JP2001500164A - ドナー器官のためのフラッシュ保存溶液 - Google Patents
ドナー器官のためのフラッシュ保存溶液Info
- Publication number
- JP2001500164A JP2001500164A JP11508642A JP50864299A JP2001500164A JP 2001500164 A JP2001500164 A JP 2001500164A JP 11508642 A JP11508642 A JP 11508642A JP 50864299 A JP50864299 A JP 50864299A JP 2001500164 A JP2001500164 A JP 2001500164A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- donor
- organ
- kidney
- mannitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ドナー器官をフラッシュするおよび/または保存するための溶液であって: 約50mM〜約100mMの範囲の量のマンニトール、 約130mM〜約160mMの範囲の量のナトリウム、 を含む、溶液。 2.6mM未満の量のカリウムをさらに含む、請求項1に記載の溶液。 3.前記溶液が、約0℃の温度で約6.6〜約7.0の範囲のpHを有する、請求項1に 記載の溶液。 4.20mM未満の量のグルコースをさらに含む、請求項1に記載の溶液。 5.100mMを越える量のラクトビオネートをさらに含む、請求項1に記載の溶液 。 6.グリシンをさらに含む、請求項1に記載の溶液。 7.前記溶液の計算重量モル浸透圧濃度が、約340mOs/Kg〜約390mOs/Kgの範囲で ある、請求項1に記載の溶液。 8.10mM未満のHPO4 -2およびH2PO4 -1の組み合わせ濃度をさらに含む、請求項1 に記載の溶液。 9.10mM未満の量のマグネシウムをさらに含む、請求項1に記載の溶液。 10.10mM未満の量のSO4 -2をさらに含む、請求項1に記載の溶液。 11.前記溶液が、アロプリノール、グルタチオン、アデノシン、およびヒドロ キシエチルデンプンを実質的に含まない、請求項1に記載の溶液。 12.ドナー器官からのドナーの血液の少なくとも一部をフラッシュし、そして /またはドナー器官を保存するための溶液であって: 約130mM〜約160mMの範囲の量のナトリウム、および約3mM〜約6mMの範囲の量 のカリウムを含み、そしてここで、該溶液が、約0℃の温度で約6.6〜約7.0の範 囲のpHを有し、そして該溶液が、アロプリノール、グルタチオン、アデノシン、 およびヒドロキシエチルデンプンを実質的に含まない、溶液。 13.前記溶液が、約50mM〜約100mMの範囲の量のマンニトールをさらに含む、 請求項12に記載の溶液。 14.前記溶液が、20mM未満の量のグルコースをさらに含む、請求項12に記載 の溶液。 15.前記溶液が、100mMを越える量のラクトビオネートをさらに含む、請求項 12に記載の溶液。 16.前記溶液が、グリシンをさらに含む、請求項12に記載の溶液。 17.前記溶液の計算重量モル浸透圧濃度が、約340mOs/Kg〜約390mOs/Kgの範囲 である、請求項12に記載の溶液。 18.前記溶液が、10mM未満のHPO4 -2およびH2PO4 -1の組み合わせ濃度をさらに 含む、請求項12に記載の溶液。 19.前記溶液が、11mM未満の量のマグネシウムをさらに含む、請求項12に記 載の溶液。 20.ドナー器官をフラッシュし、そして/または保存するための溶液であって : ナトリウム 130〜160mM カリウム 3〜6 mM マグネシウム 0〜5 mM ラクトビオネート 100〜150mM スルフェート 0〜5 mM ホスフェート 0〜10 mM グルコース 0〜10 mM マンニトール 50〜100 mM グリシン 0〜5 mM を含む、溶液。 21.前記溶液のpHが、約0℃の温度で、約6.7〜約6.9の範囲である、請求項2 0に記載の溶液。 22.前記溶液の計算重量モル浸透圧濃度が、約340mOs/Kg〜約390mOs/Kgの範囲 である、請求項20に記載の溶液。 23.ドナー器官をレシピエント患者に移植する方法であって、以下の工程: 器官をドナーから採取する工程; 該器官の外側のドナーの血液を、約50mM〜約100mMの範囲の量のマンニトール 、約130mM〜約160mMの範囲の量のナトリウムを含む溶液でフラッシュし、ここで 該溶液が、約0℃の温度で、約6.6〜約7.0の範囲のpHを有する、工程; 該溶液中で該器官を保存する工程;および 該器官をレシピエントに移植する工程、 を包含する、方法。 24.ドナー器官を移植のために調製する方法であって、以下の工程: 器官の外側のドナーの血液を、約50mM〜約100mMの範囲の量のマンニトールお よび約130mM〜約160mMの範囲の量のナトリウムを含む溶液でフラッシュし、ここ で該溶液が、アロプリノール、グルタチオン、アデノシン、およびヒドロキシエ チルデンプンを実質的に含まない、工程;および 該溶液中で該器官を保存する工程、 を包含する、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/890,269 | 1997-07-09 | ||
US08890269 US5834178C1 (en) | 1997-07-09 | 1997-07-09 | Flush-storage solution for donor organs |
PCT/US1998/011478 WO1999002034A1 (en) | 1997-07-09 | 1998-06-04 | Flush-storage solution for donor organs |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008298833A Division JP2009067811A (ja) | 1997-07-09 | 2008-11-21 | ドナー器官のためのフラッシュ保存溶液 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001500164A true JP2001500164A (ja) | 2001-01-09 |
Family
ID=25396484
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11508642A Withdrawn JP2001500164A (ja) | 1997-07-09 | 1998-06-04 | ドナー器官のためのフラッシュ保存溶液 |
JP2008298833A Pending JP2009067811A (ja) | 1997-07-09 | 2008-11-21 | ドナー器官のためのフラッシュ保存溶液 |
JP2010122939A Withdrawn JP2010180257A (ja) | 1997-07-09 | 2010-05-28 | ドナー器官のためのフラッシュ保存溶液 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008298833A Pending JP2009067811A (ja) | 1997-07-09 | 2008-11-21 | ドナー器官のためのフラッシュ保存溶液 |
JP2010122939A Withdrawn JP2010180257A (ja) | 1997-07-09 | 2010-05-28 | ドナー器官のためのフラッシュ保存溶液 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5834178C1 (ja) |
EP (1) | EP0967863B1 (ja) |
JP (3) | JP2001500164A (ja) |
AU (1) | AU739632B2 (ja) |
CA (1) | CA2266012C (ja) |
DE (1) | DE69818435T2 (ja) |
WO (1) | WO1999002034A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007502130A (ja) * | 2003-05-09 | 2007-02-08 | ライフブラッド メディカル インコーポレーテッド | 臓器および細胞の生存能力を維持するための組成物 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544726B1 (en) | 1999-05-05 | 2003-04-08 | Knox Van Dyke | KVD solution for transplantable organs |
