JP3496726B2 - Agent for contact lenses - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for contact lenses which makes it difficult for dirt to adhere to the surfaces of contact lenses when they are worn.

[0002]

2. Description of the Related Art Conventionally, contact lenses have been used for vision correction together with spectacles. However, when wearing contact lenses, it is inevitable that stains such as proteins secreted from the eye, eye oil, carbohydrates, mucopolysaccharides, and inorganic substances will adhere. If such dirt is left as it is and the wear is continued, the wettability and optical transparency of the contact lens are affected, resulting in discomfort to the wearer. Further, it is known that not only causes eye irritation, but also attached bacteria and fungi proliferate by using this as a nutrient source and cause various serious damages to the eyes.

In order to remove such stains, there is known a method of removing stains on contact lenses with a cleaning agent using an abrasive such as silica or titanium dioxide (Japanese Patent Laid-Open No. 4-81813). But in this way,
Repeated use of the abrasive for a long time may damage the contact lens.

There is also known a method of removing dirt on a contact lens with a cleaning agent containing an anionic surfactant, a nonionic surfactant, an abrasive and a salt of a Cl ^- ion-containing strong electrolyte. -19217). However, in such a method, the surfactant is adsorbed in the contact lens, and the surfactant is released when the contact lens is worn, which may cause irritation to the eyes. Further, the contact lens itself may be deformed due to the influence of the surfactant.

A contact lens cleaning method using a mixture of an oxidizing agent such as permanganate and a mild reducing substance is also known (JP-A-5-11222).
However, such a method may adversely affect the material of the contact lens and change the shape of the contact lens.

There is also known a method of removing stains on contact lenses with a detergent containing a proteolytic enzyme (Japanese Patent Laid-Open No. 76587/1993). However, such a method has a low cleaning power and cannot be said to be sufficient as a cleaning liquid.

Furthermore, the above-mentioned various cleaning agents require cleaning operations such as rubbing with fingers, which is troublesome.

The present invention has been made in view of the above circumstances, and an object of the present invention is to simply immerse a contact lens without causing scratches on the surface of the contact lens, deformation of the contact lens, or the like. It is an object of the present invention to provide a contact lens agent that can make dirt less likely to adhere to contact lenses.

[0009]

The present invention has been made to achieve the above object, and contains at least one selected from alginic acid and salts thereof dissolved in water , and contains a surfactant. It is a contact lens agent characterized by the absence thereof.

The contact lens preparation of the present invention contains at least one selected from alginic acid and its salts as an essential component.

Here, alginic acid is a linear molecule consisting of β-1,4 bond of D-mannouronic acid, and industrially, for example, seaweed is washed with calcium chloride solution and hydrochloric acid and then extracted with sodium carbonate solution. Then, the product obtained by precipitating with hydrochloric acid or calcium chloride and purifying can be used.

Examples of the alginate include alkali metal salts such as sodium alginate and potassium alginate, and alkaline earth metal salts such as calcium alginate.

At least one selected from inorganic salts, organic acid salts, preservatives and stabilizers can be added to the agent for contact lenses of the present invention together with alginic acids. Examples of the inorganic salts include sodium chloride, potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, boric acid, sodium borate, sodium sulfate, sodium carbonate, sodium hydrogen carbonate and the like. These inorganic salts are mainly used for adjusting osmotic pressure and pH, but one or more kinds thereof may be used. In addition, it may be added with the expectation of other secondary effects. The addition amount may be appropriately determined depending on the purpose.

Examples of the organic acid salts include sodium citrate, sodium tartrate, sodium oxalate, sodium lactate, sodium glutamate, sodium malate and the like. These organic acid salts are mainly used for adjusting the pH, but one or more kinds thereof may be used. In addition, it may be added with the expectation of other secondary effects. The addition amount may be appropriately determined depending on the purpose.

As preservatives, sorbic acid, sodium sorbate, potassium sorbate, sodium benzoate, methyl ester, ethyl ester, propyl ester or butyl ester of paraoxybenzoic acid, sodium salicylate, polyhexamethylene biguanide hydrochloride, chloro butanol, benzyl alcohol, black Le f <br/> chlorhexidine salts, such as benzalkonium chloride. The amount to be added may be appropriately determined as long as it is at least an amount sufficient to kill and suppress the target bacteria, mold and the like.

In addition, an alkali such as sodium hydroxide or potassium hydroxide or an acid such as hydrochloric acid or citric acid may be added to adjust the pH.

