JP2001054553A - Transfusion bag - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a transfusion bag of a block sealing shape which eliminates the possibility of the occurrence of stress concentration leading to rupture in strong sealing parts of a place connected thus far to a weak sealing part in spite of the exertion of a slight internal pressure to the bag in a stage of washing, dispensing or sterilizing, etc., prior to transfusion after mixing of medicinal liquids and the of a rapid internal pressure owing to an enonious dropping of the bag, is capable of preventing the occurrence of rupture and pinholing as far as possible and does not stagnate the medicinal liquid at the time of transfusion work. SOLUTION: This transfusion bag 1 is constituted by segmenting the bag to plural cells by means of a block sealing part 9 and packing the different medicines into the respective cells. These medicines are transported without being mixed with each other and can be mixed at the time of use. The sealing part 9 consists of the strong sealing parts 3 at both end ends of the bag and the belt-like weak sealing part 2 in the central part held by the same. The strong sealing parts 3 are formed at a specified width longer than the width of the weak sealing part 2 and are disposed symmetrically orthogonally in its vertical direction.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a flat multi-chamber infusion bag made of a plastic sheet. In particular, the infusion bag is divided into a plurality of chambers by a weak seal portion, and pressurizes the liquid storage portion to separate the weak seal portion during use, and mixes the chemical solution. For infusion bags without pills.

[0002]

2. Description of the Related Art In one field in which a medical infusion bag is used, a plurality of chemicals may be mixed and infused immediately before infusion. There has been a demand for an infusion bag having a sanitary quarantine function that can prevent contamination and invasion of various bacteria, but as a countermeasure, weakly seal the inner wall surface of the bag-shaped container made of a cylindrical synthetic resin film. By dividing into a plurality of chambers, each chamber is pre-filled with a medicinal solution or drug for mixing, and when an infusion is required, the seals of these compartments are peeled or broken, and the entire infusion bag is made into one chamber. 2. Description of the Related Art There is known an infusion bag capable of mixing various chemical solutions in a sterile environment.

[0003] In such an infusion bag, the weakly sealed portion must be placed in the infusion bag because the mixed chemicals must be separated and placed until the infusion is performed by mixing the separated chemicals. The necessary normal handling processes, such as washing, dispensing, sterilization, etc., should not be such that they can be easily peeled off, but when mixing the drug solution and using it for the original purpose of infusion It is required that a characteristic that only the weak seal portion can be peeled or broken by appropriate means such as pressurizing the bag by hand without peeling the strong seal portion of the infusion bag main body.

Various types of infusion bags have been proposed to satisfy such demands (for example, JP-A-63-19149, JP-A-1-240469, JP-A-2-4671; JP-A-6-39018
However, the conventional method uses a bag-like container formed by mixing two types of synthetic resins having high compatibility with each other as a means for forming the weak seal portion, and the inner surface of the container is subjected to normal heat bonding. Typical examples include an easy-peel type in which a high adhesive strength cannot be obtained by doing so, and a type in which another film is laminated on the inner surface of the infusion bag as a layer having a function of fusing and peeling.

Conventionally, for infusion bags, synthetic resins having relatively low rigidity, such as polyethylene and ethylene-vinyl acetate copolymer, have been mainly used due to demands for high productivity and the like, in addition to easy flattening characteristics during infusion of a chemical solution. . These synthetic resins are formed into a tubular film by inflation molding or folding and heat bonding of a flat band-like film, and this is cut into a desired length. At least one of the upper and lower cut openings is made of synthetic resin pharmaceutical. High air-tightness, liquid-tightness, and non-peeling thermal bonding are required together with the liquid filling or taking out port member. Usually, under high-temperature and high-pressure conditions, a wide strong sealing heat-bonding zone is formed. In this heat bonding, even if the synthetic resin is relatively low in rigidity, the folded portions at both end portions along the length direction of the tubular film have an elastic recovery force peculiar to the synthetic resin. In consideration of the melting point of the synthetic resin used, liquid leakage occurs unless heat fusion is performed at a considerably high temperature, a high pressure, and a long pressurizing time.

