JP2000098310A - Solution for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a soln. having an antiseptic effect which gives antifouling property and hydrophilicity to lens. SOLUTION: This soln. contains 0.001 to 5 w/v % polymer as a component A having a (meth)acrylic acid deriv. having phosphorylcholine analogue groups on the side chain as a structural component, 10-6 to 1 w/v % polyhexamethylenebiguanide as a component B, 0.01 to 1.5 w/v % buffer as a component C, 0.01 to 1.5 w/v % inorg. chloride as a component D, 0 to 5 w/v % surfactant as a component E, and 0 to 1 w/v % chelating agent as a component F.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a solution for contact lenses. More specifically, contact lens cleaning,
The present invention relates to a contact lens solution for preserving, rinsing, disinfecting, etc. and at the same time imparting antifouling property and hydrophilicity to a contact lens.

[0002]

2. Description of the Related Art Contact lenses generally used at present are roughly classified into non-hydrated contact lenses (including hard contact lenses and soft contact lenses) and hydrous contact lenses (including soft contact lenses). Is done. Non-hydrous contact lenses are more stable than hydrous contact lenses and are easier to maintain.For example, non-hydrous contact lenses are mainly made of methyl methacrylate, silyl methacrylate or fluorine methacrylate. A high oxygen permeable hard contact lens or the like as a component is used. However, when a non-hydrous hard contact lens is worn, the surface is hydrophobic, so that a foreign-body sensation is felt. In particular, since the high oxygen permeable hard contact lens has a high hydrophobicity, it has a drawback that the feeling of wearing is lowered and dirt of proteins and lipids easily adheres. As a method for solving these drawbacks, a plasma treatment for hydrophilizing a hydrophobic surface and a method of performing a chemical treatment with an acidic or basic substance are known. However, it is difficult to maintain hydrophilicity by these methods, and there are also problems such as denaturation of the lens due to the treatment and trouble in the treatment step. As another method, for example, Japanese Patent Publication No. 48-37910 proposes a method of immersing a contact lens in a solution containing a water-soluble polymer such as polyvinyl alcohol, hydroxyethylcellulose, and polyvinylpyrrolidone. U.S. Pat. No. 4,421,748 discloses the use of polyvinyl alcohol or soluble cellulose with artificial tears composed of a physiological saline solution. However, all of these methods have no effect when the lenses are washed with a commercially available cleaning preservation solution for contact lenses, so that there is a limit to the improvement of the hydrophilicity of contact lenses, the durability thereof, the feeling of wearing, and the like. . Further, it is not effective for washing and preventing adhesion of dirt such as proteins and lipids. Thus, development of a solution that imparts hydrophilicity and antifouling property to a non-hydrated contact lens is desired.

