WO2007055355A1

WO2007055355A1 - Multichamber container

Info

Publication number: WO2007055355A1
Application number: PCT/JP2006/322564
Authority: WO
Inventors: Shoji Igota; Kaoru Shimizu
Original assignee: Ajinomoto Co., Inc.
Priority date: 2005-11-14
Filing date: 2006-11-13
Publication date: 2007-05-18
Also published as: JPWO2007055355A1; JP4962733B2

Abstract

A drug storing bag (10) made of a soft synthetic resin film material the inner space of which is divided into multiple chambers (20, 22) by a weak seal part (18) and in which a discharge aperture (12) is formed in such a manner as to open toward one chamber (20). A sealing bag (13) having a small capacity is provided within the drug storing bag (10) so that the sealing bag (13) seals the opening end of the discharge aperture (12) toward the inner space of the drug storing bag (10). A synthetic resin film that is more fragile than the synthetic resin film constituting the drug storing bag (10) is selected as the material constituting the sealing bag (13). The inner face of the drug storing bag (10) is strongly melt-bonded to the inner face of the sealing bag (13) at a rectangular part which has a sharp corner shape with a small area. When the weak seal part is unsealed, the outer bag is enlarged due to a fluid pressure applied thereto, which results in the burst and opening of the inner bag.

Description

Multi-chamber container

Technical field

[0001] According to the present invention, the internal cavity is separated by the weak seal portion, thereby forming a plurality of compartments for individually storing and storing the drug, and opening the weak seal portion during use. The present invention relates to a multi-chamber container that is mixed and discharged.

Background art

[0002] There are multi-liquid mixing type multi-chamber containers for infusion and dialysis. In a multi-chamber container, the internal cavity of a medicine bag made of a soft film is separated into a plurality of compartments each containing a different chemical solution by a weak seal. The outer periphery of the medicine storage bag is provided with a chemical liquid discharge port as a rigid plastic molded product capable of maintaining its shape, the chemical liquid discharge port is formed in a cylindrical shape, and the internal cavity is at one end on one side. Force opening to the chamber The other end has a rubber stopper. Prior to administration of the drug solution to the patient, the weak seal part is opened by applying external force to the drug storage bag, and the internal cavity of the drug storage bag becomes a single chamber. The puncture needle can be used to puncture a rubber stopper, allowing the drug solution to be administered from the drug storage bag. Therefore, in this type of multi-chamber container, it is essential to open the weak seal part by mixing the two liquids prior to the administration of the chemical liquid. On the other hand, it is necessary to discharge the chemical liquid without opening the weak seal part. When the rubber stopper was punctured at the outlet, there was a possibility of an erroneous operation in which only the drug solution in the compartment on the drug solution outlet side was administered. As a conventional technique for dealing with this problem, in addition to the first weak seal portion that separates the internal cavity of the medicine storage bag into two compartments, a second weak seal portion is provided immediately before the chemical solution discharge port. By making the second second weak seal part equal to or higher than the pressure required to open the first weak seal part, the second weak seal part is placed next to the first weak seal part. It has been proposed to open the doors in order so that discharge is performed after mixing of the chemicals (see Patent Document 1).

Patent Document 1: Japanese Patent Laid-Open No. 9 327498

Disclosure of the invention Problems to be solved by the invention

[0003] In the technique of Patent Document 1, in addition to the first weak seal portion that separates the two compartments, a second weak seal portion is provided immediately before the chemical solution outlet, and these weak seal portions are sequentially opened. The strength of trying to prevent the administration of unmixed chemicals is provided with two weak seals, which complicates the manufacturing process and makes it very difficult to accurately manufacture multiple weak seals with different strengths. This is a difficult task, increases costs, and forces the user to perform two-stage pressurization work, which is always good for workability. In addition, depending on the method of pressurizing the medicine storage bag, the first weak seal part → the second weak seal part may not always be opened, but the second weak seal part on the chemical solution outlet side is not necessarily opened. If the part is opened first, there is a possibility of shifting to the administration work as it is, and in this case, only one solution is administered without mixing.

[0004] The present invention has been made in view of the above-mentioned problems. Administration is performed in an unopened state, and a novel structure of a multi-chamber container is provided. The purpose is to more surely eliminate the possibility of erroneous operation in which administration is performed in an unmixed state despite good side workability.

