JP2001302475A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for oral cavity capable of exhibiting an antimicrobial capability necessary for hygienic point satisfactorily and excellent in use feeling. SOLUTION: This composition for oral cavity is characterized by blending 1 kind or >=2 kinds selected from 2-methylresorcinol, p-methoxyphenol, cathechol, pyrogallol, glycelaldehyde dimmer, furfural, salicylaldehyde, p-hydroxybezaldehyde, m- hydroxybenzaldehyde, terephthalaldehyde, isophthalaldehyde, 2,4-dihydroxybenzaldehyde, 3,4-hydroxybenzaldehyde, nonanol, decanol, undecanol, dodecanol, undecenol, tridecenol, 4-tert-amylcyclohexanol, 2-cyclohexyl-cyclohexanol, cyclodecanol, 2-hydroxy-2,5,5- trimethyloctalin-2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-bute n-1-ol, bisabolol, patchouli alcohol, rhodinol, menthenol, dimethyloctenol, ledol, phenyl ethylisoamyl ethex muscogene, bicyclodihydrofarnesyl oxide, muguetaldehyde, enpetal, junipal, hydrojasmal, undecanone, docecanone, cyclododecanone, heptylcyclopentanone, cyclohexylmethylpentanone, trimethylcyclohexenylbutenone, acetylisopropylmethylbicyclooctene, menthenylpropanone, isolongifolanone, methylcyclopentanone, butylidenetrimethylcyclopentanone, trimethylcyclohexenyl butanone, silanburene, nutcatone, ionone, hexanal, t-2-hexanal, cis-3-hexanal, t-2-hexanal dimethylacetal, t-2-hexanal diethylacetal, t-2-hexanal propylene glycolacetal and p- methoxycinnamicaldehyde.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having a sufficient preservative power without impairing the feeling of use.

[0002]

2. Description of the Related Art
Preservatives such as sodium benzoate and paraoxybenzoate are widely used in oral compositions. If these preservatives are added in a large amount, they may affect the flavor of the composition and reduce the feeling of use, so that sweet flavors and sweeteners (JP-A-60-130509) and lower alcohols (Japanese Patent Publication No. Sho 61-130) may be used. Japanese Patent Application Laid-Open No. 4812) and a higher alcohol (Japanese Patent Application Laid-Open No. 60-75423) have been proposed to improve the usability by using the same in combination.

[0003] However, in these techniques, it is essential to incorporate a preservative such as sodium benzoate and paraoxybenzoate in the composition in terms of preservation.
At present, it has not been sufficiently improved in the usability. Therefore, development of an oral composition having both an excellent preservative effect and a feeling of use is desired.

[0004] The present invention has been made to meet the above-mentioned demands, and an object of the present invention is to provide a composition for oral cavity which exhibits high antiseptic properties and has an excellent feeling in use.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and as a result, have found that 2-methyl-resorcinol, p-methoxyphenol, catechol, pyrogallol, glycerol Aldehyde dimer, furfural, salicylaldehyde, p-hydroxybenzaldehyde, m-hydroxybenzaldehyde, terephthalaldehyde, isophthalaldehyde, 2,4-dihydroxybenzaldehyde, 3,4-
Hydroxybenzaldehyde, nonanol, decanol, undecanol, dodecanol, undecenol,
Tridecenol, 4-tert-amylcyclohexanol, 2-cyclohexylcyclohexanol, cyclododecanol, 4-cyclohexylcyclohexanol, cyclodecanol, 2-hydroxy-2,5,5-
Trimethyloctalin-2-ethyl-4- (2,2,3
-Trimethyl-3-cyclopenten-1-yl) -2-
Buten-1-ol, bisabolol, patchouli alcohol, rhinol, maintenancenol, dimethyloctenol, redol, phenylethylisoamyl ether, muscogen, bicyclodihydrofarnesyl oxide,
Mugealdehyde, Empetal, Junipal, Hydrojasmar, Undecanone, Dodecanone, Cyclododecanone, Heptylcyclopentanone, Cyclohexylmethylpentanone, Trimethylcyclohexenylbutenone, Acetylisopropylmethylbicyclooctene, Menthenylpropanone, Isolondiphora Non, hexylcyclopentanone, butylidenetrimethylcyclopentanone, trimethylcyclohexenylbutenone, silanebrene, nootkatone, ionone, hexanal, t-2
-Hexenal, cis-3-hexenal, t-2-
Hexenal dimethyl acetal, t-2-hexenal diethyl acetal, t-2-hexenal propylene glycol acetal and p-methoxycinnamic aldehyde exhibit surprisingly excellent antiseptic effects, and one or more selected from these compounds By blending in the oral composition as a preservative component, even without adding any preservative selected from benzoic acid and its salts and alkyl esters of p-hydroxybenzoic acid, it exhibits excellent preservative properties and is hygienic. It has been found that the necessary antibacterial activity is sufficiently imparted, a hygienic composition can be provided, and a composition for the oral cavity that has a favorable use feeling with little adverse effect on the flavor of the composition can be obtained. Invented the invention.