On the other hand, a water-containing contact lens is a hydrogel made of polyhydroxyethyl methacrylate or another water-soluble polymer, and methacrylic acid is added to the composition to improve the water content. . The higher the moisture content, the better the feeling of wearing. However, since it is a hydrogel, it is easily attacked by bacteria, and maintenance such as boiling disinfection, hydrogen peroxide disinfection, and chemical disinfection is essential. Methacrylic acid used for improving the water content also has a problem of causing protein stains. Therefore, development of a solution having a disinfecting effect and an antifouling property for a hydrous contact lens is desired.
In order to solve the above problems, Japanese Patent Application Laid-Open Nos. 5-107512 and 7-166154 propose a method using a solution containing a polymer having a phosphorylcholine group. However, these methods can suppress the adhesion of dirt and impart hydrophilicity, but cannot disinfect contact lenses or clean dirt. Also,
Solutions for contact lenses using polyhexamethylene biguanide are disclosed in French Patent FR2517208 and US Pat. No. 4,758,595. These patents describe the disinfecting, antiseptic, and cleaning effects, but describe the effects of combination with a polymer having a specific phosphorylcholine-like group that imparts antifouling and hydrophilic properties to contact lenses. It has not been. Therefore, development of a contact lens solution having a function of imparting antifouling property and hydrophilicity to a contact lens in addition to functions such as washing, storage, rinsing, and disinfection necessary as a contact lens solution is desired. Is the current situation.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to wash, store, rinse, and disinfect a contact lens by a simple immersion treatment, and at the same time, impart antifouling properties and hydrophilicity to the contact lens. An object of the present invention is to provide a contact lens solution.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above problems, and as a result, have found that a polymer having a specific phosphorylcholine-like group and polyhexamethylene biguanide, a buffer, an inorganic chloride, The inventors have found that the problem can be solved by a combination of an activator and a chelating agent, and completed the present invention. That is, the present invention provides the following (1) to (3)
(1) 0.001 to 5 w / v% of a polymer containing, as a component, a (meth) acrylic acid derivative having a phosphorylylcholine-like group in a side chain, and polyhexamethylene as a B component Biguanide 10-6 to 1 w / v
% C component, buffer 0.01-1.5 w / v% D component, inorganic chloride 0.01-1.5 w / v% E component, surfactant 0-5 w / v% F component And a chelating agent of 0 to 1 w / v%. (2) The component of the polymer of the component A is represented by the following general formula [1]:

[0006]

Embedded image

Wherein R ¹ , R ² and R ³ represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, which may be the same or different, and R ⁴ is an alkylene group having 2 to ⁴ carbon atoms. It is. R ⁵ is a hydrogen atom or a methyl group, and R ⁶ is-
(GO) A group represented by mG- (where G is a group having 2 to 2 carbon atoms)
In the divalent hydrocarbon group of 12, m is an average addition mole number of the oxyalkylene group, and is 0 to 10. ). ｝
The solution for contact lenses, wherein the solution is a (meth) acrylic acid derivative represented by the formula: wherein the polymer has a weight average molecular weight of 1,000 to 5,000,000. (3) The component of the polymer of the component A is represented by the following general formula [2]:

[0008]

Embedded image

(Wherein, R ⁵ is a hydrogen atom or a methyl group.) The above-mentioned contact lens which is a polymer of a monomer composition containing 2- (meth) acryloyloxyethyl phosphorylcholine represented by the formula: For solution.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION In the contact lens solution of the present invention, the polymer used is a polymer having a phosphorylcholine-like group in the side chain (abbreviated as PC polymer 1). It is a polymer containing (meth) acrylate monomer (hereinafter abbreviated as PC monomer 2) as a constituent. PC monomer 2 is represented by the following general formula [1].

[0011]

Embedded image

In the formula, R ¹ , R ² and R ³ represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, which may be the same or different, and R ⁴ has 2 to ⁴ carbon atoms. It is an alkylene group. Also, R ⁵ is a hydrogen atom or a methyl group, R ⁶
Is a group represented by-(GO) mG- (where G is a divalent hydrocarbon group having 2 to 12 carbon atoms, m is an average addition mole number of the oxyalkylene group, and is 0 to 10) ). Examples of the PC monomer 2 constituting the polymer of the present invention include:
Specifically, for example, 2- (meth) acryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate, 3- (meth) acryloyloxypropyl-2 ′
-(Trimethylammonio) ethyl phosphate, 4-
(Meth) acryloyloxybutyl-2 '-(trimethylammonio) ethyl phosphate, 2- (meth) acryloyloxyethyl-2'-(triethylammonio) ethyl phosphate, 2- (meth) acryloyloxyethyl-2'- (Tributylammonio) ethyl phosphate, 2- (meth) acryloyloxyethoxyethyl-2 ′-(trimethylammonio) ethylphosphate, 2- (meth) acryloyloxydiethoxyethyl-2 ′-(trimethylammonio) ethylphosphate , 2- (meth) acryloyloxyethyl-2'-
(2 "-trihydroxyethylammonio) ethyl phosphate and the like. Among these, from the viewpoint of availability and the like, more preferably, 2- (meth) acryloyloxyethyl-2 ′-(trimethylammonio) is used. 2- (meth) acryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate is also referred to as 2-methacryloyloxyethyl phosphorylcholine, and has the following general formula [2].

