JP2000517292A5 - - Google Patents

Download PDF

Info

Publication number
JP2000517292A5
JP2000517292A5 JP1997537492A JP53749297A JP2000517292A5 JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5 JP 1997537492 A JP1997537492 A JP 1997537492A JP 53749297 A JP53749297 A JP 53749297A JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997537492A
Other languages
English (en)
Japanese (ja)
Other versions
JP4155598B2 (ja
JP2000517292A (ja
Filing date
Publication date
Priority claimed from GBGB9619082.2A external-priority patent/GB9619082D0/en
Priority claimed from GBGB9707394.4A external-priority patent/GB9707394D0/en
Application filed filed Critical
Priority claimed from PCT/NZ1997/000117 external-priority patent/WO1998011101A2/en
Publication of JP2000517292A publication Critical patent/JP2000517292A/ja
Publication of JP2000517292A5 publication Critical patent/JP2000517292A5/ja
Application granted granted Critical
Publication of JP4155598B2 publication Critical patent/JP4155598B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP53749297A 1996-09-12 1997-09-12 抗癌剤としての縮合n−アシルインドール Expired - Fee Related JP4155598B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9619082.2A GB9619082D0 (en) 1996-09-12 1996-09-12 Further cyclopropylindoles and their seco precursors,and their use as prodrugs
GB9619082.2 1997-04-10
GB9707394.4 1997-04-10
GBGB9707394.4A GB9707394D0 (en) 1997-04-10 1997-04-10 Further cyclopropylindoles and their seco precursors, and their use as prodrugs
PCT/NZ1997/000117 WO1998011101A2 (en) 1996-09-12 1997-09-12 Condensed n-aclyindoles as antitumor agents

Publications (3)

Publication Number Publication Date
JP2000517292A JP2000517292A (ja) 2000-12-26
JP2000517292A5 true JP2000517292A5 (OSRAM) 2005-01-13
JP4155598B2 JP4155598B2 (ja) 2008-09-24

Family

ID=26310030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53749297A Expired - Fee Related JP4155598B2 (ja) 1996-09-12 1997-09-12 抗癌剤としての縮合n−アシルインドール

Country Status (9)

Country Link
EP (1) EP0938474B1 (OSRAM)
JP (1) JP4155598B2 (OSRAM)
AT (1) ATE310725T1 (OSRAM)
AU (1) AU721037B2 (OSRAM)
CA (1) CA2265874C (OSRAM)
DE (1) DE69734722T2 (OSRAM)
ES (1) ES2253786T3 (OSRAM)
NZ (1) NZ334344A (OSRAM)
WO (1) WO1998011101A2 (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
ES2260570T3 (es) 1998-08-27 2006-11-01 Spirogen Limited Pirrolobenziodiazepinas dimericas.
GB9909612D0 (en) * 1999-04-26 1999-06-23 Cancer Res Campaign Tech N-protected amines and their use as prodrugs
US6909006B1 (en) * 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
BR0110414A (pt) * 2000-04-28 2003-02-11 Baxter Healthcare Sa Derivados de 2-acil indol e seu uso como agentes antitumores
WO2001083448A2 (de) * 2000-05-02 2001-11-08 Tietze Lutz F Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo[3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo[e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo[f]chinolin-derivaten für eine selektive krebstherapie
DE60211905T2 (de) * 2001-02-22 2007-01-18 School Of Pharmacy, University Of London Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
US7235578B2 (en) * 2002-05-17 2007-06-26 Auckland Uniservices Limited Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
US20050032868A1 (en) * 2003-05-02 2005-02-10 Garofalo Albert W. Selected substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
TW200509910A (en) 2003-05-02 2005-03-16 Elan Pharm Inc Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
NZ536107A (en) * 2004-10-22 2007-06-29 Auckland Uniservices Ltd Nitrobenzindoles and their use in cancer therapy
WO2007059404A2 (en) * 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
US8940784B2 (en) * 2006-02-02 2015-01-27 Syntarga B.V. Water-soluble CC-1065 analogs and their conjugates
WO2008039087A2 (en) * 2006-09-29 2008-04-03 Auckland Uniservices Limited Indoline derivatives and uses thereof
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
TW200900059A (en) 2007-02-21 2009-01-01 Medarex Inc Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
RU2562232C2 (ru) 2008-11-03 2015-09-10 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
DE102009051438A1 (de) 2009-10-30 2011-05-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Fluoreszenzfarbstoffe
HUE030846T2 (en) 2010-04-21 2017-06-28 Syntarga Bv Conjugates of cc-1065 analogs and bifunctional linkers
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
JP6224268B2 (ja) 2014-01-10 2017-11-01 シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. 子宮内膜癌の治療において使用するためのデュオカルマイシンadc
HRP20160697T1 (hr) 2014-01-10 2016-07-15 Synthon Biopharmaceuticals B.V. Duokarmicin adcs koji pokazuje poboljšanu antitumorsku aktivnost in vivo
CN108653288B (zh) * 2018-05-29 2020-05-05 福建医科大学孟超肝胆医院(福州市传染病医院) 一种乏氧响应聚合物纳米粒及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2598819B2 (ja) * 1986-12-19 1997-04-09 ジ・アップジョン・カンパニー 新規なcc‐1065同族体
JP2642165B2 (ja) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 新規dc−89化合物およびその製造法
KR100208957B1 (ko) * 1990-04-25 1999-07-15 로렌스 티. 마이젠헬더 신규한 cc-1065 유사체
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6548530B1 (en) * 1995-10-03 2003-04-15 The Scripps Research Institute CBI analogs of CC-1065 and the duocarmycins
EP0888301B1 (en) * 1996-03-08 2005-08-10 The Scripps Research Institute Mcbi analogs of cc-1065 and the duocarmycins

Similar Documents

Publication Publication Date Title
JP2000502280A5 (OSRAM)
JP2000506348A5 (OSRAM)
JP2002505592A5 (OSRAM)
JP2000501771A5 (OSRAM)
JP2000504884A5 (OSRAM)
JP2000501599A5 (OSRAM)
JP2000501018A5 (OSRAM)
JP2001503295A5 (OSRAM)
JP2000501324A5 (OSRAM)
JP2001524152A5 (OSRAM)
JP2001512478A5 (OSRAM)
JP2000509515A5 (OSRAM)
JP2000501825A5 (OSRAM)
JP2000501338A5 (OSRAM)
JP2000500874A5 (OSRAM)
JP2000506091A5 (OSRAM)
JP2000502568A5 (OSRAM)
JP2000501774A5 (OSRAM)
JP2000500912A5 (OSRAM)
JP2000502570A5 (OSRAM)
JP2001527517A5 (OSRAM)
JP2000501876A5 (OSRAM)
JP2000501744A5 (OSRAM)
JP2000501229A5 (OSRAM)
JP2000500857A5 (OSRAM)