JOP20220074A1 - أجسام مضادة لـ nrp1a واستخداماتها لعلاج العين أو أمراض العين - Google Patents

أجسام مضادة لـ nrp1a واستخداماتها لعلاج العين أو أمراض العين

Info

Publication number
JOP20220074A1
JOP20220074A1 JOP/2022/0074A JOP20220074A JOP20220074A1 JO P20220074 A1 JOP20220074 A1 JO P20220074A1 JO P20220074 A JOP20220074 A JO P20220074A JO P20220074 A1 JOP20220074 A1 JO P20220074A1
Authority
JO
Jordan
Prior art keywords
nrp1a
antibodies
ocular diseases
treating eye
eye
Prior art date
Application number
JOP/2022/0074A
Other languages
English (en)
Inventor
Pankaj Gupta
Juergen Prestle
Leo Thomas
Nina Zippel
Fei Han
Sarah Low
Yining Huang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of JOP20220074A1 publication Critical patent/JOP20220074A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

يتعلق الاختراع الحالي بأجسام مضادة antibodies وشظايا fragments منها تستهدف مجال A لنيوروبيلين-1 A-domain of Neuropilin-1 (Nrp1A). وبشكل أكثر تحديدًا، تم الكشف عن أجسام مضادة لمجال A لنيوروبيلين-1 وطرق استخدامها لعلاج أمراض أو اضطرابات مختلفة.
JOP/2022/0074A 2019-09-24 2020-09-24 أجسام مضادة لـ nrp1a واستخداماتها لعلاج العين أو أمراض العين JOP20220074A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19199099 2019-09-24
EP20150942 2020-01-09
PCT/EP2020/076685 WO2021058636A1 (en) 2019-09-24 2020-09-24 Anti-nrp1a antibodies and their uses for treating eye or ocular diseases

Publications (1)

Publication Number Publication Date
JOP20220074A1 true JOP20220074A1 (ar) 2023-01-30

Family

ID=72752879

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2022/0074A JOP20220074A1 (ar) 2019-09-24 2020-09-24 أجسام مضادة لـ nrp1a واستخداماتها لعلاج العين أو أمراض العين

Country Status (16)

Country Link
US (2) US11661458B2 (ar)
EP (1) EP4034161A1 (ar)
JP (1) JP2022549005A (ar)
KR (1) KR20220069076A (ar)
CN (1) CN114423788A (ar)
AU (1) AU2020355599A1 (ar)
BR (1) BR112022005024A2 (ar)
CA (1) CA3154654A1 (ar)
CO (1) CO2022003324A2 (ar)
CR (1) CR20220122A (ar)
IL (1) IL291522A (ar)
JO (1) JOP20220074A1 (ar)
MX (1) MX2022003544A (ar)
PE (1) PE20221315A1 (ar)
TW (1) TW202126685A (ar)
WO (1) WO2021058636A1 (ar)

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
DE68925971T2 (de) 1988-09-23 1996-09-05 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
ES2206447T3 (es) 1991-06-14 2004-05-16 Genentech, Inc. Anticuerpo humanizado para heregulina.
CA2149329C (en) 1992-11-13 2008-07-15 Darrell R. Anderson Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
AU2011253904B2 (en) * 2005-11-08 2014-02-13 Genentech, Inc. Neuropilin antagonists
UA96139C2 (uk) 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
AU2007353779B2 (en) 2007-05-17 2013-11-07 Genentech, Inc. Crystal structures of neuropilin fragments and neuropilin-antibody complexes
AU2014221144B2 (en) 2013-02-21 2018-03-22 Rsem, Limited Partnership Inhibition of Sema3A in the prevention and treatment of ocular hyperpermeability
SI3189074T1 (sl) * 2014-09-05 2021-08-31 Rsem, Limited Partnership Sestavki in postopki za zdravljenje in preprečevanje vnetja
CA2969402C (en) * 2014-12-03 2019-06-11 Samsung Life Public Welfare Foundation Antibody binding to neuropilin 1 and use thereof
JOP20190134A1 (ar) * 2016-12-23 2019-06-02 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها

Also Published As

Publication number Publication date
CN114423788A (zh) 2022-04-29
US20230416378A1 (en) 2023-12-28
BR112022005024A2 (pt) 2022-06-21
PE20221315A1 (es) 2022-09-07
CR20220122A (es) 2022-05-05
KR20220069076A (ko) 2022-05-26
CO2022003324A2 (es) 2022-04-19
MX2022003544A (es) 2022-04-11
US20210087282A1 (en) 2021-03-25
EP4034161A1 (en) 2022-08-03
US11661458B2 (en) 2023-05-30
TW202126685A (zh) 2021-07-16
AU2020355599A1 (en) 2022-04-07
IL291522A (en) 2022-05-01
CA3154654A1 (en) 2021-04-01
WO2021058636A1 (en) 2021-04-01
JP2022549005A (ja) 2022-11-22

Similar Documents

Publication Publication Date Title
MX2022013526A (es) Degradadores de proteinas y usos de los mismos.
CR20210559A (es) Anticuerpos anti-sema3a y sus usos para tratar enfermedades oculares
GEP20247593B (en) Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders
MY196448A (en) Anti-Htra1 Antibodies and Methods of use Thereof
PH12020551071A1 (en) Compositions and methods for treating retinal disorders
ZA201907371B (en) Methods and compositions for treating allergic ocular diseases
MX2022006073A (es) Metodos para utilizar anticuerpos anti-trem2.
MX2017005522A (es) Tratamiento novedoso de la cornea usando laminina.
MX2021002652A (es) Uso de inhibidores de caseina-cinasa 1 para el tratamiento de enfermedades vasculares.
AU2017259966A1 (en) TrkB agonist antibodies for treating neurodegenerative disorders
WO2019165158A8 (en) Il-6 inhibitors and methods of treatment
EP3709982A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISORDERS AND SKIN DISEASES
PH12017500998A1 (en) Treatment of ocular conditions using progenitor cells
WO2020142740A8 (en) Treatment of sjogren's disease with nuclease fusion proteins
MX2020012014A (es) Conjugados y derivados de prostaglandina para tratar el glaucoma y la hipertension ocular.
EP3813794A4 (en) OPHTHALMIC COMPOSITIONS AND METHODS OF TREATING EYE DISORDERS
CR20220122A (es) Anticuerpos anti-nrp1a y sus usos para tratar enfermedades oculares
MX2019010060A (es) Composiciones y metodo para tratar cancer.
MX2023005591A (es) Metodos de tratamiento de enfermedades y trastornos.
MY190021A (en) Anti-gm-csf antibodies and uses thereof
CR20220072A (es) Derivados de piridina como moduladores de tmem16a para su uso en el tratamiento de afecciones respiratorias
EA202191058A1 (ru) Антитела против муцина-16 и способы их применения
EA201991395A1 (ru) Новые композиции для лечения суставных нарушений
WO2019150050A8 (fr) Dimères de variants du facteur x
WO2017184578A3 (en) Implants and methods for treatments of pelvic conditions