[0013]

Embedded image

(Wherein, R ⁵ is a hydrogen atom or a methyl group). These PC monomers 2 can impart water solubility, antifouling property, hydrophilicity and the like to the obtained polymer.

The polymer of the component A in the present invention is a polymer obtained by polymerizing the PC monomer 2 alone or a polymer obtained by copolymerizing another vinyl monomer which can be further copolymerized with the PC monomer. is there. Specific examples of the other copolymerizable vinyl monomers include, for example, styrene monomers such as styrene, methylstyrene, and chlorostyrene; vinyl ester monomers such as vinyl acetate and vinyl propionate; and vinyl ether monomers such as ethyl vinyl ether. Monomer: methyl (meth) acrylate, ethyl (meth)
Alkyl (meth) acrylate monomers such as acrylate, n-butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, 2-ethylhexyl (meth) acrylate; (meth) acrylic acid, (meth) acrylic acid Sodium; 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycerol mono (meth)
Hydroxyl-containing (meth) acrylates such as acrylates; polyalkylene glycol mono (meth) acrylates such as polyethylene glycol mono (meth) acrylate and polypropylene glycol mono (meth) acrylate;
Nitrogen-containing monomers such as (meth) acrylamide, N-vinylpyrrolidone, and acrylonitrile; and halogen-substituted hydrocarbon-based or hydrocarbon-based monomers such as vinyl chloride, vinylidene chloride, ethylene, propylene, and isobutylene. One of these other copolymerizable vinyl monomers may be used alone, or two or more thereof may be used in combination. More preferably, an n-alkyl (meth) acrylate and a hydroxyl group-containing (meth) acrylate are mentioned.

When the PC monomer 2 of the present invention is copolymerized with another copolymerizable vinyl monomer, the amount of the charged PC monomer 2 is preferably from 10 to less than 100% by weight, more preferably from 40 to 100% by weight. 1 to 90% by weight, more preferably 2 to 60% by weight of the other copolymerizable vinyl monomer,
% By weight. If the charged amount is less than 10% by weight, the effect of imparting hydrophilicity to the copolymer cannot be exhibited. The component A in the present invention can impart antifouling properties, hydrophilicity, and the like to a contact lens in a contact lens solution, and also acts as a viscosity modifier of the solution.

The PC polymer 1 of the component A is prepared by mixing each monomer component used in the present invention in the presence of a polymerization initiator.
It can be adjusted by a known method such as radical polymerization, for example, bulk polymerization, suspension polymerization, emulsion polymerization, or solution polymerization in an atmosphere replaced with an inert gas such as nitrogen, carbon dioxide, or helium. At this time, the polymerization initiator to be used is not particularly limited as long as it is a normal radical polymerization initiator. For example, benzoyl peroxide, lauroyl peroxide, diisopropyl peroxydicarbonate, t
-Butylperoxy-2-ethylhexanoate, t-
Examples thereof include butyl peroxypivalate, t-butyl peroxydiisobutyrate, azobisisobutyronitrile, azobisisodimethylvaleronitrile, persulfate, and persulfate-bisulfite.

The amount of the polymerization initiator charged is determined based on the amount of the monomer component 10
0.0001 to 10 parts by weight, preferably 0.01 to 5 parts by weight, per 0 parts by weight. The polymerization temperature is preferably from 20 to 100 ° C, and the polymerization time is from 0.5 to 72 ° C.
Time is desirable. The molecular weight of the obtained polymer varies depending on the polymerization temperature, the amount of the polymerization initiator and the amount of the polymerization degree modifier used, but is 1,000 to 5,000 in weight average molecular weight.
000 is preferred, and especially 1 from the viewpoint of solubility in a contact lens solution, viscosity of the solution and adhesion to a contact lens.
It is preferably from 000 to 1,000,000.