US6492103B1 (en) * | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
EP1305040B1 (en) * | 2000-07-28 | 2009-09-09 | Christopher J. Murphy | Transplant media |
ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
US20050142121A1 (en) * | 2003-12-24 | 2005-06-30 | Gold Joseph D. | System for improving acceptance of tissue grafts made from embryonic stem cells |
US7989157B2 (en) * | 2005-01-11 | 2011-08-02 | Medtronic, Inc. | Solution for storing bioprosthetic tissue used in a biological prosthesis |
WO2007106912A2 (en) | 2006-03-16 | 2007-09-20 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peroxisome-proliferator activated receptor-alpha agonists for organ preservation |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8403912D0 (sv) * | 1984-07-30 | 1984-07-30 | Pharmacia Ab | Lekemedelssats eller -komposition |
US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
US4994444A (en) * | 1987-07-31 | 1991-02-19 | The Trustees Of Columbia In The City Of New York | Macromolecules for sealing capillary endothelial junctions |
ES2007994A6 (es) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Medio liquido para perfusion y preservacion de organos. |
US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
US5002965A (en) * | 1989-05-09 | 1991-03-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Use of ginkgolides to prevent reperfusion injury in organ transplantation |
US5082831A (en) * | 1989-12-05 | 1992-01-21 | Cryovita Laboratories, Inc. | Total body washout solution and method of use |
WO1992012722A1 (en) * | 1990-01-17 | 1992-08-06 | The Regents Of The University Of California | Antifreeze glycopeptide compositions to protect cells and tissues during freezing |
US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
US5145771A (en) * | 1990-04-12 | 1992-09-08 | The University Of North Carolina At Chapel Hill | Rinse solution for organs and tissues |
US5217860A (en) * | 1991-07-08 | 1993-06-08 | The American National Red Cross | Method for preserving organs for transplantation by vitrification |
WO1993002653A1 (en) * | 1991-08-08 | 1993-02-18 | Segel Leigh D | Fluorocarbon blood substitute |
US5200398A (en) * | 1991-09-12 | 1993-04-06 | Mount Sinai Hospital Corporation | Composition for the preservation of organs comprising glucuronic acid or a physiologically tolerated salt or ester thereof |
US5407793A (en) * | 1991-10-18 | 1995-04-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | An aqueous heart preservation and cardioplegia solution |
US5328821A (en) * | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
RU2025973C1 (ru) * | 1992-02-10 | 1995-01-09 | Научно-производственное предприятие "Биофарм" | Раствор для консервации живых органов |
US5370989A (en) * | 1992-04-03 | 1994-12-06 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
US5552267A (en) * | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
US5306711A (en) * | 1992-06-24 | 1994-04-26 | Georgetown University | Organ preservative solution |
US5565317A (en) * | 1992-06-26 | 1996-10-15 | Torii Pharmaceutical Co., Ltd. | Perfusion and storage solution containing sodium lactobionate, sodium dihydrogenphosphate, raffinose, glutathione, allopurinol and nafamostat mesylate |
BE1007500A3 (fr) * | 1992-09-18 | 1995-07-18 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
US5403834A (en) * | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
AU681675B2 (en) * | 1993-06-04 | 1997-09-04 | Biotime, Inc. | Plasma-like solution |
US5405742A (en) * | 1993-07-16 | 1995-04-11 | Cyromedical Sciences, Inc. | Solutions for tissue preservation and bloodless surgery and methods using same |
EP0713363B1 (en) * | 1993-08-12 | 2002-06-12 | The University Of North Carolina At Chapel Hill | Rinse solution for organs and tissues |
KR950030791A (ko) * | 1994-01-25 | 1995-12-18 | 아키요 시게마주 | 생물조직 보존방법 및 그를 위한 관류액 |
US5554497A (en) * | 1994-12-12 | 1996-09-10 | Charlotte-Mecklenburg Hospital Authority | Cardioplegic solution for arresting an organ |
