JP2000516196A - 3,000〜14,000ダルトンの平均分子量を有するpvpからなる組成物 - Google Patents
3,000〜14,000ダルトンの平均分子量を有するpvpからなる組成物Info
- Publication number
- JP2000516196A JP2000516196A JP09524995A JP52499597A JP2000516196A JP 2000516196 A JP2000516196 A JP 2000516196A JP 09524995 A JP09524995 A JP 09524995A JP 52499597 A JP52499597 A JP 52499597A JP 2000516196 A JP2000516196 A JP 2000516196A
- Authority
- JP
- Japan
- Prior art keywords
- pvp
- solution
- composition
- molecular weight
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.3,000から14,000ダルトンの範囲の重量平均分子量を有する生理学的に不活 性なPVPの水溶液からなる医薬用組成物。 2.50,000ダルトンより大きい分子量を有するPVPを実質的に含まない請求項 1記載の組成物。 3.K-値が17より低い、好ましくは15から16の範囲である請求項1また は2に記載の組成物。 4.約10ppmより少ないアミンおよび/または約20ppmより少ない過酸化物を 含む請求項1〜3のいずれか1項に記載の組成物。 5.PVPの重量平均分子量が7,000から11,000ダルトンの範囲である請求項1 〜4のいずれか1項に記載の組成物。 6.PVPの濃度が4から10重量%の範囲である請求項1〜5のいずれか1項 に記載の組成物。 7.さらに有効濃度のタウロリジンおよび/またはタウルルタムを含む請求項1 〜6のいずれか1項に記載の組成物。 8.0.5から2.0重量%の範囲のタウロリジンおよび/または1から10重 量%の範囲のタウルルタムを含む請求項7記載の組成物。 9.注入液、血液希釈液または外科用リンス液として使用するための請求項1〜 8のいずれか1項に記載の組成物。 10.注入液、血液希釈液または外科用リンス液の製造における請求項1〜8のい ずれか1項に記載の組成物の使用。 11.請求項1〜8のいずれか1項に記載の組成物でヒトまたはヒトでない動物の 身体組織を灌流する該組織への注入または外科的すすぎの方法。 12.PVP溶液を陽イオン交換樹脂上に通過させ、場合により限外ろ過を 行う工程からなる請求項1に定義した生理学的に不活性なPVPの溶液の製造 方法。 13.陽イオン交換樹脂が強酸陽イオン交換体である請求項12記載の方法。 14.限外ろ過を100から500mmHgの範囲の圧力で行う請求項12または13に記載 の方法。 15.請求項12〜14のいずれか1項に記載の方法で得られるPVP溶液。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9600426.2A GB9600426D0 (en) | 1996-01-10 | 1996-01-10 | Compositions |
GB9600426.2 | 1996-01-10 | ||
PCT/GB1997/000069 WO1997025052A2 (en) | 1996-01-10 | 1997-01-09 | Compositions comprising pvp having an average molecular weight in the range of 3,000 to 14,000 daltons |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000516196A true JP2000516196A (ja) | 2000-12-05 |
JP4245192B2 JP4245192B2 (ja) | 2009-03-25 |
Family
ID=10786817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52499597A Expired - Lifetime JP4245192B2 (ja) | 1996-01-10 | 1997-01-09 | 3,000〜14,000ダルトンの平均分子量を有するpvpからなる組成物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6080397A (ja) |
EP (1) | EP0873130B1 (ja) |
JP (1) | JP4245192B2 (ja) |
DE (1) | DE69728376T2 (ja) |
ES (1) | ES2218652T3 (ja) |
GB (1) | GB9600426D0 (ja) |
WO (1) | WO1997025052A2 (ja) |
Cited By (7)
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JP2002363102A (ja) * | 2001-04-03 | 2002-12-18 | Ed Geistlich Soehne Ag Fuer Chemische Industrie | 新形成細胞の細胞消滅死を誘導する方法 |
JP2010059166A (ja) * | 2001-09-26 | 2010-03-18 | Ed Geistlich Soehne Ag Fuer Chemische Industrie | 安定性タウロリジン電解質溶液 |
US7892530B2 (en) | 1999-06-04 | 2011-02-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
US7910580B2 (en) | 1999-06-04 | 2011-03-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-Fluorouracil in treatment of tumor metastases and cancer |
US8030301B2 (en) | 1999-06-04 | 2011-10-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
US8202860B2 (en) | 1999-06-04 | 2012-06-19 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) |
US8304390B2 (en) | 1997-07-31 | 2012-11-06 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method of treatment for preventing or reducing tumor growth in the liver of patient |
Families Citing this family (44)
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US20050124608A1 (en) * | 2001-04-03 | 2005-06-09 | Redmond H. P. | Treatment of cancers |
US20060199811A1 (en) * | 1997-07-31 | 2006-09-07 | Pfirrmann Rolf W | Method of treatment for preventing or reducing tumor growth in the liver of patient |
US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
US20050096314A1 (en) * | 2001-04-03 | 2005-05-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
JP2003515558A (ja) | 1999-12-06 | 2003-05-07 | ロード アイランド ホスピタル, ア ライフスパン パートナー | 腫瘍を治療するためのメチロール含有化合物の使用 |
CN100519525C (zh) * | 1999-12-06 | 2009-07-29 | 葛兰素集团有限公司 | 芳香砜类及其医疗用途 |