The concentration of the component A used in the solution of the present invention is 0.001 to 5 w / v%, more preferably 0.05 to 5 w / v%.
It is in the range of 3% w / v. The concentration is 0.001 w / v
%, The effect of the polymer of the component A is insufficient.
On the other hand, if it exceeds 3% w / v, the viscosity is undesirably high.

The component B used in the present invention is polyhexamethylene biguanide (hereinafter abbreviated as PHMB).
The following general formula [3]

[0021]

Embedded image

## EQU2 ## Here, n is a number indicating a repeating unit in [], and is 2 to 500, preferably,
n is 4-18. Examples of the water-soluble salt of PHMB include hydrochloride, borate, acetate, gluconate, sulfonate, tartrate, and citrate. More preferably, PH in which n is 4 to 14 from the viewpoint of availability.
MB hydrochloride. As a commercial product, for example,
Proxel IB, trade name, manufactured by Zeneca K.K. Polyhexamethylene biguanide functions as a disinfectant and its concentration is 10 ^-6 w /
v% to 1 w / v%. The concentration is 10 ⁻⁶ w /
If it is less than v%, the disinfecting ability is insufficient, and if it exceeds 1 w / v%, there is a problem in irritation to eyes and skin and safety to corneal cells, which is not preferable.

The C component used in the present invention is a buffer and has a function of controlling pH. Specific examples of the buffer include hydrochloric acid, acetic acid, citric acid, sodium hydroxide, boric acid, borates (borax and the like), phosphates (monosodium phosphate, disodium phosphate, monopotassium phosphate, Preferable examples include dipotassium phosphate), citrate salts (such as sodium citrate), tris (hydroxymethyl) aminomethane, and mixtures thereof. The concentration of the buffer described above is 0.01 to 1.5 w / v%,
More preferably, it is in the range of 0.05 to 1 w / v%. When the concentration is less than 0.01 w / v%, the buffer capacity is low and the pH is low.
Is difficult to control, and if it exceeds 1.5 w / v%, the solubility of other components is impaired, which is not preferable.

The D component used in the present invention is an inorganic chloride and has a function of controlling the degree of penetration. Specific examples of the inorganic chloride preferably include sodium chloride (NaCl), potassium chloride, magnesium chloride, and mixtures thereof. The inorganic chloride has a concentration of 0.01 to 1.5 w / v%, more preferably 0.1 to 1.5 w / v%.
It is in the range of 0.5 to 1 w / v%. The concentration is 0.01w
If it is less than / v% or more than 1.5 w / v%, it is not preferable because the shape of the soft contact lens changes and the eye is irritated.

The E component used in the present invention is a surfactant and has a cleaning function. Examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and the like.
Among them, it is particularly preferable to use a nonionic surfactant having low eye irritation. As nonionic surfactants,
Preferable examples include block copolymers of polyethylene glycol and polypropylene glycol.
The concentration of the above-mentioned surfactant ranges from 0 to 5 w / v%, preferably from 0 to 2 w / v%. The concentration is 5 w / v
%, It is not preferable because eye irritation becomes high. Even when the concentration is 0 w / v%, the component A imparts antifouling property to the contact lens, so that the component is less contaminated, so that high detergency is not necessarily required.

The F component used in the present invention is a chelating agent and has a function of suppressing calcium deposition on a contact lens. Preferred examples of the chelating agent include citric acid, 2Na or 4Na salt of ethylenediaminetetraacetic acid (abbreviated as EDTA), cyclohexadiaminetetraacetic acid, alkali metal salts thereof, and mixtures thereof. The concentration of the above-mentioned chelating agent is in the range of 0-5 w / v%, preferably 0-2 w / v%. If the concentration exceeds 5 w / v%, eye irritation will increase, which is not preferable. Even when the concentration is 0 w / v%, the addition of a chelating agent is not always necessary because the component A prevents contamination of the contact lens and prevents deposition of calcium ions.

