JP2000239696A - Treating solution for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a treating solution which has a good balance among compounding ingredients, is stable for a long term and highly safe for eyes, and can efficiently clean dirt, such as protein or lipid, attached to a contact lens by compounding a nonionic or amphoteric surfactant, a hydrolase, a polyhydric alcohol, and a boron compound. SOLUTION: This solution contains (A) 0.05-2 wt.% nonionic or amphoteric surfactant, (B) 10-10-0.008 wt.% hydrolase, (C) 5-30 wt.% polyhydric alcohol, and (D) 0.1-2 wt.% boron compound. Further incorporation of (E) 0.001-5 wt.% at least one water-soluble polymer selected from the group consisting of polymers having groups represented by the formula (wherein R1 to R3 are each H, 1-8C alkyl or 1-8C hydroxyalkyl; and R4 is 2-4C alkylene) on the side chains, polyvinyl alcohol, polyvinylpyrrolidone, polysaccharides, and polysaccharide derivatives into the solution further enhances the performance of the solution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a treatment solution for contact lenses. More specifically, the present invention relates to a contact lens treatment solution suitable for, for example, cleaning dirt attached to a contact lens, and at the same time imparting antifouling properties and hydrophilicity.

[0002]

2. Description of the Related Art Contact lenses conventionally used can be divided into non-hydrous contact lenses and hydrous contact lenses. Non-hydrous contact lenses include hard contact lenses and soft contact lenses, and hydrous contact lenses. Soft contact lenses are known as the sexual contact lenses. Non-hydrous contact lenses are more stable in material and easier to maintain than hydrous contact lenses. For example, those using methyl methacrylate as a main component, and recently, high oxygen permeable hard contact lenses mainly containing silyl methacrylate or fluorine methacrylate whose influence on the eyes has been reduced are used.

However, a hard contact lens has a hydrophobic surface, so that a foreign object is felt when worn. In particular, high oxygen permeable hard contact lenses are highly hydrophobic,
There is a drawback that dirt of proteins and lipids tends to adhere as well as a feeling of wearing, and therefore, a treatment solution for contact lenses which has an effect of enhancing hydrophilicity has been demanded. In order to efficiently remove dirt from contact lenses, a method of adding an enzyme to a contact lens cleaning solution has been widely used. Generally, when the enzyme is dissolved in water, its stability is significantly reduced, but glycerin, propylene glycol,
It is known that the stability of the enzyme is improved by adding a polyhydric alcohol such as sorbitol.
No. 47810, JP-A-1-180515, JP-A-6-95043, JP-A-8-271841, and the like. However, for example, JP-A-1-180515, JP-A-4-243215, JP-A-4-370
No. 197 discloses that polyhydric alcohol contains 50% by weight.
Although the above is included, if the contact lens is immersed directly in these solutions, the physical properties of the lenses will be affected.Therefore, it is necessary to dilute the solution with another solution such as purified water immediately before use, which is convenient. There was a problem with sex.

As a method for solving the problems of detergency and enzyme stability, it is conceivable to increase the amount of enzyme. However, enzymes are originally capable of exhibiting sufficient performance with only a small amount if they are in an optimal state.If more enzymes are used than necessary, allergic reactions are likely to occur when they come into contact with the enzymes themselves or their degradation products, There is a possibility that various bacteria may be easily propagated by using the enzyme decomposition product as a nutrient source. Compositions are also known in which additional surfactants are added to increase detergency. For example, JP-A-4-51015 discloses a liquid composition for contact lenses containing a proteolytic enzyme, a polyhydric alcohol, an alkali metal salt, and a surfactant. However, when the enzyme is added in an amount of 0.01% by weight or more as described in this publication, the skin may be irritated when touching a finger or the like as described above due to the large amount of the enzyme. is there. In addition, there are drawbacks such as poor storage stability depending on the type of surfactant. From these problems, there has been a demand for a contact lens treatment solution having a low enzyme concentration, high detergency, and good stability and other physical properties of the solution and having a balance in all aspects.

[0005]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a contact lens having an appropriate enzyme concentration, high detergency, good long-term stability of a solution and other physical properties, and a balance in all aspects. To provide a processing solution. Another object of the present invention is to provide a contact lens processing method that can use a contact lens processing solution without diluting and remove dirt attached to the contact lens by a simple immersion process.

[0006]

Means for Solving the Problems In view of the above problems, the present inventors have conducted intensive studies, and as a result, selected a specific surfactant and further added a compounding concentration of a hydrolase, a polyhydric alcohol, and a boric acid compound. The present inventors have found that the problem can be solved by examining the balance of the factors, and completed the present invention. That is, the present invention is as follows (1) to (7). (1) 0.05 to 2% by weight of a nonionic or amphoteric surfactant as the A component, 10 ^{-10 to} 0.008% by weight of the hydrolase as the B component, and a polyhydric alcohol as the C component A treatment solution for a contact lens, comprising 5 to 30% by weight and 0.1 to 2% by weight of a boron compound as a D component. (2) As the E component, the following general formula [I]

[0007]

Embedded image

(Wherein R ¹ , R ² and R ³ represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, which may be the same or different, and R ⁴ is a carbon atom) Two
4 represents an alkylene group. Or a polymer having at least one water-soluble polymer selected from polyvinyl alcohol, polyvinylpyrrolidone, or a polysaccharide, or a polysaccharide derivative. The treatment solution for a contact lens according to (1), further comprising:

The polymer having a group represented by the general formula [I] described in (3) or (2) in the side chain is represented by the following general formula [II]

[0010]

Embedded image

Wherein R ¹ , R ² and R ^{3 each} have 1 carbon atom
-8 alkyl groups or hydroxyalkyl groups having 1-8 carbon atoms. R ⁴ is -CH ₂ CH ₂ -, or -CH ₂ CH ₂ CH ₂ - is either. R5 ^is- (C
HR ⁷⁾ _m -, or ^{_{- (CH 2 CHR 7 O)}} n -CH 2 CH
A group represented by any of R ⁷ — (where R ⁷ represents a hydrogen atom or a methyl group; _m represents an integer of 2 to 18; _n represents an integer of 1 to 16). . R ⁶ is a hydrogen atom or a methyl group. A polymer obtained by polymerizing the phosphorylcholine group-containing (meth) acrylate monomer represented by｝ alone, or the phosphorylcholine group-containing (meth) acrylate monomer represented by the general formula [II] and the general formula [II] The contact lens treatment according to (2), which is a polymer obtained by copolymerizing a phosphorylcholine group-containing (meth) acrylate monomer represented by the formula (1) with another copolymerizable vinyl monomer. solution.

