CN108355127A - A kind of composite marine fish oligopeptide capsule and preparation method thereof - Google Patents
A kind of composite marine fish oligopeptide capsule and preparation method thereof Download PDFInfo
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- CN108355127A CN108355127A CN201810328586.2A CN201810328586A CN108355127A CN 108355127 A CN108355127 A CN 108355127A CN 201810328586 A CN201810328586 A CN 201810328586A CN 108355127 A CN108355127 A CN 108355127A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention belongs to oligopeptide processing technique field, specifically a kind of composite marine fish oligopeptide capsule and preparation method thereof.Its constituent and its weight part ratio are：30 ~ 40 parts of ocean fish oligopeptide powder, 25 ~ 35 parts of Isin glue collagen, 12 ~ 15 parts of fructose, 10 ~ 12 parts of maltodextrin, 15 ~ 20 parts of sweet orange powder, 15 ~ 18 parts of xylitol, 12 ~ 16 parts of tea polyphenols, 13 ~ 15 parts of theanine, 12 ~ 15 parts of chitosan oligosaccharide, 3 ~ 6 parts of vitamin E, 12 ~ 16 parts of tangerine oil, 10 ~ 12 parts of sucrose ester, 8 ~ 12 parts of Rhizoma Polygonati Odorati extract, 6 ~ 8 parts of houttuynia extract, 6 ~ 8 parts of Herba Oxalidis Corniculatae extract, 6 ~ 8 parts of madder extract, appropriate pure water.Preparation method is：It prepares Rhizoma Polygonati Odorati extract, houttuynia extract, Herba Oxalidis Corniculatae extract, madder extract respectively from raw material, then raw material is prepared into microemulsion, microemulsion is finally prepared into capsule.
Description
Technical field
The invention belongs to oligopeptide processing technique field, specifically a kind of composite marine fish oligopeptide capsule and its preparation
Method.
Background technology
The flesh of fish is good protein source, and fish meat protein is about 15 ~ 24%, and these protein adsorption rates are high, can
Be absorbed by the body utilization.The flesh of fish not only contains high protein, also contains more fat, and wherein ω -3 series fatty acids send out human body
Give birth to good facilitation.With the processing of fishery -ies product, fish head, fish tail, fish scale, fish-bone, internal organ and residual fish will produce
Meat the like waste, these wastes contain a large amount of nutriment, are generally used for the low value-added product such as feed, fertilizer, or
These wastes are directly abandoned and waste a large amount of resource while also resulting in serious environmental pollution by person.Fish are processed into by-product
Object is further processed, and can effectively prevent the wasting of resources.
Oligopeptide is also known as oligopeptides, is generally made of 2 ~ 6 amino acid.Studies have shown that oligopeptide can directly be inhaled by small intestine
It receives.Oligopeptide is easier to be absorbed compared with protein, amino acid in animal body, and oligopeptide has unique physiology work(
Energy and physicochemical property, this is not available for crude protein or composition amino acid.Currently, people are mainly to the research of oligopeptide
In the raw materials such as soybean, fish-skin, poultry bone.Oligopeptide can be divided into animal sources oligopeptide, plant source oligopeptide and micro- by raw material sources
Biological source oligopeptide, the oligopeptide being prepared can be applied in the fields such as medicine, cosmetics, health products.
Ocean fish collagen oligopeptide is refined and adds using pollution-free or the relatively small deep-sea fish of pollution skin, bone as raw material
Work forms, and is the dispensing of novel nutritious and healthy food.Ocean fish oligopeptide powder has the function of a variety of beneficial to human body.Ocean
Oligomeric Gly-His-Lys be small-molecular peptides, can be absorbed by the body reduce human collagen albumen loss, play prevent human skin atrophy,
There is wrinkle aging phenomenon in drying.Ocean fish oligopeptide powder also have antioxidation, reduce cholesterol, inhibit blood pressure increase,
A variety of physiological activity such as strengthen immunity.
Ocean fish oligopeptide powder is prepared into product, is conducive to the deep processing and utilization of marine oligopeptide powder, it is low to promote ocean
The application value of poly- Gly-His-Lys.
Invention content
A kind of composite marine fish oligopeptide capsule of present invention offer and preparation method thereof, the composite marine fish oligopeptide capsule
Stability is good, dissolubility is strong, is easily absorbed by the body, and can take orally and external application.The outer used time can be effectively improved skin quality, play U.S.
White muscle anti-aging, light spot and other effects；Palatability is good when for oral administration, can effectively remove human free radical, delaying senility function, simultaneously
It can also contribute to reduce cholesterol, adjusting hypertension, enhance human immunity.
The scheme of the invention is realize in this way：Each constituent of composite marine fish oligopeptide capsule and its parts by weight
Counting ratio is：30 ~ 40 parts of ocean fish oligopeptide powder, 25 ~ 35 parts of Isin glue collagen, 12 ~ 15 parts of fructose, 10 ~ 12 parts of maltodextrin, sweet tea
15 ~ 20 parts of orange powder, 15 ~ 18 parts of xylitol, 12 ~ 16 parts of tea polyphenols, 13 ~ 15 parts of theanine, 12 ~ 15 parts of chitosan oligosaccharide, vitamin E 3 ~
6 parts, 12 ~ 16 parts of tangerine oil, 10 ~ 12 parts of sucrose ester, 8 ~ 12 parts of Rhizoma Polygonati Odorati extract, 6 ~ 8 parts of houttuynia extract, creeping oxalis extraction
6 ~ 8 parts of object, 6 ~ 8 parts of madder extract, appropriate pure water.
