JP2001316400A - ローヤルゼリーの鮮度の指標物質 - Google Patents
ローヤルゼリーの鮮度の指標物質Info
- Publication number
- JP2001316400A JP2001316400A JP2000326370A JP2000326370A JP2001316400A JP 2001316400 A JP2001316400 A JP 2001316400A JP 2000326370 A JP2000326370 A JP 2000326370A JP 2000326370 A JP2000326370 A JP 2000326370A JP 2001316400 A JP2001316400 A JP 2001316400A
- Authority
- JP
- Japan
- Prior art keywords
- royal jelly
- protein
- freshness
- indicator
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940109850 royal jelly Drugs 0.000 title claims abstract description 59
- 239000000126 substance Substances 0.000 title claims abstract description 21
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 58
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 58
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 claims description 5
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000006866 deterioration Effects 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000009182 swimming Effects 0.000 description 15
- 238000000034 method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 238000001962 electrophoresis Methods 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000001766 physiological effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000002523 gelfiltration Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000005571 anion exchange chromatography Methods 0.000 description 3
- 230000002929 anti-fatigue Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000001641 gel filtration chromatography Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009661 fatigue test Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- DJXDNYKQOZYOFK-GUBZILKMSA-N (4s)-4-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-5-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O DJXDNYKQOZYOFK-GUBZILKMSA-N 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- GQRDIVQPSMPQME-ZPFDUUQYSA-N Asn-Ile-Leu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O GQRDIVQPSMPQME-ZPFDUUQYSA-N 0.000 description 1
- SOEPMWQCTJITPZ-SRVKXCTJSA-N Glu-Met-Lys Chemical compound CSCC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCC(=O)O)N SOEPMWQCTJITPZ-SRVKXCTJSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- DBXXASNNDTXOLU-MXAVVETBSA-N Ile-Leu-His Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N DBXXASNNDTXOLU-MXAVVETBSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- LXKNSJLSGPNHSK-KKUMJFAQSA-N Leu-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)N LXKNSJLSGPNHSK-KKUMJFAQSA-N 0.000 description 1
- YPLVCBKEPJPBDQ-MELADBBJSA-N Lys-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCCN)N YPLVCBKEPJPBDQ-MELADBBJSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- KAJLHCWRWDSROH-BZSNNMDCSA-N Phe-Phe-Asp Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(O)=O)C1=CC=CC=C1 KAJLHCWRWDSROH-BZSNNMDCSA-N 0.000 description 1
- 108010052388 RGES peptide Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 108010068265 aspartyltyrosine Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 108010038320 lysylphenylalanine Proteins 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000326370A JP2001316400A (ja) | 2000-03-02 | 2000-10-26 | ローヤルゼリーの鮮度の指標物質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000056563 | 2000-03-02 | ||
| JP2000-56563 | 2000-03-02 | ||
| JP2000326370A JP2001316400A (ja) | 2000-03-02 | 2000-10-26 | ローヤルゼリーの鮮度の指標物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001316400A true JP2001316400A (ja) | 2001-11-13 |
| JP2001316400A5 JP2001316400A5 (https=) | 2006-08-10 |
Family
ID=26586571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000326370A Pending JP2001316400A (ja) | 2000-03-02 | 2000-10-26 | ローヤルゼリーの鮮度の指標物質 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001316400A (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003192541A (ja) * | 2001-12-26 | 2003-07-09 | Pola Chem Ind Inc | 育毛促進剤及び育毛用の皮膚外用剤 |
| JP2006008597A (ja) * | 2004-06-25 | 2006-01-12 | Pola Chem Ind Inc | 美肌用のキット |
-
2000
- 2000-10-26 JP JP2000326370A patent/JP2001316400A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003192541A (ja) * | 2001-12-26 | 2003-07-09 | Pola Chem Ind Inc | 育毛促進剤及び育毛用の皮膚外用剤 |
| JP2006008597A (ja) * | 2004-06-25 | 2006-01-12 | Pola Chem Ind Inc | 美肌用のキット |
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Legal Events
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| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060622 |
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| A621 | Written request for application examination |
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