JP2001333973A - Antibacterial sheet of active carbon and antibacterial deodorant covering material for wound - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antibacterial sheet of active carbon and an antibacterial deodorant covering material for wound which have excellent antibacterial and deodorant efficiency, and in which the cost is low and the strength is also excellent. SOLUTION: The antibacterial sheet of active carbon comprises active carbon and a polylactic acid fiber, and the bacteriostatic potency is more than 2.2.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antibacterial activated carbon sheet and an antibacterial deodorant wound dressing.
The present invention relates to an antibacterial deodorant wound dressing that can effectively prevent and relieve pressure ulcers (so-called bedsores) that tend to occur in patients such as bedridden elderly people who are unable to act on their own.

[0002]

2. Description of the Related Art Activated carbon sheets are processed into corrugated or corrugated sheets to remove malodorous gases and organic compounds in the air, and processed into cartridges to decompose hypochlorite ions in water, remove moldy odor and trihalomethane. , And also used for wastewater treatment such as plating.

[0003] In recent years, there has been a growing demand for activated carbon sheets for environmental uses such as for air cleaning and middle drainage treatment.
Applications requiring antimicrobial properties are also increasing. As a method of imparting antibacterial properties to an activated carbon sheet, there is a method of using activated carbon carrying a compound such as silver or copper. However, the processing cost for supporting the activated carbon sheet is high, resulting in an expensive sheet. There is also a method of surface-treating the sheet with an antibacterial substance. However, this method has a disadvantage that the antibacterial substance flows out when used for water treatment.

[0004] Incidentally, pressure ulcers are a risk factor for the onset of friction and slippage between the skin and those in contact with it, such as the perceived cognition of the patient, the degree of skin wetness, activity, mobility, and nutritional status. Methods for evaluating these factors are described in Brain Scale (Bran Scale).
e scale).

[0005] As a method of preventing pressure ulcers, caregivers should change their positions at regular intervals to avoid pressure on certain parts over a long period of time, and use hot water or massage to cleanse, dry, and promote blood circulation. The use of hygroscopic bedding to reduce friction with the skin, not to cause trauma, and to improve the nutrition of the whole body.

[0006] In addition, the treatment method is initially
It is effective to apply a hydrocolloid dressing agent after disinfection and wiping. From the middle stage onwards, in addition to the removal of necrotic tissue by surgical debridement, topical drugs such as silver sulfadiazine preparations, purified sucrose, and ointments containing povidone-iodine are effective. When there is a lot of leachate, cadoxomer iodine preparation,
Dextran polymer preparations and the like can be used. In the final stage, in addition to tretinointocopheryl ointment and lysozyme chloride ointment, bucladecin sodium ointment, hydrocolloid dressing and the like are used. In addition, pressure ulcers
It is well known that there is no commonly available drug for each stage and that this is an extremely intractable injury.

However, recent treatment methods not only treat wounds but also improve the quality of life of patients. For example, for pressure ulcers that can be infected,
The odor may be severe and the patient and the surrounding people may suffer from this odor. Japanese Patent Application Laid-Open No. H10-155891 discloses a wound dressing with odor removal and antibacterial properties.
A wound dressing is disclosed in which activated carbon containing at least 10% of mesopores and impregnated with a silver salt are wrapped in a bacterial resistant zipper. However, it has the disadvantage that it becomes an expensive dressing for wounds, such as impregnating activated carbon with a silver salt or using a wrapping bag that has been treated with bacteria.

[0008] JP-A-11-332924 and JP-A-2000-274 disclose sanitary materials using activated carbon having a broad antibacterial spectrum against various bacteria. Activated carbon having a broad antibacterial spectrum against various bacteria described in each publication is obtained by activating and firing a carbon-based material in an inert atmosphere such as nitrogen using a reactive gas such as steam. It is stated that it will be.

[0009] However, the method described here is a general method for producing activated carbon, and the activated carbon produced by this method is used for biological treatment in water treatment. Is very generally used, and is very weak even if it has antibacterial performance. Therefore, it is necessary to use a woven fabric, a knitted fabric, or a nonwoven fabric of 100% activated carbon fiber, which causes a disadvantage that the sheet strength is weak.

[0010]

DISCLOSURE OF THE INVENTION The present invention solves the above-mentioned problems and provides an inexpensive antibacterial activated carbon sheet which is excellent in strength, does not lose antibacterial properties due to outflow of antibacterial substances and has excellent strength. An object of the present invention is to provide an antibacterial deodorant wound dressing.