A method of preparing composite marine fish oligopeptide capsule, including following preparation process：
(1) preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction after crushing
70% ethanol solution is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 30 ~ 40 DEG C, are soaked under agitation
Carry 4 ~ 5h, then by temperature rise to 50 ~ 60 DEG C carry out 15 ~ 20min of ultrasonic extraction obtain extraction mixture, by extraction mixture into
Row membrane filtration obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 10 ~ 15% of original volume, and it is dry then to carry out spraying
It is dry to obtain Rhizoma Polygonati Odorati extract；
(2) preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and body after crushing
The ethanol solution of fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and 30 ~ 40 DEG C are maintained the temperature at, in stirring bar
4 ~ 5h is extracted under part, temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains extraction mixture, and extraction is mixed
It closes object progress membrane filtration and obtains mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 10 ~ 15% of original volume, then carry out
Spray drying obtains houttuynia extract；
(3) preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains jealous woman slurry after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by grass meal:10 (w/v) are uniformly mixed, and keep temperature
At 30 ~ 40 DEG C, 4 ~ 5h is extracted under agitation, and temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains
Extraction mixture progress membrane filtration is obtained mixed liquor, then mixed liquor is carried out vacuum-concentrcted to substance by extraction mixture
Then long-pending 10 ~ 15% are spray-dried to obtain Herba Oxalidis Corniculatae extract；
(4) preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder after crushing, will
The ethanol solution of madder powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and maintain the temperature at 30 ~ 40
DEG C, 4 ~ 5h is extracted under agitation, and temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains extraction mixing
Extraction mixture progress membrane filtration is obtained mixed liquor by object, then by mixed liquor carry out vacuum-concentrcted to original volume 10 ~
15%, it is then spray-dried to obtain madder extract；
(5) preparation of lotion：Take 30 ~ 40 parts of ocean fish oligopeptide powder, 25 ~ 35 parts of Isin glue collagen, 12 ~ 15 parts of fructose, malt
10 ~ 12 parts of dextrin, 15 ~ 20 parts of sweet orange powder, 15 ~ 18 parts of xylitol, 12 ~ 16 parts of tea polyphenols, 13 ~ 15 parts of theanine, chitosan oligosaccharide 12 ~
15 parts, 8 ~ 12 parts of Rhizoma Polygonati Odorati extract, 6 ~ 8 parts of houttuynia extract, 6 ~ 8 parts of Herba Oxalidis Corniculatae extract, the addition of 6 ~ 8 parts of madder extract
In reaction kettle, 50 ~ 60 parts of pure water is then added, is uniformly mixed in the case where rotating speed is 80 ~ 120r/min, vitamin is then added
E3 ~ 6 part, 12 ~ 16 parts of tangerine oil, 10 ~ 12 parts of sucrose ester, 1min is stirred under 10000 ~ 12000r/min rotating speeds, is then utilized
High pressure microjet nanometer homogenizer homogeneous 3min, obtains lotion；
(6) preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) at room temperature
Stirring and dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) exist
Stirring and dissolving at room temperature obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that seaweed
Acid sodium solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred 1 ~ 2h of reaction, so
After vacuumize cancellation bubble, then be filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule system
Grain machine is connected, and lotion is added in hopper, adjusts 38 ~ 42 DEG C of glue box and sprinkler body temperature, and lotion loading amount is 0.5g/, adjusts glue
Skin thickness is 1.0mm, and barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, in 25 DEG C, relative humidity 25% ~ 30% after compacting
Under the conditions of, dry 10 ~ 12h is up to composite marine fish oligopeptide capsule.
As a further improvement on the present invention, the composite marine fish oligopeptide capsule being prepared takes orally or external application.
The technical principle that the present invention realizes is：
The present invention is mixed as main raw material(s) with other materials compounding using marine oligopeptide powder to prepare.Isin glue collagen is from fresh
Shearing technique extraction is oriented by biological enzyme in fish-skin, fish scale.Ocean fish oligopeptide powder is the intensive processing production of Isin glue collagen
Product are small molecule hybrid peptide, can directly be absorbed by body.Raw material is prepared into microemulsion, microemulsion can make grease mix
Property it is strong, to enhance the intermiscibility in raw material between each component, also improve component between stability, the microemulsion being prepared
Small more can quickly penetrate into skin of molecule is quickly absorbed by the skin, and improves the utilization rate of lotion.Microemulsion is prepared into capsule,
Influence that can be to avoid light, heat, water etc. to microemulsion, improves the bin stability of microemulsion.