As the stabilizer, a sequestering agent such as edetate or a water-soluble polymer for improving wettability,
For example, polyvinyl alcohol, polyvinylpyrrolidone,
Carboxymethyl cellulose, hydroxypropyl methyl cellulose and the like may be added.

The embodiment of the present invention by agent for contact lenses, if solutions or commonly are dosage forms known similar thereto is used by dissolving in diluted or water with water may be any of these agents Additives necessary for preparing the mold may be appropriately used as long as they do not affect the contact lens.

The preferred concentration of alginates in water is
It is 0.001 to 1.0 W / V%. 0.001W / V
If it is less than%, the effect of preventing dirt adhesion is small, and 1.0 W
If it exceeds / V%, it will not dissolve in water and will be in a suspended state, so conversely alginic acid may adhere to the surface of the contact lens. A particularly preferred concentration is 0.0
It is 1 to 0.5 W / V%.

[0020]

EXAMPLES The present invention will now be described in detail with reference to examples, but the present invention is not limited to these examples.

The contact lenses used in the following examples are soft contact lenses made of a copolymer mainly composed of 2-hydroxyethyl methacrylate and alkyl methacrylate, and hard contact lenses made of a polymer mainly composed of methyl methacrylate. , Or full
A o b methacrylate and oxygen permeability hard contact lens made a siloxanyl alkyl methacrylates a copolymer mainly. Further, a pseudo artificial protein soiling solution was prepared with the following formulation. Albumin 0.2 g Lysozyme chloride 0.2 g Immunoglobulin 0.2 g Sodium chloride 0.5 g was used, and water was added to these to make the total volume 100 ml.

A pseudo artificial lipid soiling liquid was prepared with the following composition. Span80 ^{* 1} 6g Span85 ^{* 2} 4g Lanolitin 35g Palm oil 16g Oleic acid 5g Cholesterol 2g Cholesterol acetate 30g Cetyl alcohol 2g 2.5g of the melted mixture was dissolved in 100ml of ethanol: hexane (1: 1) mixture. . * 1: Product name of sorbitan monooleate * 2: Product name of sorbitan trioleate

(Example 1) Purified water was added to 0.01 g of alginic acid to make the total amount 100 ml. Five soft contact lenses were immersed in this solution and left at room temperature for 1 hour. Then, after that, the artificial artificial protein stain liquid is used at room temperature for 30 minutes.
After soaking for a minute, it was rinsed lightly with purified water, and the degree of dirt adhesion on the lens surface was observed with a dark-field stereomicroscope (manufactured by Olympus Optical Co., Ltd.). The result is 5 as shown in Table 1.
No turbidity was observed on the entire surface of the lenses.

Example 2 Sodium alginate 0.0
Purified water was added to 1 g to make the total amount 100 ml. Five soft contact lenses were immersed in this solution and left at room temperature for 1 hour. Then, after immersing in a pseudo artificial protein stain solution for 30 minutes at room temperature, it was lightly rinsed with purified water, and the stain on the lens surface was observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses.

(Example 3) Sodium alginate 0.0
Purified water was added to 1 g, boric acid 0.5 g, sodium borate 0.1 g, and sodium chloride 0.75 g to bring the total amount to 1
It was set to 00 ml. Five soft contact lenses were immersed in this solution and left at room temperature for 1 hour. Then, after immersing in a pseudo artificial protein stain solution for 30 minutes at room temperature, it was lightly rinsed with purified water, and the stain on the lens surface was observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

Example 4 Sodium alginate 0.0
Purified water is added to 5 g, disodium hydrogen phosphate dihydrate 0.1 g, sodium dihydrogen phosphate dodecahydrate 1.3 g, and sodium chloride 0.6 g to make the total volume 100 ml. Soak 5 hard contact lenses in this solution,
It was left at room temperature for 1 hour. Then, after immersing in a pseudo artificial protein stain solution for 30 minutes at room temperature, it was lightly rinsed with purified water, and the stain on the lens surface was observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

Example 5 Sodium alginate 0.5
g, disodium hydrogen phosphate dihydrate 0.3 g, sodium dihydrogen phosphate dodecahydrate 0.6 g, sodium citrate 0.2 g, sodium sorbate 0.1 g and potassium chloride 0.8 g Purified water is added to bring the total volume to 100 ml.
And Oxygen-permeable hard contact lens 5
The sheet was immersed and left at room temperature for 1 hour. And then
After being immersed in the artificial artificial protein stain solution at room temperature for 30 minutes, it was lightly rinsed with purified water, and stains on the lens surface were observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

