JP2000509969A - 非対称ハンマーヘッド型リボザイム - Google Patents

非対称ハンマーヘッド型リボザイム

Info

Publication number
JP2000509969A
JP2000509969A JP09534751A JP53475197A JP2000509969A JP 2000509969 A JP2000509969 A JP 2000509969A JP 09534751 A JP09534751 A JP 09534751A JP 53475197 A JP53475197 A JP 53475197A JP 2000509969 A JP2000509969 A JP 2000509969A
Authority
JP
Japan
Prior art keywords
compound
host cell
ribozyme
nucleotides
helix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP09534751A
Other languages
English (en)
Japanese (ja)
Inventor
ヘンドリー・フィリップ
マッコール、マキシン・ジェイ
Original Assignee
コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション filed Critical コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション
Publication of JP2000509969A publication Critical patent/JP2000509969A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP09534751A 1996-04-02 1997-04-02 非対称ハンマーヘッド型リボザイム Pending JP2000509969A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62703396A 1996-04-02 1996-04-02
US1465996P 1996-04-02 1996-04-02
US08/627,033 1996-04-02
US60/014,659 1996-04-02
PCT/AU1997/000210 WO1997037013A1 (fr) 1996-04-02 1997-04-02 Ribozymes asymetriques en forme de tete de marteau

Publications (1)

Publication Number Publication Date
JP2000509969A true JP2000509969A (ja) 2000-08-08

Family

ID=26686341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09534751A Pending JP2000509969A (ja) 1996-04-02 1997-04-02 非対称ハンマーヘッド型リボザイム

Country Status (5)

Country Link
EP (1) EP0902836A4 (fr)
JP (1) JP2000509969A (fr)
AU (1) AU721758B2 (fr)
CA (1) CA2250857A1 (fr)
WO (1) WO1997037013A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004512810A (ja) * 1999-08-31 2004-04-30 サーナ・セラピューティクス・インコーポレイテッド 核酸に基づく遺伝子発現の調節剤
WO2001030362A2 (fr) * 1999-10-26 2001-05-03 Immusol Incorporated Therapie ribozymique destinee au traitement de maladies proliferantes de la peau et des yeux
GB0224663D0 (en) * 2002-10-23 2002-12-04 Isis Innovation DNAzyme

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019789A1 (fr) * 1990-06-19 1991-12-26 Commonwealth Scientific And Industrial Research Organisation Endonucleases
WO1993023569A1 (fr) * 1992-05-11 1993-11-25 Ribozyme Pharmaceuticals, Inc. Procede et reactif d'inhibition de la replication virale
EP0641212A4 (fr) * 1992-05-14 1997-05-21 Ribozyme Pharm Inc Procede et reactif destines a empecher l'evolution du cancer.
JPH07509133A (ja) * 1992-07-17 1995-10-12 リボザイム・ファーマシューティカルズ・インコーポレイテッド 動物疾患の処置のための方法および剤
AU5334294A (en) * 1993-10-15 1995-05-04 Dkfz Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Asymmetric hammerhead ribozymes and nucleotide sequences for their construction

Also Published As

Publication number Publication date
EP0902836A4 (fr) 2004-12-22
AU721758B2 (en) 2000-07-13
WO1997037013A1 (fr) 1997-10-09
EP0902836A1 (fr) 1999-03-24
CA2250857A1 (fr) 1997-10-09
AU2145097A (en) 1997-10-22

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