(4) The hydrolase of component B according to (1) is characterized in that it is at least one selected from the group consisting of proteolytic enzymes, lipolytic enzymes and glycolytic enzymes ( The treatment solution for a contact lens according to 1) or 2).

(5) The polyhydric alcohol of component C according to (1) is at least one selected from glycerin, propylene glycol and sorbitol (1) or (2). The treatment solution for contact lenses according to 1.

(6) The contact lens treating solution according to (1) or (2), wherein the boron compound as the component D according to (1) is boric acid.

(7) The contact lens treatment solution according to (1) to (6), wherein the treatment solution is used without dilution, and the contact lens is immersed in the solution for treatment. That is all for the processing method.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The surfactant of the component A used in the contact lens treatment solution of the present invention is a tear component such as protein and lipid adhered to the contact lens, or stains on the contact lens by fingers or cosmetics. It is blended for the purpose of removing. In the treatment solution for a contact lens of the present invention, a non-ionic surfactant or an amphoteric surfactant is used as the A component, and the specific composition of the present invention and
By adding in a specific concentration range, the detergency can be increased without impairing the activity of the enzyme and the stability of the solution, no precipitation occurs, and there is little irritation to the skin.

As the nonionic surfactant, there is generally known as a nonionic surfactant, which is available and can be added to the contact lens treatment solution of the present invention. Specifically, for example, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, sorbitan monoalkylate, polyoxyethylene sorbitan monoalkylate, glycerol monoalkylate, fatty acid diethanolamide, polyoxyethylene alkyl Amines, polyoxyethylene fatty acid amides,
Examples thereof include di (polyoxyethylene) alkylamine and polyoxyethylene polyoxypropylene block copolymer. Further, as the amphoteric surfactant, it is generally known as an amphoteric surfactant, is available, refers to all that can be blended in the contact lens treatment solution of the present invention, specifically, for example, dimethyl Examples thereof include alkyl betaine, alkyl glycine, alkyl alanine, alkyl amide betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, and the like. In the treatment liquid for a contact lens of the present invention, either a nonionic surfactant or an amphoteric surfactant may be used alone as the component A, or a mixture of two or more may be used. However, the content of the surfactant of the component A is in the range of 0.05 to 2% by weight, preferably 0.2 to 1.5% by weight based on the total amount of the contact lens processing solution. If the content of the component A is less than 0.05% by weight, the washing ability is insufficient, which is not preferable. If the content exceeds 2% by weight, not only the stability of the enzyme is impaired, but also the eye is irritated with great safety. It is not preferable because there is a problem in terms of sex.

As the hydrolase of the B component used in the contact lens treatment solution of the present invention, any hydrolase which does not affect the physical properties of the contact lens can be used without departing from the object of the present invention. Preferably, in order to decompose and remove strong dirt that cannot be completely removed with a surfactant, glycoproteins such as mucin, proteins such as lysozyme, and hydrophobic compounds such as lipids are preferred. It is preferable to use a substance which has a function of decomposing a kind of dirt component derived from tear fluid and easily removing dirt on the contact lens. As such a hydrolase, for example, a proteolytic enzyme, a lipolytic enzyme, a sugar chain degrading enzyme and the like can be used. The proteolytic enzyme used in the present invention may be any as long as it is commonly used as a proteolytic enzyme.
(Nagase Seikagaku Corporation), "Clear Lens Pro" (Novo Nordisk Bio-Industry), "Alkaline Protease GL-440" (Kyowa Enzyme), etc. And animal and plant-derived proteolytic enzymes such as trypsin, chymotrypsin, elastase, and papain.

The lipolytic enzyme used in the present invention may be any lipolytic enzyme that is commonly used as a lipolytic enzyme. From the viewpoint of availability and the like, for example, "Clear lens lipo" ( Novo Nordisk Bioindustry), phospholipase A, phospholipase B, phospholipase C, phospholipase D, cholesterol esterase, and other lipolytic enzymes are preferably used. The sugar chain degrading enzymes used in the present invention include:
Any type may be used as long as it is normally used as a glycolytic enzyme, but from the viewpoint of availability and the like, for example, α
-Amylase, endoglycosidase D, endo-β-
Glycosidases such as galactosidase, β-galactosidase, cellulase and dextranase are used.
In the present invention, a complex of a hydrolase such as pancreatin may be used.

In the treatment solution for contact lenses of the present invention, one of the hydrolases used in the present invention may be used alone as the B component, or two or more thereof may be used in combination. However, the content ratio of the hydrolase of the component B is 10% of the total amount of the contact lens treatment solution.
It is preferably from ^-10 % to 0.008% by weight, more preferably from 10 ^-6 % to 0.005% by weight. When the content ratio of the component B is less than 10 ^-10 % by weight, the cleaning ability is insufficient, so that it is not preferable.
If it exceeds 08% by weight, irritation to eyes and skin will increase,
In addition, there is a case where there is a problem in terms of safety such as a case where an allergic reaction is caused. Further, there is a possibility that excessive hydrolase may be adsorbed to the lens, which is not preferable.
In addition, among commercially available enzymes, there are various kinds such as those supplied as a solution to which a stabilizer or the like is added, or those only available in a powder state. In such a case, the B component is used for the contact lens of the present invention. It is blended with the treatment solution and used after being adjusted such as concentration and dilution so that the final amount of the hydrolase is the content ratio shown in the present invention.

