JP2000516230A - Ｉｉｂ／ｉｉｉａ拮抗薬としての環状カルバメート類およびイソオキサゾリジン類 - Google Patents

Ｉｉｂ／ｉｉｉａ拮抗薬としての環状カルバメート類およびイソオキサゾリジン類

Info

Publication number
JP2000516230A
JP2000516230A JP10509820A JP50982098A JP2000516230A JP 2000516230 A JP2000516230 A JP 2000516230A JP 10509820 A JP10509820 A JP 10509820A JP 50982098 A JP50982098 A JP 50982098A JP 2000516230 A JP2000516230 A JP 2000516230A
Authority
JP
Japan
Prior art keywords
acetyl
cis
alkyl
amino
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10509820A
Other languages
English (en)
Japanese (ja)
Inventor
ジン，フーチャン．
コンファローネ，パスクォーレ，ニコラス．
Original Assignee
デュポン ファーマシューティカルズ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デュポン ファーマシューティカルズ カンパニー filed Critical デュポン ファーマシューティカルズ カンパニー
Publication of JP2000516230A publication Critical patent/JP2000516230A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10509820A 1996-08-15 1997-08-13 Ｉｉｂ／ｉｉｉａ拮抗薬としての環状カルバメート類およびイソオキサゾリジン類 Pending JP2000516230A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2422596P 1996-08-15 1996-08-15
US60/024,225 1996-08-15
US70090696A 1996-08-21 1996-08-21
US08/700,906 1996-08-21
PCT/US1997/013761 WO1998006707A1 (fr) 1996-08-15 1997-08-13 Carbamates et isoxazolidines cycliques antagonistes de l'iib/iiia

Publications (1)

Publication Number Publication Date
JP2000516230A true JP2000516230A (ja) 2000-12-05

Family

ID=26698197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10509820A Pending JP2000516230A (ja) 1996-08-15 1997-08-13 Ｉｉｂ／ｉｉｉａ拮抗薬としての環状カルバメート類およびイソオキサゾリジン類

Country Status (5)

Country Link
EP (1) EP0922039A1 (fr)
JP (1) JP2000516230A (fr)
AU (1) AU3970697A (fr)
CA (1) CA2263311A1 (fr)
WO (1) WO1998006707A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000481A1 (fr) * 1998-06-29 2000-01-06 Du Pont Pharmaceuticals Company Isoxazolidines et carbamates cycliques utilises comme antagonistes de iib/iiia
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
WO2010149684A1 (fr) * 2009-06-24 2010-12-29 Boehringer Ingelheim International Gmbh Nouveaux composés, composition pharmaceutique et procédés correspondants

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW223629B (fr) * 1992-03-06 1994-05-11 Hoffmann La Roche
ATE198748T1 (de) * 1993-11-24 2001-02-15 Du Pont Pharm Co Isoxazoline und isoxazole derivate als fibrinogen rezeptor antagonisten
JPH09505589A (ja) * 1993-11-24 1997-06-03 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー フィブリノーゲン受容体アンタゴニストとして有用なイソオキサゾリン化合物
IL118007A0 (en) * 1995-05-24 1996-08-04 Du Pont Merck Pharma Isoxazoline compounds pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
EP0922039A1 (fr) 1999-06-16
CA2263311A1 (fr) 1998-02-19
WO1998006707A1 (fr) 1998-02-19
AU3970697A (en) 1998-03-06

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