Means for solving the problem

[0005] The mixed drug-sealed bag-like material according to the present invention includes a drug storage bag formed of a flexible film, a discharge port for discharging the drug, and an internal cavity of the drug storage bag. A weak seal portion that separates into a plurality of compartments for storing the medicines, is opened by a pressing force applied to the medicine storage bag from the outside, and mixes the medicines stored in the respective compartments. It is equipped with. The sealing bag, which is formed of a flexible film that is more fragile than the flexible film that constitutes the medicine storage bag and is located inside the medicine storage bag, is provided in the space between the medicine storage bag and the inner space of the medicine storage bag. The outlet is surrounded and disposed so as to close the open end to the chamber, and the inner surface of the medicine storage bag is welded and joined to the opposite outer surface of the sealing bag at a small area to form an opening portion, and the pressing at the time of opening is performed. As the drug storage bag is expanded by pressure, the sealing bag is broken at the opening, the discharge port is opened in the internal cavity of the drug storage bag, and the mixed drug is discharged from the discharge port. By making the opening part an acute angle part, stress concentration is caused and the sealing bag is surely ruptured by the fluid pressure generated by opening the weak seal part. be able to.

The invention's effect

[0006] The discharge port is normally closed by a sealing bag inside the medicine storage bag, and the sealing bag is firmly welded and joined to the opposite surface of the medicine storage bag at the opening portion as a small area portion. . Therefore, by appropriately selecting the material and thickness of the synthetic resin film constituting the sealing bag, the size of the opening portion, the shape of the opening portion, etc., the internal fluid pressure during the mixing operation can reliably destroy only the sealing bag. Thus, the mixed drug can be discharged from the discharge port. The separation seal (weak seal) that should be mixed with the two liquids and the opening part that prevents the administration of the mixed drug to be opened by a separate mechanism can achieve reliable “step-by-step” communication. It is.

Brief Description of Drawings

[0007] FIG. 1 is a plan view of the multi-chamber container of the present invention (a view taken in the direction of arrow I in FIG. 2).

[FIG. 2] FIG. 2 is a cross-sectional view of the multi-chamber container of the present invention, and is a view taken along the line II-II in FIG.

[FIG. 3] FIG. 3 is a partial view of the vicinity of the discharge port in FIG. 2 and schematically shows the state when the multi-chamber container of the present invention is opened.

FIG. 4 is a schematic view showing an example of a point seal method in a series of steps.

[FIG. 5] FIG. 5 is a schematic view showing another example of the point sealing method in FIG. 4 in a series of steps.

[FIG. 6] FIG. 6 shows a discharge port with an internal bag mounted with a point seal support plate.

FIG. 7 is a perspective view schematically showing a state in which the point seal support plate is attached to the discharge port in FIG.

[FIG. 8] FIG. 8 shows the vicinity of the discharge port of the multi-chamber container in another embodiment in which the opposing surfaces of the drug storage bag 10 and the inner bag 13 are connected by a substantially full-width heat seal portion in addition to the point seal. FIG.

Explanation of symbols

[0008] 10 ··· Drug storage bag

12 ... Discharge port 13… Sealing bag

18 ... Weak seal

20, 22 ...

30… Small area (point seal)

50 ... Point seal receiving plate

BEST MODE FOR CARRYING OUT THE INVENTION

In FIG. 1 to FIG. 2, the multi-chamber container is a flat medicine storage bag (external bag) 10 for storing medicine, a discharge port 12 fixed to the outer periphery of the medicine storage bag 10, and a medicine. A force is also configured with a small-capacity sealing bag (inner bag) 13 that seals the outlet 12 in the normal state against the inner cavity of the storage bag 10. The drug storage bag 10 is made of a soft film (a flexible material of the present invention) having a multilayer structure such as a polypropylene film or a polyethylene film having a thickness of 200 microns. Two pieces of synthetic resin film are sealed at the outer periphery with a strong seal 14 formed by pressing at a high temperature (120 ° C in the case of polypropylene) sufficiently higher than the soft temperature. And has a substantially rectangular bag shape. This medicine storage bag 10 can be a bag made of tube-like inflation film or a container made of blow-molded bag, in addition to the above-described bag-making from a film. A suspension hole 16 is formed in the strong seal portion 14, and the medicine storage bag 10 is suspended and held by the suspension hole 16 on an infusion stand or the like to perform infusion or dialysis.

