WO2012092812A1 - Anti-bacterial, moisture absorptive and calcium ion donating wound dressing - Google Patents

Anti-bacterial, moisture absorptive and calcium ion donating wound dressing

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Publication number
WO2012092812A1
WO2012092812A1 PCT/CN2011/084370 CN2011084370W WO2012092812A1 WO 2012092812 A1 WO2012092812 A1 WO 2012092812A1 CN 2011084370 W CN2011084370 W CN 2011084370W WO 2012092812 A1 WO2012092812 A1 WO 2012092812A1
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WO
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Patent type
Prior art keywords
fibers
calcium
dressing
wound
chitosan
Prior art date
Application number
PCT/CN2011/084370
Other languages
French (fr)
Chinese (zh)
Inventor
王晓东
张大伟
史福军
Original Assignee
佛山市优特医疗科技有限公司
南方医科大学珠江医院
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • DTEXTILES; PAPER
    • D04BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04HMAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/44Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling
    • D04H1/46Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/0054Plasters use for deep wounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00727Plasters means for wound humidity control
    • A61F2013/00731Plasters means for wound humidity control with absorbing pads
    • A61F2013/00744Plasters means for wound humidity control with absorbing pads containing non-woven

Abstract

An anti-bacterial, moisture absorptive and calcium ion donating wound dressing and a preparation method therefor. The wound dressing comprises chitosan fibers, calcium alginate fibers and chemically modified cellulose fibers. The preparation method comprises blending chitosan fibers, calcium alginate fibers and chemically modified cellulose fibers to obtain a fabric, cutting, packaging, and sterilizing. The wound dressing is useful in treatment of venous stasis ulcers, pressure ulcers, diabetic foot ulcers and other chronic ulcers.

Description

Has antibacterial, moisture absorption and technical fields contribute calcium wound dressing

The present invention relates to a wound dressing comprising the chitosan fibers, calcium alginate fibers and chemically modified cellulose fibers. In particular, the present invention relates to a wound dressing, the wound dressing from chitosan fibers, chemically modified cellulose fibers and fiber blends from seaweeds, and the advantages of three fibers acting in combination on wound healing play. The present invention also relates to wound dressings for chronic wounds, such as venous stasis ulcers, pressure ulcers and diabetic foot ulcers and other chronic ulcers. Background technique

It is well known in the selection process of wound dressing wounds, nursing a difficult problem to face is also provided to the favorable wound healing environment while addressing chronic wound exudate, these favorable environmental conditions, including, not limited to inhibit microbial growth and can provide calcium ions.

Chitosan fibers having antibacterial effect, negative charges positive charges wherein the bacterial cell wall and NH 2 groups of chitosan with binding, thereby inhibiting bacterial growth. In addition, small molecules penetrate into the cell walls of chitosan in order to inhibit the formation of the enzyme. It is easily observed in a typical antibacterial test, when the sample is placed chitosan non-woven fabric coated with a bacterial culture dish 24 hours can be observed region below the nonwoven fabric is "clean", i.e., the shell there is no region of the nonwoven fabric glycans growth of bacteria, and the bacteria can be observed in the area of ​​the non chitosan significant growth of the nonwoven fabric, whereby the chitosan fibers have described inhibitory effect. So, generally chitosan dressing can be used for infected wounds or wounds at risk of infection.

Antibacterial wound dressings typically have efficacy in the art further comprise silver-containing wound dressing, the wound dressing but these have certain toxicity significantly.

EP 0690344 and US 3589364 disclose absorbent dressing made from carboxymethyl cellulose fibers, WO 2010/061225 discloses a method of modifying cellulose fibers, which are formed by the water insoluble sulfonated alkyl with fibers always improve moisture absorption. According to the disclosure, the cellulose fibers known in particular through chemical treatment with a strong hygroscopicity.

It is known that calcium ions released alginate fibers capable of absorbing wound exudate, published by Qin Yiming functional medical dressings (Textile Industry Press, 2007.02, page 125) relates to a calcium alginate dressing released calcium ions in solution A concentrations up to 560mg / Kg. Collins F, Hampton S and White R, et al. (Collins F, Hampton S, White R (2002) AZ Dictionary of Wound Care. Mark Allen Publishing Ltd., Dinton Wiltshire) also reported on the case of calcium ions to promote wound healing.

Calcium alginate dressing can absorb wound exudate, but the high absorption amount is less than the dressing made from chemically modified cellulose fibers.

