JP2000515640A - 移動度を基礎とし、且つそれにより標準化されたキャピラリー電気泳動 - Google Patents
移動度を基礎とし、且つそれにより標準化されたキャピラリー電気泳動Info
- Publication number
- JP2000515640A JP2000515640A JP11500731A JP50073199A JP2000515640A JP 2000515640 A JP2000515640 A JP 2000515640A JP 11500731 A JP11500731 A JP 11500731A JP 50073199 A JP50073199 A JP 50073199A JP 2000515640 A JP2000515640 A JP 2000515640A
- Authority
- JP
- Japan
- Prior art keywords
- sample
- mobility
- marker
- zero
- charged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
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- OZXIZRZFGJZWBF-UHFFFAOYSA-N 1,3,5-trimethyl-2-(2,4,6-trimethylphenoxy)benzene Chemical compound CC1=CC(C)=CC(C)=C1OC1=C(C)C=C(C)C=C1C OZXIZRZFGJZWBF-UHFFFAOYSA-N 0.000 description 2
- LULAYUGMBFYYEX-UHFFFAOYSA-N 3-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
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- 235000010233 benzoic acid Nutrition 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000001917 fluorescence detection Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 2
- SHOJXDKTYKFBRD-UHFFFAOYSA-N mesityl oxide Natural products CC(C)=CC(C)=O SHOJXDKTYKFBRD-UHFFFAOYSA-N 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000001121 post-column derivatisation Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IKCLCGXPQILATA-UHFFFAOYSA-N 2-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1Cl IKCLCGXPQILATA-UHFFFAOYSA-N 0.000 description 1
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- XRHGYUZYPHTUJZ-UHFFFAOYSA-N 4-chlorobenzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1 XRHGYUZYPHTUJZ-UHFFFAOYSA-N 0.000 description 1
- LATIUAUOIHKLQY-UHFFFAOYSA-N ClC1=C(C2=C3C(=CC=C2C=C1)C=CC=C3)C(=O)O Chemical compound ClC1=C(C2=C3C(=CC=C2C=C1)C=CC=C3)C(=O)O LATIUAUOIHKLQY-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- -1 N-acetyl methyl ester Chemical class 0.000 description 1
- HHZVGTSZLAQRSM-UHFFFAOYSA-N Phenanthrene-4-carboxylate Chemical compound C1=CC=CC2=C3C(C(=O)O)=CC=CC3=CC=C21 HHZVGTSZLAQRSM-UHFFFAOYSA-N 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
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- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000001818 capillary gel electrophoresis Methods 0.000 description 1
- 238000000533 capillary isoelectric focusing Methods 0.000 description 1
- 238000001649 capillary isotachophoresis Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
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- 230000031700 light absorption Effects 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 238000000504 luminescence detection Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- 238000001012 micellar electrokinetic chromatography Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/866,282 | 1997-05-30 | ||
| US08/866,282 US5932080A (en) | 1997-05-30 | 1997-05-30 | Mobility-based and normalized capillary electrophoresis |
| PCT/US1998/009930 WO1998054567A1 (en) | 1997-05-30 | 1998-05-14 | Mobility-based and normalized capillary electrophoresis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000515640A true JP2000515640A (ja) | 2000-11-21 |
| JP2000515640A5 JP2000515640A5 (https=) | 2005-12-08 |
Family
ID=25347287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11500731A Ceased JP2000515640A (ja) | 1997-05-30 | 1998-05-14 | 移動度を基礎とし、且つそれにより標準化されたキャピラリー電気泳動 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5932080A (https=) |
| EP (1) | EP0916088A1 (https=) |
| JP (1) | JP2000515640A (https=) |
| AU (1) | AU7388098A (https=) |
| WO (1) | WO1998054567A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7713703B1 (en) | 2000-11-13 | 2010-05-11 | Biosite, Inc. | Methods for monitoring the status of assays and immunoassays |
