JP2000103719A - Preparation for external use for skin and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain preparation for external use for skin capable of drawing out an excellent effect, having excellent safety to skin by combining a citron with aloe and leaves of Cryptomeria japonica. SOLUTION: A citron preserved in sugar is filtered to give a citron extract, which is held in a container, to which aloe and leaves of Cryptomeria japonica are added. The mixture is boiled until it becomes soft, stirred and finely cut. Then the mixture is filtered to give a filtrate, which is fermented and aged to give a preparation for external use for skin comprising the extracted solution as a component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a method for improving rough skin,
The present invention relates to a highly safe skin external preparation which has an effect of moisturizing the skin, an effect of treating wounds such as cuts and abrasions, and an effect of treating dermatitis and fever.

[0002]

2. Description of the Related Art Conventionally, yuzu has been used as a medicine for preventing rough skin, sweating, and antipyretic. Suginina has been used as a remedy for liver disease, kidney disease, diabetes, and hypertension. Aloe has been used for cuts, burns, rough skin, eczema, and rash. It has been used for a long time as an effective drug for the treatment of skin and the like, and has been used alone as a medicinal ingredient in an external preparation for skin and the like.

[0003]

By the way, in various external preparations for skin, two or more kinds of active ingredients are often used in combination.
It is difficult to predict and may be contraindicated, and it is important to examine the interaction. There is a demand for the development of an external preparation for skin that is excellent in safety and efficacy by blending two or more kinds of medicinal ingredients.

[0004]

Means for Solving the Problems The present inventors have demonstrated a synergistic effect by combining citron, aloe, and cedar, which are effective even when used alone, as a medicinal ingredient of a folk medicine or a skin external preparation. As a result of intensive studies, it is possible to obtain excellent safety, improve skin roughness, moisturize the skin, treat wounds such as cuts and abrasions, and treat dermatitis and hot flashes. The present invention has been completed.

That is, according to the present invention, a citron extract obtained by filtering candied citron is put in a container, aloe and cedar are added, and the mixture is boiled until it becomes soft, followed by stirring and shredding. It is intended to provide a skin external preparation characterized by comprising, as a component, an extract obtained by fermenting and aging a filtrate obtained by filtration.

[0006] The present invention firstly, as a raw material, citron, aloe,
Use cedar. The citron is Citrus j
unos Sied. All of the above, including flesh, pericarp, fruit juice and seeds, are shredded and used. Next, aloe is Aloe arborscen, a member of the genus Aloe.
s Mill. ), Aloe vera
N. L. Bur. ), Cape Aloe Ferox (A
loe feroxMill. ), Cape Aloe africana MiL
L. ), Socotra aloe (Aloe perryi B)
ak. ), Nightless Castle (Aloe nobilis Ha)
k. And aloe vera are particularly preferable, and fresh leaves or dried powders are used without removing the thorns and epidermis. Next, the cedar is the horsetail family (E
quisetum arvense L. Use fresh or dried vegetative stems of (1).

[0007] Yuzu, aloe and cedar are washed with water and completely drained before use.

[0008] Except for citron, aloe, and cedar, which are raw materials of the present invention, only white sugar is added, so there is no problem in safety.

[0009] Extracts of citrus fruits such as citron, fruits and pericarp and seeds may exhibit an antibacterial and antiseptic effect at a low concentration (JP-A-08-295621, JP-A-02-2602).
47106, JP-A-04-346933, JP-A-04-346
279517), so that long-term storage is possible without adding a synthetic preservative.

The external preparation for skin of the present invention includes cosmetics, pharmaceuticals,
It refers to those applied to the outer skin, such as quasi-drugs, and the dosage form can take a wide range of forms such as an aqueous solution type, a solubilizing type, an emulsifying type, a powder type, an oil liquid type, a gel type, and an ointment type.

