JP2000297025A - Skin leaching cosmetic - Google Patents
Skin leaching cosmeticInfo
- Publication number
- JP2000297025A JP2000297025A JP11103765A JP10376599A JP2000297025A JP 2000297025 A JP2000297025 A JP 2000297025A JP 11103765 A JP11103765 A JP 11103765A JP 10376599 A JP10376599 A JP 10376599A JP 2000297025 A JP2000297025 A JP 2000297025A
- Authority
- JP
- Japan
- Prior art keywords
- cosmetic
- skin
- component
- wheat germ
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は化粧品及び医薬部外
品に関する。The present invention relates to cosmetics and quasi-drugs.
【０００２】[0002]
【従来の技術】従来より、肌のしみやそばかす等の予防
や治療を目的とする美白化粧料には、Ｌ−アスコルビン
酸及びその誘導体、ハイドロキノン誘導体、コウジ酸の
ピロン類、プラセンターエキス等の胎盤抽出物が配合さ
れている。2. Description of the Related Art Conventionally, whitening cosmetics for the purpose of preventing or treating skin spots and freckles include L-ascorbic acid and its derivatives, hydroquinone derivatives, pyrones of kojic acid, placenta extract and the like. A placenta extract is included.
【０００３】これらは、メラニン生成の抑制、生成した
メラニンの淡色漂白作用等の効果を有し、美白効果を有
する物質として広く知られている。しかし、これらの物
質を単独で使用した場合、例えばＬ−アスコルビン酸及
びその誘導体は保存安定性が十分ではなくその効果が十
分に発揮されなかったり、またハイドロキノン誘導体は
安全性に問題があるなど十分なものではなかった。[0003] These substances have effects such as suppression of melanin production and light-color bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, when these substances are used alone, for example, L-ascorbic acid and its derivatives have insufficient storage stability and their effects are not sufficiently exerted, and hydroquinone derivatives have insufficient safety, for example, they have a problem in safety. It was not something.
【０００４】Ｎ−メチル−Ｌ−セリンは、低分子である
ため、皮膚に塗布した場合、表皮層及び基底膜を通過
し、繊維芽細胞の存在する真皮層（結合組織）にまで到
達することができ、細胞によるヒアルロン酸産生能を促
進させることによって、皮膚の老化防止あるいはヒアル
ロン酸の異常分解にともなう疾病の治療に利用でき、し
かも人体に対する影響の少ない、安全なヒアルロン酸産
生促進剤として、化粧料、医薬の組成物等として提案さ
れている（特開平６−１８９７８０号広報）。しかし、
チロシナーゼ活性阻害効果やメラニン生成抑制効果とい
った美白効果が期待できるかは定かではない。Since N-methyl-L-serine is a small molecule, when applied to the skin, it passes through the epidermal layer and basement membrane and reaches the dermal layer (connective tissue) where fibroblasts are present. By promoting the ability of cells to produce hyaluronic acid, it can be used to prevent aging of the skin or treat diseases associated with abnormal degradation of hyaluronic acid, and has little effect on the human body. It has been proposed as a cosmetic or pharmaceutical composition (JP-A-6-189780). But,
It is not clear whether a whitening effect such as a tyrosinase activity inhibitory effect or a melanin production inhibitory effect can be expected.
【０００５】[0005]
【発明が解決しようとする課題】本発明者らは、上記の
欠点を解消すべく鋭意検討を行った結果、後記の美白化
粧料が紫外線障害によるメラニン産生を抑制するととも
にメラニン色素の排泄を促し、相乗的に美白効果を発現
することを見出し、本発明を完成した。The inventors of the present invention have conducted intensive studies to solve the above-mentioned drawbacks. As a result, the whitening cosmetics described below inhibit melanin production due to ultraviolet damage and promote excretion of melanin pigments. The present inventors have found that the whitening effect is synergistically expressed, and completed the present invention.