EP 0740554 and US 6471982 both disclose a fiber with a dressing may be one kind of gel fibers and fibers such as ordinary non-gelling alginate fibers, such as cellulose fiber blend obtained. Fibers can reduce the production cost of the dressing by the above method.

US 7385101 discloses a blend of silver-coated nylon fibers and absorbent fibers made of a wound dressing, the dressing for treating infected wounds generally.

US 5836970 describes a mixture of chitosan and alginate wound dressing made of two kinds of fibers. Discloses a bacteriostatic and hemostatic chitosan and alginic acid fibers have a moderate hygroscopicity this patent application.

US 6458460, EP0927013 and CN1303355 describe a wound dressing made from two fiber mixed gel made of a carboxymethylcellulose fiber, alginic acid fiber and the other is to promote the absorption of moisture absorption and achieve best wound exudate.

EP 1318842 discloses a wound dressing, the dressing may comprise one silver binding fibers as the first fibers and a second fiber-free silver fiber. The dressing also have both antibacterial function moisture absorption.

CN 1313416 discloses a method of blending cotton fibers and chitosan fibers. Although the object of the invention of this application is not wound care, but also disclosed a product obtained above blend has some antibacterial effect.

Thus known in the art may be chitosan fibers, chemically modified cellulosic fibers and calcium alginate fibers, alone or in a combination of both applied to the chronic wound care and each having a respective bacteriostatic in clinical applications, high hygroscopic and provide calcium ions. However, the inventors noted that so far, prior art wound dressing is typically formed from two types of fibers simultaneously, it is not implemented while dressing for the three fibers are formed on the same wounds. Thus there remains a need to provide optimal conditions for the healing of a wound dressing for chronic wounds. Summary of the Invention The present invention relates to a wound dressing, wherein the wound dressing comprises cellulose fibers after the chitosan fibers, calcium alginate fibers and chemical modification. In particular, the present invention relates to a wound dressing, the chitosan fibers, chemically modified cellulosic fibers and calcium alginate fibers are uniformly blended together, the respective strengths of the three fibers wound healing play a joint, such as chronic wound healing provide an optimum healing conditions. The present invention further relates to the use of such wound dressings for the treatment of chronic wounds.

In particular, the present invention relates to a wound dressing, the wound dressing of 5-90% by weight of chitosan fibers, the percent of 5 to 90% of calcium alginate fibers and chemically modified cellulose 5-90 wt. laced fibers, chitosan fibers, the total weight of the chemically modified cellulose fibers and calcium alginate fiber weight.

The present invention further relates to a certain rate, by the chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber blends, provide antimicrobial activity to the wound dressing, and the hygroscopicity while the supply of calcium ions.

The present invention has the following advantages compared with the prior art:

In the wound dressing of the present invention obtained three fibers blended, the inhibitory effect of chitosan fibers protruding, chemically modified cellulose fibers have good hygroscopicity, is easy to form a hydrogel, and into a transparent plastic, alginic The main contribution of fiber, calcium, calcium ions. Compared to the prior art, the dressing functions in a set of three advantages of the present invention can meet the environmental requirements of wound healing.

In particular, chitosan blend fibers, chemically modified cellulosic fibers and calcium alginate fiber wound dressing obtained at the same time achieve three functional advantages, as compared with a single fiber or a fiber blend of any two, but also for the dressing itself It provides the best wet strength.

Furthermore, different states or stages of the wound, in particular, the wound dressing of the present invention according to the needs of the healing environment, adjusting proportions of the three functions at the benefits dressings, flexible use of combined action of the wound dressing according to the present invention accurately . BRIEF DESCRIPTION

Figure 1 shows an embodiment of wound dressing in Bacillus subtilis dish for 2 days, 3 days, 8 days inhibition zones embodiment.

Release capability changes over time and Figure 2 is an embodiment of the wound dressing embodiment of calcium ions. 3 shows Example 4 of the wound dressing in B. subtilis culture dishes for 2 days, 3 days, 8 days inhibition zones embodiment. FIG 4 is changed to the release time and the ability of calcium ions embodiment of the wound dressing of Example 4. Figure 5 shows an embodiment of a wound dressing of the B. subtilis culture dishes for 2 days, the zone of inhibition for 3 days 8 days.

