JP2000507828A - アルツハイマー病の診断および治療法 - Google Patents
アルツハイマー病の診断および治療法Info
- Publication number
- JP2000507828A JP2000507828A JP9535410A JP53541097A JP2000507828A JP 2000507828 A JP2000507828 A JP 2000507828A JP 9535410 A JP9535410 A JP 9535410A JP 53541097 A JP53541097 A JP 53541097A JP 2000507828 A JP2000507828 A JP 2000507828A
- Authority
- JP
- Japan
- Prior art keywords
- amyloid
- protein
- peptide
- growth factor
- nerve growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
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- General Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Toxicology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62576596A | 1996-03-29 | 1996-03-29 | |
| US08/625,765 | 1996-03-29 | ||
| PCT/US1997/004966 WO1997037228A1 (en) | 1996-03-29 | 1997-03-28 | Methods for diagnosing and treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000507828A true JP2000507828A (ja) | 2000-06-27 |
| JP2000507828A5 JP2000507828A5 (OSRAM) | 2004-11-25 |
Family
ID=24507498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9535410A Ceased JP2000507828A (ja) | 1996-03-29 | 1997-03-28 | アルツハイマー病の診断および治療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6242416B1 (OSRAM) |
| EP (1) | EP0890105B1 (OSRAM) |
| JP (1) | JP2000507828A (OSRAM) |
| AT (1) | ATE346303T1 (OSRAM) |
| AU (1) | AU719038B2 (OSRAM) |
| CA (1) | CA2250075C (OSRAM) |
| DE (1) | DE69736976T2 (OSRAM) |
| WO (1) | WO1997037228A1 (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016525095A (ja) * | 2013-07-09 | 2016-08-22 | ニューロ−バイオ リミテッドＮｅｕｒｏ−Ｂｉｏ Ｌｔｄ | 神経変性疾患 |
| JP2019178148A (ja) * | 2014-05-28 | 2019-10-17 | テクニスチェ ユニベルシタト ドレスデン | 免疫療法のための医薬の組合わせ |
| JP2022066234A (ja) * | 2017-03-06 | 2022-04-28 | リュー，ジュン | Ａβ誘導性損傷抑制又は軽減剤 |
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| US7196055B2 (en) * | 1994-08-31 | 2007-03-27 | Trustees Of Boston University | Inhibition of apoptosis in keratinocytes by a ligand of p75 nerve growth factor receptor |
| US6867179B1 (en) | 1994-08-31 | 2005-03-15 | Trustees Of Boston University | Methods of inducing hair growth and coloration |
| EP0890105B1 (en) * | 1996-03-29 | 2006-11-22 | The Trustees Of Boston University | Methods related to Alzheimer's disease for diagnosis, manufacture of medicaments and screening of substances and beta-amyloid related peptides |
| IL147970A0 (en) * | 1999-08-09 | 2002-09-12 | Tripep Ab | Pharmaceutical compositions containing tripeptides |
| US6258932B1 (en) * | 1999-08-09 | 2001-07-10 | Tripep Ab | Peptides that block viral infectivity and methods of use thereof |
| KR20020007432A (ko) * | 2000-07-13 | 2002-01-29 | 박현석 | 멜라노트랜스페린에 대한 단클론 항체를 유효성분으로포함하는 알츠하이머병의 진단시약 |
| US6593455B2 (en) * | 2001-08-24 | 2003-07-15 | Tripep Ab | Tripeptide amides that block viral infectivity and methods of use thereof |
| US6455670B1 (en) * | 2001-09-06 | 2002-09-24 | Tripep Ab | Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof |
| WO2003024995A1 (en) * | 2001-09-19 | 2003-03-27 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
| AUPS230702A0 (en) * | 2002-05-14 | 2002-06-13 | Walter And Eliza Hall Institute Of Medical Research, The | A method of treatment |
| US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
| HK1079984A1 (zh) * | 2003-02-21 | 2006-04-21 | Tripep Ab | 抑制hiv复制的甘氨酰胺衍生物 |
| US20070054848A1 (en) * | 2003-03-28 | 2007-03-08 | Masaya Tohyama | Composition and method for nerve regeneration |
| WO2004099237A1 (de) * | 2003-05-08 | 2004-11-18 | Pentapharm Ag | Tripeptide und deren derivate für die kosmetische verwendung zur verbesserung der hautstruktur |
| EP1718324A4 (en) * | 2003-06-11 | 2009-07-15 | Socratech L L C | A SOLUBLE PROTEIN RELATED TO THE LOW DENSITY LIPOPROTEIN RECEPTOR BINDS DIRECTLY TO THE ALZHEIMER BETA AMYLOID PEPTIDE |
| EP1500399A1 (en) * | 2003-07-24 | 2005-01-26 | Institut Pasteur | Active or passive immunization against proapoptotic neurotrophins for the treatment or prevention of neurodegenerative deseases |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| WO2006116400A2 (en) * | 2005-04-27 | 2006-11-02 | Massachusetts Institute Of Technology | Promoter engineering and genetic control |
| CA2667260A1 (en) * | 2006-10-23 | 2008-05-02 | National University Corporation Nagoya University | Intracerebral oxidation inhibitor and use thereof |
| MX2011005481A (es) | 2008-11-25 | 2011-08-17 | Biogen Idec Inc | Uso de antagonistas de receptor de muerte 6 (drg6) y de p75 para promover la supervivencia de células del sistema nervioso. |