The infusion bag according to the present invention has at least one partition seal in the middle between the upper and lower ends, and both end portions of the partition seal have elastic recovery characteristics of the folded portion of the film. In order to achieve a complete seal, considerably severe conditions are required, and as a result, a strong sealing state close to the strong seal at the upper and lower ends of the bag-shaped container must be obtained. Therefore, it is difficult to make the seal at this portion into a weak seal state that can be peeled off during the infusion operation, like the weak seal portion at the central portion of the partition seal portion. Conventionally, both ends of the compartment seal are non-peelable strong seal parts even when mixing the chemical solution before the infusion work,
A mode has been adopted in which only a central portion sandwiched between the strong seal portions on both side ends is a peelable weak seal portion.

However, the shape of the conventional strong seal portion is as follows.
A shape in which a narrow, band-shaped weak seal portion at the center portion is continuously widened toward the folds on both side ends, specifically disclosed in, for example, Japanese Patent Laid-Open No. 6-39018 (see FIG. 2). As described above, the linear weak seal portion 2 has a shape which is vertically symmetrical and continuously widens by drawing a curve which is concave inside the infusion bag 1, and the widened shape portion corresponds to the strong seal portion 3. It was a section seal part to do. As a matter of course, the strong seal portion 3 of this shape also includes fold portions at both side ends, so that considerably stricter sealing conditions are adopted as compared with the weak seal portion 2 at the central portion. For example, conditions such as high-temperature pressurization, multiple pressurization, and long-time pressurization can be considered. Further, in the seal portion of this type as described above, since the curve is concave inward of the bag, there is a problem that the medicine is likely to stay at the time of infusion, and complete infusion of all the medicine cannot be expected.

Since the strong seal portion 3 of the infusion bag shown in FIG. 2 is on a continuous extension line of the weak seal portion 2, the boundary with the weak seal portion 2 has a sharp projection shape, and If the bag is mistakenly dropped after peeling or breaking the weak seal portion 2 for a short time, the instantaneous tensile elongation stress tends to concentrate on the boundary of the protruding shape, and the breakage or pinhole is apt to occur in the portion. Have.

[0009]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problem of breakage of a conventional infusion bag partitioned near the center after the weak seal portion is peeled off. More specifically, the weak seal portion of the compartment seal portion is peeled off, and a slight internal pressure is applied in a process such as washing, dispensing, or sterilizing the infusion bag after the chemical solution is mixed and before the infusion, or the infusion bag is accidentally dropped. Even if the internal pressure is suddenly applied by bagging, there is no risk of bursting stress concentration occurring at the strong seal portion connected to the weak seal portion, so that rupture at this portion,
The purpose of this invention is to find a section seal shape that can prevent the occurrence of pinholes as much as possible and that can easily drop without a stagnation of a drug solution during infusion work, and in particular, to find a preferable shape of a strong seal portion constituting the partition seal shape. It is an object of the present invention to provide an infusion bag capable of efficiently forming a preferable partition sealing portion.

[0010]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, it has been found that the problem can be solved by making the shape of the strong seal portion in the conventional partition seal portion a specific shape. As a result, the present invention has been completed. That is, the gist of the present invention is as follows. [1] An infusion bag that is divided into a plurality of chambers by a seal portion, each chamber is filled with a different drug, transported without being mixed with each other, and these drugs can be mixed at the time of use, wherein the seal portion is a bag. It consists of a strong seal at both ends and a band-shaped weak seal at the center sandwiched between the strong seals. The strong seal has a constant width, is longer than the width of the weak seal, and is symmetrically perpendicular to the vertical direction. [2] The infusion bag according to [1], which is manufactured from a hollow film, and [3] the length of the strong seal portion is weak. 1. Seal width
The above problem was solved by developing the infusion bag according to the above [1] or [2], which is 1 to 3 times and the width is 0.3 to 2 times.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The material used for the infusion bag of the present invention is preferably a soft thermoplastic plastic which does not elute substances harmful to the living body. In particular, the above three kinds of resins or a mixture thereof are preferably used, such as high-pressure low-density polyethylene, linear low-density polyethylene, high-density polyethylene, and polypropylene.

Hereinafter, the present invention will be described with reference to FIG. 1 which is an infusion bag having two upper and lower chambers, but there may be three or more chambers. Creases are formed at both ends along the length direction of the hollow film of the infusion bag 1 before molding, and the lower end is provided with a chemical liquid filling port member 7 and a chemical liquid filling port member 8 at respective cut openings. An infusion bag in which the strong sealing portions 5 and 6 adhered in a liquid-tight manner together with the hollow film is obtained. A partition seal portion 9 is formed in a widthwise direction at an intermediate portion of the infusion bag in the vertical direction. The partition seal portion 9 includes a weak seal portion 2 and a strong seal portion 3. By the formation of the partition seal portion 9, the infusion bag 1 becomes the infusion bag 1 divided into the upper medicine chamber 4 and the lower medicine chamber 4 ', and the medicines filled in both chambers are not mixed until the infusion work. Put in isolation.