The composite marine fish oligopeptide capsule outer used time can be that skin supplements the nutrients, and adjust skin.Isin glue collagen is rich in
The amino acid such as glycine, proline, the hydroxyproline that human body needs.Ocean fish oligopeptide powder and collagen can be inhaled by skin
It receives hence into dermal tissue local collapse in human body, can be mended, repairs the elastic fibers network of fracture or aging, and exclusive
Triple-helix structure can lock moisture, enable skin repair tissue, tighten skin, improve the nonelastic problem of skin relaxation, make
Skin jade-like stone moistens gloss, additionally it is possible to remove melanin, skin and muscles are fair, color spot fades out for order.Fructose, maltodextrin have hygroscopic effect, energy
Enough and ocean fish oligopeptide powder, collagen effect make skin keep moist.In addition fructose can also inhibit skin surface harmful
The growth of bacterium is played the role of protecting skin.Sweet orange powder is to be used in compounding orange juice and maltodextrin, is contained in sweet orange powder
Abundant vitamin C, maltodextrin, the outer used time can play skin the moist effect of whitening, with ocean fish oligopeptide powder, glue
Former protein-interacting can effectively be discharged interior free yl and resist skin aging.The xylitol outer used time has glycerine identical
Moisturizing and the effect for improving pachylosis, and it is not tacky when use, sweet orange powder interacts with corn oligopeptide powder, xylitol,
It can be effectively improved skin problem, skin is made to moisten flexible, anti-aging.Tea polyphenols and madder radiation resistance, can be effectively
It prevents radioactive substance from invading in human body, while also there is stronger antioxidation, the generation of skin free radical can be removed,
Delaying skin aging.Tea polyphenols have certain deodorization fungistatic effect, can inhibit the growth of microorganism in product, delay product
Shelf-life.Theanine, radix polygonati officinalis and houttuynia extract can play the role of skin moisturizing, and radix polygonati officinalis, cordate houttuynia can also improve
Cell activity has skin-active effect, and can inhibit the generation of melanin, achievees the effect that skin whitening, light spot.Vitamin E has
Wheat Protein, outer used time can have nti-freckle, wrinkle-proof effect, and vitamin E can also help cell preferably to absorb in addition
The nutritional ingredient of external skin care item, makes beauty functions double.Tangerine oil has whitening and moisturizing moistening effect.Creeping oxalis, madder tool
There are clearing heat and detoxicating effect, external application to allow to subdhing swelling and detoxicating, there is certain elimination to act on acne on the face, creeping oxalis and madder are also
With antibacterial, bactericidal effect, the outer used time can remove the bacterium of skin epidermis, with the compound guarantor that can also improve product of tea polyphenols
Deposit the phase.By the interaction of each ingredient of raw material, the composite marine fish oligopeptide capsule of the invention outer used time can to skin
Play whitening, wetting, anti-aging, desalination spot and other effects.
When for oral administration, ocean fish oligopeptide, collagen contain the collagens eggs such as proline, the hydroxyproline needed rich in human body
White characteristic amino acid is important component in human body cell especially skin cell epimatrix, and being absorbed by the body when for oral administration has
Conducive to health.Hydroxyl in tea polyphenols structure can provide active hydrogen to make free radical inactivate.Radix polygonati officinalis general flavone and dimension
Raw element C has similar antioxidant activity in vitro.The flavone compound that creeping oxalis contains has antioxidant activity.Madder extract
Also contain antioxidant.It, can by the interaction of tea polyphenols, Rhizoma Polygonati Odorati extract, Herba Oxalidis Corniculatae extract, madder extract
It effectively removes people's interior free yl to reach, improves the antioxidation of human body, delaying human body caducity.Theanine can be adjusted in vivo
It saves antioxidase activity, reduce oxidative stress, can alleviate to a certain extent and preventing hypertension.Theanine can lead to
Crossing mesencephalic centre nerve conveys the concentration of substance to play hypotensive activity.By theanine to the adjusting of enzyme and theanine in god
After the adjustment, hypertension can effectively be reduced.Theanine can resolve into ethamine in human liver, to transfer T lymphocytes
Interferon is generated, the defence line for resisting infection is formed, enhances human immunity.Chitosan oligosaccharide can activated T lymphocytes, it is huge to make
The release of phagocyte activity factor, and then activating macrophage has the function that strengthen immunity.Fish in houttuynia extract
Raw meat grass element is combined by hydrophobic effect in immunocyte, activation occurs to the enzyme system of macrophage, to improve immunity.
Corn oligopeptide powder, chitosan oligosaccharide, cordate houttuynia interaction under, can effectively enhance human immunity.In anti-tumor aspect, tea
Polyphenol can block the synthesis of a variety of carcinogen in vivo such as nitrite, have and directly kill cancer cell effect, chitosan oligosaccharide
There can be good inhibition growth of tumour cell and inhibit Nasopharyngeal neoplasms.Polysaccharide and anthraquinone in madder is certain
The indirectly-acting of direct effect and strengthen immunity that the apoptosis of tumour cell can be induced in degree has the antitumor work of anticancer
With the flavones in Rhizoma Polygonati Odorati extract, creeping oxalis also has function of tumor inhibition, in tea polyphenols, chitosan oligosaccharide, radix polygonati officinalis, madder, jealous woman slurry
Under the action of careless madder, have certain effect to the prevention and auxiliary treatment of tumour.
In addition, when for oral administration, ocean fish oligopeptide and collagen can in human body with elastin laminin and polysaccharide protein phase
Mutually interweave and form network structure, keeps vessel wall elasticity, prevent angiorrhoxis, embolism.Glue in ocean fish oligopeptide and raw material
Collagen compatibility in former albumen and human body can be that human body supplement enough collagens also, promote wound healing and
It repairs.Sweet orange powder and xylitol can adjust the palatability for the composite marine fish oligopeptide capsule being prepared, and xylitol can also
Enough improve the reservation of the absorption and internal calcium of enteral calcium.Vitamin E can be effective against free radical in human body, inhibit oxidation fat
Matter generates, eliminating chloasma, additionally it is possible to which the activity for inhibiting tyrosinase achievees the effect that nti-freckle to reduce melanin production.
There are tangerine oil a variety of unsaturated fatty acids various unsaturated fatty acids can be provided for human body, effectively facilitate health.It is beautiful
Bamboo, cordate houttuynia, creeping oxalis can be played when for oral administration moisturize, heat-clearing, promote the production of body fluid, cough-relieving and other effects, effectively adjust health.
The present invention has following good result：
1. the composite marine fish oligopeptide capsule stability that the present invention obtains is easy to preserve by force, bioactivity is high, phase between component
Dissolubility is good, is easily absorbed by the body, and utilization rate is high, and palatability is good, and raw material sources safety, environmentally protective.
2. the composite marine fish oligopeptide capsule oral administration that the present invention is prepared can external application, the outer used time can be effectively relieved
Skin aging desalinates the effect of spot whitening, can improve skin；Have the function of anti-blood pressure, protect liver when for oral administration, can enough have
Effect adjusts human body internal and external environment, enhances human immunity, promotes health, has a wide range of application.
