JP2001213792A5 - - Google Patents
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- JP2001213792A5 JP2001213792A5 JP2000324977A JP2000324977A JP2001213792A5 JP 2001213792 A5 JP2001213792 A5 JP 2001213792A5 JP 2000324977 A JP2000324977 A JP 2000324977A JP 2000324977 A JP2000324977 A JP 2000324977A JP 2001213792 A5 JP2001213792 A5 JP 2001213792A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- royal jelly
- stress
- amino acid
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【特許請求の範囲】
【請求項1】
ローヤルゼリーからなる、抗ストレス剤。
【請求項2】
前記ローヤルゼリーが、下記に示す、蛋白質を9重量%以上含有するものであることを特徴とする、請求項1に記載の抗ストレス剤。
1)還元条件下でのSDS−ポリアクリルアミドゲル電気泳動により測定される分子量が約57キロダルトンである。
2)配列番号1のアミノ酸番号1〜8のアミノ酸配列を含む。
【請求項3】
請求項1項又は2項に記載の抗ストレス剤を含有することを特徴とする、抗ストレス用組成物。
【請求項4】
食品、化粧料又は医薬品であることを特徴とする、請求項3項に記載の抗ストレス用組成物。
[Claims]
(1)
An anti-stress agent consisting of royal jelly.
(2)
The anti-stress agent according to claim 1, wherein the royal jelly contains the following protein in an amount of 9% by weight or more.
1) The molecular weight measured by SDS-polyacrylamide gel electrophoresis under reducing conditions is about 57 kilodalton.
2) Includes the amino acid sequence of amino acid numbers 1 to 8 of SEQ ID NO: 1.
(3)
An anti-stress composition comprising the anti-stress agent according to claim 1 or 2.
(4)
The anti-stress composition according to claim 3, which is a food, a cosmetic, or a pharmaceutical.
一方、ローヤルゼリーは、滋養強壮作用を有する素材として知られており、これを主成分とした健康食品などが広く販売されているが、その生理活性の本体全てが未だ決定されておらず、その為、その生理活性には、ロット差が大きく、活性値としてコントロールされていないのが現状であった。これは生理活性本体が未だ突き止め切れていないためである。又、ローヤルゼリー中に、1)還元条件下でのSDS−ポリアクリルアミドゲル電気泳動により測定される分子量が約57キロダルトンである、2)配列番号1のアミノ酸番号1〜8のアミノ酸配列を含む蛋白を含有していることも、該蛋白がローヤルゼリーの生理活性の中で、抗ストレス作用の活性成分であることも全く知られていなかった。又、ローヤルゼリーが、副腎皮質に作用しコルチゾールの分泌をコントロールすることも知られておらず、これに起因する抗ストレス作用を有することも知られていなかった。
On the other hand, royal jelly is known as a material with a nourishing and tonic effect, and health foods containing it as a main component are widely sold. However, all of its physiological activities have not yet been determined. At present, the biological activity has a lot difference and is not controlled as an activity value. This is because the bioactive body has not yet been located. Also, in royal jelly , 1) the molecular weight measured by SDS-polyacrylamide gel electrophoresis under reducing conditions is about 57 kilodaltons; 2) a protein comprising the amino acid sequence of amino acids 1 to 8 of SEQ ID NO: 1 And it was not known at all that the protein was an active component having an anti-stress effect in the physiological activity of royal jelly. In addition, it has not been known that royal jelly acts on the adrenal cortex to control the secretion of cortisol, and it has not been known that royal jelly has an anti-stress effect resulting therefrom.
【0005】
【課題の解決手段】
この様な状況に鑑みて、本発明者らは鋭意研究努力を重ねた結果、ローヤルゼリーが血中コルチゾール産生抑制作用を有し、その活性本体が次の特性を有するの蛋白質であることを見い出し、発明を完成させるに至った。即ち、その蛋白とは、1)還元条件下でのSDS−ポリアクリルアミドゲル電気泳動により測定される分子量が約57キロダルトンである、2)配列番号1のアミノ酸番号1〜8のアミノ酸配列を含むものである。この蛋白について、以後、単に「57キロダルトンの蛋白」或いは「分子量57キロダルトンの蛋白」と表現することがある。以下、本発明について、実施の形態を中心に更に詳細に説明を加える。
[0005]
[Means for solving the problem]
In view of such a situation, the present inventors have made intensive research efforts and found that royal jelly has a blood cortisol production inhibitory action, and that its active substance is a protein having the following properties, The invention has been completed. That is, the protein includes 1) a molecular weight of about 57 kilodaltons as measured by SDS-polyacrylamide gel electrophoresis under reducing conditions, and 2) an amino acid sequence of amino acids 1 to 8 of SEQ ID NO: 1. It is a thing. Hereinafter, this protein may be simply referred to as “protein of 57 kilodalton” or “protein of molecular weight of 57 kilodalton”. Hereinafter, the present invention will be described in more detail focusing on embodiments.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000324977A JP2001213792A (en) | 1999-11-25 | 2000-10-25 | Antistress composition |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33364499 | 1999-11-25 | ||
JP11-333644 | 1999-11-25 | ||
JP2000324977A JP2001213792A (en) | 1999-11-25 | 2000-10-25 | Antistress composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001213792A JP2001213792A (en) | 2001-08-07 |
JP2001213792A5 true JP2001213792A5 (en) | 2007-07-19 |
Family
ID=26574586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000324977A Pending JP2001213792A (en) | 1999-11-25 | 2000-10-25 | Antistress composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2001213792A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003192541A (en) * | 2001-12-26 | 2003-07-09 | Pola Chem Ind Inc | Hair growth-promoting agent and skin care preparation for hair growth |
JP2006008597A (en) * | 2004-06-25 | 2006-01-12 | Pola Chem Ind Inc | Kit for beautiful skin |
JPWO2010008005A1 (en) * | 2008-07-16 | 2012-01-05 | 国立大学法人 琉球大学 | Improving immune function modulation induced by stress |
JP5592640B2 (en) * | 2009-11-30 | 2014-09-17 | アピ株式会社 | Antistress agent containing lactic acid bacteria fermented royal jelly, method for producing the same, hypothalamus-pituitary-adrenocortical activity inhibitor, and sympathetic-adrenal medullary activity inhibitor |
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2000
- 2000-10-25 JP JP2000324977A patent/JP2001213792A/en active Pending
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