[0011]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that a sheet made of activated carbon and polylactic acid fiber has excellent deodorizing performance and antibacterial performance. The present invention has been reached. That is, the present invention has the following configuration. (1) Consisting of activated carbon and polylactic acid fiber, bacteriostatic activity value is 2.
An antibacterial activated carbon sheet characterized by having at least two. (2) An antibacterial deodorant wound dressing comprising the antibacterial activated carbon sheet according to (1).

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail. The antibacterial activated carbon sheet of the present invention is mainly composed of activated carbon and polylactic acid fiber, and has an excellent bacteriostatic activity value of 2.2 or more according to a unified test method (antibacterial effect test method certified by the Textile Sanitation Processing Council). It has antibacterial properties. The bacteriostatic activity value is defined as B (cells / ml), the number of viable cells in a standard sample after a certain period of inoculation of the test sample with a certain number of test bacteria in the standard sample and the target sample, The viable cell count of a sample is defined as C (cells / ml), and the value is expressed as Log B-Log C. When the bacteriostatic activity value is less than 2.2, the proliferation of bacteria cannot be suppressed, and it becomes difficult to use in fields requiring antibacterial properties. In addition, the antibacterial activated carbon sheet has a specific surface area of 500 m ² / g or more to maintain excellent deodorizing performance,
The basis weight is preferably 40 g / m ² or more.

As the activated carbon in the present invention, powdered or granular activated carbon whose precursor is obtained from coconut shell charcoal, coke, charcoal, wood resin carbide, phenol resin carbide, or the like, or pitch-based, phenol-based, or cellulose-based activated carbon fibers is used. it can. The pitch-based activated carbon fiber can be obtained, for example, by steam-activating the pitch fiber that has been subjected to melt spinning and infusibilization using coal-based pitch as a raw material. This activated carbon fiber is marketed by Unitika Ltd. under the trademark Adol and is readily available.

The specific surface area of the activated carbon used in the present invention is as follows:
It is preferably at least 550 m ² / g, more preferably at least 800 m ² / g. When the specific surface area is less than 550 m ² / g, it becomes difficult to sufficiently exert the deodorizing ability as activated carbon. The specific surface area is determined by the BET method using nitrogen gas adsorption.

Next, the polylactic acid fiber constituting the antibacterial activated carbon sheet together with activated carbon is a thermoplastic aliphatic polyester having poly (α-hydroxy acid) as a main repeating unit. As the polylactic acid fiber used in the present invention, a fiber made of polylactic acid (melting point 170 ° C.)
Polylactic acid having different melting points is composed of a core component (high melting point, eg, melting point of 170 ° C.) and a sheath component (low melting point, eg, melting point of 130 ° C.)
It is preferable to use the binder fiber used in the above in combination as necessary. These fibers are readily available from Unitika Fibers under the trade name Terramac.

The mixing ratio of activated carbon and polylactic acid fibers constituting the antibacterial activated carbon sheet of the present invention is not particularly limited as long as the bacteriostatic activity value of the sheet is 2.2 or more. When the fiber is contained in an amount of 30% by mass or more, the bacteriostatic activity value is 2.2 or more and the antibacterial property is obtained, and the strength is also excellent. In consideration of antibacterial properties, deodorizing ability, strength and the like, it is preferable that the polylactic acid fiber contains 40 to 80% by mass.

The antibacterial activated carbon sheet of the present invention has excellent antibacterial properties because it contains polylactic acid fibers. The reason why the polylactic acid fibers exhibit antibacterial performance is as follows.
It is presumed to be due to the action of trace amounts of lactic acid, lactide and other oligolactic acids in polylactic acid.

The antibacterial activated carbon sheet of the present invention has a very high strength because the polylactic acid fiber is firmly bonded to the activated carbon fiber as a binder fiber as compared with the conventional sheet using 100% activated carbon fiber. Sheet, and
The cost can be reduced as compared with a sheet using conventional silver-impregnated activated carbon.

Next, a method for producing the antibacterial activated carbon sheet of the present invention will be described. As a production method, either a dry method or a wet method is selected depending on the form of activated carbon. I will explain each method with an example,
It is not limited to this method. In the case of activated carbon fiber, any of a dry method and a wet method can be adopted, but in the case of powdered or granular activated carbon, a wet method is preferred.

