|
EP0850221B1
(en)
*
|
1995-08-30 |
2001-07-18 |
G.D. Searle & Co. |
Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
|
|
US6245809B1
(en)
|
1996-12-09 |
2001-06-12 |
Cor Therapeutics Inc. |
Integrin antagonists
|
|
DE69720062D1
(de)
*
|
1996-12-09 |
2003-04-24 |
Lilly Co Eli |
Integrin antagonisten
|
|
AU8063098A
(en)
*
|
1997-06-10 |
1998-12-30 |
Eli Lilly And Company |
Combinatorial process for preparing substituted phenylalanine libraries
|
|
AU739511B2
(en)
*
|
1997-08-22 |
2001-10-11 |
F. Hoffmann-La Roche Ag |
N-aroylphenylalanine derivatives
|
|
US6455550B1
(en)
|
1997-08-22 |
2002-09-24 |
Hoffmann-La Roche Inc. |
N-alkanoylphenylalanine derivatives
|
|
SI1005445T1
(en)
*
|
1997-08-22 |
2004-12-31 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
|
US6229011B1
(en)
|
1997-08-22 |
2001-05-08 |
Hoffman-La Roche Inc. |
N-aroylphenylalanine derivative VCAM-1 inhibitors
|
|
EP1009758B1
(en)
*
|
1997-08-29 |
2005-06-01 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
|
US6740682B2
(en)
|
1997-08-29 |
2004-05-25 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
|
WO1999023063A1
(en)
|
1997-10-31 |
1999-05-14 |
Aventis Pharma Limited |
Substituted anilides
|
|
IL136584A
(en)
*
|
1997-12-23 |
2005-03-20 |
Aventis Pharma Ltd |
SUBSTITUTED beta-ALANINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USES THEREOF
|
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
|
DE69919334T2
(de)
*
|
1998-02-26 |
2005-08-04 |
Celltech Therapeutics Ltd., Slough |
Phenylalaninderivate als inhibitoren von alpha4 integrinen
|
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6521626B1
(en)
*
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
|
NZ507222A
(en)
|
1998-04-09 |
2003-05-30 |
Meiji Seika Kaisha |
Aminopiperidine derivatives useful as integrin antagonists
|
|
GB9811159D0
(en)
|
1998-05-22 |
1998-07-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9811969D0
(en)
|
1998-06-03 |
1998-07-29 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9812088D0
(en)
|
1998-06-05 |
1998-08-05 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6352977B1
(en)
|
1998-07-13 |
2002-03-05 |
Aventis Pharma Limited |
Substituted β-alanines
|
|
GB9821061D0
(en)
*
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9821222D0
(en)
|
1998-09-30 |
1998-11-25 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9826174D0
(en)
|
1998-11-30 |
1999-01-20 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
SK8432001A3
(en)
*
|
1998-12-16 |
2001-12-03 |
Bayer Ag |
New biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
US6677360B2
(en)
|
1998-12-16 |
2004-01-13 |
Bayer Aktiengesellschaft |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
JP2002533422A
(ja)
|
1998-12-23 |
2002-10-08 |
ジー・ディー・サール・アンド・カンパニー |
新形成の治療における併用療法としてシクロオキシゲナーゼ−２阻害剤とインテグリン拮抗剤を使用する方法
|
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6291503B1
(en)
|
1999-01-15 |
2001-09-18 |
Bayer Aktiengesellschaft |
β-phenylalanine derivatives as integrin antagonists
|
|
US6344484B1
(en)
|
1999-02-12 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Tyrosine alkoxyguanidines as integrin inhibitors
|
|
DK1154993T3
(da)
|
1999-02-18 |
2005-02-14 |
Hoffmann La Roche |
Thioamid-derivater
|
|
DE60010049T2
(de)
*
|
1999-02-18 |
2005-03-31 |
F. Hoffmann-La Roche Ag |
Phenylalaninolderivate
|
|
FR2792314B1
(fr)
*
|
1999-04-15 |
2001-06-01 |
Adir |
Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
|
EP1209152A4
(en)
|
1999-08-05 |
2003-03-12 |
Meiji Seika Kaisha |
OMEGA-AMINO-ALPHA-HYDROXY-CARBONIC ACID DERIVATIVES WITH AN INTEGRIN ALPHA V BETA ANTAGONISM
|
|
DE60021521T4
(de)
|
1999-09-29 |
2006-09-21 |
Ortho-Mcneil Pharmaceutical, Inc. |
Isonipecotamide zur behandlung von integrin vermittelten störungen
|
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
|
AU7961200A
(en)
*
|
1999-10-29 |
2001-05-14 |
Kaken Pharmaceutical Co., Ltd. |
Urea derivative, process for producing the same, and medicine containing the urea derivative
|
|
EP1238971A4
(en)
*
|
1999-12-16 |
2003-02-26 |
Sumitomo Pharma |
SUBSTITUTED GUANIDINE DERIVATIVES
|
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
|