[0010] A weak seal portion across the entire width of the intermediate portion in the length direction of the medicine storage bag 10

(Peelable weld part) 18 extends, and the weak seal part 18 welds the front and back surfaces of the medicine storage bag 10 to each other, and the inner cavity of the medicine storage bag 10 is divided into the first compartment 20 and the second compartment 22. It is divided. The first compartment 20 is filled with the first chemical solution, and the second compartment 22 is filled with the second chemical solution. The weak seal portion 18 is formed by pressurizing the front and back surfaces of the synthetic resin film section forming the drug storage bag 10 at a low temperature (110 ° C. in the case of polypropylene) slightly higher than its softening temperature. Therefore, the strong seal portion 14 remains as it is by pressurizing the drug solution in the drug storage bag 10 from the outside in the compartments 20 and 22 while the respective drug solutions are stored in the first compartment 20 and the second compartment 22. In addition, the weak seal portion 18 can be broken and opened by fluid pressure (pressure of the chemical solution during pressurization) to mix the first chemical solution and the second chemical solution. [0011] The discharge port 12 is made of a synthetic resin having a thickness and rigidity capable of maintaining its form (the same plastic material as the drug storage bag 10 is used to obtain adhesion to the drug storage bag 10). (Preferred). The discharge port 12 is formed in a cylindrical shape having openings at both ends, the middle forming a tapered portion 12-1, and the upper end having a flange portion 12-2 (FIG. 1). The cap 12-3 is abutted and welded to the flange 12-2, and the rubber inner lid 12-4 (the plug of the present invention) is attached to the bottom opening of the cap 12-3. At the time of infusion such as infusion, the inner lid 12-4 is punctured by the puncture needle of the infusion set, and the inner cavity of the medicine storage bag 10 is communicated with the infusion tube to perform infusion. In this embodiment, the synthetic resin film that forms the front and back surfaces of the medicine storage bag 10 is moved up and down the cylindrical portion of the discharge port 12 through the synthetic resin film that forms the front and back surfaces of the sealing bag 13. Heating and adhering while sandwiching, the medicine storage bag 10 is sealed with respect to the discharge port 12.

As shown in FIGS. 1 and 2, the small-capacity sealing bag 13 is provided inside the medicine storage bag 10 and is provided to seal the discharge port 12 in a normal state. The sealing bag 13 is similar to the drug storage bag 10 in that the upper and lower synthetic resin film sections, such as polypropylene film and polyethylene film, are heated at the outer peripheral portion 13A (the welding temperature of the strong seal portion 14 of the drug storage bag 10). It is formed by welding at the same temperature), but as described later, it is sealed so that it can be ruptured at the point seal part by opening the medicine storage bag 10 by the fluid pressure when opening the weak seal 18. The synthetic resin film constituting the stopper bag 13 is considered to be weaker than the synthetic resin film constituting the drug storage bag 10 in terms of strength. On the other hand, from the viewpoint of thermocompression bonding at the time of point sealing, it is preferable that the inner and outer bags are made of the same synthetic resin material. The thickness can be made appropriately thinner than that of the synthetic resin film constituting the medicine storage bag 10. Alternatively, the required strength difference between the inner and outer bags can be reduced by making the polymerization degree of the synthetic resin constituting the drug storage bag 10 smaller than the polymerization degree of the synthetic resin constituting the sealing bag 13 or by using a copolymer. Can be provided. In addition, the sealing bag 13 is sterilized under the heat and humidity in the sealing bag 13 by assembling a microscopic hole through which a liquid having a flow rate very slow compared to the drip rate can pass (aseptic sterilization). ) It is advantageous for operation. For this reason, by making the point seal portion into a perforated shape, it is possible to drill at the same time as the point seal. still, In Fig. 2, it is noted that the bags 10 and 13 are drawn with a considerable thickness. This is for the convenience of drawing, and the thickness is drawn with exaggeration considerably! ,.