US6500408B2 (en) | 2001-01-27 | 2002-12-31 | Jc Technologies, Inc. | Enamel-safe tooth bleach and method for use |
US20080171738A1 (en) * | 2001-04-03 | 2008-07-17 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of Breast Cancer |
JP5280603B2 (ja) | 2001-10-01 | 2013-09-04 | ガイストリッヒ ファーマ アーゲー | 転移阻害のための方法 |
US6964571B2 (en) * | 2003-01-24 | 2005-11-15 | Ultradent Products, Inc. | Pre-shaped dental trays and treatment devices and methods that utilize such dental trays |
US7004756B2 (en) * | 2003-01-24 | 2006-02-28 | Ultradent Products, Inc. | Pre-shaped dental trays and treatment devices and methods that utilize such dental trays |
JP5346148B2 (ja) * | 2003-03-28 | 2013-11-20 | エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー | 抗新生物性組成物および治療方法 |
US7011523B2 (en) * | 2003-10-22 | 2006-03-14 | Ultradent Products, Inc. | Bleaching compositions and devices having a solid adhesive layer and bleaching gel adjacent thereto |
US7074042B2 (en) * | 2003-05-27 | 2006-07-11 | Ultradent Products, Inc. | Tray-like dental bleaching devices having a barrier layer and a substantially solid bleaching composition |
US6860736B2 (en) * | 2003-05-23 | 2005-03-01 | Ultradent Products, Inc. | Oral treatment devices that include a thin, flexible barrier layer and an endoskeleton treatment or adhesive composition |
US7040897B2 (en) * | 2003-05-23 | 2006-05-09 | Ultradent Products, Inc. | Thin, flexible membrane dental trays and systems and methods utilizing such trays |
US7059857B2 (en) * | 2003-05-27 | 2006-06-13 | Ultradent Products, Inc. | Substantially solid desensitizing compositions and devices having a tray-like configuration and methods of manufacturing and using such compositions and devices |
US7056118B2 (en) * | 2003-05-27 | 2006-06-06 | Ultradent Products, Inc. | Compositions and devices having a tray-like configuration for delivering a medicament and methods of manufacturing and using such compositions and devices |
US7048543B2 (en) | 2003-05-27 | 2006-05-23 | Ultradent Products, Inc. | Substantially solid bleaching composition in a tray-like configuration |
US7052275B2 (en) | 2003-05-27 | 2006-05-30 | Ultradent Products, Inc. | Kits and methods for bleaching and desensitizing teeth |
US6981874B2 (en) * | 2003-10-22 | 2006-01-03 | Ultradent Products, Inc. | Dental bleaching compositions and devices having a solid activation adhesive layer or region and bleaching gel layer or region |
US6997708B2 (en) * | 2003-10-22 | 2006-02-14 | Ultradent Products, Inc. | Treatment compositions and strips having a solid adhesive layer and treatment gel adjacent thereto |
US7059858B2 (en) * | 2004-02-19 | 2006-06-13 | Ultradent Products, Inc. | Universal tray design having anatomical features to enhance fit |
US7192280B2 (en) * | 2004-02-19 | 2007-03-20 | Ultradent Products, Inc. | Dental bleaching devices having a protective adhesive region |
US7264471B2 (en) | 2004-05-05 | 2007-09-04 | Ultradent Products, Inc. | Methods and kits for bleaching teeth while protecting adjacent gingival tissue |
US7625210B2 (en) * | 2004-08-09 | 2009-12-01 | Ultradent Products, Inc. | Treatment devices for providing oral treatments and kits and methods that utilize such treatment devices |
US7696182B2 (en) | 2004-11-02 | 2010-04-13 | Nd Partners, Llc | Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin |
US20060171905A1 (en) * | 2005-01-31 | 2006-08-03 | Allred Peter M | Dental bleaching compositions having a protective coating applied thereto |
DE102005005974A1 (de) | 2005-02-09 | 2006-08-10 | Basf Ag | Verfahren zur Stabilisierung von Polyvinylpyrrolidonen |
US7452209B2 (en) | 2005-05-02 | 2008-11-18 | Ultradent Products, Inc. | Exoskeleton support for placement of a dental treatment strip |
US8007277B2 (en) | 2006-08-25 | 2011-08-30 | Ultradent Products, Inc. | Non-custom dental treatment trays and mouth guards having improved anatomical features |