EP1250935A1
(en)
*
|
2000-01-25 |
2002-10-23 |
Meiji Seika Kaisha Ltd. |
REMEDIES FOR REPERFUSION INJURY CONTAINING INTEGRIN ALPHAvBETA3 ANTAGONIST
|
|
WO2001056607A1
(en)
|
2000-02-03 |
2001-08-09 |
Eisai Co., Ltd. |
Integrin expression inhibitors
|
|
WO2001079173A2
(en)
*
|
2000-04-17 |
2001-10-25 |
Celltech R & D Limited |
Enamine derivatives as cell adhesion molecules
|
|
GB0011817D0
(en)
*
|
2000-05-16 |
2000-07-05 |
Pharmacia & Upjohn Spa |
Antagonists of integrin receptors
|
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
|
DE10032256C2
(de)
*
|
2000-07-03 |
2003-06-05 |
Infineon Technologies Ag |
Chip-ID-Register-Anordnung
|
|
EP1301488A1
(en)
|
2000-07-07 |
2003-04-16 |
Celltech R&D Limited |
Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
|
|
US7015216B2
(en)
|
2000-07-21 |
2006-03-21 |
Elan Pharmaceuticals, Inc. |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
|
|
JP2004505038A
(ja)
*
|
2000-08-02 |
2004-02-19 |
スミスクライン・ビーチャム・コーポレイション |
脂肪酸シンターゼ阻害剤
|
|
JP2004505110A
(ja)
|
2000-08-02 |
2004-02-19 |
セルテック アール アンド ディ リミテッド |
３位置換イソキノリン−１−イル誘導体
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
US7163681B2
(en)
|
2000-08-07 |
2007-01-16 |
Centocor, Inc. |
Anti-integrin antibodies, compositions, methods and uses
|
|
US6486174B2
(en)
|
2000-08-07 |
2002-11-26 |
3-Dimensional Pharmaceuticals, Inc. |
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
|
|
AU2001277720A1
(en)
*
|
2000-08-09 |
2002-02-25 |
Kaken Pharmaceutical Co., Ltd. |
(thio)urea derivatives, process for their production and medicines containing the derivatives
|
|
DZ3415A1
(fr)
|
2000-08-31 |
2002-03-07 |
Chiron Corp |
Guanidinobenzamides comme mc4-r agonistes.
|
|
MXPA03006772A
(es)
|
2001-01-29 |
2004-10-15 |
Dimensional Pharm Inc |
Indoles sustituidos y su uso como antogonistas de integrina.
|
|
ITTO20010110A1
(it)
*
|
2001-02-08 |
2002-08-08 |
Rotta Research Lab |
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
|
|
ES2278016T3
(es)
*
|
2001-04-09 |
2007-08-01 |
Novartis Vaccines And Diagnostics, Inc. |
Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
|
|
JP2004529918A
(ja)
|
2001-04-09 |
2004-09-30 |
オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド |
インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物
|
|
US6872730B2
(en)
|
2001-04-27 |
2005-03-29 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
|
|
KR20040058229A
(ko)
|
2001-10-22 |
2004-07-03 |
더 스크립스 리서치 인스티튜트 |
항체 표적화 화합물
|
|
US20050124652A1
(en)
*
|
2002-02-04 |
2005-06-09 |
Rustum Boyce |
Guanidino compounds
|
|
US20030207814A1
(en)
*
|
2002-02-04 |
2003-11-06 |
Chiron Corporation |
Novel guanidinyl derivatives
|
|
US20030195187A1
(en)
*
|
2002-02-04 |
2003-10-16 |
Chiron Corporation |
Guanidino compounds
|
|
US20070004743A1
(en)
*
|
2002-02-25 |
2007-01-04 |
Xiao Linda L |
Intranasal administration of mc4-r agonists
|
|
US7858631B2
(en)
*
|
2002-05-23 |
2010-12-28 |
Novartis Vaccines And Diagnostics, Inc. |
Substituted pyrido [2,3-d] pyrimidinone compounds
|
|
AU2004249120B2
(en)
*
|
2003-05-23 |
2008-07-24 |
Glaxosmithkline |
Guanidino-substituted quinazolinone compounds as MC4-R agonists
|
|
PL1635824T3
(pl)
*
|
2003-06-03 |
2010-01-29 |
Novartis Ag |
5-Członowe heterocykliczne inhibitory P-38
|
|
AU2004293012A1
(en)
*
|
2003-11-19 |
2005-06-09 |
Rustum S. Boyce |
Quinazolinone compounds with reduced bioaccumulation
|
|
JP2009512443A
(ja)
*
|
2005-10-20 |
2009-03-26 |
ザ スクリップス リサーチ インスチチュート |
免疫染色及び免疫標的化のためのＦｃ標識化
|
|
WO2007147763A1
(en)
|
2006-06-20 |
2007-12-27 |
F. Hoffmann-La Roche Ag |
Arylsulfonyl naphthalene derivatives and uses thereof
|
|
WO2010093706A2
(en)
|
2009-02-10 |
2010-08-19 |
The Scripps Research Institute |
Chemically programmed vaccination
|
|
US20140010783A1
(en)
*
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
|
CA2878469A1
(en)
|
2012-07-18 |
2014-01-23 |
Saint Louis University |
Beta amino acid derivatives as integrin antagonists
|
|
CN108779077A
(zh)
|
2015-12-30 |
2018-11-09 |
圣路易斯大学 |
作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
|
|
CN107652210B
(zh)
*
|
2017-09-30 |
2021-01-01 |
瑞阳（上海）新药研发有限公司 |
一种胍类化合物或其药学上可接受的盐、其制备方法和应用
|