JP2001226286A - Skin cell activator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an skin cell activator which can activate the skin cell to increase metabolism and maintain the effect for a long period of time. SOLUTION: This skin cell activator is obtained by including at least three components of I type collagen peptide, hyaluronic acid and elastic which constitute a main component of collagen fiber 31, humor 33 and elastic fiber 32, respectively. By ingesting this activator into the body, cell main three components necessary to from the cell of good quality can be supplied. Namely, in comparison with the case that necessary cell constituent components are supplied from the surface of the skin 10 similarly to conventional cosmetics or the like, the supply of the cell constituent components can be carried out in the substantial meaning correspondent to the formation and transition process of the skin cell.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cell active substance that activates skin cells, and is used, for example, when activating aging skin, or when maintaining and recovering skin firmness and luster. It can be used for internal or external products. Internal products include beauty foods such as tablets and drinks to be taken, health foods, medicinal foods, and the like. External products include cosmetics and bath agents.

[0002]

2. Description of the Related Art The skin is the skin of the body, and serves as the outer skin, covering the surface of the body and protecting it. The human body is made up of 60 trillion to 100 trillion cells, and the skin is made up of individual cells. Particularly, in recent years, due to changes in the living environment, external factors have a strong effect on the skin, the fatigue of the skin is conspicuous, and various disorders have been complained. The basis of that measure is to create moist skin by increasing skin metabolism, which requires the activation of cells.

FIG. 1 is a sectional view of normal skin tissue in a normal state, and FIG. 2 is a sectional view of aging skin tissue. The state as shown in FIG. 2 is a result of a decrease in cellular elements that have kept fresh skin as the person ages, and a weakening of the ability to generate and supplement them in the body.

In FIGS. 1 and 2, the skin, that is, the skin 10 of the body, is histologically characterized by an epidermis 20 which is a surface epithelial cell layer and a dermis 3 which is a base connective tissue layer.
And three sub-layers, not shown, consisting mainly of adipose tissue and a subcutaneous tissue (not shown).

[0005] The epidermis 20 occupies the outermost layer of the skin 10, and is composed of a stratum corneum 21 in which flat, non-nucleated cells are in close contact with each other and formed in multiple layers, and a layer immediately below the stratum corneum 21. A transparent layer (not shown) in which the cells are in close contact with no intercellular space, the cell morphology has disappeared, and the nucleus has been lost.
2 is constituted.

[0006] The cellular components of the dermis 30 consist of fibroblasts, histiocytes, and mast cells. The fiber components of the dermis 30 are composed of collagen fibers 31, elastic fibers 32, and fine mesh fibers (not shown).

[0007] The collagen fiber 31 accounts for 90% or more of the new fiber component of the dermis 30, and the main component is collagen.
The collagen present at 0 is type I. Elastic fiber 32
Is yellow and wavy, runs between the bundles of collagen fibers 31 in a state of being parallel or oblique thereto, exhibits a reticulated structure by anastomosis, and is made of elastin which is a fibrous protein. The reticulated fiber forms a network by interweaving fine fibers, and the constituent protein is reticuline, which is called juvenile collagen and prolagen.

Further, a space between cells constituting the dermis 30 is filled with a body fluid 33 made of hyaluronic acid. And the cells of the skin 10 are generated in the dermis 30,
Most of the components are collagen, and are called the three components of the skin 10, including elastin and hyaluronic acid.

As a cause of the normal skin in the state of FIG. 1 becoming the aged skin in the state of FIG. That is, the aging may cause a decrease in the function of excreting waste products due to a decline in metabolism, deterioration of proteins in the body such as collagen, and a decrease in the function of production in the body. In addition to aging, for example, skin fatigue due to ultraviolet rays or cooling and heating, constipation due to irregular living, lack of nutrition, and the like also cause skin aging.

Due to these various causes, FIG.
In order to restore the function of the skin and return to the normal skin in the state of FIG. 1 or to maintain the normal state of FIG. It is necessary to activate the cells and enhance the metabolism of the skin.

