|
RO118290B1
(ro)
*
|
1995-08-30 |
2003-04-30 |
Gdsearle & Co |
Derivati de fenilcarboniluree si compozitie farmaceutica
|
|
US6245809B1
(en)
|
1996-12-09 |
2001-06-12 |
Cor Therapeutics Inc. |
Integrin antagonists
|
|
DE69720062D1
(de)
*
|
1996-12-09 |
2003-04-24 |
Lilly Co Eli |
Integrin antagonisten
|
|
AU8063098A
(en)
*
|
1997-06-10 |
1998-12-30 |
Eli Lilly And Company |
Combinatorial process for preparing substituted phenylalanine libraries
|
|
EP1403247A1
(en)
*
|
1997-08-22 |
2004-03-31 |
F.Hoffmann-La Roche Ag |
N-Alkanoylphenylalanine derivatives
|
|
CN100369888C
(zh)
*
|
1997-08-22 |
2008-02-20 |
霍夫曼-拉罗奇有限公司 |
芳酰基苯丙氨酸衍生物
|
|
US6455550B1
(en)
|
1997-08-22 |
2002-09-24 |
Hoffmann-La Roche Inc. |
N-alkanoylphenylalanine derivatives
|
|
US6229011B1
(en)
|
1997-08-22 |
2001-05-08 |
Hoffman-La Roche Inc. |
N-aroylphenylalanine derivative VCAM-1 inhibitors
|
|
WO1999011657A1
(en)
*
|
1997-08-29 |
1999-03-11 |
Proteus Molecular Design Ltd. |
1-amino-7-isoquinoline derivatives as serine protease inhibitors
|
|
US6740682B2
(en)
|
1997-08-29 |
2004-05-25 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
|
TR200001179T2
(tr)
|
1997-10-31 |
2000-11-21 |
Aventis Pharma Ltd. |
Değiştirilmiş anilidler
|
|
ATE289991T1
(de)
*
|
1997-12-23 |
2005-03-15 |
Aventis Pharma Ltd |
Substituierte beta-alaninen
|
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
|
DE69919334T2
(de)
*
|
1998-02-26 |
2005-08-04 |
Celltech Therapeutics Ltd., Slough |
Phenylalaninderivate als inhibitoren von alpha4 integrinen
|
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6521626B1
(en)
*
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
|
KR20010042587A
(ko)
|
1998-04-09 |
2001-05-25 |
기따자또 이찌로 |
인테그린 알파브이베타3 길항제로서 아미노피페리딘 유도체
|
|
GB9811159D0
(en)
|
1998-05-22 |
1998-07-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9811969D0
(en)
|
1998-06-03 |
1998-07-29 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9812088D0
(en)
|
1998-06-05 |
1998-08-05 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6352977B1
(en)
|
1998-07-13 |
2002-03-05 |
Aventis Pharma Limited |
Substituted β-alanines
|
|
GB9821061D0
(en)
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9821222D0
(en)
|
1998-09-30 |
1998-11-25 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9826174D0
(en)
*
|
1998-11-30 |
1999-01-20 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
ES2249059T3
(es)
*
|
1998-12-16 |
2006-03-16 |
Bayer Healthcare Ag |
Nuevos compuestos de bifenilo y analogos de bifenilo como antagonista de integrina.
|
|
US6677360B2
(en)
|
1998-12-16 |
2004-01-13 |
Bayer Aktiengesellschaft |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
|
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
CA2356462A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
US6291503B1
(en)
|
1999-01-15 |
2001-09-18 |
Bayer Aktiengesellschaft |
β-phenylalanine derivatives as integrin antagonists
|
|
US6344484B1
(en)
|
1999-02-12 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Tyrosine alkoxyguanidines as integrin inhibitors
|
|
DK1154993T3
(da)
*
|
1999-02-18 |
2005-02-14 |
Hoffmann La Roche |
Thioamid-derivater
|
|
ATE264835T1
(de)
*
|
1999-02-18 |
2004-05-15 |
Hoffmann La Roche |
Phenylalaninolderivate
|
|
FR2792314B1
(fr)
*
|
1999-04-15 |
2001-06-01 |
Adir |
Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
|
WO2001010844A1
(fr)
|
1999-08-05 |
2001-02-15 |
Meiji Seika Kaisha, Ltd. |
DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
|
|
WO2001023376A1
(en)
|
1999-09-29 |
2001-04-05 |
Ortho-Mcneil Pharmaceutical, Inc. |
Isonipecotamides for the treatment of integrin-mediated disorders
|
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
|
WO2001032610A1
(en)
*
|
1999-10-29 |
2001-05-10 |
Kaken Pharmaceutical Co., Ltd. |
Urea derivative, process for producing the same, and medicine containing the urea derivative
|
|
WO2001044186A1
(en)
*
|
1999-12-16 |
2001-06-21 |
Sumitomo Pharmaceuticals Company, Limited |
Substituted guanidine derivatives
|
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
|