As shown in FIG. 1, the sealing bag 13 has a width that is somewhat larger than the outer diameter of the discharge port 12 and extends toward the internal cavity of the drug storage bag 10 when the drug storage bag 10 is not opened. By closing the discharge port 12 with respect to the internal cavity of the drug storage bag 10 when the compartments 20 and 22 are separated by the weak seal portion 18, the drug solution is discharged from the discharge port 12 without mixing. To prevent it. Then, when the medicine storage bag 10 that opens the weak seal portion 18 for mixing the medicines in the compartments 20 and 22 is pressurized in the compartment 20 on the side away from the discharge port 12 as much as possible, the medicine storage bag is used. The opening of the medicine storage bag 10 due to the shocking chemical liquid flow (arrow F in FIG. 3) generated inside the 10 causes the sealing bag 13 to break, and the internal cavity of the medicine storage bag 10 containing the medicine is discharged. The mixture 12 is communicated with the outlet 12, and the mixed chemical solution can be discharged from the outlet 12. In this embodiment, the sealing bag 13 is attached to the discharge port 12 together with the medicine storage bag 10 as described later. That is, the strong seal portion 14 on the outer periphery of the medicine storage bag 10 is welded to the outer periphery of the discharge port 12 in the portion 14-1, and the outer peripheral portion 13-1 of the sealing bag 13 is also overlapped and welded at the time of this welding. (See Figure 2). On the other hand, the sealing bag 13 is normally closed with respect to the internal cavity (compartment 22) of the medicine storage bag 10, that is, when the weak seal portion 18 is not opened, the medicine in the medicine storage bag 10 is closed. Is blocked from going to the outlet 12. The outer surface of the sealing bag 13 is welded (point-sealed) to the opposing inner surface (upper and lower inner surfaces) of the medicine storage bag 10 with a small area portion 30. This small area portion 30 where the outer surface of the sealing bag 13 is welded to the opposite inner surface of the drug storage bag 10 has a rectangular shape with a sharp corner as shown by the hatched area in FIG. The temperature is as high as the welding temperature of the strong seal portion 14 on the outer periphery of the drug storage bag 10. When the weak seal portion 18 is opened, the medicine storage bag 10 is expanded, and the sealing bag 13 whose outer surface is welded to the opposite inner surface of the medicine storage bag 10 with a small area portion 30 receives a tensile force in the vertical direction and is small. Since the welding of the area portion 30 is strong, a tearing force is generated in the sealing bag 13, and the synthetic resin film constituting the sealing bag 13 is stronger than the synthetic resin film constituting the drug storage bag 10. There is also the effect of stress concentration caused by the weak and sharp shape of the small area part 30. As the drug storage bag 10 is expanded, the sealing bag 13 is strongly bowed at the point seal part 30 as shown in Fig. 3. The sealing bag 13 is It is ruptured at the into-seal portion 30 and the discharge port 12 is opened, so that the chemical solution can be discharged. That is, in order to open the medicine storage bag 10, the medicine storage bag 10 is placed flat on a desk or the like as shown in FIG. 2, and the medicine storage bag 10 is pressurized with a palm from the top as shown by an arrow b ( As shown in FIG. 3, it is preferable to pressurize the medicine storage bag 10 on the compartment 20 side, but the compartment 22 side may be pressurized or both sides may be pressurized. By pressurizing the medicine storage bag 10, a hydraulic pressure is applied to the weak seal portion 18, and the weak seal portion 18 is instantaneously broken and opened by a predetermined pressure. The internal pressure of the medicine storage bag 10 is increased by pressurization, and this increased pressure is released at once by opening and closing the weak seal portion 18, so that a shocking flow of the chemical solution flows into the medicine storage bag 10. Induced. In FIG. 3, the flow of the shocking chemical liquid induced in the medicine storage bag 10 is schematically shown by an arrow F. The rapid flow F of the chemical solution induced in the medicine storage bag 10 when the weak seal portion 18 is opened causes the medicine storage bag 10 to be greatly expanded as shown in FIG. Therefore, a large tearing force is generated in the small-capacity sealing bag 13 firmly welded to the opposite surface of the medicine storage bag 10 at the small area portion 30, and the synthetic resin film constituting the sealing bag 13. Since the tear strength is weaker than that of the synthetic resin film constituting the drug storage bag 10, it can be ruptured. In FIG. 3, the point seal portion of the sealing bag 30 is torn while it is welded to the medicine storage bag 10 as shown by 13 '. As a result, an opening 40 is formed in the sealing bag 13, and the medicine opens as indicated by an arrow. In this state, the rubber plug 12-3 is punctured with a puncture needle of an infusion set (not shown) to discharge the mixed drug solution. It becomes possible. In this way, according to the present invention, the opening of the isolation seal (weak seal 18) to be mixed with the two liquids and the opening of the opening (point seal 30) for preventing the administration of the mixed drug are said to be “stepwise”. 〃 Because of the opening structure, it is possible to achieve reliable communication during opening work.