Specific implementation mode
A kind of composite marine fish oligopeptide capsule of the description present invention and preparation method thereof with reference to embodiments, these descriptions
It is not to be further limited to the content of present invention.
Embodiment 1
The preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction 70% after crushing
Ethanol solution according to solid-liquid ratio be 1:10 (w/v) are uniformly mixed, and are maintained the temperature at 32 DEG C, are extracted 5h under agitation, so
Temperature is risen into 58 DEG C of progress ultrasonic extraction 15min afterwards and obtains extraction mixture, extraction mixture progress membrane filtration is mixed
Liquid is closed, then mixed liquor is subjected to vacuum-concentrcted to the 11% of original volume, is then spray-dried to obtain Rhizoma Polygonati Odorati extract；
The preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and volume after crushing
The ethanol solution of score 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 35 DEG C, are soaked under agitation
4.5h is carried, temperature, which is then risen to 60 DEG C of progress ultrasonic extraction 18min, obtains extraction mixture, and extraction mixture is carried out film mistake
Filter obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 12% of original volume, is then spray-dried to obtain fish raw meat
Careless extract；
The preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains creeping oxalis after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by powder:10 (w/v) are uniformly mixed, and are maintained the temperature at
30 DEG C, 4.5h is extracted under agitation, temperature, which is then risen to 50 DEG C of progress ultrasonic extraction 15min, obtains extraction mixture,
Extraction mixture progress membrane filtration is obtained into mixed liquor, then to the 10% of original volume, then mixed liquor is subjected to vacuum-concentrcted
It is spray-dried to obtain Herba Oxalidis Corniculatae extract；
The preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder, by madder after crushing
The ethanol solution of powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 30 DEG C, are being stirred
Under the conditions of extract 4h, then by temperature rise to 60 DEG C carry out ultrasonic extraction 20min obtain extraction mixture, by extraction mixture into
Row membrane filtration obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 14% of original volume, then carries out being spray-dried
To madder extract；
The preparation of lotion：Take 40 parts of ocean fish oligopeptide powder, 25 parts of Isin glue collagen, 13 parts of fructose, 12 parts of maltodextrin, sweet orange
18 parts of powder, 16 parts of xylitol, 14 parts of tea polyphenols, 15 parts of theanine, 13 parts of chitosan oligosaccharide, 10 parts of Rhizoma Polygonati Odorati extract, cordate houttuynia extraction
In 8 parts of 7.5 parts of object, 7 parts of Herba Oxalidis Corniculatae extract, madder extract addition reaction kettles, 50 ~ 60 parts of pure water is then added, in rotating speed
To be uniformly mixed under 90r/min, 6 parts of vitamin E, 15 parts of tangerine oil, 10 parts of sucrose ester is then added, in 10000r/min
1min is stirred under rotating speed, is then utilized high pressure microjet nanometer homogenizer homogeneous 3min, is obtained lotion；
The preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) it is stirred at room temperature
Dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) in room temperature
Lower stirring and dissolving obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sodium alginate
Solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred reaction 1h, then take out true
Sky eliminates bubble, then is filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule granulator phase
Even, lotion is added in hopper, adjusts 38 DEG C of glue box and sprinkler body temperature, lotion loading amount is 0.5g/, adjusts rubber thickness and is
1.0mm, barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, dry after compacting under the conditions of 25 DEG C, relative humidity 25%
10h is up to composite marine fish oligopeptide capsule.
Embodiment 2
The preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction 70% after crushing
Ethanol solution according to solid-liquid ratio be 1:10 (w/v) are uniformly mixed, and are maintained the temperature at 30 DEG C, are extracted 4h under agitation, so
Temperature is risen into 55 DEG C of progress ultrasonic extraction 20min afterwards and obtains extraction mixture, extraction mixture progress membrane filtration is mixed
Liquid is closed, then mixed liquor is subjected to vacuum-concentrcted to the 10% of original volume, is then spray-dried to obtain Rhizoma Polygonati Odorati extract；
The preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and volume after crushing
The ethanol solution of score 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 30 DEG C, are soaked under agitation
4h is carried, temperature, which is then risen to 50 DEG C of progress ultrasonic extraction 20min, obtains extraction mixture, and extraction mixture is carried out membrane filtration
Mixed liquor is obtained, then mixed liquor is subjected to vacuum-concentrcted to the 14% of original volume, is then spray-dried to obtain cordate houttuynia
Extract；
The preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains creeping oxalis after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by powder:10 (w/v) are uniformly mixed, and are maintained the temperature at
40 DEG C, 4.8h is extracted under agitation, temperature, which is then risen to 60 DEG C of progress ultrasonic extraction 18min, obtains extraction mixture,
Extraction mixture progress membrane filtration is obtained into mixed liquor, then to the 13% of original volume, then mixed liquor is subjected to vacuum-concentrcted
It is spray-dried to obtain Herba Oxalidis Corniculatae extract；
The preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder, by madder after crushing
The ethanol solution of powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 40 DEG C, are being stirred
Under the conditions of extract 4.8h, then by temperature rise to 50 DEG C carry out ultrasonic extraction 18min obtain extraction mixture, by extraction mixture
It carries out membrane filtration and obtains mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 13% of original volume, be then spray-dried
Obtain madder extract；
The preparation of lotion：Take 30 parts of ocean fish oligopeptide powder, 27 parts of Isin glue collagen, 14 parts of fructose, 10.5 parts of maltodextrin, sweet tea
20 parts of orange powder, 15 parts of xylitol, 16 parts of tea polyphenols, 13 parts of theanine, 15 parts of chitosan oligosaccharide, 8 parts of Rhizoma Polygonati Odorati extract, cordate houttuynia extraction
In 7 parts of 8 parts of object, 6.5 parts of Herba Oxalidis Corniculatae extract, madder extract addition reaction kettles, 50 ~ 60 parts of pure water is then added, in rotating speed
To be uniformly mixed under 80r/min, 3 parts of vitamin E, 16 parts of tangerine oil, 11 parts of sucrose ester is then added, in 12000r/min
1min is stirred under rotating speed, is then utilized high pressure microjet nanometer homogenizer homogeneous 3min, is obtained lotion；
The preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) it is stirred at room temperature
Dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) in room temperature
Lower stirring and dissolving obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sodium alginate
Solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred reaction 2h, then take out true
Sky eliminates bubble, then is filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule granulator phase
Even, lotion is added in hopper, adjusts 42 DEG C of glue box and sprinkler body temperature, lotion loading amount is 0.5g/, adjusts rubber thickness and is
1.0mm, barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, dry after compacting under the conditions of 25 DEG C, relative humidity 30%
11h is up to composite marine fish oligopeptide capsule.
