JP2000512979A - 自己デコンボリューション法によるコンビナトリアルライブラリー - Google Patents
自己デコンボリューション法によるコンビナトリアルライブラリーInfo
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- JP2000512979A JP2000512979A JP09539622A JP53962297A JP2000512979A JP 2000512979 A JP2000512979 A JP 2000512979A JP 09539622 A JP09539622 A JP 09539622A JP 53962297 A JP53962297 A JP 53962297A JP 2000512979 A JP2000512979 A JP 2000512979A
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- WGTODYJZXSJIAG-UHFFFAOYSA-N tetramethylrhodamine chloride Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C(O)=O WGTODYJZXSJIAG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9608457.9A GB9608457D0 (en) | 1996-04-24 | 1996-04-24 | Inhibitors of proteolytic enzymes |
| GBGB9616115.3A GB9616115D0 (en) | 1996-07-31 | 1996-07-31 | Substrate and inhibitors of proteolytic enzymes |
| GB9608457.9 | 1996-11-27 | ||
| GBGB9624584.0A GB9624584D0 (en) | 1996-11-27 | 1996-11-27 | Substances and inhibitors of proteolytic enzymes |
| GB9616115.3 | 1996-11-27 | ||
| GB9624584.0 | 1996-11-27 | ||
| PCT/GB1997/001158 WO1997042216A1 (en) | 1996-04-24 | 1997-04-24 | Auto-deconvoluting combinatorial libraries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000512979A true JP2000512979A (ja) | 2000-10-03 |
| JP2000512979A5 JP2000512979A5 (enExample) | 2004-12-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP09539622A Abandoned JP2000512979A (ja) | 1996-04-24 | 1997-04-24 | 自己デコンボリューション法によるコンビナトリアルライブラリー |
| JP53786497A Expired - Fee Related JP4215822B2 (ja) | 1996-04-24 | 1997-04-24 | タンパク質分解酵素の基質および阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53786497A Expired - Fee Related JP4215822B2 (ja) | 1996-04-24 | 1997-04-24 | タンパク質分解酵素の基質および阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6528275B1 (enExample) |
| EP (2) | EP0906334A1 (enExample) |
| JP (2) | JP2000512979A (enExample) |
| AT (1) | ATE203545T1 (enExample) |
| AU (2) | AU706855B2 (enExample) |
| CA (2) | CA2252508A1 (enExample) |
| DE (1) | DE69705838T2 (enExample) |
| DK (1) | DK0906333T3 (enExample) |
| ES (1) | ES2162277T3 (enExample) |
| WO (2) | WO1997040065A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015508414A (ja) * | 2012-01-12 | 2015-03-19 | イエール ユニバーシティ | Ｅ３ユビキチンリガーゼによる標的タンパク質および他のポリペプチドの分解増強のための化合物および方法 |
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| US6149869A (en) * | 1996-10-23 | 2000-11-21 | Glaxo Wellcome Inc. | Chemical synthesizers |
| US6042789A (en) * | 1996-10-23 | 2000-03-28 | Glaxo Group Limited | System for parallel synthesis of organic compounds |
| US6617114B1 (en) | 1996-10-31 | 2003-09-09 | Karo Bio Ab | Identification of drug complementary combinatorial libraries |
| JP2001510453A (ja) * | 1996-10-31 | 2001-07-31 | ノヴァロン ファーマスーチカル コーポレイション | 相補的組み合わせライブラリーを使用する薬剤の同定 |
| US6083761A (en) * | 1996-12-02 | 2000-07-04 | Glaxo Wellcome Inc. | Method and apparatus for transferring and combining reagents |
| US6054325A (en) * | 1996-12-02 | 2000-04-25 | Glaxo Wellcom Inc. | Method and apparatus for transferring and combining distinct chemical compositions with reagents |
| GB9722818D0 (en) * | 1997-10-30 | 1997-12-24 | Peptide Therapeutics Ltd | A method for mapping the active sites bound by enzymes that covalently modify substrate molecules |
| AU734992B2 (en) * | 1997-11-26 | 2001-06-28 | Medivir Uk Ltd | A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring |
| US6083682A (en) | 1997-12-19 | 2000-07-04 | Glaxo Group Limited | System and method for solid-phase parallel synthesis of a combinatorial collection of compounds |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6569636B2 (en) | 1998-05-29 | 2003-05-27 | Hawaii Biotechnology Group, Inc. | Assay for modulators of metallo-enzyme activity |
| DE19925402C2 (de) * | 1999-06-02 | 2001-12-20 | Molecular Machines & Ind Gmbh | Screening von Target-Ligand-Wechselwirkungen |
| CA2398583A1 (en) | 2000-02-11 | 2001-08-16 | Cellomics, Inc. | Peptide biosensors for anthrax protease |
| JP2002250730A (ja) * | 2001-02-27 | 2002-09-06 | Shinwa Kako Kk | 分子センサー及びその製造方法 |
| MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| WO2004014844A2 (en) * | 2002-08-09 | 2004-02-19 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| WO2005014534A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| US8015064B2 (en) * | 2005-04-20 | 2011-09-06 | At&T Intellectual Property I, Lp | System and method of providing advertisements to cellular devices |
| DE602006009117D1 (de) * | 2005-07-26 | 2009-10-22 | Council Scient Ind Res | Verfahren zur identifizierung von die stresstoleranz in hefe erhöhenden genen sowie verwendung dieser gene zur verbesserung von hefestämmen |
| WO2010052244A1 (en) | 2008-11-05 | 2010-05-14 | Morphosys Ag | Deconvolution method |
| EP2189536A1 (en) * | 2008-11-20 | 2010-05-26 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Rapid FRET based anthrax diagnosis |
| JP5798487B2 (ja) * | 2008-11-20 | 2015-10-21 | ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー | Ｆｒｅｔに基づく病原体の迅速診断 |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| BR112018008918A8 (pt) | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
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| EP0428000A1 (en) | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogenic substrates for the detection of proteolytic enzyme activity |
| US5164300A (en) | 1989-12-28 | 1992-11-17 | Washington University | Method for determining activity of retroviral protease |
| US5011910A (en) * | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
| DK93990D0 (da) * | 1990-04-17 | 1990-04-17 | Carlsberg As | Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet |
| HU9201687D0 (en) | 1992-05-21 | 1992-08-28 | Arpad Furka | Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides |
| US5585275A (en) * | 1992-09-02 | 1996-12-17 | Arris Pharmaceutical Corporation | Pilot apparatus for peptide synthesis and screening |
| SG48166A1 (en) | 1993-12-15 | 1998-04-17 | Conbichem Inc | Combinatorial libraries and methods for their use |
| US5506115A (en) | 1994-04-29 | 1996-04-09 | G. D. Searle & Co. | Reagent and method for determining activity of herpes protease |
| US5738996A (en) * | 1994-06-15 | 1998-04-14 | Pence, Inc. | Combinational library composition and method |
| EP1019528B1 (en) * | 1996-01-04 | 2003-10-29 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method for assaying proteolytic enzymes using fluorescence-quenched substrates |
| US7135288B2 (en) * | 2002-09-27 | 2006-11-14 | Ut-Battelle, Llc | Combinatorial synthesis of ceramic materials |
-
1997
- 1997-04-24 EP EP97918253A patent/EP0906334A1/en not_active Withdrawn
- 1997-04-24 DE DE69705838T patent/DE69705838T2/de not_active Expired - Fee Related
- 1997-04-24 WO PCT/GB1997/001157 patent/WO1997040065A2/en not_active Ceased
- 1997-04-24 AT AT97918252T patent/ATE203545T1/de not_active IP Right Cessation
- 1997-04-24 ES ES97918252T patent/ES2162277T3/es not_active Expired - Lifetime
- 1997-04-24 AU AU26449/97A patent/AU706855B2/en not_active Ceased
- 1997-04-24 US US09/171,680 patent/US6528275B1/en not_active Expired - Fee Related
- 1997-04-24 CA CA002252508A patent/CA2252508A1/en not_active Abandoned
- 1997-04-24 JP JP09539622A patent/JP2000512979A/ja not_active Abandoned
- 1997-04-24 EP EP97918252A patent/EP0906333B1/en not_active Expired - Lifetime
- 1997-04-24 JP JP53786497A patent/JP4215822B2/ja not_active Expired - Fee Related
- 1997-04-24 WO PCT/GB1997/001158 patent/WO1997042216A1/en not_active Ceased
- 1997-04-24 CA CA002252408A patent/CA2252408A1/en not_active Abandoned
- 1997-04-24 DK DK97918252T patent/DK0906333T3/da active
- 1997-04-24 AU AU26450/97A patent/AU728263B2/en not_active Ceased
-
2002
- 2002-09-30 US US10/259,420 patent/US20030092067A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015508414A (ja) * | 2012-01-12 | 2015-03-19 | イエール ユニバーシティ | Ｅ３ユビキチンリガーゼによる標的タンパク質および他のポリペプチドの分解増強のための化合物および方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6528275B1 (en) | 2003-03-04 |
| EP0906333A2 (en) | 1999-04-07 |
| AU728263B2 (en) | 2001-01-04 |
| EP0906334A1 (en) | 1999-04-07 |
| AU2645097A (en) | 1997-11-26 |
| CA2252408A1 (en) | 1997-11-13 |
| DE69705838T2 (de) | 2002-04-11 |
| US20030092067A1 (en) | 2003-05-15 |
| DE69705838D1 (de) | 2001-08-30 |
| ES2162277T3 (es) | 2001-12-16 |
| DK0906333T3 (da) | 2001-11-12 |
| AU2644997A (en) | 1997-11-12 |
| CA2252508A1 (en) | 1997-10-30 |
| EP0906333B1 (en) | 2001-07-25 |
| WO1997040065A3 (en) | 1997-12-04 |
| JP4215822B2 (ja) | 2009-01-28 |
| WO1997040065A2 (en) | 1997-10-30 |
| WO1997042216A1 (en) | 1997-11-13 |
| ATE203545T1 (de) | 2001-08-15 |
| JP2001501170A (ja) | 2001-01-30 |
| AU706855B2 (en) | 1999-06-24 |
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