The acute rectangular shape of the small area portion 30 can contribute to causing the sealing bag 13 to burst more reliably due to the stress concentration effect. Then, by optimally setting the composition and thickness of the synthetic resin film constituting the sealing bag 13, the medicine to the outlet 12 when the medicine storage bag is not opened (when the weak seal 18 is closed) is used. Inflow prevention (maintaining the closed state of the outlet / outlet 12 by the sealing bag 13), while the drug storage bag is opened (when the weak seal 18 is opened) It can be discharged Can be done.

An example of the process for forming the multi-chamber container of the present invention by sealing the medicine storage bag 10 will be described with reference to FIG. 4. The upper and lower synthetic resin films forming the medicine storage bag 10 are arranged on the outer periphery as shown in (a). The strong seal portion 14 is not welded at the portion 14A, and an opening is exhibited at the unwelded portion. The sealing bag 13 is already stored in the medicine storage bag 10, and the outer peripheral portion 13A is temporarily welded inside the opening portion 14A of the outer bag leaving an opening in the mounting portion 13B of the discharge port 12.

[0016] Next, a welding tool receiver is inserted toward the unsealed opening 13B of the sealing bag 13, and point sealing is performed with the external welding tool. That is, the welding tool having a welded part shape conforming to the shape of the point seal part and the receiver are brought into contact with each other via the film slice constituting the drug storage bag 10 and the film slice constituting the sealing bag 13, and the drug Point seal (high temperature welding at small area 30) between inner surface of storage bag 10 and outer surface of sealing bag 13 is performed

Then, the discharge port 12 is inserted toward the non-welding opening of the sealing bag 13 as indicated by the arrow f in (b), and welding is performed from the outside of the medicine storage bag 10. Therefore, the unsealed portion 14A of the synthetic resin film section constituting the medicine storage bag 10 is heat-pressed against the outer periphery of the discharge port 12 through the unsealed portion of the synthetic resin film constituting the sealing bag 13. The sealing bag 10 is welded to the discharge port 12 through the sealing bag 13.

(0018) (c) shows the state after the discharge port 12 is welded. In this state, the weak seal portion 18 shown in FIG. 1 is welded and the compartments 20 and 22 are filled with chemicals and the filling port is sealed. The multi-chamber container of the present invention is completed.

FIG. 5 shows a point seal method according to another embodiment. As shown in FIG. 5A, a sealed bag 13 having a welded seal bag 13 is first prepared as a discharge port 12. The medicine storage bag 10 has an unwelded portion 14A left on the outer peripheral strong seal portion 14, and this unwelded portion forms an opening, and the sealing bag 13 is stored in the medicine through the unsealed opening. Insert into bag 10 (Fig. 5 (b)). Then, the unwelded portion 14B is welded to the discharge port 12, and the strong seal portion 14 on the entire circumference is completed. Then, as shown in (c), point sealing is performed, and the medicine storage bag 10 and the sealing bag 13 are welded at a rectangular small area portion 30 on the opposing surface. Point sea in this case The welding tool is arranged so that the medicine storage bag 10 and the inner sealing bag 13 are sandwiched from the outside, and the welding tool is crimped via the inner and outer bags, so that the inner surface of the medicine storage bag 10 and the medicine storage bag It is performed so that 10 outer surfaces are welded in a small area.

In order to improve the weldability of the point seal in the embodiment of FIG. 5, the discharge port 12 is provided with a point seal receiving plate 50 protruding into the internal cavity of the sealing bag 13 as shown in FIG. Can be used. As shown in FIG. 7, the point seal tool receiving plate 50 is somewhat wider than the inner diameter of the discharge port 12, and includes a substrate portion 50-1 and a receiving plate portion 50-2 orthogonal to the substrate portion 50-1. The part 50-1 is press-fitted and fixed to a groove part 52 formed in the diameter opposite position on the inner diameter part of the discharge port 12. The point seal device receiving plate 50 is made of a material that is difficult to weld to the synthetic resin film constituting the inner and outer nogs. Point sealing is performed so that the medicine storage bag 10 and the inner bag 13 are sandwiched by the welding tool from the outside via the receiving plate portion 50-2. Therefore, it is possible to efficiently perform point sealing in a small area between the inner surface of the drug storage bag 10 and the outer surface of the inner sealing bag 13, and a sufficient flow path for the drug is secured because a gap remains. can do

