|
IL123164A
(en)
*
|
1995-08-30 |
2001-03-19 |
Searle & Co |
Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
|
|
US6245809B1
(en)
|
1996-12-09 |
2001-06-12 |
Cor Therapeutics Inc. |
Integrin antagonists
|
|
WO1998025892A1
(en)
*
|
1996-12-09 |
1998-06-18 |
Eli Lilly And Company |
Integrin antagonists
|
|
AU8063098A
(en)
*
|
1997-06-10 |
1998-12-30 |
Eli Lilly And Company |
Combinatorial process for preparing substituted phenylalanine libraries
|
|
SI1005445T1
(en)
*
|
1997-08-22 |
2004-12-31 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
|
EP1005445B1
(en)
*
|
1997-08-22 |
2004-05-26 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
|
US6455550B1
(en)
|
1997-08-22 |
2002-09-24 |
Hoffmann-La Roche Inc. |
N-alkanoylphenylalanine derivatives
|
|
US6229011B1
(en)
|
1997-08-22 |
2001-05-08 |
Hoffman-La Roche Inc. |
N-aroylphenylalanine derivative VCAM-1 inhibitors
|
|
US6740682B2
(en)
|
1997-08-29 |
2004-05-25 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
|
US6262069B1
(en)
*
|
1997-08-29 |
2001-07-17 |
Protherics Molecular Design Limited |
1-amino-7-isoquinoline derivatives as serine protease inhibitors
|
|
PT1027328E
(pt)
|
1997-10-31 |
2006-11-30 |
Aventis Pharma Ltd |
Anilidas substituídas
|
|
IL136584A
(en)
*
|
1997-12-23 |
2005-03-20 |
Aventis Pharma Ltd |
SUBSTITUTED beta-ALANINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USES THEREOF
|
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
|
DE69919334T2
(de)
*
|
1998-02-26 |
2005-08-04 |
Celltech Therapeutics Ltd., Slough |
Phenylalaninderivate als inhibitoren von alpha4 integrinen
|
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6521626B1
(en)
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
|
CN1140511C
(zh)
|
1998-04-09 |
2004-03-03 |
明治制果株式会社 |
作为整合素αvβ3拮抗剂的氨基哌啶衍生物
|
|
GB9811159D0
(en)
|
1998-05-22 |
1998-07-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9811969D0
(en)
|
1998-06-03 |
1998-07-29 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9812088D0
(en)
|
1998-06-05 |
1998-08-05 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6352977B1
(en)
|
1998-07-13 |
2002-03-05 |
Aventis Pharma Limited |
Substituted β-alanines
|
|
GB9821061D0
(en)
*
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9821222D0
(en)
|
1998-09-30 |
1998-11-25 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9826174D0
(en)
*
|
1998-11-30 |
1999-01-20 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DE69927050T2
(de)
*
|
1998-12-16 |
2006-06-29 |
Bayer Healthcare Ag |
Biphenylverbindungen und biphenyl-analoge als intergrin-antagonisten
|
|
US6677360B2
(en)
|
1998-12-16 |
2004-01-13 |
Bayer Aktiengesellschaft |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
AU2592600A
(en)
|
1998-12-23 |
2000-07-31 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6291503B1
(en)
|
1999-01-15 |
2001-09-18 |
Bayer Aktiengesellschaft |
β-phenylalanine derivatives as integrin antagonists
|
|
US6344484B1
(en)
|
1999-02-12 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Tyrosine alkoxyguanidines as integrin inhibitors
|
|
ES2218116T3
(es)
|
1999-02-18 |
2004-11-16 |
F. Hoffmann-La Roche Ag |
Derivados de fenilalaninol.
|
|
KR100649819B1
(ko)
|
1999-02-18 |
2007-02-28 |
에프. 호프만-라 로슈 아게 |
티오아미드 유도체
|
|
FR2792314B1
(fr)
*
|
1999-04-15 |
2001-06-01 |
Adir |
Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
|
WO2001010844A1
(fr)
|
1999-08-05 |
2001-02-15 |
Meiji Seika Kaisha, Ltd. |
DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
|
|
CZ20011872A3
(cs)
|
1999-09-29 |
2002-03-13 |
Ortho-Mcneil Pharmaceutical, Inc. |
Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny
|
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
|
AU7961200A
(en)
*
|
1999-10-29 |
2001-05-14 |
Kaken Pharmaceutical Co., Ltd. |
Urea derivative, process for producing the same, and medicine containing the urea derivative
|
|
WO2001044186A1
(en)
*
|
1999-12-16 |
2001-06-21 |
Sumitomo Pharmaceuticals Company, Limited |
Substituted guanidine derivatives
|
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
|
US20030040531A1
(en)
*
|
2000-01-25 |
2003-02-27 |
Kazuyuki Fujishima |
Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist
|
|
MXPA02007249A
(es)
|
2000-02-03 |
2002-12-09 |
Eisai Co Ltd |
Inhibidor de la expresion de integrina.