| US6194222B1 (en) * | 1998-01-05 | 2001-02-27 | Biosite Diagnostics, Inc. | Methods for monitoring the status of assays and immunoassays |
| US6156179A (en) * | 1998-07-09 | 2000-12-05 | Bio-Rad Laboratories | Computer directed identification of paraproteins |
| US20020167665A1 (en) * | 2000-05-19 | 2002-11-14 | Yeung Edward S. | High-throughput methods of distinguishing at least one molecule individually in a sample comprising multiple molecules and systems for use therein |
| JP3709123B2 (ja) * | 2000-06-20 | 2005-10-19 | 独立行政法人科学技術振興機構 | 電気泳動分析方法 |
| US20050059017A1 (en) * | 2003-09-11 | 2005-03-17 | Oldham Mark F. | System and method for extending dynamic range of a detector |
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7846676B2 (en) | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US8945361B2 (en) * | 2005-09-20 | 2015-02-03 | ProteinSimple | Electrophoresis standards, methods and kits |
| EP2049233A4 (en) | 2006-07-10 | 2011-08-31 | Convergent Bioscience Ltd | METHOD AND DEVICE FOR PRECISELY SELECTION AND EXTRACTION OF A FOCUSED COMPONENT IN ISOLELECTRIC FOCUSING PERFORMED IN MICRO CHANNELS |
| US8306939B2 (en) * | 2007-03-12 | 2012-11-06 | Kochi University | Examination value predicting device using electrophoresis waveform, prediction method, and predicting program |
| US8247235B2 (en) | 2007-06-08 | 2012-08-21 | Quest Diagnostics Investments Incorporated | Lipoprotein analysis by differential charged-particle mobility |
| US10107782B2 (en) * | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
| US9354200B1 (en) | 2008-08-07 | 2016-05-31 | Quest Diagnostics Investments Incorporated | Detection apparatus for differential-charged particle mobility analyzer |
| US9250211B2 (en) | 2010-12-30 | 2016-02-02 | Quest Diagnostics Investments Incorporated | Magnetic separation of lipoproteins using dextran sulfate |
| US9804079B2 (en) | 2012-04-19 | 2017-10-31 | ProteinSimple | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
| US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
| CN110954587B (zh) * | 2019-12-11 | 2020-11-20 | 中国科学院化学研究所 | 一种基于迁移电荷密度的高重现毛细管电泳方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3941678A (en) * | 1974-02-28 | 1976-03-02 | Shimadzu Seisakusho Ltd. | Apparatus for electrophoretic analysis |
| US4920498A (en) * | 1985-08-17 | 1990-04-24 | Olympus Optical Co., Ltd. | Method of processing and analyzing electrophoretic image, and method of displaying electrophoregram and a medium for recording electrophoregram |
| US5139630A (en) * | 1991-05-31 | 1992-08-18 | Beckman Instruments, Inc. | Identification of sample constituents utilizing capillary electrophoresis |
| US5310462A (en) * | 1991-05-31 | 1994-05-10 | Beckman Instruments, Inc. | Quantitation of samples utilizing capillary electrophoresis |
| US5316630A (en) * | 1993-03-30 | 1994-05-31 | Dionex Corporation | Methods for chromatography analysis |
| ATE429490T1 (de) * | 1995-05-05 | 2009-05-15 | Novozymes As | Protease-varianten und verbindungen |
-
1997
- 1997-05-30 US US08/866,282 patent/US5932080A/en not_active Expired - Lifetime
-
1998
- 1998-05-14 JP JP11500731A patent/JP2000515640A/ja not_active Ceased
- 1998-05-14 AU AU73880/98A patent/AU7388098A/en not_active Abandoned
- 1998-05-14 EP EP98921218A patent/EP0916088A1/en not_active Withdrawn
- 1998-05-14 WO PCT/US1998/009930 patent/WO1998054567A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998054567A1 (en) | 1998-12-03 |
| EP0916088A1 (en) | 1999-05-19 |
| US5932080A (en) | 1999-08-03 |
| AU7388098A (en) | 1998-12-30 |
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Legal Events
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