For this reason, various cosmetics, external preparations for the skin, external preparations and the like have been conventionally developed to prevent or suppress aging of the skin, or to recover and maintain the function (Japanese Patent Application Laid-Open No. 9-183718). Gazette). This is generally
Keeping the skin dry and free of wrinkles, sagging, spots and freckles can be said to be a countermeasure based on the requirement for activation.

[0012]

However, even if the above-mentioned cosmetics, external preparations for the skin, external preparations and the like are used to supplement the cellular elements necessary for keeping the skin fresh from the surface of the skin 10, the effect is not so great. Has the problem that it becomes temporary.

That is, the above-mentioned condition for activation of keeping the skin dry without wrinkles, loosening, spots and freckles is a condition obtained from external observation, and is a condition obtained by observing the surface of the epidermis 20 of the body. It is only a condition that is desirable in the part, that is, in the state when it appears on the outer skin.

However, as described in the description of FIGS. 1 and 2 above, the cells of the outer skin are generated in the inner dermis 30, which is the innermost layer, and gradually migrate to the epidermis 20. Becomes the stratum corneum 21 and becomes lime and falls off. The life of the cells is said to be about 28 days. Therefore, it is necessary to activate the cells in an essential sense in accordance with such a cell generation / transition process. Rather, it has been desired to develop a countermeasure capable of obtaining a long-term effect.

An object of the present invention is to provide a skin cell active substance which can activate skin cells to enhance metabolism and maintain its effect for a long period of time.

[0016]

The present invention provides a skin cell active substance for activating skin cells by internal use, comprising at least a type I collagen peptide, hyaluronic acid,
It is characterized by containing three components of elastin.

Here, "by internal use" means external use, that is, ingestion from the mouth, not directly applied to the skin, and the form of ingestion is a skin cell active substance or a substance containing the same. Not only when eating and drinking food alone,
This includes the case of eating and drinking these and other foods at the same time.

In the present invention, the type I collagen peptide, hyaluronic acid, which is a component of cells necessary for producing high-quality cells in the above-described series of skin cell generation and migration processes, By ingesting the skin cell active substance containing the three components of elastin into the body, it becomes possible to generate firm and activated cells, and these three components are Because it acts as a nutrient source necessary for the birth of a cell, it can speed up metabolism.

For this reason, compared with the case where the necessary cell components are supplemented from the surface of the skin as in conventional cosmetics and the like, the essential components of the cell components in accordance with the process of generation and migration of skin cells are compared. Replenishment can be performed, and a long-term effect can be obtained instead of a temporary effect as in conventional cosmetics. In other words, the skin cell active substance containing the above three components is actively taken into the body as a nutrient along with daily habits to supplement it, so that it is possible to easily keep young skin forever.

Since the collagen used is of type I, its activity is particularly limited to the skin, that is, the skin.
Since the superior effect is obtained as compared with other types of collagen such as type II, it is possible to further enhance the production ability and metabolism of collagen which is a main component of skin. In addition, since the skin is of type I, cow hide collagen can be used, and cow hide that has been discarded without being used conventionally can be used. Therefore, there is an advantage that it is inexpensive and easily available.

That is, collagen has 8 genetically
It is said that there are different types. Looking at the body part, most of the dermis is type I, type II is cartilage, type III is mostly in fire extinguishers and blood vessels, and type IV is in the basement membrane part and forms a net-like planar structure. is there. Although type V exists widely in various tissues, its function has not been elucidated yet. Furthermore, types VI and VII are types that produce fine fibers, and type VI is found in the intima and placenta of the aorta. Type VII has a particularly long molecule (usually 300 nm;
50 nm), and the anchoring fibril in the surface cells is understood to be type VII collagen. And it is said that it is particularly related to the skin, type I, type IV, type VII. Normally commercially available collagen is made by boiling cow skin, cow bone, pig skin, etc. and purifying it. Will be mixed. In the present invention, from among collagens having other types and various properties as described above, type I collagen having properties most suitable for use as a skin cell active substance was selected and adopted. There are features.