Embodiment 3
The preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction 70% after crushing
Ethanol solution according to solid-liquid ratio be 1:10 (w/v) are uniformly mixed, and are maintained the temperature at 40 DEG C, are extracted 4.2h under agitation,
Then temperature is risen into 52 DEG C of progress ultrasonic extraction 16min and obtains extraction mixture, extraction mixture progress membrane filtration is obtained
Mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 15% of original volume, it is then spray-dried to obtain radix polygonati officinalis extraction
Object；
The preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and volume after crushing
The ethanol solution of score 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 40 DEG C, are soaked under agitation
5h is carried, temperature, which is then risen to 58 DEG C of progress ultrasonic extraction 15min, obtains extraction mixture, and extraction mixture is carried out membrane filtration
Mixed liquor is obtained, then mixed liquor is subjected to vacuum-concentrcted to the 13% of original volume, is then spray-dried to obtain cordate houttuynia
Extract；
The preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains creeping oxalis after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by powder:10 (w/v) are uniformly mixed, and are maintained the temperature at
38 DEG C, 4.2h is extracted under agitation, temperature, which is then risen to 58 DEG C of progress ultrasonic extraction 20min, obtains extraction mixture,
Extraction mixture progress membrane filtration is obtained into mixed liquor, then to the 15% of original volume, then mixed liquor is subjected to vacuum-concentrcted
It is spray-dried to obtain Herba Oxalidis Corniculatae extract；
The preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder, by madder after crushing
The ethanol solution of powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 38 DEG C, are being stirred
Under the conditions of extract 4.2h, then by temperature rise to 55 DEG C carry out ultrasonic extraction 15min obtain extraction mixture, by extraction mixture
It carries out membrane filtration and obtains mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 10% of original volume, be then spray-dried
Obtain madder extract；
The preparation of lotion：Take 38 parts of ocean fish oligopeptide powder, 30 parts of Isin glue collagen, 12 parts of fructose, 10 parts of maltodextrin, sweet orange
16 parts of powder, 17 parts of xylitol, 15 parts of tea polyphenols, 13 parts of theanine, 12 parts of chitosan oligosaccharide, 9 parts of Rhizoma Polygonati Odorati extract, houttuynia extract
6 parts, 7 parts of Herba Oxalidis Corniculatae extract, in 7.5 parts of addition reaction kettle of madder extract, 50 ~ 60 parts of pure water is then added, is in rotating speed
It is uniformly mixed under 100r/min, 5 parts of vitamin E, 14 parts of tangerine oil, 10.5 parts of sucrose ester is then added, in 11000r/
1min is stirred under min rotating speeds, is then utilized high pressure microjet nanometer homogenizer homogeneous 3min, is obtained lotion；
The preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) it is stirred at room temperature
Dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) in room temperature
Lower stirring and dissolving obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sodium alginate
Solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred reaction 1.5h, then take out
Vacuum eliminates bubble, then is filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule granulator
It is connected, lotion is added in hopper, adjust 40 DEG C of glue box and sprinkler body temperature, lotion loading amount is 0.5g/, adjusts rubber thickness and is
1.0mm, barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, dry after compacting under the conditions of 25 DEG C, relative humidity 28%
10.5h is up to composite marine fish oligopeptide capsule.