Accordingly, the present invention provides an oral composition comprising one or more selected from the above specific compounds as a preservative.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention includes dentifrices such as toothpaste, liquid toothpaste, lubricating toothpaste, powdered toothpaste, mouthwash, mouthwash,
Lozenges, oral pastas, solid oral fresheners, tablets for gargle, etc., which are 2-methyl-resorcinol, p-methoxyphenol, catechol, pyrogallol, glyceraldehyde dimer, furfural, salicylaldehyde, p -Hydroxybenzaldehyde,
m-hydroxybenzaldehyde, terephthalaldehyde, isophthalaldehyde, 2,4-dihydroxybenzaldehyde, 3,4-hydroxybenzaldehyde,
Nonanol, decanol, undecanol, dodecanol, undecenol, tridecenol, 4-tert-
Amylcyclohexanol, 2-cyclohexylcyclohexanol, cyclododecanol, 4-cyclohexylcyclohexanol, cyclodecanol, 2-hydroxy-2,5,5-trimethyloctalin-2-ethyl-4- (2,2,3 -Trimethyl-3-cyclopenten-1-yl) -2-buten-1-ol, bisabolol, patchouli alcohol, rosinol, maintenancenol,
Dimethyl octenol, redol, phenylethyl isoamyl ether, muscogen, bicyclodihydrofarnesyl oxide, mugealdehyde, empetal,
Junipearl, hydrojasmar, undecanone, dodecanone, cyclododecanone, heptylcyclopentanone, cyclohexylmethylpentanone, trimethylcyclohexenylbutenone, acetylisopropylmethylbicyclooctene, maintenancenylpropanone, isorondiphoranone, hexylcyclopentane Nonyl, butylidenetrimethylcyclopentanone, trimethylcyclohexenylbutenone, silanebrene, nootkatone, ionone, hexanal, t-2-hexenal, cis-3-hexenal, t-2-hexenal dimethyl acetal,
One or two selected from t-2-hexenal diethyl acetal, t-2-hexenal propylene glycol acetal and p-methoxycinnamic aldehyde
More than one kind is blended as a preservative component.

In this case, as the preservative component, among the above compounds, glyceraldehyde dimer, p-hydroxybenzaldehyde, m-hydroxybenzaldehyde, terephthalaldehyde, isophthalaldehyde,
2,4-dihydroxybenzaldehyde and 3,4-hydroxybenzaldehyde are preferably used.

The content of the above preservative component is 0.0001 to 1% (% by mass, hereinafter the same) of the whole composition, especially 0.0%.
The range of 01 to 0.2%, particularly 0.005 to 0.15%, is suitable. If the amount is too small, a satisfactory preservative effect may not be obtained. If the amount is too large, the flavor is adversely affected. It may be inferior in usability.