Furthermore, since hyaluronic acid is used as a skin cell active substance, the hyaluronic acid has a water retention capacity of 6 liters per gram of hyaluronic acid, so that this hyaluronic acid becomes an intracellular body fluid and has an activity on various functions of cells. Give and promote metabolism. In other words, hyaluronic acid is a body fluid that fills the space between cells and protects cells,
It plays a role in supporting the structure of the cell population and carrying nutrients to the cells. By supplying it to the body, normal skin functions can be maintained.

[0023] For this reason, the lack of hyaluronic acid causes the deterioration of collagen and the decrease of elastin, and as a result,
It is possible to prevent the disadvantage that the skin loses elasticity and wrinkles are formed on the skin. It should be noted that hyaluronic acid decreases with age, and that infants and
%, It decreases to 65% at 30 years old, 45% at 50 years old, and 25% at 60 years old. As aging progresses, the older the elderly, the more nutrients are needed to activate skin cells. become.

Since elastin is used as the skin cell active substance, the elasticity of the skin cells in the dermis cells can be maintained, and fresh skin with moisturizing properties can be maintained. In other words, elastin is a histologically amorphous fibrous substance that is widely distributed not only in arteries, but also in vascular connective tissues, ligaments, Achilles tendons, skin, cartilage, and other organs such as lung tissue and ducts. Since it functions as a person responsible for maintaining physiological elasticity, by supplying it to the body, normal skin functions can be maintained. In addition, as the elastin peptide, a product obtained by subjecting a bovine section (nape) to an enzyme treatment and then extracting and purifying the same can be used. Thus, the above object is achieved.

Further, in the above-mentioned skin cell active substance,
The mixing ratio of the three components is such that the type I collagen peptide is 5
0-98.5% by weight, hyaluronic acid 0.1-25.0
% By weight and elastin is preferably 0.1 to 25.0% by weight.

Here, the "mixing ratio of the three components" means
The ratio of the weight occupied by each component when the total weight of the three components is 100%.
The purpose is to arbitrarily determine the numerical value of the weight% of each component within the above range so as to be%. Therefore, even when components other than the three components are added, the weight of the added components is not considered, but the relative weight ratio of only the three components is taken into consideration.

With such a mixing ratio, the skin cell active substance can be more easily absorbed into the body, so that each effect by the activation of skin cells can be more reliably obtained. It becomes possible.

Further, in the above-mentioned skin cell active substance, it is desirable to add vitamin C to the above three components. When vitamin C is added in this manner, the production of collagen is promoted, and pigmentation such as spots and freckles is prevented.

In the skin cell active substance to which vitamin C has been added, the above three components and vitamin C
Is 50 to 98.% of the type I collagen peptide.
5% by weight, 0.1 to 25.0% by weight of hyaluronic acid, 0.1 to 25.0% by weight of elastin, and 1.0% of vitamin C.
Desirably, the content is 0 to 5.0% by weight.

Here, the "combination ratio of the above three components and vitamin C" means the ratio of the weight of each component when the total weight of the three components and vitamin C is 100%, and the weight% of each component. The purpose is to arbitrarily determine the numerical value of the weight% of each component within the above range so that the total value of is 100%. Therefore, even when components other than the three components and vitamin C are added, the weight of the added components is not considered, but the relative weight ratio of only the three components and vitamin C is taken into account. .

With such a mixing ratio, the skin cell active substance can be more easily absorbed into the body, so that each effect by the activation of skin cells can be more reliably obtained. It becomes possible.

In addition, in the above-mentioned skin cell active substances, placenta extract, chondroitin sulfate, DNA /
At least one of nucleic acid, Pueraria mirifica, coixol, papaya enzyme, silk powder, or fructooligosaccharide may be added.

By adding the components having various functions as described above, the skin cell active substance has the main functions such as activation of skin cells, maintenance and recovery of skin firmness and gloss, and intestinal aging. Various functions such as an object exclusion function can be provided.