US8202091B2 (en) * | 2007-08-31 | 2012-06-19 | Ultradent Products, Inc. | Dental treatment trays comprising silicone elastomeric material |
US20100028829A1 (en) * | 2008-07-31 | 2010-02-04 | Ultradent Products, Inc. | Chemically activated dental bleaching trays |
DE202009000692U1 (de) | 2008-11-04 | 2009-04-16 | Basf Se | Verpackungsform |
US9982074B2 (en) | 2008-04-11 | 2018-05-29 | Basf Se | Use of composite films as a packaging material for oxidation-sensitive polymers, method for packaging oxidation-sensitive polymers, and packaging containing said composite films |
US8623978B2 (en) | 2010-11-23 | 2014-01-07 | Basf Se | Process for the preparation of low-peroxide crosslinked vinyllactam polymer |
DE202011005055U1 (de) | 2011-04-12 | 2011-09-12 | Basf Se | Peroxidarmes Polymer enthaltend Phosphorverbindung |
CN103459480B (zh) | 2011-04-12 | 2017-02-22 | 巴斯夫欧洲公司 | 包含至少一种无机磷化合物的氧化敏感性低过氧化物聚合物 |
US9023931B2 (en) | 2011-04-12 | 2015-05-05 | Basf Se | Oxidation-sensitive, low-peroxide polymer comprising at least one inorganic phosphorus compound |
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US9260546B2 (en) | 2012-08-08 | 2016-02-16 | Basf Se | Producing aqueous solutions of vinyllactam polymers and powders thereof |
JP6246809B2 (ja) | 2012-08-08 | 2017-12-13 | ビーエイエスエフ・ソシエタス・エウロパエアBasf Se | ビニルラクタムポリマーの水溶液およびその粉末の製造 |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4350156A (en) * | 1980-05-29 | 1982-09-21 | Japan Foundation For Artificial Organs | Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid |
GB8328111D0 (en) * | 1983-10-20 | 1983-11-23 | Geistlich Soehne Ag | Chemical compounds |
GB8328074D0 (en) * | 1983-10-20 | 1983-11-23 | Geistlich Soehne Ag | Chemical compositions |
GB8426922D0 (en) * | 1984-10-24 | 1984-11-28 | Sandoz Ltd | Galenic formulation |
-
1996
- 1996-01-10 GB GBGB9600426.2A patent/GB9600426D0/en active Pending
-
1997
- 1997-01-09 JP JP52499597A patent/JP4245192B2/ja not_active Expired - Lifetime
- 1997-01-09 WO PCT/GB1997/000069 patent/WO1997025052A2/en active IP Right Grant
- 1997-01-09 US US09/091,228 patent/US6080397A/en not_active Expired - Lifetime
- 1997-01-09 ES ES97900318T patent/ES2218652T3/es not_active Expired - Lifetime
- 1997-01-09 DE DE69728376T patent/DE69728376T2/de not_active Expired - Lifetime
- 1997-01-09 EP EP97900318A patent/EP0873130B1/en not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8304390B2 (en) | 1997-07-31 | 2012-11-06 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method of treatment for preventing or reducing tumor growth in the liver of patient |
US7892530B2 (en) | 1999-06-04 | 2011-02-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
US7910580B2 (en) | 1999-06-04 | 2011-03-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-Fluorouracil in treatment of tumor metastases and cancer |
US8030301B2 (en) | 1999-06-04 | 2011-10-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
US8202860B2 (en) | 1999-06-04 | 2012-06-19 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) |
US9012444B2 (en) | 1999-06-04 | 2015-04-21 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
JP2002363102A (ja) * | 2001-04-03 | 2002-12-18 | Ed Geistlich Soehne Ag Fuer Chemische Industrie | 新形成細胞の細胞消滅死を誘導する方法 |
JP2010059166A (ja) * | 2001-09-26 | 2010-03-18 | Ed Geistlich Soehne Ag Fuer Chemische Industrie | 安定性タウロリジン電解質溶液 |
Also Published As
Publication number | Publication date |
---|---|
WO1997025052A2 (en) | 1997-07-17 |
DE69728376T2 (de) | 2005-02-24 |
DE69728376D1 (de) | 2004-05-06 |
ES2218652T3 (es) | 2004-11-16 |
WO1997025052A3 (en) | 1997-12-18 |
GB9600426D0 (en) | 1996-03-13 |
EP0873130A2 (en) | 1998-10-28 |
EP0873130B1 (en) | 2004-03-31 |
JP4245192B2 (ja) | 2009-03-25 |
US6080397A (en) | 2000-06-27 |
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