The contact lens solution of the present invention is a solution in which each of the above components is dissolved in a solvent. As the solvent,
Any solvent that can dissolve the polymer of the component A, has little effect on the contact lens, and can achieve the object by a simple operation such as a method of contacting the contact lens with the contact lens by immersion, washing, etc. with water. Often,
Specifically, for example, water such as purified water can be preferably mentioned. Further, a solvent such as ethanol, isopropanol, ethylene glycol, propylene glycol, and glycerin having a property of being miscible with water at an arbitrary ratio can be used alone. Further, a mixed solution of the above-mentioned solvent and water can be used as the solvent.

In the method for producing a contact lens solution of the present invention, the components A, B and C, and if necessary, the components D, E and F are further added and dissolved in a solvent in a usual manner. Heating may be used for dissolution, or an ordinary stirring machine,
For example, a stirrer or a homomixer may be used.

As a method of using the contact lens solution of the present invention, the contact lens is immersed in the contact lens solution at room temperature for 1 minute to 24 hours, and then rinsed with water, physiological saline, or the contact lens solution. And the like. It is effective for both hard contact lenses and soft contact lenses. For non-hydrated contact lenses, it is preferable to rinse with water, physiological saline, or a solution for contact lenses. Then, it is preferable to rinse with a saline solution or a contact lens solution.

The contact lens solution of the present invention may contain, in addition to the above essential components, a water-soluble polymer compound for adjusting the viscosity. This is not particularly limited as long as it does not impair the properties of the essential components of the present invention.For example, polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, ethylene oxide And a block copolymer of propylene oxide and a copolymer of maleic anhydride and methyl vinyl ether.

[0031]

According to the contact lens solution of the present invention, the contact lens can be washed, stored, rinsed and disinfected by immersing the contact lens in the solution, and at the same time, the contact lens has an antifouling property and a hydrophilic property. Can be provided. In addition, since the adhesion and deposition of stains such as proteins and lipids can be suppressed, the denaturation of the contact lens can be prevented, the feeling of wearing can be improved by imparting hydrophilicity, and the safety to eyes can be improved. As described above, the present invention is effective for hard contact lenses and soft contact lenses.

[0032]

The present invention will be described in more detail with reference to Examples and Comparative Examples. Synthesis Example 1 As PC monomer 2 described in Table 1, 25 parts by weight of 2-methacryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate (abbreviated as MPC) and n-butyl methacrylate (vinyl monomer) n
-BMA) and 0.01 part by weight of azobisisobutyronitrile (AIBN) as a radical polymerization initiator were dissolved in 450 parts by weight of methanol, placed in a glass reaction tube for polymerization, and purged with nitrogen. Polymerization was performed in a tank at 50 ° C. for 72 hours. After completion of the polymerization, reprecipitation purification was performed using ethanol as a good solvent and diethyl ether as a poor solvent, followed by drying by heating to obtain Polymer 1.

Synthesis Examples 2 and 3 Polymerization was carried out in the same manner as in Synthesis Example 1 with the composition shown in Table 1 to obtain Polymers 2 and 3. In the table, LMA indicates lauryl methacrylate.

[Preparation of RGP; Preparation of High Oxygen Permeability Hard Contact Lens (referred to as RGP) Test Piece] Tris (trimethylsiloxy) silylpropyl methacrylate 40 g, trifluoroethyl methacrylate 30 g, methyl methacrylate 10 g, triethylene glycol dimethacrylate Fifteen
g, 5 g of methacrylic acid and 0.2 g of azobisisobutyronitrile were injected into a test tube, and sealed after replacement with nitrogen.
The starting monomer in the test tube was cured by heating at 24 ° C. for 24 hours to obtain a colorless and transparent polymer. The obtained polymer is cut and polished by a usual processing method to obtain a predetermined shape (diameter: 1).
An RGP test piece having a thickness of 4 mm and a thickness of 1 mm) was prepared.

