JP2000502714A - ヒアルロン酸の型の有効量の経口投与 - Google Patents
ヒアルロン酸の型の有効量の経口投与Info
- Publication number
- JP2000502714A JP2000502714A JP9524694A JP52469497A JP2000502714A JP 2000502714 A JP2000502714 A JP 2000502714A JP 9524694 A JP9524694 A JP 9524694A JP 52469497 A JP52469497 A JP 52469497A JP 2000502714 A JP2000502714 A JP 2000502714A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronan
- human body
- body weight
- oral administration
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 108700034465 rat GOPC Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229940019127 toradol Drugs 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- -1 tracheal dilators Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002167044A CA2167044C (en) | 1996-01-11 | 1996-01-11 | Oral administration of effective amounts of forms of hyaluronic acid |
| CA2,193,921 | 1996-12-24 | ||
| CA 2193921 CA2193921A1 (en) | 1996-12-24 | 1996-12-24 | Oral administration of effective amounts of forms of hyaluronic acid according to various standards |
| CA2,167,044 | 1996-12-24 | ||
| PCT/CA1997/000007 WO1997025051A1 (en) | 1996-01-11 | 1997-01-08 | Oral administration of effective amounts of forms of hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000502714A true JP2000502714A (ja) | 2000-03-07 |
| JP2000502714A5 JP2000502714A5 (it) | 2004-11-11 |
Family
ID=25678296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9524694A Ceased JP2000502714A (ja) | 1996-01-11 | 1997-01-08 | ヒアルロン酸の型の有効量の経口投与 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6537978B1 (it) |
| EP (1) | EP0873128B1 (it) |
| JP (1) | JP2000502714A (it) |
| AT (1) | ATE282418T1 (it) |
| AU (1) | AU732344B2 (it) |
| DE (1) | DE69731610T2 (it) |
| ES (1) | ES2231854T3 (it) |
| HU (1) | HUP9902285A3 (it) |
| IL (2) | IL124977A0 (it) |
| MX (1) | MX9805588A (it) |
| WO (1) | WO1997025051A1 (it) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002161040A (ja) * | 2000-11-27 | 2002-06-04 | Taisho Pharmaceut Co Ltd | 鉄イオン配合内服液剤 |
| JP2005213210A (ja) * | 2004-01-30 | 2005-08-11 | Seikagaku Kogyo Co Ltd | ヒアルロナン結合性タンパク質とヒアルロナンとの複合体の形成促進剤 |
| JP2011042632A (ja) * | 2009-08-24 | 2011-03-03 | Q P Corp | 経口用ドライアイ改善剤、ならびに前記経口用ドライアイ改善剤を含む食品組成物および医薬品組成物 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| US6875753B1 (en) | 1996-03-14 | 2005-04-05 | The Governors Of The University Of Alberta | Methods for cell mobilization using in vivo treatment with hyaluronan (HA) |
| CN1116044C (zh) * | 1998-06-24 | 2003-07-30 | 凌沛学 | 含有透明质酸钠的防粘连颗粒剂和粉雾剂及其制作方法 |
| DE60034667T2 (de) * | 1999-02-01 | 2008-03-13 | Dermal Research Laboratories, Inc. | Pharmazeutische zusammensetzung aus komplexen kohlenhydraten und deren anwendung |
| AU2005227417C1 (en) * | 2000-07-31 | 2008-10-16 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
| US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
| EP1369119B1 (en) * | 2001-03-15 | 2008-12-17 | Seikagaku Corporation | Il-12 expression controlling agents |
| US7635489B2 (en) | 2001-05-18 | 2009-12-22 | Leneau Holdings, Llc | Ingestion of hyaluronic acid for improved joint health |
| US6806259B2 (en) * | 2001-12-21 | 2004-10-19 | Soft Gel Technologies, Inc. | Hyaluronic Acid in soft gel form |
| EP1476471A4 (en) * | 2002-01-23 | 2005-03-16 | Inst Of Nutraceutical Res Pty | FUNCTIONAL FOODS FOR THE TREATMENT, PROTECTION AND RESTORATION OF CONNECTIVE TISSUES |
| DE10246340A1 (de) * | 2002-10-04 | 2004-04-29 | Wohlrab, David, Dr. | Kombinationspräparat aus Hyaluronsäure und mindestens einem Lokalanästhetikum und dessen Verwendung |
| US7060691B2 (en) * | 2002-10-10 | 2006-06-13 | Giuseppe Petrigni | Pharmaceutical colloidal preparation useful in the treatment of respiratory diseases |
| US7956180B2 (en) * | 2004-05-27 | 2011-06-07 | Novozymes A/S | Dried and agglomerated hyaluronic acid product |
| US7405871B2 (en) * | 2005-02-08 | 2008-07-29 | Intel Corporation | Efficient EUV collector designs |
| US9492381B1 (en) | 2005-11-10 | 2016-11-15 | Reyn Pharma, Llc | Method of administering hyaluronan formulation for preventing and ameliorating osteoarthritis |