As the polyhydric alcohol of the component C used in the contact lens treatment solution of the present invention, any type of polyhydric alcohol can be used as long as the enzyme can be kept stable. For example,
Polyhydric alcohols such as ethylene glycol, glycerin, propylene glycol, sorbitol, sucrose and trehalose can be preferably used. Among them, sorbitol, propylene glycol, and glycerin can be more preferably used as the C component because of their high stabilizing effect on enzymes. In the treatment liquid for a contact lens of the present invention, either one of the polyhydric alcohols used in the present invention as the C component or a mixture of two or more thereof may be used. However, the content ratio of the polyhydric alcohol of the component C is preferably 5 to 30% by weight, more preferably 1 to 30% by weight based on the total amount of the contact lens treatment solution.
It is preferably from 0 to 25% by weight. Content ratio of C component is 5
If the amount is less than 30% by weight, the stabilizing effect of the enzyme is not sufficient, so that it is not preferable. If the amount exceeds 30% by weight, the viscosity becomes so high that the removal by washing or the like becomes difficult and the lens may be adversely affected.

As the boron compound of component D used in the contact lens treatment solution of the present invention, any known boron compound can be used as long as it has a stabilizing effect on proteolytic enzymes. For example, boric acid, borax, phenylboronic acid and the like are used, but boric acid is particularly preferably used from the viewpoint of availability, the effect of adjusting pH, and the stability of enzymes and solutions. In the treatment liquid for contact lenses of the present invention,
As the D component, either one of the boron compounds used in the present invention or a mixture of two or more thereof may be used. However, the content ratio of the boron compound of the component D is preferably 0.1 to 2% by weight, more preferably 0.3 to 1% by weight, of the total amount of the contact lens processing solution.
It is good. If the content of the component D is less than 0.1% by weight, the stabilizing effect of the enzyme and the effect of adjusting the pH are insufficient, which is not preferable. If it exceeds 2% by weight, precipitation tends to occur, and the stability of the solution is deteriorated. It is not preferable because it causes a problem.

The contact lens treatment solution of the present invention includes:
If necessary, at least one or more selected from a polymer having a group represented by the general formula [I] in the side chain as an E component, or polyvinyl alcohol, polyvinyl pyrrolidone, or a polysaccharide or a derivative thereof. Can be added. These E components impart hydrophilicity or the like to the contact lens by being mixed with the contact lens treatment solution of the present invention,
It acts as a viscosity modifier for the solution, a corneal protective agent, a stabilizer for the enzyme and the like, and works to further enhance the performance of the contact lens treatment solution of the present invention. E used in the present invention
The water-soluble polymer of the component is a polymer having a group represented by the general formula [I] in a side chain, or a water-soluble polymer selected from polyvinyl alcohol, polyvinylpyrrolidone, or a polysaccharide or a derivative thereof. Any material can be used as long as it does not affect the physical properties of the contact lens and does not impair the stability of the enzyme. Among the water-soluble polymers of the component E used in the present invention, a polymer having a group represented by the general formula [I] in a side chain is represented by the following general formula [I]

[0024]

Embedded image

Wherein R ¹ , R ² and R ³ are a hydrogen atom or an alkyl group having 1 to 8 carbon atoms or a hydroxyalkyl group having 1 to 8 carbon atoms. Represents an alkyl group having 1 to 8 carbon atoms, for example, a methyl group, an ethyl group, a propyl group,
Isopropyl group, butyl group, pentyl group, hexyl group,
A heptyl group, an octyl group, and a group such as a 2-ethylhexyl group are preferably exemplified. Examples of the hydroxyalkyl group having 1 to 8 carbon atoms include hydroxymethyl, hydroxyethyl,
Hydroxypropyl, hydroxybutyl, hydroxypentyl, hydroxyhexyl, hydroxyheptyl, hydroxyoctyl and the like, but for reasons of stability and safety, an alkyl group or hydroxyalkyl group having 1 to 4 carbon atoms is preferable, Further, a methyl group is most preferable. R ¹ , R ² and R ³ may be the same or different groups. R ⁴ represents an alkylene group having 2 to ⁴ carbon atoms, for example, an ethylene group,
Groups such as a propylene group and a butylene group are preferred, and an ethylene group is most preferred for reasons of stability and safety. Further, having the general formula [I] in the side chain means that the polymer has a shape branched from the polymer main chain and has the general formula [I]
Means that the side chain represented by the general formula [I] is 10 mol / mol% in one polymer molecule.
If it is contained as described above, it can be included in the range of the polymer having the group represented by the general formula [I] in the side chain as referred to in the present invention. The side chain represented by the general formula [I] is 10 mol / mol.
%, It is not preferable because the solubility deteriorates. Further, the polymer main chain of the polymer at this time may have any shape, and the molecular weight of the polymer is 1,000 to 5,000.
About 000, more preferably 30,000 to 1,0
It is good to be about 00,000. More specifically, as an example of a polymer having a group represented by the general formula [I] in a side chain, a phosphorylcholine group-containing (meth) acrylate monomer represented by the general formula [II] is polymerized alone. Or a copolymer capable of being copolymerized with a phosphorylcholine group-containing (meth) acrylate monomer represented by the general formula [II] and a phosphorylcholine group-containing (meth) acrylate monomer represented by the general formula [II] Polymers obtained by copolymerizing a vinyl monomer of
From the viewpoints of high hydrophilicity, high enzyme stabilizing effect, and the like, this is preferably used as the polymer having a group represented by the general formula [I] in the side chain, and is preferably used in the E component of the present invention. it can. Here, the phosphorylcholine group-containing (meth) acrylate monomer (hereinafter abbreviated as PC (meth) acrylate) represented by the general formula [II] is defined by the following general formula [II]

[0026]

