EP0902836A4 - Ribozymes asymetriques en forme de tete de marteau - Google Patents
Ribozymes asymetriques en forme de tete de marteauInfo
- Publication number
- EP0902836A4 EP0902836A4 EP97913997A EP97913997A EP0902836A4 EP 0902836 A4 EP0902836 A4 EP 0902836A4 EP 97913997 A EP97913997 A EP 97913997A EP 97913997 A EP97913997 A EP 97913997A EP 0902836 A4 EP0902836 A4 EP 0902836A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- hammerhead ribozymes
- man
- asymmetric
- asymmetric hammerhead
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
Abstract
L'invention concerne un composé ayant la formule (I). Dans cette formule, N peut être un nucléotide, n est égal à 1-5 et n' est égal à 1-3. Ces ribozymes asymétriques présentent des vitesses de scission plus élevées que la normale. Le composé peut être lié par covalence à un agent d'administration. L'invention concerne, en outre, une composition qui comprend le composé en association avec un vecteur acceptable. L'invention concerne également une méthode pour scinder une séquence cible d'ARN avec le composé décrit ci-dessus. L'invention concerne, également, une méthode pour traiter une maladie associée à un ARN particulier, chez un humain ou chez un animal, qui consiste à administrer le composé à cet humain ou à cet animal. En outre, l'invention concerne un réactif de diagnostic qui comprend le composé.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1465996P | 1996-04-02 | 1996-04-02 | |
US62703396A | 1996-04-02 | 1996-04-02 | |
US14659P | 1996-04-02 | ||
US627033 | 1996-04-02 | ||
PCT/AU1997/000210 WO1997037013A1 (fr) | 1996-04-02 | 1997-04-02 | Ribozymes asymetriques en forme de tete de marteau |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0902836A1 EP0902836A1 (fr) | 1999-03-24 |
EP0902836A4 true EP0902836A4 (fr) | 2004-12-22 |
Family
ID=26686341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97913997A Withdrawn EP0902836A4 (fr) | 1996-04-02 | 1997-04-02 | Ribozymes asymetriques en forme de tete de marteau |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0902836A4 (fr) |
JP (1) | JP2000509969A (fr) |
AU (1) | AU721758B2 (fr) |
CA (1) | CA2250857A1 (fr) |
WO (1) | WO1997037013A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004512810A (ja) * | 1999-08-31 | 2004-04-30 | サーナ・セラピューティクス・インコーポレイテッド | 核酸に基づく遺伝子発現の調節剤 |
WO2001030362A2 (fr) * | 1999-10-26 | 2001-05-03 | Immusol Incorporated | Therapie ribozymique destinee au traitement de maladies proliferantes de la peau et des yeux |
GB0224663D0 (en) * | 2002-10-23 | 2002-12-04 | Isis Innovation | DNAzyme |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991019789A1 (fr) * | 1990-06-19 | 1991-12-26 | Commonwealth Scientific And Industrial Research Organisation | Endonucleases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU687736B2 (en) * | 1992-05-11 | 1998-03-05 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
EP0641212A4 (fr) * | 1992-05-14 | 1997-05-21 | Ribozyme Pharm Inc | Procede et reactif destines a empecher l'evolution du cancer. |
EP0654077A4 (fr) * | 1992-07-17 | 1996-03-13 | Ribozyme Pharm Inc | Procede et reactif pour le traitement de maladies chez les animaux. |
AU5334294A (en) * | 1993-10-15 | 1995-05-04 | Dkfz Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Asymmetric hammerhead ribozymes and nucleotide sequences for their construction |
-
1997
- 1997-04-02 JP JP09534751A patent/JP2000509969A/ja active Pending
- 1997-04-02 CA CA 2250857 patent/CA2250857A1/fr not_active Abandoned
- 1997-04-02 WO PCT/AU1997/000210 patent/WO1997037013A1/fr not_active Application Discontinuation
- 1997-04-02 EP EP97913997A patent/EP0902836A4/fr not_active Withdrawn
- 1997-04-02 AU AU21450/97A patent/AU721758B2/en not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991019789A1 (fr) * | 1990-06-19 | 1991-12-26 | Commonwealth Scientific And Industrial Research Organisation | Endonucleases |
Non-Patent Citations (7)
Title |
---|
AMIRI KHALED M A ET AL: "Global conformation of a self-cleaving hammerhead RNA", BIOCHEMISTRY, vol. 33, no. 45, 1994, pages 13172 - 13177, XP002303024, ISSN: 0006-2960 * |