First, the dry method will be described. After mixing a predetermined amount of activated carbon fiber and polylactic acid fiber, a nonwoven web is formed using a card machine such as a random card or a parallel card. At this time, the nonwoven web is cross-wrapped by a cross wrapper or the like according to the basis weight, and three-dimensionally entangled with the fibers is mechanically generated by a needle punch device, and integrated to obtain an antibacterial activated carbon sheet.

Next, the wet method will be described. A predetermined amount of activated carbon fiber or granular or powdered activated carbon and polylactic acid fiber are mixed in water, then formed into a sheet using a paper machine and dried to obtain an antibacterial activated carbon sheet. In addition, pulp-like multibranched fibers such as polyolefins, aromatic polyamides, and natural fibers, acrylic polymers having anionic or cationic functional groups, and styrene / butadiene polymers and the like are substantially insoluble in water. A binder can be added to water to improve the strength of the sheet. Further, in order to improve the strength of a sheet manufactured by a dry or wet method, the sheet can be pressed at a pressure of 10 kg / cm ² or less and a temperature of 130 to 150 ° C.

Next, the antibacterial deodorant wound dressing of the present invention will be described. The antibacterial deodorant wound dressing of the present invention is constituted by an antibacterial activated carbon sheet having a bacteriostatic activity value of 2.2 or more. Activated carbon constituting the antibacterial deodorizing wound dressing material has good entanglement with the polylactic acid fiber, provides a strong sheet, and can be cut into any shape at the time of use. Fibrous activated carbon which generates very little is preferred.

The antibacterial deodorizing wound dressing of the present invention covers a pressure ulcer occurring in a living body, and may be directly applied to the skin. Further, if the antibacterial deodorizing wound dressing is provided with an inner surface material, it can be in contact with the skin via the inner surface material and soften the hit. The inner surface material may be a thin cloth material such as cotton or silk, a polyolefin nonwoven fabric, a polyolefin porous film, or the like. In addition, the inner surface material may contain alginic acid, a hydrocolloid dressing agent, or the like in order to keep the pressure sore in a moderately moist state. Further, in order to prevent the exudate and pus from leaking from the pressure sore to the outside, an outer material may be provided with a material equivalent to the inner material. More preferably, both the inner surface material and the outer surface material have antibacterial performance.

[0024]

Next, the present invention will be described in detail with reference to examples. Note that the present invention is not limited to these examples. The antimicrobial performance in the examples was measured as follows. The bacteriostatic activity value was measured by a unified test method (antibacterial effect test method certified by the Textile Sanitation Processing Council), and the antibacterial performance was evaluated. Staphylococcus aureu as used strain
sATCC 6538P (Staphylococcus aureus) was used. As a measuring method, 0.2 ml of a bacterial solution having a viable cell number adjusted to 1 ± 0.3 × 10 ⁵ was inoculated as uniformly as possible into 0.4 g of a sterilized sample placed in a vial, and cultured at 37 ° C. for 18 hours. I do. Next, 20 m of physiological saline containing 0.2% of Twin 80
Add 1 and stir to wash out the bacteria. The required number of 10-fold dilutions of this solution were prepared, mixed with a nutrient agar medium, cultured at 37 ° C. for 24 hours or more, the number of colonies was counted, and the number of viable bacteria was determined. For the calculation of the bacteriostatic activity value, the above test was performed on each of the standard sample and the test sample, and the bacteriostatic activity value was determined from the following equation. Bacteriostatic activity value = logB-logCB B: Number of bacteria recovered after 18 hours of cultivation of standard sample C: Number of bacteria recovered after 18 hours of cultivation of test sample

Example 1 Activated carbon fiber (Unitika Adol A10: specific surface area 12)
00m ² / g, fiber diameter 16.5 μm: cut length 2 to 6 mm) 60% by mass, polylactic acid fiber (Terramac S94: cut length 5)
1%, 1.7dtex) 20% by mass, polylactic acid binder (Terramac S95: cut length 51mm, 2.2detex) 20
After blending the mass%, the mixture is passed through a parallel card, a cross wrapper, a needle punch device, and a dryer adjusted to 135 ° C. to obtain a specific surface area of 720 m ² / g, a basis weight of 100 g / m ² , and a thickness of 0.6 mm. An antibacterial activated carbon sheet was produced. Table 1 shows the antibacterial performance of the obtained sheet.

Example 2 Activated carbon fiber (Unitika Adol A10: fiber diameter 16.5)
μm, cut length 2 to 6 mm) 70 mass%, polylactic acid fiber (Terramac S94: cut length 5 mm, 1.7 dtex) 10
20% by mass of polylactic acid binder (Terramac S95: cut length 5mm, 2.2dtex) 20% by mass in water
Wet papermaking was performed using a sheet machine (manufactured by Kumagai Riki Kogyo).