The skin cell active substance of the present invention can be used in the following various forms. That is, without mixing the skin cell active substance with other raw materials, it may be finished as it is into various foods such as beauty foods, health foods, medicinal foods, or the skin cell active substance is used as a main raw material or an auxiliary raw material. By mixing with other raw materials, foods for various purposes may be finished. Also, in any of the former and the latter, the form of the food may be any form of powder, granule, gel, solid, tablet, capsule, beverage, etc., in short, by internal use It just needs to be taken into the body.

Further, in the latter case, particularly when the skin cell active substance is used as an auxiliary material, the cell active substance of the present invention is obtained by taking the form of general food when eating or drinking general food. You may make it ingestible simultaneously.
For example, noodles such as udon flour, buckwheat flour, cup ramen,
Processed seafood kneaded products such as kamaboko and chikuwa, sausages,
Livestock products such as ham and hamburger, chocolate, gum,
Sweets such as caramel, candy, ice cream, sauces, soy sauce, miso, sauce, sugar, honey, etc., spices such as curry powder, mustard powder, pepper powder, dairy products such as cheese, butter, yogurt, Packed tea, packed tea, fruit juice, vegetable juice, soft drinks, drinks such as alcoholic beverages, and other general foods such as jam, marmalade, pickles, prepared dishes, sprinkles, canned fruits and vegetables, etc. The cell active substance of the present invention may be mixed.

The skin cell active substance of the present invention may be used externally in place of the above-mentioned internal use.

[0037]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment in which the present invention is applied internally will be described below. The beauty food of the present embodiment is obtained by finishing the skin cell active substance of the present invention as it is without mixing it with other raw materials. This beauty food has a thickness of about 5 mm and a diameter of about 20 m, for example.
The tablet is a flat, substantially cylindrical tablet of about m, and the weight per tablet is about 1.6 g.

The components of this beauty food are, in addition to the three main components of type I collagen peptide, hyaluronic acid and elastin, acerola powder (natural vitamin C), placenta extract, chondroitin sulfate, DNA / nucleic acid, pueraria mirifica, coixol (Hato barley extract), papaya enzyme, silk powder, and various components of fructooligosaccharides.

Also, out of the weight of about 1.6 g of one tablet of beauty food, about 0.55 is occupied by three main ingredients and four ingredients of natural vitamin C. Further, of this about 0.55 g,
For example, 97.5% by weight (hereinafter, simply referred to as “%”).
Type I collagen peptide, 0.1% hyaluronic acid, 0.1% elastin and the remaining 2.
Natural vitamin C accounts for 3%.

In producing such a beauty food of the present embodiment, for example, cow skin collagen is used as a type I collagen peptide, and a cow section (nape) is treated with an enzyme as an elastin peptide, followed by extraction and purification. Use what you have done.

According to the present embodiment, the following effects can be obtained. That is, the beauty food of the present embodiment is formed by a skin cell active substance containing type I collagen peptide, hyaluronic acid, and elastin, which are the three main components of cells required to generate high-quality cells. ,
For example, habitual ingestion of about 3 tablets per day can produce firm activated cells and accelerate metabolism.

For this reason, by taking the beauty food of the present embodiment into the body, the generation and transfer process of skin cells is compared with the case where necessary cell components are supplemented from the skin surface as in conventional cosmetics and the like. Thus, it is possible to replenish the constituents of cells in an essential sense according to the above, and to obtain a long-term effect, not a temporary effect as in conventional cosmetics. That is, by actively taking in and supplementing the skin cell active substance containing the three main components as a nutrient with daily habits in the body, it is possible to keep young skin forever.

Since the collagen used was type I, the activity was particularly limited to the skin, that is, the skin.
Since it has an advantageous effect as compared with other types of collagen such as type II, it is possible to further enhance the production ability and metabolism of collagen which is a main component of skin.

Further, since the collagen used is of type I, cowhide collagen can be used, and cowhide that has not been conventionally used and discarded can be used. It can be obtained and the manufacturing cost can be reduced.