Embedded image

Is a compound represented by the formula: Wherein R ¹ , R ²
And R ³ is either an alkyl group having 1 to 8 carbon atoms or a hydroxyalkyl group having 1 to 8 carbon atoms. Examples of the alkyl group having 1 to 8 carbon atoms include a methyl group, an ethyl group, and a propyl group. Isopropyl group, butyl group, pentyl group, hexyl group, heptyl group, octyl group, groups such as 2-ethylhexyl group, and the hydroxyalkyl group having 1 to 8 carbon atoms is hydroxymethyl, hydroxyethyl, hydroxypropyl, Hydroxybutyl,
Examples thereof include groups such as hydroxypentyl, hydroxyhexyl, hydroxyheptyl, and hydroxyoctyl. From the viewpoint of stability, an alkyl group or a hydroxyalkyl group having 1 to 4 carbon atoms is preferable, and a methyl group is most preferable. R ⁴ is either —CH ₂ CH ₂ — or —CH ₂ CH ₂ CH ₂ —, and among them, an ethylene group having the same skeleton as a phospholipid that is a component of a biological membrane is preferable. R ⁵ is - (CHR ⁷⁾ _m -, or -
(CH ₂ CHR ⁷ O) _n —CH ₂ CHR ⁷ — (where R ⁷ represents a hydrogen atom or a methyl group; _m is an integer of 2 to 18; It is preferable that _m is 2 to 10 from the viewpoint of solubility of _n .
It is preferable that _n is 1 to 4 in order to sufficiently exhibit the performance of the side chain represented by the general formula [I]. ), R ² in order to sufficiently exhibit the performance of the side chain represented by the Among the general formula [I] an ethylene group is preferred. R ⁶ represents a hydrogen atom or a methyl group.

As the PC (meth) acrylate represented by the general formula [II], any structure can be used as long as it falls within the range of the general formula [II]. For example, 2- (meth) acryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate and 3- (meth) acryloyloxypropyl-2 ′-(trimethylammonio) ethyl from the viewpoint of antifouling property and hydrophilicity. Phosphate, 4- (meth) acryloyloxybutyl-2 '-(trimethylammonio)
Ethyl phosphate, 2- (meth) acryloyloxyethyl-2 ′-(triethylammonio) ethyl phosphate, 2- (meth) acryloyloxyethyl-2 ′
-(Tributylammonio) ethyl phosphate, 2-
(Meth) acryloyloxyethoxyethyl-2'-
(Trimethylammonio) ethyl phosphate, 2-
(Meth) acryloyloxydiethoxyethyl-2'-
(Trimethylammonio) ethyl phosphate, 2-
PC (meth) acrylates such as (meth) acryloyloxyethyl-2 ′-(2 ″ -trihydroxyethylammonio) ethyl phosphate are preferred. From the viewpoint of availability and the like, 2- (meth) acryloyl is preferred. Oxyethyl-2 '-(trimethylammonio) ethyl phosphate is most preferred.

Among the polymers having a group represented by the general formula [I] in the side chain of the component E used in the present invention, preferred are those obtained by polymerizing the PC (meth) acrylate alone or And a vinyl monomer copolymerizable with PC (meth) acrylate and PC (meth) acrylate. PC
When copolymerizing (meth) acrylate, any other vinyl monomer that can be copolymerized with PC (meth) acrylate can be used as long as it is a commonly known vinyl monomer. For example, styrene, methylstyrene, Styrene monomers such as chlorostyrene; vinyl ether monomers such as vinyl acetate and vinyl propionate; methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) Alkyl (meth) acrylate monomers such as acrylate and 2-ethylhexyl (meth) acrylate;
(Meth) acrylic acid; hydroxyl-containing (meth) acrylates such as 2-hydroxyethyl (meth) acrylate and glycerol (meth) acrylate; polyalkylene glycol (meth) such as polyethylene glycol (meth) acrylate and polypropylene glycol (meth) acrylate Acrylate; (meth) acrylamide, N
-Nitrogen-containing monomers such as vinylpyrrolidone and acrylonitrile; halogen-substituted hydrocarbon-based or hydrocarbon-based monomers such as vinyl chloride, vinylidene chloride, ethylene, propylene, and isobutylene can be used. Of these, n
-Butyl (meth) acrylate is most preferably used. By copolymerizing one or more of these vinyl monomers with PC (meth) acrylate, a copolymer contained in the range of the polymer having the group represented by the general formula [I] in the side chain is obtained. Can be synthesized.

The amount of the PC (meth) acrylate to be copolymerized with the other copolymerizable vinyl monomer is preferably from 10 to 99%.
It is 1 to 90 parts by weight, more preferably 2 to 60 parts by weight, of the other copolymerizable vinyl monomer with respect to parts by weight, more preferably 40 to 98 parts by weight. If the amount is less than 10 parts by weight, the effect of imparting hydrophilicity to the copolymer cannot be exerted, which is not preferable. If the amount exceeds 99 parts by weight, the water solubility etc. imparted by the PC (meth) acrylate Is not preferred because the characteristics of Further, the conditions for polymerizing PC (meth) acrylate alone or for copolymerizing PC (meth) acrylate with a vinyl monomer copolymerizable with PC (meth) acrylate are based on the knowledge of conventional polymer chemistry. Preferably, each of the above-mentioned monomers (monomer) components is replaced with an inert gas such as nitrogen, carbon dioxide, helium or the like in the presence of a radical polymerization initiator or radical polymerization in an atmosphere, for example, It can be adjusted by a known method such as bulk polymerization, suspension polymerization, emulsion polymerization, and solution polymerization.

The polymerization initiator is not particularly limited as long as it is a usual radical polymerization initiator. For example, benzoyl peroxide, lauroyl peroxide, diisopropylperoxydicarbonate, t-butylperoxy-2-ethyl Hexanoate, t-butylperoxypivalate, t-butylperoxydiisobutyrate, azobisisobutyronitrile, azoisobisdimethylvaleronitrile, persulfates and persulfates-bisulfites, and the like. it can. The amount of the polymerization initiator to be charged is preferably 0.0001 to 10 parts by weight, more preferably 0.01 to 5 parts by weight, based on 100 parts by weight of the monomer component.
The polymerization temperature is preferably from 20 to 100 ° C., and the polymerization time is preferably from 0.5 to 72 hours. Further, the molecular weight of the obtained polymer varies depending on the polymerization temperature, the amount of the polymerization initiator and the amount of the polymerization degree modifier used, but the weight average molecular weight is 1,000.
From 5,000,000, and especially from 10,000 to 1,000,000 from the viewpoint of solubility in a contact lens solution, viscosity of the solution and adhesion to a contact lens.