[0010] The composition of the present invention contains the above preservative component as an essential component, and can exhibit sufficient preservative properties without the addition of any other preservative. If necessary, preservatives selected from benzoic acid and its salts and paraoxybenzoic acid alkyl esters known as preservatives conventionally blended in oral compositions, specifically benzoic acid, sodium benzoate and the like Alkali metal benzoate, methyl parahydroxybenzoate,
An alkyl ester of paraoxybenzoic acid, such as ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate, and the like can be blended as long as the effects of the present invention are not impaired. The content of these preservatives is preferably not more than 0.3%, more preferably not more than 0.1% of the total composition, and more preferably not added. The feeling may be inferior.

The oral composition of the present invention can be prepared by an ordinary method by further blending other additives as optional components according to the dosage form.

In the case of dentifrices, for example, abrasives, binders,
Thickeners, surfactants, sweeteners and the like may be included. Specifically, dibasic calcium phosphate dihydrate and anhydride, calcium carbonate, calcium pyrophosphate, calcium sulfate, insoluble sodium metaphosphate, silicic anhydride, hydrous silicic acid, aluminosilicate, alumina, aluminum hydroxide, One or more abrasives such as magnesium phosphate, magnesium carbonate, synthetic resin and the like may be blended (the blending amount is usually 10 to 90% of the whole, especially 20 to 60% for toothpaste). Further, as the thickener, one or more of sorbitol, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, xylit, maltit, lactit and the like can be blended (the blending amount is usually 5 to 85% ), One or two or more of sodium carboxymethylcellulose, carrageenan, sodium alginate, polyacrylic acid and its salts, gums, polyvinyl alcohol, hydroxyethylcellulose, etc. may be blended as the binder (the blending amount is usually 0.1%). 3-5%).

Further, anionic surfactants such as sodium lauryl sulfate, lauroyl sarcosinate, α-olefin sulfonate, taurate, lauryl monoglyceride sulfate, lauryl monoglyceride sulfonate, N-long chain acyl amino acid salt, and soap;
Nonionic surfactants such as lauric acid diethanolamide, stearyl monoglyceride, sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, polyoxyethylene sorbitan monostearate, polyglycerin fatty acid ester, betaine type, amino acid One or more surfactants such as an amphoteric surfactant such as a mold may be blended (the blending amount is usually 0.5 to 7%).

[0014] One or more sweeteners such as saccharin sodium, stevioside, neohesperidyl dihydrochalcone, thaumatin, glycyrrhizin, perillartin, sucralose and the like may be blended.

Still further, the composition of the present invention includes peppermint oil, spearmint oil, peppermint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, Lime oil,
Grapefruit oil, mandarin oil, cardamom oil, coriander oil, lavender oil, lemongrass oil, rosemary oil, laurel oil, camomill oil, caraway oil,
Natural flavors such as marjoram oil, bay oil, origanum oil, pine needle oil, neroli oil, jasmine oil, iris concrete, mastic oil, menthol, l-carvone, anethole, thymol, linalool, linalyl acetate, limonene, menthol, menthol Individual flavors such as acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, etc.
Ethyl acetate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, amyl alcohol, hexenol, dimethyl sulfide, cycloten, trimethyl pyrazine, ethyl lactate, ethyl One or two types of strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, fruit flavor, etc. which contain a single flavor such as thioacetate or natural flavor. The above fragrances can be blended. The amount of the fragrance as these optional ingredients is usually
0.1-2.0%, especially 0.5-1.5% of the total composition
Is preferred.

Further, in the present invention, as active ingredients, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, and alkali such as sodium monofluorophosphate and potassium monofluorophosphate are used. Fluorine compounds such as metal monofluorophosphate and sodium fluoride, polyethylene glycol, polyvinylpyrrolidone, allantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, ε-aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, triclosan , Chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, ascorbic acid and its salts, tokoff Roll, Scutellaria, Oobaku,
One or more active ingredients such as crude drug extracts such as rosemary, clove, and thyme may be blended.

Further, oral compositions of other dosage forms can be produced by a usual method using components according to the kind.

The oral composition thus obtained is
An aluminum tube, a laminated tube in which both surfaces of an aluminum foil are laminated with a plastic or the like, a plastic tube, or a predetermined container such as a bottle-shaped container or an aerosol container can be used for use.