US20030040531A1
(en)
*
|
2000-01-25 |
2003-02-27 |
Kazuyuki Fujishima |
Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist
|
|
CN100356979C
(zh)
|
2000-02-03 |
2007-12-26 |
卫材R&D管理有限公司 |
整联蛋白表达抑制剂
|
|
ATE375330T1
(de)
*
|
2000-04-17 |
2007-10-15 |
Ucb Pharma Sa |
Enamin-derivate als zell-adhäsionsmoleküle
|
|
GB0011817D0
(en)
*
|
2000-05-16 |
2000-07-05 |
Pharmacia & Upjohn Spa |
Antagonists of integrin receptors
|
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
|
DE10032256C2
(de)
*
|
2000-07-03 |
2003-06-05 |
Infineon Technologies Ag |
Chip-ID-Register-Anordnung
|
|
AU2001267753A1
(en)
|
2000-07-07 |
2002-01-21 |
Celltech R And D Limited |
Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
|
|
US7015216B2
(en)
*
|
2000-07-21 |
2006-03-21 |
Elan Pharmaceuticals, Inc. |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
|
|
WO2002009688A1
(en)
*
|
2000-08-02 |
2002-02-07 |
Smithkline Beecham Corporation |
Fatty acid synthase inhibitors
|
|
EP1305291A1
(en)
|
2000-08-02 |
2003-05-02 |
Celltech R&D Limited |
3-substituted isoquinolin-1-yl derivatives
|
|
US7163681B2
(en)
|
2000-08-07 |
2007-01-16 |
Centocor, Inc. |
Anti-integrin antibodies, compositions, methods and uses
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
US6486174B2
(en)
|
2000-08-07 |
2002-11-26 |
3-Dimensional Pharmaceuticals, Inc. |
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
|
|
WO2002014272A1
(en)
*
|
2000-08-09 |
2002-02-21 |
Kaken Pharmaceutical Co., Ltd. |
(thio)urea derivatives, process for their production and medicines containing the derivatives
|
|
DZ3415A1
(fr)
|
2000-08-31 |
2002-03-07 |
Chiron Corp |
Guanidinobenzamides comme mc4-r agonistes.
|
|
MXPA03006772A
(es)
|
2001-01-29 |
2004-10-15 |
Dimensional Pharm Inc |
Indoles sustituidos y su uso como antogonistas de integrina.
|
|
ITTO20010110A1
(it)
|
2001-02-08 |
2002-08-08 |
Rotta Research Lab |
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
|
|
WO2002081467A1
(en)
|
2001-04-09 |
2002-10-17 |
Ortho-Mcneil Pharmaceutical, Inc. |
Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
|
|
PT1385823E
(pt)
|
2001-04-09 |
2007-01-31 |
Novartis Vaccines & Diagnostic |
Compostos de guanidino como agonistas do receptor de melanocortina-4 (r-mc4)
|
|
US6872730B2
(en)
|
2001-04-27 |
2005-03-29 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
|
|
CN100560131C
(zh)
|
2001-10-22 |
2009-11-18 |
斯克里普斯研究学院 |
抗体靶向化合物
|
|
US20030207814A1
(en)
*
|
2002-02-04 |
2003-11-06 |
Chiron Corporation |
Novel guanidinyl derivatives
|
|
US20030195187A1
(en)
*
|
2002-02-04 |
2003-10-16 |
Chiron Corporation |
Guanidino compounds
|
|
US20050124652A1
(en)
*
|
2002-02-04 |
2005-06-09 |
Rustum Boyce |
Guanidino compounds
|
|
EP1487474A4
(en)
*
|
2002-02-25 |
2006-11-29 |
Chiron Corp |
INTRANASAL ADMINISTRATION OF MC4-R AGONISTS
|
|
DE60333937D1
(de)
*
|
2002-05-23 |
2010-10-07 |
Novartis Vaccines & Diagnostic |
Substituierte quinazolinone verbindungen
|
|
JP2007501861A
(ja)
*
|
2003-05-23 |
2007-02-01 |
カイロン コーポレイション |
Mc4−rアゴニストとしてのグアニジノ置換キナゾリノン化合物
|
|
ATE439837T1
(de)
*
|
2003-06-03 |
2009-09-15 |
Novartis Ag |
5-gliedrige heterocyclische p-38 inhibitoren
|
|
US7368453B2
(en)
*
|
2003-11-19 |
2008-05-06 |
Chiron Corporation |
Quinazolinone compounds with reduced bioaccumulation
|
|
WO2007048127A2
(en)
*
|
2005-10-20 |
2007-04-26 |
The Scripps Research Institute |
Fc labeling for immunostaining and immunotargeting
|
|
JP2009541249A
(ja)
|
2006-06-20 |
2009-11-26 |
エフ.ホフマン−ラ ロシュ アーゲー |
アリールスルホニルナフタレン誘導体およびその使用
|
|
WO2010093706A2
(en)
|
2009-02-10 |
2010-08-19 |
The Scripps Research Institute |
Chemically programmed vaccination
|
|
US20140010783A1
(en)
*
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
|
IN2015DN00099A
(OSRAM)
|
2012-07-18 |
2015-05-29 |
Univ Saint Louis |
|
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
|
CA3008023A1
(en)
|
2015-12-30 |
2017-07-06 |
Saint Louis University |
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
|
|
CN107652210B
(zh)
*
|
2017-09-30 |
2021-01-01 |
瑞阳(上海)新药研发有限公司 |
一种胍类化合物或其药学上可接受的盐、其制备方法和应用
|