|
PL186370B1
(pl)
*
|
1995-08-30 |
2003-12-31 |
Searle & Co |
Związki, pochodne kwasu aminobenzoesowego, zawierające je kompozycje farmaceutyczne oraz zastosowanie tych związków
|
|
EP0963370B1
(en)
*
|
1996-12-09 |
2003-03-19 |
Eli Lilly And Company |
Integrin antagonists
|
|
US6245809B1
(en)
|
1996-12-09 |
2001-06-12 |
Cor Therapeutics Inc. |
Integrin antagonists
|
|
WO1998057173A1
(en)
*
|
1997-06-10 |
1998-12-17 |
Eli Lilly And Company |
Combinatorial process for preparing substituted phenylalanine libraries
|
|
NZ502813A
(en)
*
|
1997-08-22 |
2002-10-25 |
F |
N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1
|
|
US6229011B1
(en)
|
1997-08-22 |
2001-05-08 |
Hoffman-La Roche Inc. |
N-aroylphenylalanine derivative VCAM-1 inhibitors
|
|
US6455550B1
(en)
|
1997-08-22 |
2002-09-24 |
Hoffmann-La Roche Inc. |
N-alkanoylphenylalanine derivatives
|
|
SI1005445T1
(en)
*
|
1997-08-22 |
2004-12-31 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
|
DE69830410T2
(de)
*
|
1997-08-29 |
2006-01-26 |
Tularik Ltd. |
Meta-benzamidinderivate als serinprotease-inhibitoren
|
|
US6740682B2
(en)
|
1997-08-29 |
2004-05-25 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
|
CA2303848C
(en)
|
1997-10-31 |
2008-09-30 |
Rhone-Poulenc Rorer Limited |
Substituted anilides
|
|
CA2316235A1
(en)
*
|
1997-12-23 |
1999-07-08 |
Aventis Pharma Limited |
Substituted .beta.-alanines
|
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
|
JP2002504534A
(ja)
*
|
1998-02-26 |
2002-02-12 |
セルテック・セラピューティクス・リミテッド |
α４インテグリンの阻害剤としてのフェニルアラニン誘導体
|
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6521626B1
(en)
*
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
|
JP4064059B2
(ja)
|
1998-04-09 |
2008-03-19 |
明治製菓株式会社 |
インテグリンαＶβ３拮抗剤としてのアミノピペリジン誘導体
|
|
GB9811159D0
(en)
|
1998-05-22 |
1998-07-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9811969D0
(en)
|
1998-06-03 |
1998-07-29 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9812088D0
(en)
|
1998-06-05 |
1998-08-05 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6352977B1
(en)
|
1998-07-13 |
2002-03-05 |
Aventis Pharma Limited |
Substituted β-alanines
|
|
GB9821061D0
(en)
*
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9821222D0
(en)
|
1998-09-30 |
1998-11-25 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9826174D0
(en)
*
|
1998-11-30 |
1999-01-20 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6677360B2
(en)
|
1998-12-16 |
2004-01-13 |
Bayer Aktiengesellschaft |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
IL143484A0
(en)
*
|
1998-12-16 |
2002-04-21 |
Bayer Ag |
New biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
EA006294B1
(ru)
|
1998-12-23 |
2005-10-27 |
Дж.Д.Сирл Энд Ко. |
Применение комбинации целекоксиба и гемцитабина в комбинированном способе лечебного воздействия при лечении рака поджелудочной железы
|
|
US6291503B1
(en)
|
1999-01-15 |
2001-09-18 |
Bayer Aktiengesellschaft |
β-phenylalanine derivatives as integrin antagonists
|
|
US6344484B1
(en)
|
1999-02-12 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Tyrosine alkoxyguanidines as integrin inhibitors
|
|
WO2000048994A1
(en)
|
1999-02-18 |
2000-08-24 |
F. Hoffmann-La Roche Ag |
Thioamide derivatives
|
|
DK1154987T3
(da)
*
|
1999-02-18 |
2004-08-09 |
Hoffmann La Roche |
Phenylalaninolderivater
|
|
FR2792314B1
(fr)
*
|
1999-04-15 |
2001-06-01 |
Adir |
Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
|
WO2001010844A1
(fr)
|
1999-08-05 |
2001-02-15 |
Meiji Seika Kaisha, Ltd. |
DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
|
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
|
CA2352957A1
(en)
|
1999-09-29 |
2001-04-05 |
Ortho-Mcneil Pharmaceutical, Inc. |
Isonipecotamides for the treatment of integrin-mediated disorders
|
|
WO2001032610A1
(en)
*
|
1999-10-29 |
2001-05-10 |
Kaken Pharmaceutical Co., Ltd. |
Urea derivative, process for producing the same, and medicine containing the urea derivative
|
|
WO2001044186A1
(en)
*
|
1999-12-16 |
2001-06-21 |
Sumitomo Pharmaceuticals Company, Limited |
Substituted guanidine derivatives
|
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
|
EP1250935A1
(en)
*
|
2000-01-25 |