DENMAN ROBERT B ET AL: "Differential activity of trans-acting hammerhead ribozymes targeted to beta amyloid peptide precursor mRNA by altering the symmetry of helices I and III", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 323, no. 1, 1995, pages 71 - 78, XP002303023, ISSN: 0003-9861 * |
HENDRY PHILIP ET AL: "A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes", NUCLEIC ACIDS RESEARCH, vol. 23, no. 19, 1995, pages 3928 - 3936, XP002303026, ISSN: 0305-1048 * |
HENDRY PHILIP ET AL: "Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes", NUCLEIC ACIDS RESEARCH, vol. 24, no. 14, 15 July 1996 (1996-07-15), pages 2679 - 2684, XP002303027, ISSN: 0305-1048 * |
See also references of WO9737013A1 * |
TABLER M ET AL: "A THREE-NUCLEOTIDE HELIX I IS SUFFICIENT FOR FULL ACTIVITY OF A HAMMERHEAD ROBOZYME: ADVANTAGES OF AN ASYMMETRIC DESIGN", NUCLEIC ACIDS RESEARCH, vol. 22, no. 19, 1994, pages 3958 - 3965, XP002051226, ISSN: 0305-1048 * |
ZOUMADAKIS M ET AL: "Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.", NUCLEIC ACIDS RESEARCH, vol. 23, no. 7, 11 April 1995 (1995-04-11), pages 1192 - 1196, XP002303025, ISSN: 0305-1048 * |
Also Published As
Publication number | Publication date |
---|---|
CA2250857A1 (fr) | 1997-10-09 |
AU2145097A (en) | 1997-10-22 |
WO1997037013A1 (fr) | 1997-10-09 |
EP0902836A1 (fr) | 1999-03-24 |
JP2000509969A (ja) | 2000-08-08 |
AU721758B2 (en) | 2000-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0761680A3 (fr) | Composés de tétrazole ayant une activité inhibante d'enzyme convertissant l'Interleukine-1bêta | |
DE60023841D1 (de) | Verfahren zur herstellung alkylierter salicylamide | |
CA2273907A1 (fr) | Composition d'un agent de traitement de surface de materiau metallique et le procede de traitement | |
WO1999058555A3 (fr) | Promedicaments de propofol solubles dans l'eau | |
NZ594877A (en) | Nucleic acids and proteins from streptococcus groups A & B | |
CA2209048A1 (fr) | Compositions aqueuses de polymeres sylilates alkoxysilane alkoxy durcissable se conservant plus longtemps a l'etalage | |
EP1359150A3 (fr) | Procédé et intermediaires pour la préparation de 7-alkyltriazolopyrimidines fongicides | |
PT1053313E (pt) | Oligonucleotidos ''antisense'' optimizados complementares de sequencias de dna metiltransferase | |
WO2000073764A3 (fr) | Compositions et methodes pour l'utilisation therapeutique d'une sequence associee au gene atonal dans le traitement de la surdite, de l'osteoarthrite et d'une proliferation cellulaire anormale | |
GB9916405D0 (en) | Compounds for mass spectrometry | |
AU8243198A (en) | Remedies for solid tumor containing wilms' tumor gene (wt1) expression inhibitors | |
CA2015235A1 (fr) | Povidone-iode utilise comme agent prophylactique antimicrobien ophtalmique chez les nouveau-nes | |
BG104883A (en) | Human bmp-7 promoter and method for exploring bone-related substance by using the same | |
EP0902836A4 (fr) | Ribozymes asymetriques en forme de tete de marteau | |
WO1999024077A3 (fr) | Compositions et procedes d'administration ciblee de facteurs | |
WO1999066075A3 (fr) | Methode diagnostique basee sur la quantification d'adn extramitochondrial | |
WO1996021015A3 (fr) | Combinaison de vecteurs d'administration de genes | |
FR2739098B1 (fr) | Procede d'acylation d'un compose aromatique | |
AU2180501A (en) | Novel DNA polymerase inhibitors, mikanolide and dihydromikanolide | |
AP2000001937A0 (en) | Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway. | |
CA2135200A1 (fr) | Gene s d'un coronavirus canin et applications | |
IE45285L (en) | Polyribonucleotides. | |
ES2085767T3 (es) | Aumento de la actividad catalitica de las ribozimas por un oligonucleotido facilitador proximo. | |
AU7974791A (en) | Identification of novel drugs and reagents | |
AU2002211577A1 (en) | Protecting therapeutic compositions from host-mediated inactivation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981102 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE FR GB IT |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: GENE SHEARS PTY LIMITED |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041108 |
|
17Q | First examination report despatched |
Effective date: 20050126 |
|
17Q | First examination report despatched |
Effective date: 20050126 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071215 |