|
|
DE60130910T2
(de)
*
|
2000-04-17 |
2008-07-10 |
Ucb Pharma, S.A. |
Enamin-derivate als zell-adhäsionsmoleküle
|
|
GB0011817D0
(en)
|
2000-05-16 |
2000-07-05 |
Pharmacia & Upjohn Spa |
Antagonists of integrin receptors
|
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
|
DE10032256C2
(de)
*
|
2000-07-03 |
2003-06-05 |
Infineon Technologies Ag |
Chip-ID-Register-Anordnung
|
|
US6740654B2
(en)
|
2000-07-07 |
2004-05-25 |
Celltech R & D Limited |
Squaric acid derivatives
|
|
US7015216B2
(en)
|
2000-07-21 |
2006-03-21 |
Elan Pharmaceuticals, Inc. |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
|
|
AU2001275724A1
(en)
|
2000-08-02 |
2002-02-13 |
Celltech R&D Limited |
3-substituted isoquinolin-1-yl derivatives
|
|
JP2004505038A
(ja)
*
|
2000-08-02 |
2004-02-19 |
スミスクライン・ビーチャム・コーポレイション |
脂肪酸シンターゼ阻害剤
|
|
US7163681B2
(en)
|
2000-08-07 |
2007-01-16 |
Centocor, Inc. |
Anti-integrin antibodies, compositions, methods and uses
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
US6486174B2
(en)
|
2000-08-07 |
2002-11-26 |
3-Dimensional Pharmaceuticals, Inc. |
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
|
|
AU2001277720A1
(en)
*
|
2000-08-09 |
2002-02-25 |
Kaken Pharmaceutical Co., Ltd. |
(thio)urea derivatives, process for their production and medicines containing the derivatives
|
|
DZ3415A1
(fr)
|
2000-08-31 |
2002-03-07 |
Chiron Corp |
Guanidinobenzamides comme mc4-r agonistes.
|
|
CA2436130A1
(en)
|
2001-01-29 |
2002-08-08 |
Ortho-Mcneil Pharmaceutical, Inc. |
Substituted indoles and their use as integrin antagonists
|
|
ITTO20010110A1
(it)
*
|
2001-02-08 |
2002-08-08 |
Rotta Research Lab |
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
|
|
EP1389205B1
(en)
|
2001-04-09 |
2005-12-21 |
Ortho-McNeil Pharmaceutical Research Inc. |
Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
|
|
ES2278016T3
(es)
|
2001-04-09 |
2007-08-01 |
Novartis Vaccines And Diagnostics, Inc. |
Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
|
|
US6872730B2
(en)
|
2001-04-27 |
2005-03-29 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
|
|
EP1443963B1
(en)
|
2001-10-22 |
2014-05-21 |
The Scripps Research Institute |
Antibody targeting compounds
|
|
US20050124652A1
(en)
*
|
2002-02-04 |
2005-06-09 |
Rustum Boyce |
Guanidino compounds
|
|
US20030207814A1
(en)
*
|
2002-02-04 |
2003-11-06 |
Chiron Corporation |
Novel guanidinyl derivatives
|
|
US20030195187A1
(en)
*
|
2002-02-04 |
2003-10-16 |
Chiron Corporation |
Guanidino compounds
|
|
US20070004743A1
(en)
*
|
2002-02-25 |
2007-01-04 |
Xiao Linda L |
Intranasal administration of mc4-r agonists
|
|
PT1551834E
(pt)
*
|
2002-05-23 |
2010-09-30 |
Novartis Vaccines & Diagnostic |
Compostos de quinazolinona substituídos
|
|
CA2523015A1
(en)
*
|
2003-05-23 |
2004-12-29 |
Chiron Corporation |
Guanidino-substituted quinazolinone compounds as mc4-r agonists
|
|
US7652044B2
(en)
*
|
2003-06-03 |
2010-01-26 |
Novartis A.G. |
P-38 inhibitors
|
|
MXPA06005736A
(es)
*
|
2003-11-19 |
2006-12-14 |
Chiron Corp |
Compuestos de quinazolinona con bioacumulacion reducida.
|
|
US20070122408A1
(en)
*
|
2005-10-20 |
2007-05-31 |
The Scripps Research Institute |
Fc Labeling for Immunostaining and Immunotargeting
|
|
MX2008015511A
(es)
|
2006-06-20 |
2008-12-18 |
Hoffmann La Roche |
Derivados de arilsulfonilnaftaleno y usos de los mismos.
|
|
JP2012517447A
(ja)
|
2009-02-10 |
2012-08-02 |
ザ スクリプス リサーチ インスティチュート |
化学的にプログラムされたワクチン接種法
|
|
US20140010783A1
(en)
*
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
|
WO2014015054A1
(en)
|
2012-07-18 |
2014-01-23 |
Saint Louis University |
Beta amino acid derivatives as integrin antagonists
|
|
SG11201805387RA
(en)
|
2015-12-30 |
2018-07-30 |
Univ Saint Louis |
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
|
|
CN107652210B
(zh)
*
|
2017-09-30 |
2021-01-01 |
瑞阳（上海）新药研发有限公司 |
一种胍类化合物或其药学上可接受的盐、其制备方法和应用
|