And the ability to change the release time for the wound dressing of FIG. 6 Example 7 calcium ions. detailed description

In one embodiment of the present invention, chitosan fibers, chemically modified cellulosic fibers and calcium alginate fibers can be produced separately by the respective production methods, respectively. Alginate alginate fibers by extruding it into a calcium solution prepared. Preferably, a high M alginate fibers selected type alginic acid, alginate or high G type M / G hybrid alginic acid. Chitosan fibers extruded into the polymer solution prepared NaOH solution. Chemically modified cellulose fiber obtained according to each process solution corresponding to the relevant reaction. Preferably, the chemically modified chitosan fibers by processes such as carboxymethylation, and acylation. Preferably, chemically modified cellulosic fibers are selected from carboxymethyl cellulose fibers, preferably cellulose fibers by the sulfonation of alkyl with carboxymethylated solvent-spun cellulose fiber or water-insoluble.

In one particular embodiment of the present invention, may be mixed chitosan fibers, chemically modified cellulosic fibers and calcium alginate fibers before the nonwoven fabric or nonwoven fabric process step. Mixing the fibers is generally carried out fiber opening stage. After the fiber opening stage, a good mix of fiber carding, then into a nonwoven fabric production process, such as nonwoven needle.

In a further particular embodiment of the invention, the chitosan fibers according to the present invention, chemically modified cellulose fibers and calcium alginate fibers may be added a surfactant to aid in subsequent processing.

In one particular embodiment of the invention, the chitosan fibers, chemically modified cellulosic fibers and the content of calcium alginate fiber wound dressing depend on the final requirements and functions. Chitosan fiber content of 5 to 90 wt%, based on the total weight of the chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber weight. Chemically modified cellulose fiber content of 5 to 90 wt%, based on chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber total weight. The content of calcium alginate fibers is 5-90 wt%, based on chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber total weight.

Preferably, the present invention relates to a wound dressing consisting of 45% by weight of chitosan fibers, 50% by weight of chemically modified cellulose fibers and 5% by weight of alginate fibers are uniformly blended together. The wound dressing may suitably supplying calcium ions, but with better moisture absorption and bacteriostatic function.

Preferably, the present invention relates to a wound dressing, a 33.33% by weight of chitosan fibers, 33.33% by weight of chemically modified cellulose fibers and 33.33 wt% calcium alginate fibers are uniformly blended together. The wound dressing may have the ability to provide balanced calcium ions, preferably absorbent and bacteriostatic functional.

More preferably, the desired performance requirements of the final wound dressing, chitosan fibers may be selected, chemically modified cellulose fibers and calcium alginate fibers either component to 50 wt%, or 60 wt%, even up to 90 weight%.

In one particular embodiment of the invention, the content of chitosan fiber is 5% by weight, the content of calcium alginate fibers is 5% by weight and the content of chemically modified cellulosic fibers was 90% by weight. Preferably, the fiber content of chitosan is 10% by weight, the content of calcium alginate fiber content of 10% by weight of chemically modified cellulose fibers and 80% by weight. More preferably, the content of chitosan fiber is 25% by weight, the content of calcium alginate fibers is 25% by weight and the content of chemically modified cellulosic fibers was 50% by weight.

More preferably, the wound dressing according to the present invention, when determining the content of any material, preferably additionally controls the proportion of the two materials between 1: 18: 1 to 1. For example, in determining the content of chitosan dressing, the proportion of calcium alginate fibers and chemically modified cellulose fibers is from 1: 1 to 1:18; or determining the content of calcium alginate dressing, the chitosan fibers chemically modified cellulose fibers and the ratio of 1: 1 to 1: 18 or in the dressing proportion of chemically modified cellulose fiber content of calcium alginate fibers is determined and chitosan fiber is 1: 1 to 1:18.

In the present invention, appropriately controlled chitosan fibers, chemically modified linear density and length of calcium alginate fibers and cellulosic fibers in the dressing to suit the production process. Chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber linear density of 0.5 to 5 dtex, preferably 2 to 4dtex. Chitosan fibers, chemically modified cellulosic fibers and a length of calcium alginate fibers were 10 to 125mm.