(Example 6) Sodium alginate 0.1
g, disodium hydrogen phosphate dihydrate 0.2 g, sodium dihydrogen phosphate dodecahydrate 1.3 g, and sodium chloride 0.6 g to make purified water 100 ml. Soak 5 soft contact lenses in this solution,
It was left at room temperature for 1 hour. Then, after immersing in a pseudo artificial lipid stain solution for 30 minutes at room temperature, it was lightly rinsed with purified water, and stains on the lens surface were observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

Example 7 Sodium alginate 0.0
Purified water is added to 5 g, disodium hydrogen phosphate dihydrate 0.1 g, sodium dihydrogen phosphate dodecahydrate 1.3 g, and sodium chloride 0.6 g to make the total volume 100 ml. Soak 5 hard contact lenses in this solution,
It was left at room temperature for 1 hour. Then, after immersing in a pseudo artificial protein stain solution for 30 minutes at room temperature, it was lightly rinsed with purified water, and the stain on the lens surface was observed in the same manner as in Example 1. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

Example 8 Calcium alginate 0.5
g, disodium hydrogen phosphate dihydrate 0.3 g, sodium dihydrogen phosphate dodecahydrate 0.6 g, sodium citrate 0.2 g, sodium sorbate 0.1 g, and sodium chloride 0.8 g Add purified water to 100
Set to ml. Five pieces of oxygen-permeable hard contact lenses were immersed in this solution and left at room temperature for 1 hour. Then, after immersing in the artificial artificial protein stain liquid for 30 minutes at room temperature, it was lightly rinsed with purified water to stain the lens surface.
It was observed in the same manner as. As a result, as shown in Table 1, no turbidity was observed on all surfaces of the five lenses. Further, the contact lens preparations of this example were superior to the contact lens preparations of Examples 1 and 2 in secondary effects such as shape retention of contact lenses and resistance to bacterial contamination.

(Comparative Example 1) Purified water was added to 0.5 g of boric acid, 0.1 g of sodium borate, and 0.75 g of sodium chloride to make the total amount 100 ml. Five soft contact lenses were immersed in this solution and left at room temperature for 1 hour. Then, after immersing in the artificial artificial protein stain liquid at room temperature for 30 minutes, it was lightly rinsed with purified water, and the degree of stain adhesion on the lens surface was observed in the same manner as in Example 1. As shown in Table 1, 5 pieces of soft In all of the contact lenses, it was found that cloudy stains were attached to the entire surface.

Comparative Example 2 0.2 g of disodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dodecahydrate 1.
Purified water is added to 3 g and 0.6 g of sodium chloride to make the total amount 100 ml. Five hard contact lenses were immersed in this solution and left at room temperature for 1 hour. And after that, after soaking in the artificial artificial lipid stain liquid for 30 minutes at room temperature,
When the lens surface was rinsed lightly with purified water and the degree of dirt adhesion on the lens surface was observed in the same manner as in Example 1, as shown in Table 1, four hard contact lenses had cloudy dirt adhered to all surfaces. For one hard contact lens, cloudy stain was found on a part of the surface.

[0033]

[Table 1]

[0034]

As described above, the contact lens agent of the present invention has the effect of making it difficult for dirt to adhere to the surface of the contact lens simply by immersing and leaving the contact lens therein. Therefore, by using the agent for contact lenses of the present invention, there is an advantage that the washing operation which has been conventionally performed is not required. In addition, there is an advantage that scratches on the surface of the contact lens and deformation of the contact lens do not occur.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masayo Fukai 2-7-5 Nakaochiai Shinjuku-ku, Tokyo Hoya Co., Ltd. (72) Kenji Enda 2-7-5 Nakaochiai Shinjuku-ku, Tokyo No. Hoya Co., Ltd. (56) Reference JP-A-55-115497 (JP, A) JP-A-4-104220 (JP, A) JP-A 64-52122 (JP, A) JP-A 63- 159821 (JP, A) JP 4-51015 (JP, A) JP 62-250413 (JP, A) JP 4-134317 (JP, A) JP 60-159721 (JP, A) JP-A-60-196722 (JP, A) JP-A-1-167725 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) G02C 13/00 C09K 3/00 112

Claims (2)

(57) [Claims] 1. At least one selected from alginic acid and its salts dissolved in water is 0.001 to 1.0 W.
/ V% and does not contain a surfactant. 2. At least one kind selected from alginic acid and salts thereof dissolved in water , 0.001-1.0 W /
An agent for contact lenses, which contains V% and at least one selected from an inorganic salt, an organic acid salt, a preservative and a stabilizer, and does not contain a surfactant.