Preparation of SCL; [Preparation of test piece for hydrous soft contact lens (referred to as SCL)] 2-hydroxyethyl methacrylate 99 g, ethylene glycol dimethacrylate 0.4
g and azobisisobutyronitrile were injected into a test tube, sealed after nitrogen replacement, and the raw material monomer in the test tube was heated and cured at 50 ° C. for 24 hours to obtain a colorless and transparent polymer. . The obtained polymer is cut and polished by a usual processing method to obtain a predetermined shape (diameter: 14 mm, thickness 1).
mm disk) was prepared.

[Preparation of Bacterial Solution] Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were inoculated into 5 ml of soybean casein digest broth medium and cultured at 37 ° C. with shaking. After the cells were collected by centrifugation at 5000 rpm for 10 minutes, the resulting precipitate of cells was collected at 300,000 per ml.
Each of the cells was diluted with physiological saline.

Example 1 Each component shown in Table 2 was dissolved in purified water at each mixing ratio to prepare a contact lens solution. The following tests were performed using the obtained aqueous solutions. When the RGP test piece was used, tests for contact angle, detergency, antifouling property, and disinfecting effect were performed, and the test results are shown in Table 3. When an SCL test piece was used, tests for detergency, antifouling property, disinfecting effect, and shape change were performed, and the test results are shown in Table 2.

(1) Contact Angle: The contact lens test piece was immersed and stored in the contact lens solution for 2 hours, and then rinsed with the contact lens solution. The contact angle of the test piece was measured by a water droplet method using a contact angle measuring device (manufactured by Kyowa Kagaku Co., Ltd.).

(2) Detergency: Detergency was evaluated for proteins and lipids by the following method. (A) Evaluation of protein detergency; albumin 0.39
The contact lens test piece was treated at 60 ° C. for 2 hours in a physiological saline solution containing 0.1% by weight of γ-globulin, 0.12% by weight of lysozyme, and 0.1% by weight of mucin to contaminate the test piece. . The test piece was immersed in the aqueous solution for 2 hours, rubbed with the aqueous solution, and then separated from the test piece with a 1% aqueous solution of sodium dodecyl sulfate (manufactured by Wako Pure Chemical Industries, Ltd.). The amount of protein was measured using a micro BCA kit (manufactured by Pierce), and the washing ratio (%) of the protein stain to the stain before washing was calculated. Detergency (%) for protein stain = {(mass of detached protein after washing) / mass of adsorbed protein before washing} × 100 (b) Evaluation of detergency of lipids: 0.8% by weight of triolein, 0.1% by weight of cholesterol , Egg yolk lecithin 0.1
The contact lens test piece was treated at 37 ° C. for 12 hours in physiological saline in which weight% was emulsified to contaminate the test piece. The test piece was immersed in the aqueous solution for 2 hours, rubbed with the aqueous solution, extracted with a chloroform / methanol solution (2: 1), and then the solvent was evaporated. The amount of the remaining lipid was measured by the phosphoric acid-vanillin method, and the washing rate (%) of the soil before washing with respect to the lipid soil was calculated. Washing rate (%) for lipid soil = {(amount of detached lipid after washing) / amount of adsorbed lipid before washing} x 100

(3) Antifouling property of protein: A contact lens test piece immersed in the above aqueous solution was subjected to physiological saline containing 0.39% by weight of albumin, 0.16% by weight of γ-globulin, and 0.12% by weight of lysozyme. After being immersed at 37 ° C. for 24 hours, the protein was separated from the test piece by washing with a physiological saline, and the amount of protein in the solution was measured using a micro BCA kit (manufactured by Pierce). Protein antifouling property (μg) = adhering protein content (4) Effect of disinfection 2 ml of the aqueous solution and 1 ml of the bacterial solution were mixed and mixed at room temperature.
After standing for minutes, the number of remaining viable bacteria was measured. The viable cell count was determined by diluting the solution after the reaction to an appropriate concentration with physiological saline, spraying 0.1 ml of the diluted solution on a soybean casein digest broth medium, and keeping it at 30 ° C for 24 hours, followed by appearance. The number of colonies obtained was measured.