Among the water-soluble polymers of the E component used in the present invention, polyvinyl alcohol is generally known as polyvinyl alcohol and can be obtained. The polyvinyl alcohol may be added to the contact lens treatment solution of the present invention. , But preferably has a degree of saponification of 86 to 89.
% And a degree of polymerization of 400 to 2400. In addition, among the water-soluble polymers of the E component used in the present invention, polyvinylpyrrolidone is generally known as polyvinylpyrrolidone, is available, and can be added to the contact lens treatment solution of the present invention. , But
Preferable are polyvinylpyrrolidone K25, polyvinylpyrrolidone K30 and polyvinylpyrrolidone K90 described in the Japanese Pharmacopoeia. In addition, among the water-soluble polymers of the E component used in the present invention, polysaccharides are generally known as polysaccharides, are available, and can be added to the contact lens treatment solution of the present invention. And preferably include mucopolysaccharides such as chondroitin sulfate, hyaluronic acid, heparan sulfate and heparin, sodium alginate, pullulan and the like.

Among the water-soluble polymers of the component E used in the present invention, the polysaccharide derivative is usually known as a polysaccharide derivative, is available, and is incorporated into the contact lens treatment solution of the present invention. It refers to all that can be performed, but preferably includes cellulose derivatives such as hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose and the like, low molecular weight chitosan, ethylene glycol chitin and the like. The content ratio of the E component used in the contact lens treatment solution of the present invention is 0.001 to 5% by weight, and more preferably 0.05 to 5% by weight.
It is in the range of 2% by weight. If the content is less than 0.001% by weight, the effect of the polymer of the component E is insufficient, so that it is not preferable. If it exceeds 5% by weight, the viscosity becomes high and the removal by washing or the like becomes difficult. The treatment solution for a contact lens of the present invention can be obtained by dissolving the components A, B, C, D, and optionally the component E in water such as purified water.

The treatment solution for contact lenses of the present invention has a pH value for adjusting the pH of the solution, if necessary.
As a regulator, for example, hydrochloric acid, acetic acid, citric acid, sodium hydroxide, phosphate (monosodium phosphate, disodium phosphate, monopotassium phosphate, dipotassium phosphate, etc.),
Citrates (such as sodium citrate), tris (hydroxymethyl) aminomethane, and mixtures thereof can be preferably added. These pH adjusters can be selected and added in an appropriate amount.
About 0.01 to 5% by weight can be added. A chelating agent can be added to the contact lens treatment solution of the present invention, if necessary, for stability of the solution and the like. These are not particularly limited as long as they do not impair the features of the present invention.For example, polycarboxylic acids and the like are preferably added, more preferably citric acid, ethylenediaminetetraacetic acid, cyclohexanediaminetetraacetic acid and these. Or a mixture thereof can be preferably added. These chelating agents can be selected and added in an appropriate amount, preferably 0.0
About 1 to 1% by weight can be added.

Before the treatment solution for contact lenses of the present invention, an inorganic chloride can be added, if necessary, to reduce the effect on the eyes. These are not particularly limited as long as they do not impair the features of the present invention. For example, sodium chloride, potassium chloride, magnesium chloride or a mixture thereof can be preferably added. These inorganic chlorides can be selected and added in an appropriate amount, and preferably about 0.001 to 5% by weight. If necessary, a preservative can be added to the contact lens treatment solution of the present invention to prevent the propagation of various bacteria. These are not particularly limited as long as they do not impair the features of the present invention.For example, chlorobutanol, benzalkonium chloride, thimerosal, chlorhexidine gluconate, p-hydroxybenzoate, sorbic acid, polyhexamethylene biguanide One or more of these can be preferably added. These preservatives can be selected and added in an appropriate amount, preferably 0.001 to 0.2% by weight.
Can be added to the extent.

The above-mentioned components can be appropriately added to the contact lens treatment solution of the present invention, if necessary, but other components which are considered appropriate may be added as long as the characteristics of the present invention are not impaired. It doesn't matter what you try. Examples of the method of using the treatment solution for contact lenses of the present invention include immersing or contacting the contact lens in the treatment solution for contact lenses, and rinsing with water, physiological saline, an appropriate washing solution, or the like before wearing on the eyes. This makes it possible to efficiently remove stains on the contact lens. Further, the treatment solution for contact lenses of the present invention has a feature that it can be used as it is without diluting it with purified water, physiological saline or the like before treating the contact lens. Since the contact lens treatment solution of the present invention, when diluted, reduces the detergency, it is preferable to use the solution without dilution as much as possible. When treating a hydrous contact lens with the treatment solution for a contact lens of the present invention, the contact lens is immersed in the treatment solution of the present invention, then immersed in a physiological saline solution or the like, and subjected to osmotic pressure of water contained in the contact lens. It is preferable from the viewpoint of use that the state is close to the eye. When treating a non-water-containing contact lens with the treatment solution for a contact lens of the present invention, since such an operation is not necessary and simple, the types of contact lenses treated with the contact lens treatment solution of the present invention include: If anything, non-hydrous contact lenses such as hard contact lenses and non-hydrous soft contact lenses are more preferred.

[0037]

EXAMPLES The present invention will be described below in more detail with reference to Synthesis Examples, Reference Examples, Examples and Comparative Examples. Synthesis Example 1 The monomers described in Table 1 were prepared as monomers. PC
45 g of 2-methacryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate as the (meth) acrylate and n-
After dissolving 5 g of butyl methacrylate (manufactured by Mitsubishi Rayon) and 0.01 g of azobisisobutyronitrile (manufactured by Otsuka Chemical) as a radical polymerization initiator in 450 g of methanol, placing the mixture in a glass reaction tube for polymerization and purging with nitrogen, followed by constant temperature Polymerization was carried out in a tank at 50 ° C. for 72 hours. After completion of the polymerization, reprecipitation purification was performed using ethanol as a good solvent and diethyl ether as a poor solvent, followed by heating and drying to obtain a polymer (Polymer No.
1) was obtained. The weight average molecular weight of the obtained polymer No. 1 was about 500,000 as a result of measurement by gel filtration chromatography based on polyethylene glycol.