On the other hand, the wound dressing according to the present invention, chitosan fibers, chemically modified cellulosic fibers are calcium alginate fiber containing 1% by weight of Tween 20 as the surfactant. Further, the wound dressing according to the present invention, chitosan fibers, chemically modified cellulosic fibers and a fibrous calcium alginate fibers or both fibers containing 1-5% by weight of nano silver PHMB or bacteriostatic agent as a ratio . The present invention further relates to a wound dressing comprising the chitosan fibers cellulosic fibers, calcium alginate fibers, and the chemical modification of any two non-sol and fibers. In other words, the wound dressing of the chitosan fibers, calcium alginate fibers and cellulose fibers after chemical modification of any of the fibers is replaced by a non-sol fiber, thereby enhancing the strength of the wound dressing. Sol of a non-viscose fibers, polyester fibers, nylon fibers, vinylon fibers and the like.

The present invention further relates to a process for the preparation of a wound dressing, the process by the nonwoven fabric, the nonwoven fabric preferably needling process, the chitosan fibers, chemically modified cellulosic fibers and the resulting calcium alginate fibers blended fabric, and the fabric cutting, packaging and sterilization. The wound dressing of the present invention, the production process preferably needled nonwoven process, may be used other nonwoven processes such as spunbond process.

The different shape of the desired wound dressing a wound, chitosan fibers, chemically modified cellulosic fibers and the resulting calcium alginate fibers blended fabric may be cut and / or cut into squares or rectangles to meet a variety of wound care applications .

The wound dressing according to the present invention are generally known by those skilled in the packaging material, sterilizing. Gamma sterilization or ethylene oxide may be selected embankment.

The wound dressing of the present invention obtained as described above while having antimicrobial activity, calcium ions and moisture supply. Example 1

Calcium alginate was prepared containing 10%, 80% and 10% modified cellulose modified chitosan wound dressing:

Starting material: calcium alginate fibers, the fineness of 7.0 dtex or, a length of 45 mm, A solution absorption rate of more than 1400%;

Modified cellulose, which fineness of 1.7 dtex, a length of 65 mm, the fibers treated by carboxymethyl, its hygroscopic property of the sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption rate of more than 1500%;

Chitosan, which is a fineness of 2.0 dtex, a length of 50 mm, the fibers acylation treatment, the hygroscopicity of sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption of 200% or more;

7 Brookhaven mixing calcium alginate fibers, modified cellulose and 56 g 7 g modified chitosan and the opener opening by feeding the carding machine, three fibers in the feed hopper will further mixed in a carding machine. After carded web formed of a homogeneous mixture of three fibers. Afterward, by laying the web, then needle-punched non-woven fabric, basis weight 135.3 g / m.

This nonwoven fabric was cut into 10 X 10 cm pieces of wound dressing obtained after repackaging embankment sterilization with ethylene oxide.

The YY / T 0471. 1-2004 "wound dressing Test Method" § 1 and EN

13726-1: 2002 / AC: 2003 Test methods for primary wound dressings §3.2 test the absorption rate. The dressing A solution of 25.7 g of the absorption / 100 cm2, 0.9% NaCl solution was pipetted salt was 26.0 g / 100 cm2. Universal testing machine measured average wet strength CD1.8N / cm. Example 2

In order to observe the performance obtained in Example 1 Antibacterial dressing embodiment, inoculation amount about 250μΙ ^ Χ 10Ε6 cfu / mL Bacillus subtilis uniformly coated dish and then cut into the dressing 1 obtained in Example 2 X 2cm embodiment respectively discharge wherein the continuous culture and growth of bacteria was observed on each plate at a constant temperature of 37 ° C.

Figure 1 shows the dressing in B. subtilis dish 2 days, 3 days, 8 days inhibition zones, it can be seen remains inhibitory effect on Day 8. Example 3

In order to observe calcium release performance obtained in Example 1 wound dressing, in a test tube was added

10mL0.9% NaCl solution, obtained in Example 1 and the dressing was cut into 2.5 X 2.5cm, weighed and into which, parallel design, 1 to 7 days of the simulation test at 37 ° C. Obtained from the calcium content and release liquid dressing calcium content release characteristics, as shown, and the ability to release calcium ions in time shown in Figure 2, wherein the ratio of total release than the release of calcium to the total amount of liquid calcium content of the fibers. Atomic absorption spectrophotometer, the ratio of the average total release of calcium was 26.9%, mean release rate of 21.7ppm / 0.1g fiber OmL brine. Blended in as a calcium source of low levels of calcium alginate, calcium release rate also will be low. Example 4

, The wound dressing 10% and 10% modified cellulose modified chitosan of 80% calcium alginate was prepared containing:

Starting material: calcium alginate fibers, the fineness of 7.0 dtex or, a length of 45 mm, A solution absorption rate of more than 1400%;

Modified cellulose, which fineness of 1.7 dtex, a length of 65 mm, the fibers treated by carboxymethyl, its hygroscopic property of the sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption rate of more than 1500%;

Chitosan, which is a fineness of 2.0 dtex, a length of 50 mm, the fibers acylation treatment, the hygroscopicity of sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption of at least 200%.