[0019]

The oral composition of the present invention is capable of satisfactorily exhibiting the necessary antibacterial activity in terms of hygiene, provides a hygienic composition, and is excellent in the feeling of use. .

[0020]

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, all% are mass%.
It is. [Examples and Comparative Examples] Using the fragrances shown in Table 1, Tables 2-1
An oral composition having the composition shown in No. 7 was prepared by a conventional method, and the preservative power and the feeling upon use were evaluated by the following methods. The results are shown in Tables 2 to 17. Antiseptic power evaluation method Each antiseptic component was added in an amount of 0.001 to 0.2 in 30 g of the oral composition.
% Of the gram-negative bacteria (rods) from the environment
Inoculated in such a way that 0 ⁷ CFU / g, 1,4,7,1
The bacterial count was measured after 4, 28 days. <Score> ◎: Bacteria are killed within 7 days ○: Bacteria are killed within 14 days ×: Bacteria are killed for 14 days or more, or they do not die Evaluation of feeling of use Oral cavity prepared by a specialized panel of 10 people The flavor when the composition for use was used was evaluated on a 5-point scale, and the average value of the scores of the obtained 10 panels was applied to the following criteria to evaluate the feeling of use.

[0021]

[Table 1]

[0022]

[Table 2]

[0023]

[Table 3]

[0024]

[Table 4]

[0025]

[Table 5]

[0026]

[Table 6]

[0027]

[Table 7]

[0028]

[Table 8]

[0029]

[Table 9]

[0030]

[Table 10]

[0031]

[Table 11]

[0032]

[Table 12]

[0033]

[Table 13]

[0034]

[Table 14]

[0035]

[Table 15]

[0036]

[Table 16]

[0037]

[Table 17]

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Yoko Honma 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Corporation (72) Inventor Satoshi Ito 1-3-7, Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C083 AA122 AB052 AB172 AB222 AB292 AB312 AB352 AB472 AC022 AC081 AC091 AC092 AC102 AC122 AC132 AC151 AC171 AC172 AC211 AC302 AC432 AC471 AC472 AC482 AC642 AC782 AC841 AC842 AC862 AD042 AD222 AD242 AD272 AD 532 532

Claims (1)

[Claims] 1. 2-methyl-resorcinol, p-methoxyphenol, catechol, pyrogallol, glyceraldehyde dimer, furfural, salicylaldehyde, p-hydroxybenzaldehyde, m-hydroxybenzaldehyde, terephthalaldehyde, isophthalaldehyde, 2,4 -Dihydroxybenzaldehyde,
3,4-hydroxybenzaldehyde, nonanol, decanol, undecanol, dodecanol, undecenol, tridecenol, 4-tert-amylcyclohexanol, 2-cyclohexylcyclohexanol,
Cyclododecanol, 4-cyclohexylcyclohexanol, cyclodecanol, 2-hydroxy-2,5,
5-trimethyloctalin-2-ethyl-4- (2,
2,3-trimethyl-3-cyclopenten-1-yl)
-2-buten-1-ol, bisabolol, patchouli alcohol, rhinol, maintenancenol, dimethyloctenol, redol, phenylethylisoamyl ether, muscogen, bicyclodihydrofarnesyl oxide, mugealdehyde, empetal, junipearl, hydrojasmar, undecanone , Dodecanon,
Cyclododecanone, heptylcyclopentanone, cyclohexylmethylpentanone, trimethylcyclohexenylbutenone, acetylisopropylmethylbicyclooctene, maintenancenylpropanone, isorondiphoranone,
Hexylcyclopentanone, butylidenetrimethylcyclopentanone, trimethylcyclohexenylbutenone,
Silanebrene, nootkatone, ionone, hexanal, t-2-hexenal, cis-3-hexenal, t-2-hexenal dimethyl acetal, t-2
-An oral composition comprising one or more selected from hexenal diethyl acetal, t-2-hexenal propylene glycol acetal and p-methoxycinnamic aldehyde as a preservative component.