Further, since the skin cell active substance forming the beauty food of the present embodiment contains hyaluronic acid having a high water-retaining ability, by replenishing the body with hyaluronic acid, the hyaluronic acid is converted into intracellular fluid. Thus, various functions of cells can be activated to promote metabolism. For this reason, the shortage of hyaluronic acid causes deterioration of collagen and a decrease in elastin, and as a result, it is possible to prevent the inconvenience that the skin loses elasticity and the skin is wrinkled.

The skin cell active substance forming the beauty food of the present embodiment contains elastin which is an amorphous fibrous substance which functions as a carrier for maintaining physiological elasticity. Keep skin cells elastic,
Fresh and moisturizing skin can be maintained.

The mixing ratio of the four components of type I collagen peptide, hyaluronic acid, elastin, and natural vitamin C, which are the constituents of the skin cell active substance forming the beauty food of the present embodiment, is optimized by the experiments described later. Since the value is a converted value, the skin cell active substance can be more easily absorbed into the body, so that each effect by the activation of the skin cell can be more reliably obtained.

Further, since the skin cell active substance contains acerola powder (natural vitamin C), the production of collagen can be promoted, and the pigmentation such as spots and freckles can be prevented.

Further, since the placental extract is contained in the skin cell active substance, the action of the melanin producing substance is suppressed,
It can whiten the skin, prevent spots and freckles, and provide a whitening effect. The placenta extract can be extracted from domestic placenta and is a treasure trove of nutrients such as vitamins and minerals.

Since the skin cell active substance contains chondroitin sulfate, the skin can be moisturized and various physiological phenomena on the cell surface can be smoothed. In addition, chondroitin sulfate is a mucopolysaccharide,
It is one of the intercellular substances.

Further, since DNA / nucleic acid is contained in the skin cell active substance, cell metabolism can be activated, and aging of the skin and hair can be prevented. A synergistic effect can be obtained when used in combination with the three main components.

Since the skin cell active substance contains pueraria mirifica, oestrogenic action and blood flow improving effect can eliminate irregular menstruation and menopausal disorders, and it is also effective in producing proportions. be able to. Pueraria Mirifica is a grain of Thailand.

Further, since the skin cell active substance contains coixol (hato barley extract), it can be effective for analgesia, diuresis, wart, octopus, and elimination or alleviation of rough skin. Coixol is also known as a herbal medicine called yoquinin.

Further, since the papaya enzyme is contained in the skin cell active substance, the aged stratum corneum can be decomposed and the activation of skin cells can be promoted.

Since the skin cell active substance contains silk powder, beautiful skin can be produced. The silk powder is obtained by hydrolyzing silk (silk).

Furthermore, since fructooligosaccharides are contained in the skin cell active substance, bifidobacteria can be multiplied, constipation and obesity can be eliminated, and aging can be prevented.

It should be noted that the present invention is not limited to the above-described embodiment, and modifications and the like within a range that can achieve the object of the present invention are included in the present invention. That is, in the embodiment, the skin cell active substance forming the beauty food includes:
In addition to the three main components, various components such as acerola powder (natural vitamin C) and placenta extract were included. However, the skin cell active substance of the present invention does not necessarily need to include all of these various components. It is sufficient that at least three main components are contained, and preferably, vitamin C is added to the three main components.

Furthermore, the beauty food of the above embodiment is finished as it is without mixing the skin cell active substance with other raw materials, but is prepared using the skin cell active substance of the present invention. The food to be prepared is not limited to this, and may be finished by mixing the skin cell active substance as a main raw material or an auxiliary raw material with other raw materials.

The cosmetic food of the above embodiment is a tablet, but the present invention is not limited to this. The form of the food may be powder, granule, gel, solid, capsule,
Any form, such as a drink, may be used. In short, any form may be used as long as it can be taken into the body by internal use.

[0060]

Example 1 In order to confirm the effect of the present invention, a comparative experiment was performed using rats. The effect of skin cell active substances on the cell metabolic activity of the stratum corneum on the skin surface was examined by the dansyl chloride method in rats bred on a low protein diet and simulated aging and metabolic capacity was slightly degraded.