Embodiment 4
The preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction 70% after crushing
Ethanol solution according to solid-liquid ratio be 1:10 (w/v) are uniformly mixed, and are maintained the temperature at 35 DEG C, are extracted 4.8h under agitation,
Then temperature is risen into 50 DEG C of progress ultrasonic extraction 18min and obtains extraction mixture, extraction mixture progress membrane filtration is obtained
Mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 12% of original volume, it is then spray-dried to obtain radix polygonati officinalis extraction
Object；
The preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and volume after crushing
The ethanol solution of score 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 38 DEG C, are soaked under agitation
4.2h is carried, temperature, which is then risen to 52 DEG C of progress ultrasonic extraction 16min, obtains extraction mixture, and extraction mixture is carried out film mistake
Filter obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 10% of original volume, is then spray-dried to obtain fish raw meat
Careless extract；
The preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains creeping oxalis after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by powder:10 (w/v) are uniformly mixed, and are maintained the temperature at
35 DEG C, 4h is extracted under agitation, and temperature, which is then risen to 55 DEG C of progress ultrasonic extraction 16min, obtains extraction mixture, will
Extraction mixture carries out membrane filtration and obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 14% of original volume, then into
Row spray drying obtains Herba Oxalidis Corniculatae extract；
The preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder, by madder after crushing
The ethanol solution of powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 35 DEG C, are being stirred
Under the conditions of extract 5h, then by temperature rise to 52 DEG C carry out ultrasonic extraction 17min obtain extraction mixture, by extraction mixture into
Row membrane filtration obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 15% of original volume, then carries out being spray-dried
To madder extract；
The preparation of lotion：Take 32 parts of ocean fish oligopeptide powder, 35 parts of Isin glue collagen, 13 parts of fructose, 11.5 parts of maltodextrin, sweet tea
15 parts of orange powder, 18 parts of xylitol, 12 parts of tea polyphenols, 13.5 parts of theanine, 14 parts of chitosan oligosaccharide, 11 parts of Rhizoma Polygonati Odorati extract, cordate houttuynia
In 6 parts of 6.5 parts of extract, 7.5 parts of Herba Oxalidis Corniculatae extract, madder extract addition reaction kettles, 50 ~ 60 parts of pure water is then added,
It is uniformly mixed in the case where rotating speed is 110r/min, 4 parts of vitamin E, 12 parts of tangerine oil, 12 parts of sucrose ester is then added,
1min is stirred under 10500r/min rotating speeds, is then utilized high pressure microjet nanometer homogenizer homogeneous 3min, is obtained lotion；
The preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) it is stirred at room temperature
Dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) in room temperature
Lower stirring and dissolving obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sodium alginate
Solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred reaction 2h, then take out true
Sky eliminates bubble, then is filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule granulator phase
Even, lotion is added in hopper, adjusts 41 DEG C of glue box and sprinkler body temperature, lotion loading amount is 0.5g/, adjusts rubber thickness and is
1.0mm, barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, dry after compacting under the conditions of 25 DEG C, relative humidity 27%
11.5h is up to composite marine fish oligopeptide capsule.
Embodiment 5
The preparation of Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder, by radix polygonati officinalis powder and volume fraction 70% after crushing
Ethanol solution according to solid-liquid ratio be 1:10 (w/v) are uniformly mixed, and are maintained the temperature at 38 DEG C, are extracted 4.5h under agitation,
Then temperature is risen into 60 DEG C of progress ultrasonic extraction 19min and obtains extraction mixture, extraction mixture progress membrane filtration is obtained
Mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 14% of original volume, it is then spray-dried to obtain radix polygonati officinalis extraction
Object；
The preparation of houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder and volume after crushing
The ethanol solution of score 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 32 DEG C, are soaked under agitation
4.8h is carried, temperature, which is then risen to 55 DEG C of progress ultrasonic extraction 17min, obtains extraction mixture, and extraction mixture is carried out film mistake
Filter obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 15% of original volume, is then spray-dried to obtain fish raw meat
Careless extract；
The preparation of Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains creeping oxalis after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by powder:10 (w/v) are uniformly mixed, and are maintained the temperature at
32 DEG C, 5h is extracted under agitation, and temperature, which is then risen to 52 DEG C of progress ultrasonic extraction 17min, obtains extraction mixture, will
Extraction mixture carries out membrane filtration and obtains mixed liquor, then mixed liquor is carried out vacuum-concentrcted to the 12% of original volume, then into
Row spray drying obtains Herba Oxalidis Corniculatae extract；
The preparation of madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder, by madder after crushing
The ethanol solution of powder and volume fraction 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and are maintained the temperature at 32 DEG C, are being stirred
Under the conditions of extract 4.2h, then by temperature rise to 58 DEG C carry out ultrasonic extraction 16min obtain extraction mixture, by extraction mixture
It carries out membrane filtration and obtains mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 11% of original volume, be then spray-dried
Obtain madder extract；
The preparation of lotion：Take 35 parts of ocean fish oligopeptide powder, 33 parts of Isin glue collagen, 15 parts of fructose, 11 parts of maltodextrin, sweet orange
17 parts of powder, 15 parts of xylitol, 13 parts of tea polyphenols, 14.5 parts of theanine, 13 parts of chitosan oligosaccharide, 12 parts of Rhizoma Polygonati Odorati extract, cordate houttuynia carry
It takes in 6.5 parts of 7 parts of object, 6 parts of Herba Oxalidis Corniculatae extract, madder extract addition reaction kettles, 50 ~ 60 parts of pure water is then added, turning
Speed is to be uniformly mixed under 120r/min, and 4 parts of vitamin E, 13 parts of tangerine oil, 11.5 parts of sucrose ester is then added,
1min is stirred under 11500r/min rotating speeds, is then utilized high pressure microjet nanometer homogenizer homogeneous 3min, is obtained lotion；
The preparation of composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) it is stirred at room temperature
Dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19) in room temperature
Lower stirring and dissolving obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sodium alginate
Solution is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred reaction 1h, then take out true
Sky eliminates bubble, then is filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and with soft capsule granulator phase
Even, lotion is added in hopper, adjusts 39 DEG C of glue box and sprinkler body temperature, lotion loading amount is 0.5g/, adjusts rubber thickness and is
1.0mm, barreling rotating speed is the compacting that 2.5r/min carries out soft capsule, dry after compacting under the conditions of 25 DEG C, relative humidity 26%
12h is up to composite marine fish oligopeptide capsule.
In order to verify the properties for the composite marine fish oligopeptide capsule that the present invention is prepared, the present invention is obtained
Composite marine fish oligopeptide capsule is for testing.
1. external application is tested.