【０００６】即ち、本発明の目的は、紫外線障害による
メラニン産生を抑制するとともにメラニン色素の排泄を
促し、特に優れた美白効果を発現する美白化粧料を提供
することにある。[0006] That is, an object of the present invention is to provide a whitening cosmetic which suppresses melanin production due to ultraviolet damage and promotes excretion of melanin pigment, thereby exhibiting a particularly excellent whitening effect.
【０００７】[0007]
【課題を解決するための手段】上記の目的を達成する本
発明は、Ｎ−メチル−Ｌ−セリンと小麦胚芽から得られ
る抽出液を含有することを特徴とする美白化粧料であ
る。The present invention, which achieves the above object, is a whitening cosmetic comprising N-methyl-L-serine and an extract obtained from wheat germ.
【０００８】[0008]
【発明の実施の形態】本発明の実施の形態は、美白化粧
料である。以下、本発明の構成について詳述する。BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention is a whitening cosmetic. Hereinafter, the configuration of the present invention will be described in detail.
【０００９】本発明に用いられるＮ−メチル−Ｌ−セリ
ンは、公知の化合物であり、その製造方法は特に限定さ
れるものではなく、通常用いられている方法でよい。配
合量は化粧品全量中、０．００１〜３重量％が好まし
い。N-methyl-L-serine used in the present invention is a known compound, and its production method is not particularly limited, and may be a commonly used method. The compounding amount is preferably 0.001 to 3% by weight based on the total amount of the cosmetic.
【００１０】本発明に用いられる小麦胚芽から得られる
抽出物は、例えば水にて抽出し、これを濃縮した後ろ過
して得ることが出来る。但しこの製造方法に限られるも
のではない。配合量は、化粧品全量中、固形分に換算し
て０．０００１〜１０．０重量％が好ましい。The extract obtained from wheat germ used in the present invention can be obtained by, for example, extracting with water, concentrating the extract, and filtering. However, it is not limited to this manufacturing method. The compounding amount is preferably 0.0001 to 10.0% by weight in terms of solid content in the total amount of the cosmetic.
【００１１】本発明の美白化粧料には、上記の原料の他
に、色素、香料、防腐剤、界面活性剤、顔料、抗酸化
剤、保湿剤、紫外線吸収剤などを、本発明の目的を達成
する範囲内で適宜配合することができる。本発明の美白
化粧料の剤型としては、クリ−ム、乳液、化粧水、パッ
クなど化粧料に一般に使用されている剤型であればいず
れでもよい。The whitening cosmetic of the present invention contains, in addition to the above-mentioned raw materials, dyes, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers and the like. It can be appropriately blended within the range achieved. As the dosage form of the whitening cosmetic of the present invention, any dosage form generally used for cosmetics such as creams, emulsions, lotions, packs and the like may be used.
【００１２】また、本発明の美白化粧料は、例えば化粧
水の場合、各成分を混合溶解するなど、通常の方法によ
り製造することができる。The whitening cosmetic of the present invention can be produced by a usual method such as mixing and dissolving each component in the case of a lotion.
【００１３】[0013]
【実施例】以下、実施例および比較例に基づいて本発明
を詳述する。尚、実施例に示す％とは重量％である。実
施例に記載の皮膚色明度回復試験法、官能試験（美白効
果）は下記の通りである。また、実施例で用いた小麦胚
芽から得られる抽出物の調製方法は以下の通りである
が、本発明の範囲はこれらのみに限定されるものではな
い。The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. The skin color lightness recovery test method and sensory test (whitening effect) described in the examples are as follows. The method for preparing an extract obtained from wheat germ used in the examples is as follows, but the scope of the present invention is not limited to these.
【００１４】（小麦胚芽から得られる抽出物の調整
法）：小麦胚芽５０ｇを水１Ｌに浸漬して１昼夜攪拌し
ながら放置する。得られた液を濃縮した後ろ過した。こ
れにより、小麦胚芽抽出物１５．７ｇ（固形物換算：
０．１６ｇ）を得た。(Preparation method of extract obtained from wheat germ): 50 g of wheat germ is immersed in 1 L of water and left with stirring all day and night. The obtained liquid was concentrated and then filtered. Thereby, 15.7 g of wheat germ extract (solid conversion:
0.16 g).