56 Brookhaven mixing calcium alginate fibers, modified cellulose and 7 g 7 g modified chitosan and treated with the opener opening after feeding a carding machine, the fibers in the feed hopper will further mixed in a carding machine. After carded web formed of a homogeneous mixture of three fibers. Afterward, by laying the web, then needle-punched non-woven fabric, basis weight 129.1 g / m.

This nonwoven fabric was cut into 10 X 10 cm pieces of wound dressing obtained after repackaging embankment sterilization with ethylene oxide.

According YY / T 0471. 1-2004 "wound dressing test methods" § 1 and EN 13726-1: 2002 / AC: 2003 Test methods for primary wound dressings §3.2 test the absorption rate. The dressing A solution of 25.7 g of the absorption / 100 cm2, 0.9% NaCl solution was pipetted salt was 17.9 g / 100 cm2. Universal testing machine measured average wet strength CD3.09N / cm. Example 5

For antimicrobial properties of the wound dressing embodiment viewed 4 embodiment, inoculation amount about 250μΙ ^ Χ 10E6 cfu / mL Bacillus subtilis uniformly coated dish, and the embodiment were obtained in Example 1 was cut into dressings 2 X 2cm into which the continuous culture and growth of bacteria was observed on each plate at a constant temperature of 37 ° C.

Figure 3 shows the dressing in B. subtilis culture dishes for 2 days, the zone of inhibition 3 days, 8 days, sample from the dressing covering the area no bacterial growth inhibitory effect can be seen that remains on Day 8. Example 6

Calcium release properties to the wound dressing embodiment viewed Example 4, was added in a test tube

10mL0.9% NaCl solution, and then the dressing obtained in Example 4 was cut into 2.5 X 2.5cm, weighed and into which, parallel design, 1 day to 7 days simulation test at 37 ° C. Obtained from the calcium content and release liquid dressing calcium content release characteristics, and FIG. 4 is a time release capabilities of the calcium ions, the total amount of calcium release ratio of the fiber content of calcium release liquid ratio. Atomic absorption spectrophotometer, the ratio of the average total release of calcium was 20.6%, mean release rate 118.4ppm / 0.1g fiber / lOmL brine. Content of calcium alginate blend as the highest source of calcium, calcium release rate also will be the highest. Example 7

, The wound dressing 33% and 33% modified cellulose modified chitosan of 33% calcium alginate was prepared containing:

Starting material: calcium alginate fibers, the fineness of 7.0 dtex or, a length of 45 mm, A solution absorption rate of more than 1400%;

Modified cellulose, which fineness of 1.7 dtex, a length of 65 mm, the fibers treated by carboxymethyl, its hygroscopic property of the sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption rate of more than 1500%;

Chitosan, which is a fineness of 2.0 dtex, a length of 50 mm, the fibers acylation treatment, the hygroscopicity of sodium chloride and 0.368 g of calcium chloride dihydrate of 8.298 grams per liter in the fiber state the solution (a solution) absorption of at least 200%.

23 Brookhaven mixing calcium alginate fibers, modified cellulose and 23 grams Chitosan 23 grams and the opener opening by feeding the carding machine, the fibers in the feed hopper will further mixed in a carding machine. After carded web formed of a homogeneous mixture of three fibers. Afterward, by laying the web, then needle-punched non-woven fabric, basis weight 132.6 g / m.

This nonwoven fabric was cut into 10 X 10 cm pieces of wound dressing obtained after repackaging embankment sterilization with ethylene oxide.