100 ages are chosen in 25-65 experimenters, men and women is fifty-fifty, is divided into 5 groups every group 10 males, 10 women,
It uses the composite marine fish oligopeptide capsule made from embodiment 1 ~ 5 to peel off capsule respectively, lotion is uniformly applied on the face,
It using after daily face cleaning, once a day, is used continuously 30 days, record the using effect per bit test person, overall merit is given a mark,
It makes even respectively, highest is divided into 5 points, indicates that using effect is notable, and 4 points indicate that using effect is good, and 3 points of using effects are general, 3 points
It is that using effect is poor below.The experimental results are shown inthe following table.
1 composite marine fish oligopeptide capsule external application experiment effect of table
Specific test case is as follows：
(1) Huang, female is 30 years old, more using microgroove at the preceding canthus of this product, the corners of the mouth, the wing of nose, and facial skin relaxation, skin are dark
Heavy to have color spot, after this product 30 days, wrinkle depth shoals on the face, and skin is glossy, and color spot spot is thin out.
(2) Sun, female, 45 years old, using the dry and astringent coarse, relaxation of skin before this product, part was nonelastic, uses this product
After 30 days, skin moisturizing is smooth, clean.
(3) Luo, man, 26 years old, coarse using the colour of skin before this product, greasy, pore is coarse, and blackhead is more, and pore is coarse,
After this product 30 days, the smooth flexible exquisiteness of the colour of skin is clean on the face, and non-greasy, blackhead is reduced.
2. experiment for oral administration.
(1) blood fat experiment is adjusted
It is study subject to select the good hyperlipemia without other serious diseases of compliance, cuts out adjusting within tested first 2 weeks
The drug of blood fat and the health food for having similar effect, totally 120 people, wherein 59 people of male, 61 people of women, age are subject
25 ~ 50 years old, average age was 39 years old.Testing crew is randomly divided into 6 groups, every group of 20 people, the 1st ~ 5 group eats embodiment system respectively
Standby obtained composite marine fish oligopeptide capsule periodically takes 3 for each person every day, the 6th group taken for each person every day for control group it is identical
Placebo of the dosage with appearance.Experimental period is 30 days.It carries out a medical examination to all subjects before and after experiment, establishes personal disease
Example, while serum cholesterol, triglycerides, high-density lipoprotein cholesterol biochemical indicator are measured, and record clinical symptoms
Variation.
Influence of the 2 composite marine fish oligopeptide capsule of table to serum cholesterol
(2) blood pressure experiment is adjusted
Spontaneous hypertensive rat 60 is taken, female, 6 ~ 8 week old, 180 ~ 200g of weight, after animal adapts to 1 week in laboratory, root
According to surveyed basic blood pressure and the size of weight, it is divided into 6 groups by RANDOMIZED BLOCK DESIGN, the 1st ~ 5 group eats the embodiment of the present invention respectively
The composite marine fish oligopeptide capsule being prepared, the 6th group is control group, ad lib drinking-water, experiment periods totally 30 days.It surveys respectively
The blood pressure of rat before fixed experiment and after experiment 30 days.The assay method of blood pressure is：With tail tuck inside the sleeve method with BP-98A blood pressure recorders from
Rat tail artery recording blood pressure, results are averaged.
The influence of 3 composite marine fish oligopeptide Capsule in Rats blood pressure of table
(3) repair tissue is tested
Choose the identical patient 120 of hand scratch site, wherein male 61, women 59,20 ~ 60 years old age, average year
Age is 32.6 years old.120 patients are randomly divided into 6 groups, every group of 20 people, the 1st ~ 5 group is taken embodiment of the present invention system daily respectively
Standby obtained composite marine fish oligopeptide capsule, dosage are 2 tablets each time, 3 times a day.6th group is not taken any glue for control group
Capsule, other eating habits are all identical, and observation scratch patient wound's healing state, whether there is or not leave pigmentation.Test result is as follows
Shown in table 4.
4 skin abrasion of table is tested
The above embodiment of the present invention scheme is only the description of the invention and cannot limit the present invention, this is indicated in claim
The range of invention product form ingredient, component ratio, preparation method parameter, and above-mentioned explanation does not point out parameter of the present invention
Range, therefore, any change within the meaning and scope equivalent to the claims of the present invention, be all considered to be including
In the range of claims.
The present invention and is created by creative work by the oligomeric Gly-His-Lys processing staff long-term work experience accumulation of multidigit
And go out, the product properties that the present invention is prepared are good, and the outer used time can be effectively improved the skin problem of human body, interior used time energy
It is enough effectively to adjust blood fat, have certain effect to hypertension, and wound healing can be promoted, function and effect are good, are conducive to people
Body health.
Claims (3)
1. a kind of composite marine fish oligopeptide capsule, characterized in that each constituent of composite marine fish oligopeptide capsule
And its weight part ratio is：30 ~ 40 parts of ocean fish oligopeptide powder, 25 ~ 35 parts of Isin glue collagen, 12 ~ 15 parts of fructose, maltodextrin
10 ~ 12 parts, 15 ~ 20 parts of sweet orange powder, 15 ~ 18 parts of xylitol, 12 ~ 16 parts of tea polyphenols, 13 ~ 15 parts of theanine, chitosan oligosaccharide 12 ~ 15
Part, 3 ~ 6 parts of vitamin E, 12 ~ 16 parts of tangerine oil, 10 ~ 12 parts of sucrose ester, 8 ~ 12 parts of Rhizoma Polygonati Odorati extract, houttuynia extract 6 ~ 8
Part, 6 ~ 8 parts of Herba Oxalidis Corniculatae extract, 6 ~ 8 parts of madder extract, appropriate pure water.