AU4526996A (en) * | 1994-12-28 | 1996-07-19 | Biotime, Inc. | Plasma expanders and blood substitutes |
-
1997
- 1997-07-09 US US08890269 patent/US5834178C1/en not_active Expired - Lifetime
-
1998
- 1998-06-04 EP EP98926275A patent/EP0967863B1/en not_active Expired - Lifetime
- 1998-06-04 AU AU78150/98A patent/AU739632B2/en not_active Ceased
- 1998-06-04 DE DE69818435T patent/DE69818435T2/de not_active Expired - Lifetime
- 1998-06-04 CA CA2266012A patent/CA2266012C/en not_active Expired - Fee Related
- 1998-06-04 JP JP11508642A patent/JP2001500164A/ja not_active Withdrawn
- 1998-06-04 WO PCT/US1998/011478 patent/WO1999002034A1/en active IP Right Grant
-
2008
- 2008-11-21 JP JP2008298833A patent/JP2009067811A/ja active Pending
-
2010
- 2010-05-28 JP JP2010122939A patent/JP2010180257A/ja not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007502130A (ja) * | 2003-05-09 | 2007-02-08 | ライフブラッド メディカル インコーポレーテッド | 臓器および細胞の生存能力を維持するための組成物 |
Also Published As
Publication number | Publication date |
---|---|
DE69818435D1 (de) | 2003-10-30 |
JP2009067811A (ja) | 2009-04-02 |
EP0967863A1 (en) | 2000-01-05 |
CA2266012A1 (en) | 1999-01-21 |
CA2266012C (en) | 2010-05-25 |
US5834178A (en) | 1998-11-10 |
AU739632B2 (en) | 2001-10-18 |
DE69818435T2 (de) | 2004-07-08 |
US5834178C1 (en) | 2002-04-23 |
WO1999002034A1 (en) | 1999-01-21 |
AU7815098A (en) | 1999-02-08 |
EP0967863B1 (en) | 2003-09-24 |
JP2010180257A (ja) | 2010-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR950015064B1 (ko) | 기관 보존 및 저장에 적당한 조성물 | |
US9049857B2 (en) | Flush preservation solution | |
CN100381048C (zh) | 评价和保存溶液 | |
US5370989A (en) | Solution for prolonged organ preservation | |
JP2010180257A (ja) | ドナー器官のためのフラッシュ保存溶液 | |
US5693462A (en) | Organ transplant solutions and method for transplanting an organ | |
Jeevanandam et al. | University of Wisconsin solution versus crystalloid cardioplegia for human donor heart preservation: a randomized blinded prospective clinical trial | |
US8288084B2 (en) | Composition and method for flushing and cold/cryo preserving organs, tissues, and cells | |
JPH09500380A (ja) | 組織保存及び無血手術のための溶液、ならびにそれを用いた方法 | |
US5565317A (en) | Perfusion and storage solution containing sodium lactobionate, sodium dihydrogenphosphate, raffinose, glutathione, allopurinol and nafamostat mesylate | |
AU2002215131A1 (en) | Flush preservation solution | |
US6080730A (en) | Rinse solution for organs and tissues | |
JPH0656601A (ja) | 移植臓器用の電解質溶液 | |
JPH0822801B2 (ja) | 臓器保存用溶液 | |
KR100304594B1 (ko) | 이식용 장기 및 혈액세포 보존제의 조성물 | |
US20220087252A1 (en) | Solution for preserving and/or rinsing an organ to be transplanted | |
JP4570877B2 (ja) | 臓器保存用組成物および臓器の保存方法 | |
CN110868854A (zh) | 保存溶液 | |
Toledo-Pereyra | Organ preservation I. kidney and pancreas | |
WO2000030442A1 (en) | Organ preservation solution containing pyruvate | |
JP2770175B2 (ja) | 腎臓の庇護液 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050531 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080722 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080924 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20081031 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081121 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090210 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090511 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090715 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20090827 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20090903 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110607 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110613 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110704 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110711 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110803 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110808 |
|
A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20110829 |