Experiment: Effect of skin cell substance on metabolic activity of stratum corneum of rats by dansyl chloride method. (1) Purpose of the experiment: The effect of the skin cell active substance is examined by using a rat to measure the metabolic activity of the epidermal stratum corneum by measuring the fluorescence decay day.

(2) Experimental materials: Wistar rats,
Male, specified age at the time of arrival about 8 weeks old (weight about 200 g) I
Each group was divided into a group, a group II, and a group III, and eight animals were prepared for each group. As an example for confirming the effect of the skin cell active substance of the present invention, rats of group I were bred with this, and comparative examples were group II and II.
The rats in Group I were each housed differently.

(3) Breeding method: Environment: set temperature / humidity 24 ± 1 ° C. 55 ± 5% Air conditioning system 70% air circulation (return air system) Feed: Examples and comparative examples to determine the effects of skin cell active substances 1 and 2 have different contents.

(Example) An 8-week-old rat of Group I was bred on a low protein diet of 6% protein, and after 2 weeks, 1
1% equivalent of protein diet, 6 skin cell active substances of the present invention
The remainder was supplemented with milk casein by gavage at 0 mg / kg / day. In addition, the synthetic components of the skin cell active substance are only the three main components and the four components of vitamin C, and the mixing ratio of these four components is 97.5% for type I collagen peptide and 0.1% for hyaluronic acid. 1%, elastin was 0.1%, and vitamin C was 2.3%.

(Comparative Example 1) 8 weeks old rats of Group II
They were bred on a low protein diet of protein (up to now, the same as in Examples), and after 2 weeks, 6% of milk casein and 5% of type II collagen were given.

(Comparative Example 2) 6 week old rats of group III
They were bred on a low protein diet of protein (up to now, as in the examples), and after 2 weeks, were fed 11% protein diet, all with milk casein.

(4) Experimental method: The date of the disappearance of fluorescence from the skin was measured by the dansyl chloride method. First, from the day of the experiment, the rats in each group were given the specified diet and water, and 3 weeks after the day of the experiment, the back of the rat was shaved under ether anesthesia, and 2% dansyl chloride was applied to that part. 5 μl of the / EtOH solution was applied. And after application 2
After 4 hours, measure the fluorescence intensity and measure 50% of the fluorescence intensity
The day of disappearance was observed.

[0068]

[Table 1]

(5) Experimental results: Table 1 shows the experimental results. According to Table 1, the fluorescence 50 of the rats of Group III of Comparative Example 2
% Disappearance day is 3.966 ± 0.044 days, Comparative Example 1
Group II had 3.683 ± 0.056 days. In contrast, in the group I to which the skin cell active substance was administered, 3.352 ±
As early as 0.021 days, the speed was 118% for Comparative Example 1 and 110% for Comparative Example 2. Here, a high rate of fluorescence extinction indicates that skin metabolism is active and metabolism of the keratin is promoted. Therefore, this experiment showed that the example was superior to the comparative example, and the effect of the present invention was remarkably shown.

From the animal experiments described above, the effect of the skin cell active substance of the present invention on the collagen synthesis ability and skin metabolism was examined using simulated aged rats. As a result, the effect of the skin cell active substance was confirmed. Was. Therefore, it has been clarified that ingestion of a skin cell active substance can enhance skin metabolism and activate the skin.

[0071]

Embodiment 2 In order to confirm the effect of the present invention,
The following tests were performed using 10 women in their 0s to 50s as monitors. Tests were performed with the weights shown, approximately 1.
The 6 g tablets were sampled twice daily once a day for 4 weeks continuously, and the following survey items were answered every week.

Since the skin condition was greatly affected by the physical condition of the skin, the survey items included three items, that is, good sleep, good food, and good stool as a guide to the physical condition. In addition, the skin was classified into five items that can be self-observed on the surface. A total of eight judgment items are as follows. (1) I was able to sleep well. (2) I was comfortable eating. (3) I was comfortable. (4) The skin was moistened. (5) The skin was peeled. (6) The skin was elastic. 7) The skin became shiny. (8) The complexion of the skin became better. For each of the judgment items, one of “no effect”, “effective”, and “extremely effective” was checked. Table 2 shows the results. The numbers in the table indicate the number of checks except for the% column. FIGS. 3A to 3H show pie charts of the total data of Table 2 for each item. It is extremely effective for skin items, but the total data is 61% elasticity, 51% moisture,
The majority of respondents answered that the beam was 49%, which is particularly effective. Very effective for physical condition items, but comfortable stool 43%
The result is that the sleep is 33% and the food is 30%, which is slightly lower than that of the skin but has a diet effect.