2. a kind of method preparing composite marine fish oligopeptide capsule as described in claim 1, characterized in that including following system
Standby step：
The preparation of step 1) Rhizoma Polygonati Odorati extract：Radix polygonati officinalis is taken to clean, drying obtains radix polygonati officinalis powder after crushing, by radix polygonati officinalis powder and volume point
The ethanol solution of number 70% is 1 according to solid-liquid ratio:10 (w/v) are uniformly mixed, and maintain the temperature at 30 ~ 40 DEG C, under agitation
4 ~ 5h is extracted, temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains extraction mixture, by extraction mixture
It carries out membrane filtration and obtains mixed liquor, then mixed liquor is subjected to vacuum-concentrcted to the 10 ~ 15% of original volume, then spray
It is dried to obtain Rhizoma Polygonati Odorati extract；
The preparation of step 2) houttuynia extract：Cordate houttuynia is taken to clean, drying obtains herba houttuyniae powder, by herba houttuyniae powder after crushing
According to solid-liquid ratio it is 1 with the ethanol solution of volume fraction 70%:10 (w/v) are uniformly mixed, and are maintained the temperature at 30 ~ 40 DEG C, are being stirred
4 ~ 5h is extracted under the conditions of mixing, temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains extraction mixture, will carry
It takes mixture to carry out membrane filtration and obtains mixed liquor, then to the 10 ~ 15% of original volume, then mixed liquor is subjected to vacuum-concentrcted
It is spray-dried to obtain houttuynia extract；
The preparation of step 3) Herba Oxalidis Corniculatae extract：The preparation of Herba Oxalidis Corniculatae extract：Creeping oxalis is taken to clean, drying obtains after crushing
The ethanol solution of creeping oxalis powder and volume fraction 70% according to solid-liquid ratio is 1 by creeping oxalis powder:10 (w/v) are uniformly mixed, and are kept
Temperature extracts 4 ~ 5h under agitation at 30 ~ 40 DEG C, and temperature, which is then risen to 50 ~ 60 DEG C, carries out 15 ~ 20min of ultrasonic extraction
Extraction mixture is obtained, extraction mixture progress membrane filtration is obtained into mixed liquor, then mixed liquor is subjected to vacuum-concentrcted extremely
Then the 10 ~ 15% of original volume are spray-dried to obtain Herba Oxalidis Corniculatae extract；
The preparation of step 4) madder extract：The preparation of madder extract：Madder is taken to clean, drying obtains madder powder after crushing,
According to solid-liquid ratio it is 1 by the ethanol solution of madder powder and volume fraction 70%:10 (w/v) are uniformly mixed, and maintain the temperature at 30 ~ 40
DEG C, 4 ~ 5h is extracted under agitation, and temperature, which is then risen to 50 ~ 60 DEG C of progress 15 ~ 20min of ultrasonic extraction, obtains extraction mixing
Extraction mixture progress membrane filtration is obtained mixed liquor by object, then by mixed liquor carry out vacuum-concentrcted to original volume 10 ~
15%, it is then spray-dried to obtain madder extract；
The preparation of step 5) lotion：Take 30 ~ 40 parts of ocean fish oligopeptide powder, 25 ~ 35 parts of Isin glue collagen, 12 ~ 15 parts of fructose, wheat
10 ~ 12 parts of bud dextrin, 15 ~ 20 parts of sweet orange powder, 15 ~ 18 parts of xylitol, 12 ~ 16 parts of tea polyphenols, 13 ~ 15 parts of theanine, chitosan oligosaccharide
12 ~ 15 parts, 8 ~ 12 parts of Rhizoma Polygonati Odorati extract, 6 ~ 8 parts of houttuynia extract, 6 ~ 8 parts of Herba Oxalidis Corniculatae extract, 6 ~ 8 parts of madder extract
It is added in reaction kettle, 50 ~ 60 parts of pure water is then added, be uniformly mixed in the case where rotating speed is 80 ~ 120r/min, dimension is then added
Raw element E3 ~ 6 part, 12 ~ 16 parts of tangerine oil, 10 ~ 12 parts of sucrose ester, stir 1min, then under 10000 ~ 12000r/min rotating speeds
Using high pressure microjet nanometer homogenizer homogeneous 3min, lotion is obtained；
The preparation of step 6) composite marine fish oligopeptide capsule：By sodium alginate and deionized water (mass ratio 1:49) in room temperature
Lower stirring and dissolving obtains the sodium alginate soln that mass fraction is 2%；By calcium chloride is molten and deionized water (mass ratio 1:19)
Dissolving is stirred at room temperature, obtains the calcium chloride solution that mass fraction is 2%；Glycerine is added into sodium alginate soln so that sea
Solution of sodium alginate is 10 with qualities of glycerin ratio:3,70 DEG C are warming up to, calcium chloride solution is then added and is stirred 1 ~ 2h of reaction,
Then vacuumize cancellation bubble, then be filtered to obtain capsule material, by capsule material be placed in 60 DEG C of glue buckets and and soft capsule
Granulator is connected, and lotion is added in hopper, adjusts 38 ~ 42 DEG C of glue box and sprinkler body temperature, and lotion loading amount is 0.5g/, is adjusted
Rubber thickness be 1.0mm, barreling rotating speed be 2.5r/min carry out soft capsule compacting, after compacting 25 DEG C, relative humidity 25% ~
Under the conditions of 30%, dry 10 ~ 12h is up to composite marine fish oligopeptide capsule.
3. a kind of method preparing composite marine fish oligopeptide capsule according to claim 2, it is characterized in that：It is prepared
Composite marine fish oligopeptide capsule is for oral administration or external application.
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| CN113100443A (en) * | 2021-05-17 | 2021-07-13 | 卢静 | Composition and soft capsule for relieving gout and preparation method thereof |
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| CN113100443A (en) * | 2021-05-17 | 2021-07-13 | 卢静 | Composition and soft capsule for relieving gout and preparation method thereof |
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