JP2001500475A - 細胞接着を調節するための化合物および方法 - Google Patents

細胞接着を調節するための化合物および方法

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Publication number
JP2001500475A
JP2001500475A JP10505472A JP50547298A JP2001500475A JP 2001500475 A JP2001500475 A JP 2001500475A JP 10505472 A JP10505472 A JP 10505472A JP 50547298 A JP50547298 A JP 50547298A JP 2001500475 A JP2001500475 A JP 2001500475A
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Prior art keywords
cyclic peptide
cadherin
cells
mammal
cell adhesion
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP10505472A
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English (en)
Japanese (ja)
Other versions
JP2001500475A5 (https=
Inventor
ダブリュー. ブラシューク,オレスト
ジョーン グール,バーバラ
Original Assignee
マクギル ユニバーシティ
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Application filed by マクギル ユニバーシティ filed Critical マクギル ユニバーシティ
Publication of JP2001500475A publication Critical patent/JP2001500475A/ja
Publication of JP2001500475A5 publication Critical patent/JP2001500475A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP10505472A 1996-07-12 1997-07-11 細胞接着を調節するための化合物および方法 Pending JP2001500475A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2161296P 1996-07-12 1996-07-12
US60/021,612 1996-07-12
PCT/CA1997/000489 WO1998002452A2 (en) 1996-07-12 1997-07-11 Compounds and methods for modulating cell adhesion

Publications (2)

Publication Number Publication Date
JP2001500475A true JP2001500475A (ja) 2001-01-16
JP2001500475A5 JP2001500475A5 (https=) 2005-03-10

Family

ID=21805187

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10505472A Pending JP2001500475A (ja) 1996-07-12 1997-07-11 細胞接着を調節するための化合物および方法

Country Status (8)

Country Link
US (3) US6031072A (https=)
EP (1) EP0937103B1 (https=)
JP (1) JP2001500475A (https=)
AU (1) AU722985B2 (https=)
CA (1) CA2259966A1 (https=)
DE (1) DE69738326T2 (https=)
ES (1) ES2297861T3 (https=)
WO (1) WO1998002452A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2018503609A (ja) * 2014-12-19 2018-02-08 ニューロ−バイオ リミテッドNeuro−Bio Ltd 癌または転移性疾患の治療または予防における環状アセチルコリンエステラーゼc末端ペプチド
JP2021525077A (ja) * 2018-05-23 2021-09-24 キュアバイオ カンパニー リミテッド 断片化されたgrsポリペプチド、その変異体及びこれらの用途
KR20220061018A (ko) * 2020-11-05 2022-05-12 한국생명공학연구원 항염 및 조직 재생작용을 갖는 신규 펩타이드
JP2022544640A (ja) * 2019-06-21 2022-10-20 ユニバーシティ オブ カンザス 脳疾患の治療に有用な組成物および方法

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US6417325B1 (en) * 1996-07-12 2002-07-09 Mcgill University Compounds and methods for cancer therapy
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US7122623B2 (en) * 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
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US6346512B1 (en) 1996-07-12 2002-02-12 Mcgill University Compounds and methods for modulating cell adhesion
US20040006011A1 (en) * 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US6031072A (en) 1996-07-12 2000-02-29 Mcgill University Compounds and methods for modulating cell adhesion
US6465427B1 (en) * 1996-07-12 2002-10-15 Mcgill University Compounds and methods for modulating cell adhesion
US6169071B1 (en) 1996-07-12 2001-01-02 Mcgill University Compounds and methods for modulating cell adhesion
US6551994B1 (en) * 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
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JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス, インコーポレイテッド p70S6キナーゼモジュレーターおよび使用方法
BRPI0508522A (pt) * 2004-03-08 2007-08-14 Wyeth Corp moduladores de canal de ìon
US7169756B2 (en) * 2004-04-16 2007-01-30 Mcmaster University Streptogramin antibiotics
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US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
JP2009538282A (ja) * 2006-05-15 2009-11-05 バイオジェン・アイデック・エムエイ・インコーポレイテッド 乏突起膠細胞の生存を促進させるためのNogo受容体−1(NgR1)アンタゴニストの使用
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US20130072439A1 (en) * 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
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CN116535281B (zh) * 2022-01-25 2025-06-24 中国科学院大连化学物理研究所 一种手性环状单萜衍生物及其合成方法
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018503609A (ja) * 2014-12-19 2018-02-08 ニューロ−バイオ リミテッドNeuro−Bio Ltd 癌または転移性疾患の治療または予防における環状アセチルコリンエステラーゼc末端ペプチド
JP7066409B2 (ja) 2014-12-19 2022-05-13 ニューロ-バイオ リミテッド 癌または転移性疾患の治療または予防における環状アセチルコリンエステラーゼc末端ペプチド
JP2021525077A (ja) * 2018-05-23 2021-09-24 キュアバイオ カンパニー リミテッド 断片化されたgrsポリペプチド、その変異体及びこれらの用途
JP2022544640A (ja) * 2019-06-21 2022-10-20 ユニバーシティ オブ カンザス 脳疾患の治療に有用な組成物および方法
KR20220061018A (ko) * 2020-11-05 2022-05-12 한국생명공학연구원 항염 및 조직 재생작용을 갖는 신규 펩타이드
WO2022098051A1 (ko) * 2020-11-05 2022-05-12 한국생명공학연구원 항염 및 조직 재생작용을 갖는 신규 펩타이드
KR102911194B1 (ko) * 2020-11-05 2026-01-13 한국생명공학연구원 항염 및 조직 재생작용을 갖는 신규 펩타이드

Also Published As

Publication number Publication date
WO1998002452A3 (en) 1998-03-05
CA2259966A1 (en) 1998-01-22
US6326352B1 (en) 2001-12-04
AU3332297A (en) 1998-02-09
US20020151475A1 (en) 2002-10-17
WO1998002452A2 (en) 1998-01-22
DE69738326T2 (de) 2008-07-03
DE69738326D1 (de) 2008-01-10
EP0937103B1 (en) 2007-11-28
EP0937103A2 (en) 1999-08-25
US6031072A (en) 2000-02-29
US6914044B2 (en) 2005-07-05
AU722985B2 (en) 2000-08-17
ES2297861T3 (es) 2008-05-01

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