The weak seal referred to in the present invention means that the infusion bag is not easily peeled off during various handlings of the infusion bag until the infusion operation is performed, and the mixing medicine sealed in each of the compartments is stored as it is. When the medicine is filled immediately before entering the infusion work, the medicine chamber filled with the medicine is pressed by hand or the like in order to intentionally increase the internal pressure of the compartment to a predetermined value or more. It is a seal that can be peeled uniformly and stably over the entire seal portion, and is necessary for forming the infusion bag itself as in the strong seal portions 5 and 6 at the cut opening portion of the infusion bag, and has a peel strength of the seal portion that cannot be peeled. This means a seal having relatively low fusion strength, and the specific seal strength or its range is determined by the shape, size, amount of drug for mixing, etc. of the infusion bag. It is more appropriately set.

The infusion bag 1 is manufactured by flatly folding a hollow film. Both ends of the infusion bag are folds of the hollow film, and the folds have elastic recovery characteristic of a synthetic resin. Even if heat sealing is performed under the same conditions as the portions other than the folding date portion, it is difficult to obtain the same sealed state as the other portions. That is, a liquid-tight seal cannot be obtained unless the fold portion is sealed under a condition of a relatively high temperature, a high pressure, and a long time. On the other hand, portions other than the folds can be sealed liquid-tight even under weaker conditions. In addition, the partition seal portion 9 needs to have a portion having a weak sealing property that can be peeled or broken during the infusion operation. In the present invention, the partition seal portion 9 is formed with a specific strong seal portion 3 which does not cause peeling or the like at the time of mixing the medicine at the fold portions on both side ends, and a portion sandwiched between the strong seal portions 3 at both ends is a weak seal portion. 2, and when the weak seal portion 2 is peeled or broken and opened, it is intended to satisfy the requirement that the strong seal portion 3 in contact with the weak seal portion 2 does not rupture or generate a pinhole. Things.

In the present invention, the strong seal portion 3 of the partition seal portion 9 has a fixed width at both ends of the weak seal portion and is longer than the width of the weak seal portion 2 and is symmetrical and perpendicular to the vertical direction. Provided. The length (vertical direction) of the strong seal portion 3 is
Usually, it is about 1.1 to 5 times, preferably about 1.2 to 3 times the width (vertical direction) of the weak seal portion 2. If the length of the strong seal portion 3 is longer than this, there is no particular problem with respect to peeling, bag breakage, and pinholes, but it is not preferable to make the infusion bag 1 too long because it loses the flexibility in the vertical direction. Also, the width (horizontal direction) of the strong seal portion 3 is set to be 0.
It is about 2 to 2 times, preferably about 0.3 to 1.5 times. This width is also weak due to the ease of handling the infusion bag.
Is not preferable.

The seal strength of the strong seal portion 3 must have a large difference in seal strength from that of the weak seal portion. For this reason, the strong seal portion has twill-shaped or flat-shaped unevenness formed on the front and back sides of each other. It is preferable to use a sealing method or the like. In addition, the peel strength of the weak seal portion 2 must be controlled in a desired range so that a plurality of kinds of medicines stored in the infusion bag can be appropriately mixed. It is a range of values determined by the length, width, and amount of drug in the infusion bag, and cannot be expressed as a specific value. However, the internal pressure of the infusion bag is usually increased to 0.1 to 0.5 kgf / cm ² . It is preferable to have a pressure-resistant strength that starts peeling when it is removed. in this way,
A strong seal portion 3 having a fixed width longer than the width of the weak seal portion 2
Is symmetrically provided so as to extend perpendicularly to the entire width of the weak seal portion 2 and above and below the weak seal portion 2. Although the reason could not be elucidated, the intersection of the weak seal portion and the strong seal portion should be straight. As a result, bag breakage after peeling the weak seal portion could be avoided, and the bag drop strength could be greatly improved.