Synthesis Example 2 Using the same conditions as in Synthesis Example 1 except for the monomer composition, polymerization was carried out with the composition shown in Table 1 to obtain a polymer (polymer No. 2). The weight average molecular weight of the obtained polymer No. 2 is about 20
It was 10,000. Synthesis Example 3 Polymerization was carried out using the same conditions as in Synthesis Example 1 except for the monomer composition and with the composition shown in Table 1, to obtain a polymer (polymer No. 3). The weight average molecular weight of the obtained polymer No. 3 was about 80,000.

Reference Example 1 Preparation of a contact lens test piece. Tris (trimethylsiloxy) silylpropyl methacrylate 40 g,
30 g of trifluoroethyl methacrylate, 10 g of methyl methacrylate, 15 g of triethylene glycol dimethacrylate, 5 g of methacrylic acid, and 0.2 g of azobisisobutyronitrile were injected into a test tube, and sealed after replacement with nitrogen. This was heated at 60 ° C. for 24 hours to heat and cure the raw material monomer in the test tube to obtain a colorless and transparent polymer. The obtained polymer was cut and polished to a plate shape of about 40 × 10 × 2 mm to obtain a contact lens test piece.

EXAMPLE 1 1 part by weight of polyoxyethylene (9 mol) lauryl ether was used as the component A, and 0.0 g of subtilisin was used as the component B.
05 parts by weight, 20 parts by weight of glycerin as a C component, D
0.5 parts by weight of boric acid as a component, 0.3 parts by weight of sodium hydroxide, 0.1 parts by weight of disodium ethylenediaminetetraacetate, and 0.005 parts by weight of chlorhexidine gluconate as other components are each purified water. Was dissolved. A treatment solution for contact lenses having a total weight of 100 g was prepared. Using these, the following tests [1] to [6] and comprehensive evaluation were performed. [1] Detergency test The stain removal rate (%) was calculated by the following method. In a physiological saline solution containing bovine serum albumin 0.39% by weight, γ-globulin 0.16% by weight, lysozyme 0.12% by weight, and swine stomach mucin 0.1% by weight (all manufactured by Wako Pure Chemical Industries, Ltd.)
The contact lens test piece (hereinafter abbreviated as lens piece) obtained in Reference Example 1 was treated at 60 ° C. for 2 hours to contaminate the lens piece. This lens piece is immersed in a contact lens treatment solution for 2 hours, washed with tap water, and further separated from the lens piece with a 1% aqueous solution of sodium dodecyl sulfate (manufactured by Wako Pure Chemical Industries), and the amount of protein in the solution is reduced. Was measured using a micro BCA kit (manufactured by Pierce), and the removal rate (%) of protein stain relative to the stain before washing was calculated. The results are shown in Table 4. If the stain removal rate is 90% or more, usually no stain is visually observed, so it was judged to be a good contact lens treatment solution having a sufficient detergency. [2] Detergency test after long-term storage After storing the treatment solution for contact lenses at 40 ° C. for 3 months, the stain removal rate (%) was calculated in the same manner as in [1].
The stain removal (%) after long-term storage was calculated. The results are shown in Table 4. At this time, if the stain removal rate is 90% or more,
It was determined that the solution had sufficient detergency even after long-term storage, that is, it had high enzyme stability and was a good contact lens treatment solution. [3] Stability Test at Low Temperature Storage After the treatment solution for contact lenses was stored at 4 ° C. for one week, the appearance of the aqueous solution was observed, and the stability at low temperature storage was evaluated based on the following criteria. The results are shown in Table 4. ：: The solution is transparent. Δ: The solution is turbid X: The solution has a precipitate or the components are separated If the above result is ○, it was judged that the solution was a good treatment solution for contact lenses. [4] Contact Angle Test The lens pieces were immersed and stored in a contact lens treatment solution for 2 hours, and then rinsed with physiological saline. The dynamic contact angle (degree) of this lens piece was measured using a dynamic contact angle measuring device (manufactured by Orientec Co., Ltd.). The results are shown in Table 4. The hydrophilicity of the contact lens was evaluated based on the contact angle according to the following criteria. That is, when the contact angle is small, the hydrophilicity is high, which is considered to lead to a reduction in discomfort when the contact lens is worn. Therefore, if the contact angle of the lens piece is 40 degrees or less, it can be determined that the hydrophilicity has been enhanced by the contact lens processing solution, and this was determined to be a good contact lens processing solution.

[5] Influence Test on Lens A commercially available contact lens (Seiko Hard EX) was prepared, immersed and stored in a treatment solution for contact lenses at 40 ° C. for one month, and the shape and surface condition were visually observed. Investigations were made to see if there were any changes before the treatment. When there was no change, "none" was used, and when there was some change, "yes" was used.
The results are shown in Table 4. "None" was considered to have no significant effect on the contact lens, and was judged to be a good contact lens treatment solution. [6] Effect test on skin 0.5 ml of the above-mentioned contact lens treatment solution was applied to white rabbits whose backs were shaved every day for 2 weeks, and the presence or absence of edema was visually observed. Those with no edema were rated "none" and those with edema were rated "present". The results are shown in Table 4. "None" was considered to have no significant effect on the skin, and was judged to be a good contact lens treatment solution with a good feeling upon use.

[Comprehensive Evaluation] In each of the above tests [1] to [6], a comprehensive evaluation was made according to the following criteria based on the number of tests having good results. A: Good results in all tests. This was judged to be the best solution for treating contact lenses because of its good usability. ；: Good results in 5 tests. This was determined to be an excellent contact lens treatment solution. Δ: Good results in four tests. When this was used as a treatment solution for contact lenses, it was judged that the feeling of use was poor. ×: The result was good only in three or less. This was inferior in properties and judged to be unsuitable for use as a treatment solution for contact lenses. ◎, ○,
The symbols of Δ and X are shown in Table 4. If the result is Δ or ×, it is considered that it is not suitable for practical use as a treatment solution for contact lenses, but if not, it can be suitably used as a treatment solution for contact lenses.

