JP2001098000A5 - - Google Patents

Info

Publication number

JP2001098000A5

JP2001098000A5 JP1999276652A JP27665299A JP2001098000A5 JP 2001098000 A5 JP2001098000 A5 JP 2001098000A5 JP 1999276652 A JP1999276652 A JP 1999276652A JP 27665299 A JP27665299 A JP 27665299A JP 2001098000 A5 JP2001098000 A5 JP 2001098000A5

Authority

JP

Japan

Prior art keywords

peptide

amino acid

acid sequence

present

glucagon production

Prior art date

1999-09-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001413 amino acids Chemical group 0.000 description 14
• 229960004666 Glucagon Drugs 0.000 description 6
• 108060003199 Glucagon Proteins 0.000 description 6
• MASNOZXLGMXCHN-ZLPAWPGGSA-N Glucagonum Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 6
• 239000003814 drug Substances 0.000 description 6
• 239000004480 active ingredient Substances 0.000 description 4
• 230000001737 promoting Effects 0.000 description 4
• 230000000694 effects Effects 0.000 description 3
• 206010020993 Hypoglycaemia Diseases 0.000 description 2
• 229940079593 drugs Drugs 0.000 description 2
• 230000002218 hypoglycaemic Effects 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1