[0017]

Next, the present invention will be described with reference to examples and comparative examples. (Examples 1-3, Comparative Examples 1-2) 250 microns thick,
A linear low-density polyethylene hollow film having a folded diameter of 190 mm was cut into 900 mm, and the upper and lower openings were heat-sealed together with a mouth member to prepare an infusion bag as shown in FIG. A heat seal bar was used at the center of the infusion bag in the longitudinal direction to form a compartment seal.
C., pressing force: 4 kg / cm ² , pressing time: 4 seconds, to form a weak seal portion having a width of 10 mm and a length of 190 mm. Further, a heat seal bar having a length and a width shown in Table 1 was applied to both ends of the weak seal portion so that the seal portions overlap each other to form a strong seal portion. The heat sealing conditions of the strong seal portion are as follows: temperature: 145 ° C., pressing force: 4 kg / cm ² , pressing time: 2.5 seconds. Next, the upper and lower two chambers of the infusion bag were filled with a total of 1000 ml of water, and each mouth member was sealed.
After performing the retort treatment at 15 ° C. for 30 minutes, the weak seal portion was peeled off, and the upper and lower chambers were connected to each other.
, And the average of the number of drops until the bag was broken when continuously dropped five times from a height of 1.5 m was measured. Table 1 shows the results. For comparison, an infusion bag provided with a compartment seal as shown in FIG. 2 was tested in the same manner as in the example. Table 1 shows the results.

[0018]

[Table 1] Boundary shape Strong seal length Strong seal width Number of drops to break (n = 30) Example 1 Straight 15mm 4mm 5 times without breaking 2 straight 15mm 4mm 5 times without breaking 3 Straight 30mm 8mm 5 Comparative Example 1 Inward concave radius 15mm 4mm 0.7 times 2 Inward concave radius 15mm 8mm 0.4 times

[0019]

According to the present invention, an infusion bag consisting of a plurality of chambers made of a plastic film, in particular, is divided into a plurality of chambers by a weak seal portion, and when used, the liquid container is pressurized to peel off the weak seal and mix the medicine. This is an infusion bag which is highly safe to handle without risk of breakage of the peeled portion due to falling or excessive pressurization. The infusion bag of the present invention peels off the weak seal portion of the compartment seal portion, and after applying the chemical solution, applies extra internal pressure in the steps of washing, dispensing, or sterilizing the infusion bag before infusion, or erroneously. Even if the bag is dropped and the internal pressure is suddenly applied, there is no danger of bursting stress concentration at the strong seal at the place where the weak seal was connected. This is advantageous because it has a partition seal shape that can prevent the drug solution and easily drop the drug solution without stagnation during the infusion work.

[Brief description of the drawings]

FIG. 1 is a front view of an infusion bag of the present invention.

FIG. 2 is a front view of an example of a conventional infusion bag.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Infusion bag 2 Weak seal part 3 Strong seal part 4, 4 'Medicine room 5 Strong seal part 6 Strong seal part 7 Drug port member 8 Drug port member 9 Sectional seal

Continued on the front page (72) Inventor Tomohiko Ezaki 3-2 Chidori-cho, Kawasaki-ku, Kawasaki-ku, Kawasaki-shi, Kanagawa Prefecture Showa Denko Co., Ltd.Research Institute Kawasaki Laboratory Chidori (72) Inventor Isao Otake Chidori, Kawasaki-ku, Kawasaki-shi, Kanagawa Prefecture 3-2, Showa Denko Co., Ltd., Chidori, Kawasaki Laboratory, Research Institute, Inc. (72) Inventor Hitoshi Saito 3-2, Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa Prefecture, Japan Showa Denko Co., Ltd.

Claims (3)

[Claims] 1. An infusion bag which is divided into a plurality of chambers by a seal portion, each chamber is filled with a different drug, transported without being mixed with each other, and these drugs can be mixed at the time of use. Is composed of a strong seal portion at both end portions of the bag and a band-like weak seal portion at the center portion sandwiched between the strong seal portions. The strong seal portion has a constant width, is longer than the width of the weak seal portion, and is symmetrical in the vertical direction. An infusion bag, which is provided perpendicular to the bag. 2. The infusion bag according to claim 1, wherein the infusion bag is manufactured from a hollow film. 3. The length of the strong seal portion is 1.1 times the weak seal width.
The infusion bag according to claim 1 or 2, wherein the width is 0.2 to 2 times and the width is 0.2 to 2 times.