【００１５】（１）皮膚色明度回復試験法：被験者２０
名の背部皮膚にＵＶ−Ｂ領域の紫外線を最小紅斑量の２
倍照射し、試料塗布部位と非塗布部位を設定して各々の
皮膚の基準明度（Ｖ０値，Ｖ０’値）を測定した。引き
つづいて塗布部位には試料を１日２回ずつ１５週間連続
塗布した後、３，６，９，１２，１５週間後の塗布部位
及び非塗布部位の皮膚の明度（Ｖｎ値，Ｖｎ’値）を測
定し、表１の判断基準にしたがって皮膚色の回復を評価
した。尚、皮膚の明度（マンセル表色系Ｖ値）は高速分
光色彩計で測定して得られたＸ，Ｙ，Ｚ値より算出し
た。また評価は被験者２０名について、３週間後の評価
点の平均値で示した。(1) Skin lightness recovery test: 20 subjects
UV-B ultraviolet rays on the back skin of the name
Irradiation was performed twice, the sample application site and the non-application site were set, and the reference brightness (V0 value, V0 ′ value) of each skin was measured. Subsequently, the sample was applied to the application site twice a day for 15 weeks continuously, and then the lightness (Vn value, Vn 'value) of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks ) Was measured, and the recovery of skin color was evaluated according to the criteria shown in Table 1. The lightness (V value of Munsell color system) of the skin was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation was shown as an average value of the evaluation points after 3 weeks for 20 subjects.
【００１６】[0016]
【表１】 [Table 1]
【００１７】（２）官能試験：被験者２０名が試料を１
０日間連用した後の試料の特性を評価した。評価は、美
白効果のアンケート項目に対し、「美白効果が感じられ
た」と回答した人数で示した。(2) Sensory test: 20 subjects took one sample
The characteristics of the sample after continuous use for 0 days were evaluated. The evaluation was shown by the number of respondents who answered that "the whitening effect was felt" to the questionnaire item of the whitening effect.
【００１８】実施例１〜３，比較例１〜３ Ｎ−メチル−Ｌ−セリンと小麦胚芽から得られた抽出物
を表２の組成に従って配合し、下記の調製方法によって
スキンクリームを調製した。各々について前記の試験を
実施し、その結果を表３に示した。Examples 1 to 3 and Comparative Examples 1 to 3 N-methyl-L-serine and an extract obtained from wheat germ were blended according to the composition shown in Table 2, and a skin cream was prepared by the following preparation method. The above test was performed for each, and the results are shown in Table 3.
【００１９】[0019]
【表２】 [Table 2]
【００２０】[0020]
【表３】 [Table 3]
【００２１】調製方法：（Ａ）（Ｂ）を７０℃にて均一
に溶解し、（Ａ）を攪拌しながら（Ｂ）を（Ａ）に注入
して乳化分散した後、攪拌しながら温度３０℃まで冷却
して調製する。Preparation method: (A) and (B) are uniformly dissolved at 70 ° C., while (A) is stirred and (B) is poured into (A) to emulsify and disperse. Prepare by cooling to ° C.
【００２２】特性：実施例１〜３のスキンクリームは、
前記諸試験において良好な結果を示した。一方、比較例
１〜３のスキンクリームは、十分な効果が認められず、
本発明のスキンクリームに比べて劣っていた。Characteristics: The skin creams of Examples 1 to 3
Good results were shown in the above tests. On the other hand, the skin creams of Comparative Examples 1 to 3 did not show a sufficient effect,
It was inferior to the skin cream of the present invention.
【００２３】実施例４（スキンローション） 表４の組成に従ってスキンローションを下記の調製方法
によって調製した。Example 4 (Skin lotion) A skin lotion was prepared according to the composition shown in Table 4 by the following preparation method.