| TW201034684A (en) * | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| US9458427B2 (en) * | 2009-08-07 | 2016-10-04 | Case Western Reserve University | IFNγR2 compositions and methods of inhibiting neuronal cell death |
| EP2498817A2 (en) * | 2009-11-12 | 2012-09-19 | F. Hoffmann-La Roche AG | A method of promoting dendritic spine density |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| JP5863663B2 (ja) | 2009-11-12 | 2016-02-16 | ファーマトロフィックス， インコーポレイテッド | ニューロトロフィン模倣化合物およびこれらの塩の結晶形態 |
| US9216217B2 (en) * | 2010-03-03 | 2015-12-22 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| AU2013205000B2 (en) * | 2010-03-03 | 2015-05-28 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| ES2628596T3 (es) | 2010-11-29 | 2017-08-03 | Akershus Universitetssykehus | Procedimientos y composiciones para monitorizar la actividad fagocítica |
| EP2764120B1 (en) * | 2011-10-05 | 2020-06-10 | Blanchette Rockefeller Neurosciences, Institute | Stimulus-elicited genomic profile markers of a neurodegenerative condition |
| US9534016B2 (en) * | 2011-11-28 | 2017-01-03 | Buck Institute For Research On Aging | Netrin loop peptide mimetics and uses thereof |
| JP6359160B2 (ja) * | 2017-07-25 | 2018-07-18 | 株式会社Ｍｃｂｉ | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| CN119661638B (zh) * | 2024-11-22 | 2025-07-18 | 象山县第一人民医院医疗健康集团(宁波市第四医院、宁波市第四医院医院管理研究所) | 一种修复神经损伤的多肽、制备方法及其应用 |
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| US5288641A (en) | 1984-06-04 | 1994-02-22 | Arch Development Corporation | Herpes Simplex virus as a vector |
| US4918405A (en) * | 1988-10-26 | 1990-04-17 | Hewlett-Packard Company | Signal generator utilizing a combined phase locked and frequency locked loop |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| US5618822A (en) * | 1990-05-23 | 1997-04-08 | Sanofi | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them |
| IL101661A (en) * | 1991-04-23 | 1998-02-08 | Regeneron Pharma | Method for detecting, identifying or measuring agents having neurotrophin activity |
| TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
| US5976816A (en) | 1993-05-03 | 1999-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Cell tests for alzheimer's disease |
| GB9402331D0 (en) * | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
| US5576209A (en) * | 1994-10-24 | 1996-11-19 | The Regents Of The University Of California | Method for increasing the resistance of neural cells to β-amyloid peptide toxicity |
| EP0890105B1 (en) * | 1996-03-29 | 2006-11-22 | The Trustees Of Boston University | Methods related to Alzheimer's disease for diagnosis, manufacture of medicaments and screening of substances and beta-amyloid related peptides |
-
1997
- 1997-03-28 EP EP97919932A patent/EP0890105B1/en not_active Expired - Lifetime
- 1997-03-28 DE DE69736976T patent/DE69736976T2/de not_active Expired - Fee Related
- 1997-03-28 AU AU24245/97A patent/AU719038B2/en not_active Ceased
- 1997-03-28 JP JP9535410A patent/JP2000507828A/ja not_active Ceased
- 1997-03-28 AT AT97919932T patent/ATE346303T1/de not_active IP Right Cessation
- 1997-03-28 WO PCT/US1997/004966 patent/WO1997037228A1/en not_active Ceased
- 1997-03-28 CA CA002250075A patent/CA2250075C/en not_active Expired - Fee Related
-
1998
- 1998-09-29 US US09/163,095 patent/US6242416B1/en not_active Expired - Fee Related
-
2001
- 2001-05-29 US US09/866,898 patent/US6696303B2/en not_active Expired - Fee Related
-
2004
- 2004-02-24 US US10/785,924 patent/US20040254110A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016525095A (ja) * | 2013-07-09 | 2016-08-22 | ニューロ−バイオ リミテッドＮｅｕｒｏ−Ｂｉｏ Ｌｔｄ | 神経変性疾患 |
| JP2019178148A (ja) * | 2014-05-28 | 2019-10-17 | テクニスチェ ユニベルシタト ドレスデン | 免疫療法のための医薬の組合わせ |
| JP2022066234A (ja) * | 2017-03-06 | 2022-04-28 | リュー，ジュン | Ａβ誘導性損傷抑制又は軽減剤 |
| JP7417217B2 (ja) | 2017-03-06 | 2024-01-18 | リュー，ジュン | Ａβ誘導性損傷抑制又は軽減剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE346303T1 (de) | 2006-12-15 |
| US20040254110A1 (en) | 2004-12-16 |
| EP0890105B1 (en) | 2006-11-22 |
| US6242416B1 (en) | 2001-06-05 |
| CA2250075C (en) | 2008-06-10 |
| US6696303B2 (en) | 2004-02-24 |
| US20020051988A1 (en) | 2002-05-02 |
| AU719038B2 (en) | 2000-05-04 |
| AU2424597A (en) | 1997-10-22 |
| CA2250075A1 (en) | 1997-10-09 |
| EP0890105A1 (en) | 1999-01-13 |
| DE69736976D1 (de) | 2007-01-04 |
| DE69736976T2 (de) | 2007-10-18 |
| WO1997037228A1 (en) | 1997-10-09 |
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