Example 2 A component, B component, C component, D component and other components are shown in Table 2
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4. Example 3 A component, B component, C component, D component and other components are shown in Table 2
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4. Example 4 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4.

Example 5 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4. Example 6 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4. Example 7 A component, B component, C component, D component, and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4.

Example 8 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1 except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in (1). The results are shown in Table 4. Example 9 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1, except that the components and the parts by weight described in Table 2 were respectively replaced with the component E shown in Table 2 and the parts by weight shown in Table 2 were added to prepare a treatment solution for contact lenses. . The results are shown in Table 4. Example 10 A component, B component, C component, D component and other components are shown in Table 2.
All the procedures were performed in the same manner as in Example 1, except that the components and the parts by weight described in Table 2 were respectively replaced with the component E shown in Table 2 and the parts by weight shown in Table 2 were added to prepare a treatment solution for contact lenses. . The results are shown in Table 4.

Example 11 The components A, B, C, D, and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results. Example 12 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results. Example 13 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results.

Example 14 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results. Example 15 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results. Example 16 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results.

Example 17 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results. Example 18 A component, B component, C component, D component and other components are shown in Table 3.
All the procedures were performed in the same manner as in Example 1 except that the components and the parts by weight described in Table 3 were replaced with the components E shown in Table 3 and the parts by weight shown in Table 3 were further added to prepare a treatment solution for contact lenses. . Table 5 shows the results.

Example 19 A component, B component, C component, D component and other components are shown in Table 3.
, And the component E shown in Table 3 was further added by part by weight shown in Table 3 to prepare a treatment solution for contact lenses. The detergency test of [1] was changed to a new detergency test method. A new detergency test performed in place of the test of [1] in Example 1 is as follows. Triolein 0.8% by weight, cholesterol 0.1
The lens pieces were treated at 37 ° C. for 12 hours in physiological saline emulsified with 0.1% by weight of egg yolk lecithin to contaminate the lens pieces. The lens piece was immersed in the contact lens treatment solution for 2 hours, washed with tap water, and the lipid on the lens piece was extracted with a chloroform / methanol solution (2: 1), and then the solvent was evaporated. The amount of lipid remaining on the lens piece was calculated from the absorbance using the sulfuric acid-phosphoric acid-vanillin method, and the removal rate (%) of the lipid stain relative to the stain before washing was calculated. Except for this, all the procedures were the same as in Example 1, and the results are shown in Table 5.

Example 20 A contact lens treatment solution was prepared by changing the components A, B, C, D, E, and other components to the types and parts by weight shown in Table 3, respectively. Performed in the same manner as in Example 19. Table 5 shows the results. Comparative Example 1 A component, B component, C component, D component, and other components are shown in Table 6.
All were carried out in the same manner as in Example 1, except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in above. The results are shown in Table 7. From the results of Comparative Example 1,
It can be seen that when the concentration of the surfactant is low, sufficient detergency cannot be obtained. Comparative Example 2 The components A, B, C, D, and other components are shown in Table 6.
All were carried out in the same manner as in Example 1, except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in above. The results are shown in Table 7. From the results of Comparative Example 2,
When the concentration of the surfactant is too high, it is found that the stability of the enzyme is extremely deteriorated.

Comparative Example 3 A contact lens treatment solution was prepared except that the B component was not added, and the A component, the C component, the D component, and the other components were changed to the types and parts by weight shown in Table 6, respectively. Performed in the same manner as in Example 1. The results are shown in Table 7. In Comparative Example 3, it can be seen that dirt was hardly removed because there was no hydrolase. Comparative Example 4 Example 1 was repeated except that the component A was not added, and the components B, C, D, and other components were changed to the types and parts by weight shown in Table 6 to prepare contact lens treatment solutions. The same was done. The results are shown in Table 7. In Comparative Example 4, the effect was exerted on the skin because the concentration of the enzyme was high. Comparative Example 5 A component, B component, C component, D component and other components are shown in Table 6
All were carried out in the same manner as in Example 1, except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in above. The results are shown in Table 7. In Comparative Example 5, it can be seen that the stability of the enzyme was extremely poor due to the small amount of polyhydric alcohol.

Comparative Example 6 A component, B component, C component, D component and other components are shown in Table 6.
All were carried out in the same manner as in Example 1, except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in above. The results are shown in Table 7. In Comparative Example 6, too much polyhydric alcohol affected the shape of the lens. Comparative Example 7 Example 1 was used except that the component A, the component B, the component C, and the other components were changed to the types and parts by weight shown in Table 6 without adding the component D to prepare a contact lens treatment solution. The same was done. The results are shown in Table 7. In Comparative Example 7, the stability of the enzyme was poor due to the absence of the boron compound. Comparative Example 8 A component, B component, C component, D component and other components are shown in Table 6
All were carried out in the same manner as in Example 1, except that the treatment solution for contact lenses was prepared in place of the kind and the weight part described in above. The results are shown in Table 7. In Comparative Example 8, the stability of the solution was deteriorated because the concentration of the boron compound was too high.

Comparative Example 9 Except for adding the component A and changing the components B, C, D, and other components to the types and parts by weight shown in Table 6, respectively, except that a contact lens treatment solution was prepared. Performed in the same manner as in Example 1. The results are shown in Table 7. In Comparative Example 9, since the type of the surfactant of the component A is different from that of the present invention, the stability of the solution is very poor, and the stability of the enzyme is also poor. Comparative Example 10 All of Example 1 was conducted except that the component A was not added, and the components B, C, D, and other components were changed to the types and parts by weight shown in Table 6 to prepare contact lens treatment solutions. The same was done. The results are shown in Table 7. In Comparative Example 10, since the type of the surfactant of the component A was different from that of the present invention, the detergency was low, and it was found that there was an effect on the skin.