【００２４】[0024]
【表４】 [Table 4]
【００２５】調製方法：各成分を混合溶解してスキンロ
ーションを調製した。Preparation method: Each component was mixed and dissolved to prepare a skin lotion.
【００２６】特性：実施例４のスキンローションは、前
記諸試験において良好な結果を示した。Properties: The skin lotion of Example 4 showed good results in the above tests.
【００２７】実施例５（デイエッセンス） 表５の組成によりデイエッセンス（日中用美容液）を下
記の調整方法によって調製した。Example 5 (Day Essence) According to the composition shown in Table 5, a day essence (daytime serum) was prepared by the following adjusting method.
【００２８】[0028]
【表５】 [Table 5]
【００２９】調整方法：（Ａ）（Ｂ）を７０℃にて各成
分をそれぞれ混合溶解し、（Ｂ）を（Ａ）に加えて混合
攪拌し、３０℃まで冷却して調製した。Preparation method: (A) and (B) were mixed and dissolved at 70 ° C. for each component, (B) was added to (A), mixed, stirred and cooled to 30 ° C.
【００３０】特性：実施例５のデイエッセンスは、前記
諸試験において良好な結果を示した。Characteristics: The de-essence of Example 5 showed good results in the above tests.
【００３１】[0031]
【発明の効果】以上記載のごとく、本発明が特に美白効
果に優れた美白化粧料を提供することは明らかである。As described above, it is apparent that the present invention provides a whitening cosmetic which is particularly excellent in whitening effect.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 7/00 Ａ６１Ｋ 7/00 Ｎ (72)発明者 堀越 俊雄 神奈川県小田原市寿町５丁目３番28号 鐘 紡株式会社基礎科学研究所内 Ｆターム(参考） 4C083 AA082 AA111 AA112 AB242 AC012 AC022 AC102 AC122 AC242 AC422 AC442 AC472 AC482 AC581 AC582 AD092 AD352 CC02 CC04 CC05 DD23 DD27 DD31 EE16 FF01──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N (72) Inventor Toshio Horikoshi 5-28, Kotobukicho, Odawara-shi, Kanagawa No.Kanebo Co., Ltd. Basic Science Laboratory F-term (reference) 4C083 AA082 AA111 AA112 AB242 AC012 AC022 AC102 AC122 AC242 AC422 AC442 AC472 AC482 AC581 AC582 AD092 AD352 CC02 CC04 CC05 DD23 DD27 DD31 EE16 FF01
Claims (1)
得られる抽出液を含有することを特徴とする美白化粧
料。1. A whitening cosmetic comprising N-methyl-L-serine and an extract obtained from wheat germ.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10376599A JP4063446B2 (en) | 1999-04-12 | 1999-04-12 | Whitening cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10376599A JP4063446B2 (en) | 1999-04-12 | 1999-04-12 | Whitening cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000297025A true JP2000297025A (en) | 2000-10-24 |
| JP4063446B2 JP4063446B2 (en) | 2008-03-19 |
Family
ID=14362593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10376599A Expired - Fee Related JP4063446B2 (en) | 1999-04-12 | 1999-04-12 | Whitening cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4063446B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006328048A (en) * | 2005-04-28 | 2006-12-07 | Kanebo Cosmetics Inc | Skin cosmetic |
| JP2013001655A (en) * | 2011-06-14 | 2013-01-07 | Pola Chemical Industries Inc | Skin care preparation |
| JP2013001656A (en) * | 2011-06-14 | 2013-01-07 | Pola Chemical Industries Inc | Skin care preparation |
-
1999
- 1999-04-12 JP JP10376599A patent/JP4063446B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006328048A (en) * | 2005-04-28 | 2006-12-07 | Kanebo Cosmetics Inc | Skin cosmetic |
| JP2013001655A (en) * | 2011-06-14 | 2013-01-07 | Pola Chemical Industries Inc | Skin care preparation |
| JP2013001656A (en) * | 2011-06-14 | 2013-01-07 | Pola Chemical Industries Inc | Skin care preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4063446B2 (en) | 2008-03-19 |
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