The YY / T 0471. 1-2004 "wound dressing Test Method" § 1 and EN

13726-1: 2002 / AC: 2003 Test methods for primary wound dressings §3.2 test the absorption rate. The dressing A solution of 26.4 g of the absorption / 100 cm2, 0.9% NaCl solution was pipetted salt was 26.7 g / 100 cm2. Universal testing machine measured average wet strength CD4.2N / cm. Example 8

For wound dressing antibacterial activity was observed in Example 7 embodiment, inoculation amount about 250μΙ ^ Χ 10E6 cfu / mL Bacillus subtilis uniformly coated dish and then cut into the dressing obtained in Example 7, respectively Embodiment 2 X 2cm into which the continuous culture and growth of bacteria was observed on each plate at a constant temperature of 37 ° C.

Figure 5 shows the dressing in B. subtilis culture dishes for 2 days, the zone of inhibition 3 days, 8 days, it can be seen remains inhibitory effect on Day 8. Example 9

Calcium release properties to the wound dressing embodiment viewed Example 7, was added 10mL0.9% NaCl solution in a test tube, and the resulting dressing in Example 7 was cut into 2.5 X 2.5cm, weighed and into which, at 37 ° C for parallel design, 1 day to 7 days simulation test. Obtained from the calcium content and release liquid dressing calcium content release characteristics, and FIG. 6 is a time release capabilities of the calcium ions, the release ratio of the total amount of calcium in the calcium content of the fiber mixture ratio of release. Atomic absorption spectrophotometer, the ratio of the average total release of calcium was 29.3%, mean release rate of 82.9ppm / 0.1g fiber OmL brine. Blended in as a calcium source of low levels of calcium alginate, calcium release rate also will be low.

Claims

Claims
An antibacterial wound dressing having the absorbent, and the contribution of calcium ions, wherein the wound dressing comprises cellulose fibers after the chitosan fibers, calcium alginate fibers and chemical modification.
2. A wound dressing having antibacterial, absorbent, and the contribution of calcium ions, characterized in that the wound dressing from chitosan fibers, calcium alginate fibers and cellulose fibers after chemical modification laced.
3, wound dressing as claimed in any one of claims 1-2 of the wound dressing of 5-90% by weight of chitosan fibers, 5-90% by weight of calcium alginate fibers and 5-90 wt claims, characterized in that after the chemical modification of cellulose fibers laced%, based on the total weight of the chitosan fibers, chemically modified cellulosic fibers and fibers of calcium alginate meter.
4, wound dressing as claimed in any one of claims 1-3, wherein the ratio of calcium alginate fibers and chemically modified cellulose fibers is from 1: 1 to 1:18.
5, wound dressing as claimed in any one of claims 1-3, wherein the proportion of chitosan fibers and chemically modified cellulose fibers is from 1: 1 to 1:18.
6, wound dressing as claimed in any one of claims 1-3, wherein the ratio of calcium alginate fibers and chitosan fiber is 1: 1 to 1:18.
7, wound dressing as claimed in any one of claims 1-6, the chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber linear density of 0.5 to 5 dtex, preferably 2 to 4dtex.
8. A wound dressing as claimed in any one of claims 1-6, the chitosan fibers, chemically modified cellulosic fibers and calcium alginate fiber length of 10mm to 125mm, respectively, it is preferably 25 to 85mm.
9. A wound dressing according to any of claims 1-6, the chitosan fibers, chemically modified cellulosic fibers are calcium alginate fibers contain a surfactant.
10, wound dressing as claimed in any one of claims 1-6, wherein the chitosan fibers, calcium alginate fibers and cellulose fibers after chemical modification of one or both fibers contain a bacteriostatic agent.
11. A method as claimed in preparing a wound dressing according to any of claims 1-9, the process by the nonwoven fabric, the nonwoven fabric preferably needling process, the chitosan fibers, chemically modified cellulosic fibers and algae calcium fiber blended fabric obtained, the fabric is then cut, packaged and sterilized.
12. A wound dressing having antibacterial, absorbent, and the contribution of calcium ions, wherein the wound dressing comprises cellulose fibers after the chitosan fibers, calcium alginate fibers, and the chemical modification of any two non-sol fiber.
PCT/CN2011/084370 2011-01-05 2011-12-21 Anti-bacterial, moisture absorptive and calcium ion donating wound dressing WO2012092812A1 (en)

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CN103284842A (en) * 2013-05-21 2013-09-11 泰州市三易医疗科技有限公司 Preparation process of alginate surgical dressings
CN105233327A (en) * 2015-11-09 2016-01-13 佛山市优特医疗科技有限公司 Quaternized chitosan fibers and moisture-absorbing antibacterial wound dressing

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