[0011] In addition to the essential components, the skin external preparation of the present invention usually contains other components used in skin external preparations such as cosmetics and quasi-drugs, for example, squalane, liquid paraffin, α-
Olefin oligomers, paraffin wax, ceresin, microcrystalline wax and other hydrocarbons, corn oil, avocado oil, persic oil, olive oil, tallow, mink oil and other animal and vegetable oils, isopropyl myristate,
Liquid and solid synthetic esters such as cetyl octanoate, isopropyl myristate, and cetyl palmitate, jojoba oil,
Natural animal and plant waxes such as carnauba wax, candelilla wax, mokuro and beeswax, glyceryl stearate, sorbitan stearate, polyoxyethylene sorbitan monooleate, polyoxyethylene glyceryl tristearate, polyoxyethylene lauryl ether, deca trioleate Surfactants such as glyceryl, sucrose monolaurate, polyoxyethylene hydrogenated castor oil, silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane or derivatives thereof, fluorine resins such as perfluoropolyether, nicotinamide, benzyl nicotinate , Γ-oryzanol, allantoin, glycyrrhizic acid, glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymo , Inositol, saponins,
Various drugs such as pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid, cepharanthin, placenta extract, Ryewood, Clara, Kouhone, Orange, Sage, Yarrow, Zeniaoi, Senkyo,
Assembly, thyme, touki, spruce, birch, loofah,
Organic solvents such as horse chestnuts, saxifrage, arnica, lily, mugwort, peonies, gardenia, sawara, ethanol,
Alcohols such as isopropanol, glycerin, 1.3-butylene glycol, propylene glycol, diglycerin, carboxyvinyl polymers, carrageenan, xanthan gum, sodium carboxymethylcellulose, water-soluble polymers such as sodium hyaluronate, collagen, elastin, silk, lactoferrin and other proteins And its hydrolysates, titanium dioxide, zinc oxide, talc,
Mica, nylon powder, polyalkyl acrylate,
Powders such as alumina and iron oxide, UV absorbers, vitamins,
Amino acids and their derivatives, lecithin, coloring agents, flavors,
Purified water or the like can be optionally added as needed.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The embodiments of the present invention will be described in detail with reference to examples, but the present invention is not limited thereto.

[0013]

Example 1 6 kg of citron, which was shredded in a glass container,
After immersing in 900 g of white sugar and aging at room temperature for about one and a half years, the mixture was squeezed and filtered through a filter cloth to obtain a citron extract.

[0014]

Example 2 Citrus extract 2 obtained in Example 1 in a ceramic container
000CC, Aloe fresh leaf 100g, Raw cedar 200g
, Boil for 30 minutes, turn off the heat when the aloe and cedar are softened, lower the temperature, put it in a mixer as it is, stir and shred and mix. And a filtrate is obtained. The filtrate was fermented for about three months to obtain an external preparation for skin containing an extract as an ingredient.

[0015]

[Experimental example] The external preparation for skin obtained in Reference Example 2 was applied to the skin of a patient to improve skin roughness, moisturize the skin, treat wounds such as cuts and abrasions, and treat dermatitis and rash. Was determined.

[0016]

EXPERIMENTAL EXAMPLE 1 Table 1 shows a comparative example with a commercially available cosmetic which has an effect of improving rough skin and moisturizing the skin.

[0017]

[Table 1]

[0018]

EXPERIMENTAL EXAMPLE 2 Table 2 shows a comparative example with a commercially available wound remedy which is effective for treating wounds such as cuts and abrasions.

[0019]

[Table 2]

[0020]

[Experimental Example 3] Table 3 shows a comparative example with a commercially available skin external preparation having an effect of treating dermatitis and rash.

[0021]

[Table 3]

The denominator in the table is the number of patients to be studied, and the numerator is
The number of patients found to be effective.

From the above results, the external preparation for skin of the present invention
It has excellent effects of improving skin roughness and moisturizing the skin, treating wounds such as cuts and abrasions, and treating dermatitis and hot flashes.

[0024]

The present invention has an excellent effect due to the synergistic effect of citron, aloe and cedar, is highly safe to the skin, is extremely practical as a simple external preparation for skin, and its production method is also extremely simple. Therefore, no large-scale equipment is required, which is economically advantageous.

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] November 2, 1998 (1998.11.
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claim 1

[Correction method] Change

[Correction contents]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0005

[Correction method] Change

[Correction contents]

[0005] The present invention, pressure candied citron
The extract obtained by squeezing and filtering was put into a container, aloe and cedar were added, and the mixture was boiled until it became soft, followed by stirring and shredding, and then the filtrate was fermented and matured. An external preparation for skin characterized by comprising an extract as a component. ────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] June 18, 1999 (1999.6.1
8)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0011

[Correction method] Change

[Correction contents]

The external preparation for skin of the present invention contains, in addition to the essential components, auxiliary pharmaceutical or health-useful components such as various vitamins as necessary, natural fragrances and the like, as long as the effects of the present invention are not impaired. Can be added and blended.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 17/00 A61K 31/00 617 43/00 643C A61K 35/78 35/78 W

Claims (2)

[Claims] 1. A citron extract obtained by filtering candied citron is put into a container, aloe and cedar are added, and the mixture is boiled until it becomes soft, followed by stirring and shredding, followed by filtration. A method for producing a skin external preparation, wherein the obtained extract is fermented and aged. 2. An external preparation for skin, comprising as an ingredient an extract extracted by the method according to claim 1.