In the embodiment described above, the force at which the opposing surfaces of the medicine storage bag 10 and the inner bag 13 are connected only by a point seal, as shown in FIG. 8, is added to the discharge port 12 in addition to the point seal 30. The opposed surfaces of the medicine storage bag 10 and the inner bag 13 can be connected by a heat seal portion (high-temperature welded portion = additional seal portion of the present invention) 42 of substantially the full width of the inner bag 13 at a close portion. Since the heat seal part 42 is wide, the stress concentration as strong as the point seal 30 does not occur. For this reason, even if the inner bag 13 is torn at the point seal 30 portion when the medicine storage bag 10 is expanded due to the rapid flow of the chemical solution when the weak seal portion is opened, the heat seal portion 42 is not torn or difficult to break. Therefore, the inner bag 13 remains joined to the drug storage bag 10 as a whole, that is, the inflated bag shape is maintained and only the portion of the point seal 30 is opened. The hollow force can also ensure a smooth flow of the chemical solution toward the discharge port 12 through the inner bag 13 through the opening where the point seal 30 is broken.

In addition, as described in relation to FIG. 2, the medicine storage bag 10 and the inner bag 13 are joined to each other by a pair of point seals 30 on the upper and lower opposing surfaces. Ba The point seal 30 that joins the opposing surfaces of the hook 13 is provided only on one of the upper and lower surfaces in FIG. 2, and the other opposing surface is a heat seal part that covers substantially the entire width where stress concentration is unlikely to occur. You may make it join by. In this case, because of the drug mixing, when the weak seal is opened, the drug storage bag 10 is opened only by rupturing only the point seal on one side, and the other heat seal is not ruptured. Since the opposite surfaces of 13 remain bonded, the inner bag 13 is not easily crushed as in FIG. 8, and the smooth chemical flow through the opening formed by the tear at the point seal portion is the same. ½ can be kept.

Claims

The scope of the claims

[1] A medicine storage bag formed of a flexible film, a discharge port attached to the medicine storage bag for discharging the medicine, and a plurality of partitions for storing each medicine inside the medicine storage bag. Weak seal that welds the opposite inner surfaces of the drug storage bags so that they are separated and opened by the pressing force applied from the outside to the drug storage bags for mixing the drugs stored in the respective compartments And a flexible film that is more fragile than the flexible film constituting the medicine storage bag, and is located inside the medicine storage bag and surrounds and closes the opening end of the discharge port into the medicine storage bag. A sealing bag, an opening portion formed by welding and bonding in a small area in the opposite surface of the medicine storage bag and the sealing bag, and sealed by opening the medicine storage bag by the pressing force at the time of opening. The bag is broken at the opening, and an opening that connects the discharge port to the internal cavity of the drug storage bag Multiple chambers but which are formed in the sealing bag.

[2] The multi-chamber container according to claim 1, wherein the opening portion has a shape having an acute angle portion.

[3] The multi-chamber container according to claim 1 or 2, wherein the discharge port includes a welder receiving plate extending into the sealing bag so as to face the opening.

[4] In the invention according to any one of claims 1 to 3, in addition to the opening portion, an additional seal portion that welds and joins the opposing surfaces of the medicine storage bag and the sealing bag is provided. The additional seal portion is a multi-chamber container that maintains the expanded shape of the sealing bag when the sealing bag is broken.

[5] A medicine storage bag formed of a flexible film, a discharge opening attached to the medicine storage bag for discharging the medicine, a plug provided in the discharge opening, and the inside of the medicine storage bag The medicine storage bag is separated into a plurality of compartments for storing the medicines, and the medicine storage bags are separated and opened by pressing force applied to the medicine storage bags for mixing the medicines stored in the respective compartments. A method of performing an infusion operation with a multi-chamber container provided with a weak seal portion that welds the opposing inner surface, wherein the discharge port is formed of a flexible film that is more fragile than the flexible film constituting the drug storage bag A sealing bag is provided inside the medicine storage bag to surround and close the open end of the discharge port into the medicine storage bag, and the opposite surfaces of the medicine storage bag and the sealing bag are joined together. Normally, the inside of the medicine bag is substantially closed with respect to the discharge port. Weak seal with fluid pressure caused by pressurizing the medicine bag from outside during infusion By separating the parts and communicating the plurality of compartments, the medicines in the first and second compartments are mixed, and the sealing bag is opened by expanding the medicine storage bag caused by peeling off the weak seal part. An infusion method in which an infusion operation is started by puncturing a stopper with an infusion device while guiding the mixed medicine to the discharge port.