[0054]

[Table 1]

Note: The abbreviations used are as follows: MPC; 2-methacryloyloxyethyl-2
'-(Trimethylammonio) ethyl phosphate MMA; methyl methacrylate n-BMA; n-butyl methacrylate n-SMA; n-stearyl methacrylate AIBN; azobisisobutyronitrile

[0056]

[Table 2]

Note: The abbreviations used are as follows. PLE: polyoxyethylene (9) lauryl ether (manufactured by NOF Corporation) POPE; polyoxyethylene (30) octylphenyl ether (manufactured by NOF Corporation) SMO: sorbitan monooleate (manufactured by NOF Corporation) TWEEN80; Polyoxyethylene sorbitan monooleate Pronone 208; polyoxyethylene polyoxypropylene block copolymer (manufactured by NOF Corporation) LDAB; lauryl dimethylaminoacetic acid betaine (manufactured by NOF Corporation) CADB; coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine (Manufactured by NOF CORPORATION) CCHI; 2-cocoyl-N-carboxymethyl-N-
Hydroxyethyl imidazolinium betaine (manufactured by NOF Corporation) PG; propylene glycol CHG; chlorhexidine gluconate Synthesis Example 1: Polymer synthesized in Synthesis Example 1: Polymer No. 1

[0058]

[Table 3]

Note: The abbreviations used are as follows. CADB; coconut oil fatty acid amidopropyldimethylaminoacetate betaine CLL; "Clear lens lipo (trade name)" (manufactured by Novo Nordisk Industries) PVA; polyvinyl alcohol (manufactured by Kuraray Co., trade name Kuraray Poval PVA-224C) PVP Polyvinyl pyrrolidone K25 PHMB; poly (hexamethylene biguanide) Synthesis Example 2: Polymer synthesized in Synthesis Example 2: Polymer No. 2 Synthesis Example 3: Polymer synthesized in Synthesis Example 3: Polymer No. 3

[0060]

[Table 4]

[0061]

[Table 5]

[0062]

[Table 6]

Note: The abbreviations used are as follows. Pronon 208; polyoxyethylene polyoxypropylene block copolymer (manufactured by NOF Corporation) LDAB; lauryl dimethylamino acetate betaine SDS; sodium dodecyl sulfate HDAC; hexadecyl trimethyl ammonium chloride CLP; "Clear Lens Pro (trade name)" (Made by Novo Nordisk Industries)

[0064]

[Table 7]

[0065]

The treatment solution for a contact lens of the present invention is extremely stable for a long period of time and has high safety to eyes because the components are added in a well-balanced manner.
Further, by immersing the contact lens in the solution of the present invention, dirt such as proteins and lipids adhered to the contact lens could be washed more efficiently than the conventional treatment solution for contact lenses. With the contact lens treatment solution of the present invention, without diluting the solution,
By only a simple immersion treatment, an ideal contact lens treatment solution which can remove stains adhered to the contact lens and is stable even after long-term storage was obtained.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) C11D 3/386 C11D 3/386 G02C 13/00 G02C 13/00 (72) Inventor Go Tsuyoshi Miyazaki 2-Umezono Tsukuba, Ibaraki Prefecture 15-5 (72) Inventor Norio Nakabayashi 5-6-20 Koganehara, Matsudo City, Chiba Prefecture (72) Inventor Kazuhiko Ishihara 3-16-37, Josuihoncho, Kodaira City, Tokyo F-term (reference) 2H006 DA08 4H003 AC03 AC08 AC11 AD04 BA12 EA02 EA18 EA21 EB04 EB08 EB23 EB28 EB33 EB41 EC01 ED02 ED28

Claims (7)

[Claims] A non-ionic surfactant or an amphoteric surfactant is used as a component A in an amount of 0.05 to 2% by weight, a hydrolytic enzyme is used as a B component in an amount of 10 ^{-10 to} 0.008% by weight, and a C component is multivalent. A treatment solution for a contact lens, comprising 5 to 30% by weight of an alcohol and 0.1 to 2% by weight of a boron compound as a D component. 2. An E component represented by the following general formula [I]: (In the formula, R ¹ , R ² and R ^{3 each} represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or a hydroxyalkyl group having 1 to 8 carbon atoms, and are the same or different groups. R ⁴ represents an alkylene group having 2 to ⁴ carbon atoms), a polymer having a group represented by the following formula in the side chain, or polyvinyl alcohol, polyvinyl pyrrolidone, or a polysaccharide, or a polysaccharide derivative. At least one or more water-soluble polymers selected from any one of 0.001
The treatment solution for a contact lens according to claim 1, further comprising about 5% by weight. 3. The polymer having a group represented by the general formula [I] according to claim 2 in a side chain thereof is represented by the following general formula [II]: In the formula, R ¹ , R ² and R ³ represent either an alkyl group having 1 to 8 carbon atoms or a hydroxyalkyl group having 1 to 8 carbon atoms, and may be the same or different. Good. R ⁴ is —CH ₂ CH ₂ — or —CH ₂ CH ₂ C
H ₂ —. R ⁵ is a group represented by — (CHR ⁷ ) _m — or — (CH ₂ CHR ⁷ O) _n —CH ₂ CHR ⁷ — (where R ⁷ represents a hydrogen atom or a methyl group) . _m is an integer of 2 to 18. _n is an integer of 1-16.) it is. R ⁶ is a hydrogen atom or a methyl group. Phosphorylcholine group-containing (meth) represented by｝
A polymer obtained by polymerizing an acrylate monomer alone, or a phosphorylcholine group-containing (meth) acrylate monomer represented by the general formula [II] is copolymerized with another copolymerizable vinyl monomer. The treatment solution for a contact lens according to claim 2, which is a polymer obtained by the above method. 4. The hydrolyzing enzyme of component B according to claim 1, which is at least one selected from the group consisting of proteolytic enzymes, lipolytic enzymes and glycolytic enzymes. Or the treatment solution for contact lenses according to 2. 5. The contact according to claim 1, wherein the polyhydric alcohol as the component C according to claim 1 is at least one selected from glycerin, propylene glycol, and sorbitol. Processing solution for lenses. 6. The treatment solution for a contact lens according to claim 1, wherein the boron compound as the component D according to claim 1 is boric acid. 7. A method for treating a contact lens, comprising using the treatment solution for a contact lens according to claim 1 without dilution, and immersing the contact lens in the solution.