The obtained sheet was dried (135 ° C.) to obtain an antibacterial activated carbon sheet having a specific surface area of 840 m ² / g, a basis weight of 100 g / m ² and a thickness of 0.6 mm. Table 1 shows the antibacterial performance of the obtained sheet.

Example 3 Granular activated carbon (BPL manufactured by Toyo Calgon, specific surface area: 900 m ² / g) 6
0 mass%, polylactic acid fiber (Terramac S94: cut length 5 mm, 1.7 dtex) 20 mass%, polylactic acid binder (Terramac S95: cut length 5 mm, 2.2 dtex) 20
The mass% was dispersed in water using xanthan gum and a cationic polymer agent as a binder, and wet papermaking was performed using a sheet machine (manufactured by Kumagaya Riki Kogyo Co., Ltd.).

The obtained sheet was dried (135 ° C.) to obtain an antibacterial activated carbon sheet having a specific surface area of 540 m ² / g, a basis weight of 100 g / m ² and a thickness of 0.8 mm. Table 1 shows the antibacterial performance of the obtained sheet.

Comparative Example 1 Activated carbon fiber (Unitika Adol A10: fiber diameter 16.5)
μm, cut length 2 to 6 mm) 60% by mass, polyester binder (Melty 4080: cut length 51 mm)
After mixing 40% by mass of 2.2 dtex), the mixture was passed through a parallel card, a cross wrapper, a needle punch device, and a dryer adjusted to 130 ° C. to obtain a specific surface area of 72%.
An activated carbon sheet having 0 m ² / g, a basis weight of 100 g / m ² and a thickness of 0.6 mm was prepared. Table 1 shows the antibacterial performance of the obtained sheet.

[0031]

[Table 1]

As is clear from Table 1, the activated carbon sheets obtained in Examples 1 to 3 all had excellent bacteriostatic performance.

Performance Test The antibacterial activated carbon sheets obtained in Examples 2 and 3 and Comparative Example 1 were used as deodorizing wound dressings, and the performance was evaluated by the following method. First, three wounds with full-thickness skin were created on the back of a rabbit, and Pseudomonas aeruginosa was inoculated to artificially create an infected wound. When this was allowed to stand for two days, the bacteria proliferated and began to give off odors. This wound was covered with the covering materials of Examples 2 and 3 and Comparative Example 1, respectively, covered with gauze, and fixed with skin tape. The dressing was changed twice a week.

Both the coating materials of Examples 2 to 3 and Comparative Example 1 did not emit any offensive odor immediately after the application. And since the coating materials of Examples 2 and 3 have antibacterial properties as shown in Table 1, the formation of granulation was apparent from about one week after the start of the treatment. However, in the case of Comparative Example 1, granulation was not observed even after 2 weeks because of no antibacterial property. The bad smell test was a sensory test, and three test persons smelled and judged. From the above, it was clarified that the antibacterial deodorant wound dressing of the present invention had excellent antibacterial performance and deodorant performance.

[0035]

The antibacterial activated carbon sheet of the present invention has excellent deodorizing performance and antibacterial performance, and is low in cost and excellent in strength, and is suitable for use in antibacterial filters such as air purifier filters and water treatment filters. It is a sheet suitable for various fields where performance is required.

The antibacterial deodorant wound dressing of the present invention using the above-mentioned antibacterial activated carbon sheet has excellent antibacterial and deodorizing properties.
It can be used effectively as bed sheets for prevention and treatment of pressure ulcers. In particular, the patient's Qualit by odor removal
It is effective as a coating material that can be expected to improve y of life, reduce the burden on nursing and treatment personnel, and so on.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61G 7/05 A61L 15/03 A61L 2/16 A61G 7/04 F term (Reference) 4C040 AA01 AA26 AA27 GG01 4C058 AA03 AA12 AA19 BB07 CC08 JJ02 4C081 AA02 AA12 BA14 BA17 4H011 AA02 BA06 BB18 BB19 DA07 DF04 DG05 DH04

Claims (3)

[Claims] 1. An antibacterial activated carbon sheet comprising activated carbon and polylactic acid fiber and having a bacteriostatic activity value of 2.2 or more. 2. An antibacterial deodorizing wound dressing comprising the antibacterial activated carbon sheet according to claim 1. 3. The antibacterial deodorizing wound dressing according to claim 2, wherein the activated carbon is fibrous activated carbon.