2002-10-23 |
Meiji Seika Kaisha Ltd. |
REMEDIES FOR REPERFUSION INJURY CONTAINING INTEGRIN ALPHAvBETA3 ANTAGONIST
|
|
RU2240826C2
(ru)
*
|
2000-02-03 |
2004-11-27 |
Эйсай Ко., Лтд. |
Ингибитор экспрессии интегрина
|
|
EP1332132B1
(en)
|
2000-04-17 |
2007-10-10 |
UCB Pharma, S.A. |
Enamine derivatives as cell adhesion molecules
|
|
GB0011817D0
(en)
*
|
2000-05-16 |
2000-07-05 |
Pharmacia & Upjohn Spa |
Antagonists of integrin receptors
|
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
|
DE10032256C2
(de)
*
|
2000-07-03 |
2003-06-05 |
Infineon Technologies Ag |
Chip-ID-Register-Anordnung
|
|
AU2001267753A1
(en)
|
2000-07-07 |
2002-01-21 |
Celltech R And D Limited |
Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
|
|
US7015216B2
(en)
*
|
2000-07-21 |
2006-03-21 |
Elan Pharmaceuticals, Inc. |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
|
|
EP1318803A1
(en)
*
|
2000-08-02 |
2003-06-18 |
SmithKline Beecham Corporation |
Fatty acid synthase inhibitors
|
|
EP1305291A1
(en)
|
2000-08-02 |
2003-05-02 |
Celltech R&D Limited |
3-substituted isoquinolin-1-yl derivatives
|
|
US7163681B2
(en)
|
2000-08-07 |
2007-01-16 |
Centocor, Inc. |
Anti-integrin antibodies, compositions, methods and uses
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
US6486174B2
(en)
|
2000-08-07 |
2002-11-26 |
3-Dimensional Pharmaceuticals, Inc. |
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
|
|
AU2001277720A1
(en)
*
|
2000-08-09 |
2002-02-25 |
Kaken Pharmaceutical Co., Ltd. |
(thio)urea derivatives, process for their production and medicines containing the derivatives
|
|
DZ3415A1
(fr)
|
2000-08-31 |
2002-03-07 |
Chiron Corp |
Guanidinobenzamides comme mc4-r agonistes.
|
|
NZ539682A
(en)
*
|
2001-01-29 |
2006-03-31 |
Dimensional Pharm Inc |
Substituted indoles and their use as integrin antagonists
|
|
ITTO20010110A1
(it)
*
|
2001-02-08 |
2002-08-08 |
Rotta Research Lab |
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
|
|
DK1385823T3
(da)
*
|
2001-04-09 |
2007-03-26 |
Novartis Vaccines & Diagnostic |
Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister
|
|
EP1389205B1
(en)
|
2001-04-09 |
2005-12-21 |
Ortho-McNeil Pharmaceutical Research Inc. |
Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
|
|
US6872730B2
(en)
|
2001-04-27 |
2005-03-29 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
|
|
US8252902B2
(en)
|
2001-10-22 |
2012-08-28 |
The Scripps Research Institute |
Antibody targeting compounds
|
|
US20030207814A1
(en)
*
|
2002-02-04 |
2003-11-06 |
Chiron Corporation |
Novel guanidinyl derivatives
|
|
US20050124652A1
(en)
*
|
2002-02-04 |
2005-06-09 |
Rustum Boyce |
Guanidino compounds
|
|
US20030195187A1
(en)
*
|
2002-02-04 |
2003-10-16 |
Chiron Corporation |
Guanidino compounds
|
|
JP2005524649A
(ja)
*
|
2002-02-25 |
2005-08-18 |
カイロン コーポレーション |
Ｍｃ４−ｒアゴニストの鼻腔内投与
|
|
EP1551834B1
(en)
*
|
2002-05-23 |
2010-08-25 |
Novartis Vaccines and Diagnostics, Inc. |
Substituted quinazolinone compounds
|
|
KR20060018217A
(ko)
*
|
2003-05-23 |
2006-02-28 |
카이론 코포레이션 |
Ｍｃ4-ｒ 작용제로서 구아니디노-치환된 퀴나졸리논 화합물
|
|
AU2004251668B2
(en)
*
|
2003-06-03 |
2008-03-20 |
Triad Therapeutics, Inc |
5-membered heterocycle-based p-38 inhibitors
|
|
WO2005051391A1
(en)
*
|
2003-11-19 |
2005-06-09 |
Chiron Corporation |
Quinazolinone compounds with reduced bioaccumulation
|
|
WO2007048127A2
(en)
*
|
2005-10-20 |
2007-04-26 |
The Scripps Research Institute |
Fc labeling for immunostaining and immunotargeting
|
|
AU2007263076A1
(en)
|
2006-06-20 |
2007-12-27 |
F. Hoffmann-La Roche Ag |
Arylsulfonyl naphthalene derivatives and uses thereof
|
|
WO2010093706A2
(en)
|
2009-02-10 |
2010-08-19 |
The Scripps Research Institute |
Chemically programmed vaccination
|
|
US20140010783A1
(en)
*
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
|
IN2015DN00099A
(enExample)
|
2012-07-18 |
2015-05-29 |
Univ Saint Louis |
|
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
|
EP3294716B1
(en)
|
2015-12-30 |
2020-04-15 |
Saint Louis University |
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
|
|
CN107652210B
(zh)
*
|
2017-09-30 |
2021-01-01 |
瑞阳（上海）新药研发有限公司 |
一种胍类化合物或其药学上可接受的盐、其制备方法和应用
|