| US8598144B1 (en) | 2005-11-10 | 2013-12-03 | Reyn Pharma, Llc | Method of administering hyaluronan formulation for the amelioration of osteoarthritis |
| US20080051367A1 (en) * | 2006-08-23 | 2008-02-28 | Huan-Ching Hsu | Hyaluronan used in improvement of anti-oxidation and proliferation in chondrocytes |
| WO2008060466A2 (en) * | 2006-11-10 | 2008-05-22 | Cytori Therapeutics, Inc. | Individualized dosage determination for local administration of therapeutic particles |
| US8163716B1 (en) | 2008-06-30 | 2012-04-24 | Smith James D | Method of administering hyaluronan formulation for the amelioration of osteophytes |
| US8178511B1 (en) | 2008-07-02 | 2012-05-15 | Smith James D | Method of administering hyaluronan formulation for the amelioration of osteopenia |
| US8462765B2 (en) * | 2008-08-20 | 2013-06-11 | Qualcomm Incorporated | Method and apparatus to perform ranging operations for wireless stations |
| WO2012154738A1 (en) | 2011-05-09 | 2012-11-15 | The Cleveland Clinic Foundation | Composition and method to improve intestinal health |
| US20160184364A1 (en) * | 2013-08-14 | 2016-06-30 | Stempeutics Research Pvt. Ltd. | Management of osteoarthritis using pooled allogeneic mesenchymal stem cells |
| DE202017107170U1 (de) | 2017-11-27 | 2018-02-16 | Proceanis Gmbh | Hyaluronanhaltige orale Zusammensetzung |
| CN112972490B (zh) * | 2021-03-04 | 2022-02-18 | 中国人民解放军军事科学院军事医学研究院 | 透明质酸在用于制备预防或治疗铁死亡相关疾病的药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0240098A3 (en) * | 1986-04-04 | 1989-05-10 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Oligo and polysaccharides for the treatment of diseases caused by retroviruses |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| WO1994007505A1 (en) * | 1991-07-03 | 1994-04-14 | Norpharmco Inc. | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US5834444A (en) | 1991-07-03 | 1998-11-10 | Hyal Pharmaceutical Corporation | Hyaluronic acid and salts thereof inhibit arterial restenosis |
| FR2691066B1 (fr) | 1992-05-15 | 1995-06-09 | Sanofi Elf | Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies. |
-
1997
- 1997-01-08 EP EP97900058A patent/EP0873128B1/en not_active Expired - Lifetime
- 1997-01-08 DE DE69731610T patent/DE69731610T2/de not_active Expired - Lifetime
- 1997-01-08 ES ES97900058T patent/ES2231854T3/es not_active Expired - Lifetime
- 1997-01-08 IL IL12497797A patent/IL124977A0/xx active IP Right Grant
- 1997-01-08 AT AT97900058T patent/ATE282418T1/de not_active IP Right Cessation
- 1997-01-08 US US09/101,286 patent/US6537978B1/en not_active Expired - Lifetime
- 1997-01-08 HU HU9902285A patent/HUP9902285A3/hu unknown
- 1997-01-08 WO PCT/CA1997/000007 patent/WO1997025051A1/en active IP Right Grant
- 1997-01-08 AU AU11876/97A patent/AU732344B2/en not_active Ceased
- 1997-01-08 JP JP9524694A patent/JP2000502714A/ja not_active Ceased
-
1998
- 1998-06-17 IL IL124977A patent/IL124977A/en not_active IP Right Cessation
- 1998-07-10 MX MX9805588A patent/MX9805588A/es active IP Right Grant
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002161040A (ja) * | 2000-11-27 | 2002-06-04 | Taisho Pharmaceut Co Ltd | 鉄イオン配合内服液剤 |
| JP2005213210A (ja) * | 2004-01-30 | 2005-08-11 | Seikagaku Kogyo Co Ltd | ヒアルロナン結合性タンパク質とヒアルロナンとの複合体の形成促進剤 |
| JP2011042632A (ja) * | 2009-08-24 | 2011-03-03 | Q P Corp | 経口用ドライアイ改善剤、ならびに前記経口用ドライアイ改善剤を含む食品組成物および医薬品組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX9805588A (es) | 1998-10-31 |
| EP0873128A1 (en) | 1998-10-28 |
| EP0873128B1 (en) | 2004-11-17 |
| DE69731610T2 (de) | 2005-12-01 |
| HUP9902285A2 (hu) | 1999-11-29 |
| AU1187697A (en) | 1997-08-01 |
| AU732344B2 (en) | 2001-04-12 |
| IL124977A0 (en) | 1999-01-26 |
| IL124977A (en) | 2006-10-31 |
| WO1997025051A1 (en) | 1997-07-17 |
| DE69731610D1 (de) | 2004-12-23 |
| ES2231854T3 (es) | 2005-05-16 |
| HUP9902285A3 (en) | 2001-07-30 |
| ATE282418T1 (de) | 2004-12-15 |
| US6537978B1 (en) | 2003-03-25 |
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