(5) Shape change 24 contact lens test pieces were previously placed in physiological saline.
Soaked for hours. Next, the test piece was immersed and stored in the contact lens solution for 24 hours, and then rinsed with the contact lens solution. The dimensions of the test piece before and after storage in the solution were measured.

Examples 2 to 7 In the same manner as in Example 1, the components shown in Tables 2 and 3 were blended to prepare treatment solutions for contact lenses. A test was performed on these solutions in the same manner as in Example 1. The results are shown in Tables 2 and 3.

Comparative Examples 1 to 3 The treatment solutions for contact lenses were prepared according to the formulations shown in Table 3,
The same evaluation as in Example 1 was performed. Table 3 shows the results.

[0044]

[Table 1]

[0045]

[Table 2]

[0046]

[Table 3]

The following can be understood from the results of the examples and comparative examples. Comparative Example 1 has a high contact angle with the RGP test piece, and is poor in detergency and stain resistance. In Comparative Example 2, there was no disinfection performance in the SCL test piece. In Comparative Example 3, there was no disinfection performance in the SCL test piece, and further, the test piece was deformed. From this,
It can be seen that each component alone does not have a sufficient effect as a treatment solution for contact lenses. On the other hand, in each of the examples, a remarkable effect is seen in all of the decrease in the contact angle (hydrophilicity), the detergency and the antifouling property as compared with the comparative examples.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Ryota Ando 2-26-2 Kasuga, Tsukuba, Ibaraki Prefecture (72) Inventor Kazuhiko Ishihara 3-16-37, Josuihoncho, Kodaira-shi, Tokyo (72) Inventor Nakabayashi Nobuo 5-6-20 Koganbara, Matsudo-shi, Chiba F-term (reference) 2H006 DA08 4C058 AA09 BB07 JJ07 JJ08

Claims (3)

[Claims] (1) 0.001 to 5 w / v% of a polymer containing a (meth) acrylic acid derivative having a phosphorylcholine-like group in a side chain as a component A, and polyhexamethylene biguanide 10 as a B component. ^{-6 to 1} w / v
As a% C component, as a buffer 0.01-1.5 w / v% D component, as an inorganic chloride 0.01-1.5 w / v% E component, as a surfactant 0-5 w / v% F component A solution for contact lenses, comprising 0 to 1 w / v% of a chelating agent. 2. The constituent component of the polymer of the component A is represented by the following general formula [1]: 中 wherein R ¹ , R ² and R ³ represent a hydrogen atom or a carbon atom
8 represents an alkyl group, which may be the same or different, and R ⁴ is an alkylene group having 2 to ⁴ carbon atoms. Also,
R ⁵ is a hydrogen atom or a methyl group, R ⁶ is - (GO) mG-
(Where G is a divalent hydrocarbon group having 2 to 12 carbon atoms, and m is the average number of moles of the oxyalkylene group added, and is 0 to 10). The solution for contact lenses according to claim 1, which is a (meth) acrylic acid derivative represented by｝, and wherein the polymer has a weight average molecular weight of 1,000 to 5,000,000. [3] The component of the polymer of the component A is a compound represented by the following general formula [2]: (Wherein, R ⁵ is a hydrogen atom or a methyl group.)
The solution for contact lenses according to claim 1 or 2, which is 2- (meth) acryloyloxyethyl phosphorylcholine represented by the formula: