JP2000510688A - ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼ - Google Patents
ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼInfo
- Publication number
- JP2000510688A JP2000510688A JP09537430A JP53743097A JP2000510688A JP 2000510688 A JP2000510688 A JP 2000510688A JP 09537430 A JP09537430 A JP 09537430A JP 53743097 A JP53743097 A JP 53743097A JP 2000510688 A JP2000510688 A JP 2000510688A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- asps
- seq
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9607993.4 | 1996-04-18 | ||
| GBGB9607993.4A GB9607993D0 (en) | 1996-04-18 | 1996-04-18 | Novel compounds |
| PCT/US1997/006638 WO1997039014A1 (en) | 1996-04-18 | 1997-04-18 | STREPTOCOCCUS PNEUMONIAE ASPARTYL tRNA SYNTHETASE |
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| Publication Number | Publication Date |
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| JP2000510688A true JP2000510688A (ja) | 2000-08-22 |
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| JP09537430A Pending JP2000510688A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼ |
| JP9537451A Pending JP2000509264A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのヒスチジルｔＲＮＡシンセターゼ |
| JP09537450A Pending JP2000509975A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP9537449A Pending JP2000509263A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537452A Pending JP2000515366A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537428A Pending JP2000515724A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
Family Applications After (5)
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| JP9537451A Pending JP2000509264A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのヒスチジルｔＲＮＡシンセターゼ |
| JP09537450A Pending JP2000509975A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP9537449A Pending JP2000509263A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537452A Pending JP2000515366A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537428A Pending JP2000515724A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (9) | US5753479A (enExample) |
| EP (6) | EP0904104A4 (enExample) |
| JP (6) | JP2000510688A (enExample) |
| GB (1) | GB9607993D0 (enExample) |
| WO (6) | WO1997039022A1 (enExample) |
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| US5834276A (en) * | 1996-04-18 | 1998-11-10 | Smithkline Beecham Corporation | Asparaginyl TRNA synthetase polynucleotides of streptococcus |
| US5795758A (en) * | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
| US5882892A (en) * | 1997-07-23 | 1999-03-16 | Smithkline Beecham Corporation | Asps |
| US5858720A (en) * | 1997-07-23 | 1999-01-12 | Smithkline Beecham Corporation | Hiss |
| EP0916728A1 (en) * | 1997-10-17 | 1999-05-19 | Smithkline Beecham Corporation | Phenyl alanyl tRNA synthetase [EC 6.1.1.20] alpha subunit family, pheS (alpha), from Streptococcus pneumoniae |
| JP2002505849A (ja) | 1997-11-25 | 2002-02-26 | ザ ジュネラル ホスピタル コーポレーション | ビルレンス関連核酸配列およびその使用 |
| EP1087984A4 (en) * | 1998-05-28 | 2005-02-09 | Smithkline Beecham Corp | ACPs |
| US6245539B1 (en) | 1998-10-06 | 2001-06-12 | Board Of Trustees Operating Michigan State University | Human asparaginyl-tRNA synthetase DNA |
| WO2001040332A1 (en) | 1999-11-29 | 2001-06-07 | Daikin Industries, Ltd. | Fluororesin material lowly permeable to liquid chemical |
| US7112716B2 (en) | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
| MX2010013632A (es) | 2008-06-11 | 2011-06-16 | Atyr Pharma Inc | Actividad trombopoyetica de polipeptidos de tirosil-arnt sintetasa. |
| WO2009158649A1 (en) | 2008-06-26 | 2009-12-30 | Atyr Pharma, Inc. | Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities |
| US20120004185A1 (en) | 2009-02-27 | 2012-01-05 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| EP3255146B1 (en) | 2009-03-16 | 2019-05-15 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
| EP2414513B1 (en) | 2009-03-31 | 2015-10-28 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
| DK2509625T3 (en) | 2009-12-11 | 2015-04-27 | Atyr Pharma Inc | Histidyl tRNA synthetases to reduce inflammation |
| US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
| CN103118692A (zh) | 2010-04-26 | 2013-05-22 | Atyr医药公司 | 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2797259C (en) * | 2010-04-27 | 2020-09-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| US8961960B2 (en) | 2010-04-27 | 2015-02-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
| US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011140135A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| ES2623805T3 (es) | 2010-05-03 | 2017-07-12 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas |
| EP2566516B1 (en) | 2010-05-03 | 2019-07-03 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| AU2011248355B2 (en) | 2010-05-03 | 2017-01-19 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases |
| CA2798301C (en) | 2010-05-04 | 2020-09-15 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-trna synthetases |
| EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| WO2011143482A2 (en) | 2010-05-14 | 2011-11-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| WO2011146410A2 (en) * | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| CA2800375C (en) | 2010-05-27 | 2021-03-09 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| WO2011153277A2 (en) | 2010-06-01 | 2011-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| NZ603811A (en) | 2010-07-12 | 2015-03-27 | Atyr Pharma Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| EA030418B1 (ru) | 2010-07-12 | 2018-08-31 | ЭйТИР ФАРМА, ИНК. | ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS) |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| US9029506B2 (en) | 2010-08-25 | 2015-05-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases |
| CN103118696B (zh) | 2010-10-06 | 2020-02-14 | Atyr 医药公司 | 与色氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物 |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| WO2013086216A1 (en) * | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| CN104220461A (zh) * | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| DK2814514T3 (en) | 2012-02-16 | 2017-12-18 | Atyr Pharma Inc | Histidyl tRNA synthetases for the treatment of autoimmune and inflammatory diseases |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
| EP3612215B1 (en) | 2017-04-20 | 2024-08-28 | aTyr Pharma, Inc. | Compositions for treating lung inflammation |
| WO2019016772A2 (en) | 2017-07-21 | 2019-01-24 | Novartis Ag | COMPOSITIONS AND METHODS FOR TREATING CANCER |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6958194A (en) * | 1993-05-28 | 1994-12-20 | Massachusetts Institute Of Technology | Trna binding-dependent inhibition of microbial pathogen growth |
| AU5552396A (en) * | 1995-04-21 | 1996-11-07 | Human Genome Sciences, Inc. | Nucleotide sequence of the haemophilus influenzae rd genome, fragments thereof, and uses thereof |
| US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
| JPH11502425A (ja) * | 1996-01-19 | 1999-03-02 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | スタフィロコッカス・アウレウスのアスパラギニルｔＲＮＡシンセターゼ |
| EP1288299A3 (en) * | 1996-01-19 | 2003-12-17 | Smithkline Beecham Plc | TRNA synthetase |
| AU5194598A (en) * | 1996-10-31 | 1998-05-22 | Human Genome Sciences, Inc. | (streptococcus pneumoniae) antigens and vaccines |
-
1996
- 1996-04-18 GB GBGB9607993.4A patent/GB9607993D0/en active Pending
-
1997
- 1997-04-18 US US08/843,521 patent/US5753479A/en not_active Expired - Lifetime
- 1997-04-18 EP EP97918806A patent/EP0904104A4/en not_active Withdrawn
- 1997-04-18 JP JP09537430A patent/JP2000510688A/ja active Pending
- 1997-04-18 JP JP9537451A patent/JP2000509264A/ja active Pending
- 1997-04-18 JP JP09537450A patent/JP2000509975A/ja active Pending
- 1997-04-18 JP JP9537449A patent/JP2000509263A/ja active Pending
- 1997-04-18 US US08/844,055 patent/US5747313A/en not_active Expired - Fee Related
- 1997-04-18 US US08/844,154 patent/US5827708A/en not_active Expired - Fee Related
- 1997-04-18 EP EP97921302A patent/EP0904280A4/en not_active Withdrawn
- 1997-04-18 US US08/844,086 patent/US5866390A/en not_active Expired - Lifetime
- 1997-04-18 EP EP97918764A patent/EP0894006A4/en not_active Withdrawn
- 1997-04-18 WO PCT/US1997/006875 patent/WO1997039022A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006877 patent/WO1997039017A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006634 patent/WO1997038717A1/en not_active Ceased
- 1997-04-18 JP JP09537452A patent/JP2000515366A/ja active Pending
- 1997-04-18 JP JP09537428A patent/JP2000515724A/ja active Pending
- 1997-04-18 WO PCT/US1997/006879 patent/WO1997038719A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006638 patent/WO1997039014A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006876 patent/WO1997038722A1/en not_active Ceased
- 1997-04-18 EP EP97921361A patent/EP0904281A4/en not_active Withdrawn
- 1997-04-18 EP EP97923452A patent/EP0951469A1/en not_active Withdrawn
- 1997-04-18 US US08/844,280 patent/US5747315A/en not_active Expired - Fee Related
- 1997-04-18 EP EP97922434A patent/EP0909181A4/en not_active Withdrawn
-
1998
- 1998-01-14 US US09/006,849 patent/US6071731A/en not_active Expired - Fee Related
- 1998-01-23 US US09/012,871 patent/US6200787B1/en not_active Expired - Fee Related
- 1998-02-03 US US09/018,211 patent/US6048716A/en not_active Expired - Lifetime
- 1998-07-30 US US09/126,192 patent/US6040163A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997039014A1 (en) | 1997-10-23 |
| EP0951469A4 (enExample) | 1999-11-03 |
| EP0894006A4 (en) | 1999-11-24 |
| JP2000509264A (ja) | 2000-07-25 |
| EP0909181A1 (en) | 1999-04-21 |
| EP0904104A1 (en) | 1999-03-31 |
| US5747315A (en) | 1998-05-05 |
| EP0904280A4 (en) | 1999-10-20 |
| US5827708A (en) | 1998-10-27 |
| WO1997038722A1 (en) | 1997-10-23 |
| WO1997039017A1 (en) | 1997-10-23 |
| US6048716A (en) | 2000-04-11 |
| EP0904281A1 (en) | 1999-03-31 |
| US5866390A (en) | 1999-02-02 |
| WO1997038717A1 (en) | 1997-10-23 |
| EP0904104A4 (en) | 1999-11-03 |
| US5753479A (en) | 1998-05-19 |
| EP0904281A4 (en) | 2000-01-12 |
| US6040163A (en) | 2000-03-21 |
| WO1997038719A1 (en) | 1997-10-23 |
| US6071731A (en) | 2000-06-06 |
| EP0909181A4 (en) | 1999-11-03 |
| JP2000515366A (ja) | 2000-11-21 |
| US6200787B1 (en) | 2001-03-13 |
| US5747313A (en) | 1998-05-05 |
| JP2000515724A (ja) | 2000-11-28 |
| JP2000509975A (ja) | 2000-08-08 |
| EP0904280A1 (en) | 1999-03-31 |
| EP0894006A1 (en) | 1999-02-03 |
| GB9607993D0 (en) | 1996-06-19 |
| EP0951469A1 (en) | 1999-10-27 |
| JP2000509263A (ja) | 2000-07-25 |
| WO1997039022A1 (en) | 1997-10-23 |
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