[0073]

[Table 2]

FIG. 4 shows the weekly transition of the effect judgment. It can be seen that the effect was obtained in the second week for all items, and the effect was stably maintained from the third to the fourth week. In addition, FIG.
FIG. 6 shows the data of the total number of cases, and both the effective and extremely effective cases. 4 and 5, especially elasticity,
Excellent effect can be confirmed on the skin items that are firm and moist. Therefore, it has been clarified that ingestion of the skin cell active substance can enhance skin metabolism and activate the skin even in humans.

It should be noted that gloss appears to have a slightly lower effect than other skin items. However, this is not clear in the present study, which was discontinued at the fourth week, since the regeneration cycle of skin cells requires four weeks or more, and it is likely that the effect will come out later.

[0076]

As described above, according to the present invention, at least type I collagen peptide, hyaluronic acid,
Elastin and a skin cell active substance containing three components are composed, so by ingesting it into the body, skin cells can be activated and metabolism can be increased, and at the same time as temporary cosmetics such as conventional cosmetics There is an effect that the effect can be maintained for a long time instead of the effect.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of normal skin tissue in a normal state.

FIG. 2 is a cross-sectional view of aging skin tissue.

FIG. 3 is a pie chart showing the results of a female monitor according to an example.

FIG. 4 is a transition diagram of the effect determination according to the embodiment for each week.

FIG. 5 is a diagram showing the number of extremely effective cases by item according to the embodiment.

FIG. 6 is a diagram showing the total number of valid and extremely effective cases according to the embodiment for each item.

[Explanation of symbols]

 Reference Signs List 31 collagen fibers mainly composed of type I collagen 32 elastic fibers composed of elastin 33 body fluid composed of hyaluronic acid

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61P 43/00 107 A61K 37/12 F-term (Reference) 4C083 AD211 AD331 AD332 AD341 AD411 AD412 AD431 AD432 AD451 AD471 AD601 AD641 CC02 EE12 4C084 AA02 AA07 BA44 CA62 DC01 MA02 MA52 MA63 NA14 ZA891 ZB211 4C086 AA01 AA02 AA03 BA18 EA20 GA17 MA03 MA52 MA63 NA14 ZA89 ZB21

Claims (6)

[Claims] 1. A skin cell active substance that activates skin cells by internal use, comprising at least three components of type I collagen peptide, hyaluronic acid, and elastin. Active substance. 2. The skin cell active substance according to claim 1, wherein the proportion of the three components is 50 to 98.5% by weight of the type I collagen peptide and 0.1 to 0.9% by weight of the hyaluronic acid.
1 to 25.0% by weight, and the elastin is 0.1 to 25.
0% by weight of a skin cell active substance. 3. The skin cell active substance according to claim 1, wherein vitamin C is added to said three components. 4. The skin cell active substance according to claim 3, wherein the mixing ratio of the three components and vitamin C is the same as that of the I component.
Type collagen peptide is 50 to 98.5% by weight, the hyaluronic acid is 0.1 to 25.0% by weight, the elastin is 0.1 to 25.0% by weight, and the vitamin C is 1.0 to 1.0%.
A skin cell active substance, which is 5.0% by weight. 5. The skin cell active substance according to claim 1, wherein at least one of placenta extract, chondroitin sulfate, DNA / nucleic acid, Pueraria mirifica, coixol, papaya enzyme, silk powder, and fructooligosaccharide. Skin cell active substance characterized by adding one kind. 6. The skin cell active substance according to claim 1, wherein the skin cell active substance is used externally in place of said internal use.