14 1997-10-13 Chiral peptide nucleic acids

Publications (2)

Publication Number Publication Date
JP2001502673A true JP2001502673A (ja) 2001-02-27
JP2001502673A5 JP2001502673A5 (enExample) 2005-06-16

Family

ID=10801375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10518106A Ceased JP2001502673A (ja) 1996-10-14 1997-10-13 キラルペプチド核酸

Country Status (5)

Country Link
US (2) US6403763B1 (enExample)
EP (1) EP0956297A1 (enExample)
JP (1) JP2001502673A (enExample)
GB (1) GB9621367D0 (enExample)
WO (1) WO1998016550A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
GB9621367D0 (en) * 1996-10-14 1996-12-04 Isis Innovation Chiral peptide nucleic acids
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
WO2000050006A2 (en) 1999-02-26 2000-08-31 Chiron Corporation Microemulsions with adsorbed macromoelecules and microparticles
EP1335933A2 (en) * 2000-11-24 2003-08-20 Pantheco A/S Pna analogues
AU2002216946A1 (en) * 2001-01-05 2002-07-16 Pantheco A/S Modified pna molecules
US6716961B2 (en) * 2001-10-30 2004-04-06 Isis Innovation Limited Chiral peptide nucleic acids with a N-aminoethyl-d-proline backbone
ES2316776T3 (es) * 2002-02-04 2009-04-16 Isis Innovation Limited Acidos nucleicos de peptidos de pirrolidinilo.
US8604183B2 (en) * 2002-11-05 2013-12-10 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
EA009302B1 (ru) * 2003-05-20 2007-12-28 Инвестиген, Инк. Система обнаружения полинуклеотидов
US7790691B2 (en) 2003-06-20 2010-09-07 Isis Pharmaceuticals, Inc. Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US8021839B2 (en) * 2006-02-24 2011-09-20 Investigen, Inc. Methods and compositions for detecting polynucleotides
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
WO2008070525A1 (en) * 2006-12-04 2008-06-12 Luminex Corporation Oxocarbonamide peptide nucleic acids and methods of using same
US7771947B2 (en) * 2007-02-23 2010-08-10 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
US7964355B2 (en) * 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
SG186899A1 (en) 2010-07-08 2013-02-28 Bonac Corp Single-strand nucleic acid molecule for controlling gene expression
ES2533129T3 (es) 2010-08-03 2015-04-07 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
SG10201805087VA (en) 2013-12-27 2018-07-30 Bonac Corp Artificial match-type mirna for controlling gene expression and use therefor
WO2016104775A1 (ja) 2014-12-27 2016-06-30 株式会社ボナック 遺伝子発現制御のための天然型ｍｉＲＮＡおよびその用途
JP6602847B2 (ja) 2015-03-27 2019-11-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258853A (en) * 1982-04-30 1989-08-29 Rudiger D. Haugwitz Substituted 4-phenoxy prolines
US4501901A (en) * 1983-09-19 1985-02-26 E. R. Squibb & Sons, Inc. Method for making substituted prolines
US5401901A (en) 1991-09-19 1995-03-28 W. L. Gore & Associates, Inc. Weather-resistant electromagnetic interference shielding for electronic equipment enclosures
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
DE4331011A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik
GB9621367D0 (en) * 1996-10-14 1996-12-04 Isis Innovation Chiral peptide nucleic acids

Also Published As

Publication number Publication date
US6403763B1 (en) 2002-06-11
EP0956297A1 (en) 1999-11-17
US20020072586A1 (en) 2002-06-13
US6713603B2 (en) 2004-03-30
WO1998016550A1 (en) 1998-04-23
GB9621367D0 (en) 1996-12-04

Similar Documents

Publication Publication Date Title
US11279736B2 (en) Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids
EP0885189B9 (en) Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support
US6713603B2 (en) Chiral peptide nucleic acids
JP3326181B2 (ja) 連結ペプチド核酸
Gangamani et al. Chiral analogues of peptide nucleic acids: synthesis of 4-aminoprolyl nucleic acids and DNA complementation studies using UV/CD spectroscopy
AU2018240467A1 (en) Peptide nucleic acid (PNA) monomers with an orthogonally protected ester moiety
US8895739B2 (en) Acylation of hindered amines and functionalized bis-peptides obtained thereby
Laan et al. Synthesis of chirally pure ornithine based PNA analogues
Corradini et al. Epimerization of peptide nucleic acids analogs during solid-phase synthesis: optimization of the coupling conditions for increasing the optical purity
Lonkar et al. Chimeric (aeg-pyrrolidine) PNAs: synthesis and stereo-discriminative duplex binding with DNA/RNA
Tan et al. Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties
US20030157500A1 (en) Pyrrolidinyl peptide nucleic acids
EP1513871B1 (en) Pyrrolidinyl peptide nucleic acids
Aboul‐Fadl et al. Synthesis of a peptide nucleic acid with a novel 1‐methyl‐6‐mercaptopurine base
EP2291391B1 (en) Use of a tpb salt for the separation of biomolecules
Bravo A. Synthesis of an isoguaninyl amino acid and alanyl-PNA oligomers B. Cyclic peptides for DNA binding and bending
Turtle Design and Synthesis of Peptides Derived From Nucleoside beta-Amino Acids
JP2003219874A (ja) Ｒｎａに選択的に結合するペプチド核酸をアンチセンスオリゴヌクレオチドとして用いる方法、及び該ペプチド核酸の製造方法
HK1167865A1 (en) Method for the manufacture of degarelix

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20041012

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041012

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070515

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20071003

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071113