JOP20210136A1 - صيغة عقار ذات إطلاق متأخر تشتمل على طبقة خارجية مزودة ببوليمر قابل للتحلل إنزيميًا، وتركيبته وطريقة تصنيعه - Google Patents

صيغة عقار ذات إطلاق متأخر تشتمل على طبقة خارجية مزودة ببوليمر قابل للتحلل إنزيميًا، وتركيبته وطريقة تصنيعه

Info

Publication number
JOP20210136A1
JOP20210136A1 JOP/2021/0136A JOP20210136A JOP20210136A1 JO P20210136 A1 JOP20210136 A1 JO P20210136A1 JO P20210136 A JOP20210136 A JO P20210136A JO P20210136 A1 JOP20210136 A1 JO P20210136A1
Authority
JO
Jordan
Prior art keywords
core
delayed release
drug formulation
release drug
enzymaticyally
Prior art date
Application number
JOP/2021/0136A
Other languages
English (en)
Inventor
Gonzalez Roberto Carlos Bravo
Felipe Varum
Carsten Markus Fuller
Rochow Laetitia Von
Original Assignee
Tillotts Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag
Publication of JOP20210136A1 publication Critical patent/JOP20210136A1/ar

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بطريقة لإنتاج قلب قابل للتغليف لصيغة عقار ذات إطلاق متأخر للإعطاء عن طريق الفم لتوصيل العقار إلى القولون، وتشتمل الطريقة على تشكيل قلب يشتمل على عقار. يتكون مستحضر تغليف الطبقة الخارجية من خلال جمع مستحضر مائي أول من بوليمر قابل للتحلل إنزيميًا بواسطة الإنزيمات البكتيرية القولونية؛ مستحضر مائي ثانٍ لبوليمر معوي مكون لغشاء له قيمة حدية لرقم هيدروجيني يبلغ حوالي 6 أو أعلى؛ وعامل عضوي مضاد للتشقق. ويتم بعد ذلك طلاء القلب باستخدام مستحضر تغليف الطبقة الخارجية لتشكيل قلب مغطي بطبقة خارجية
JOP/2021/0136A 2018-12-07 2019-12-05 صيغة عقار ذات إطلاق متأخر تشتمل على طبقة خارجية مزودة ببوليمر قابل للتحلل إنزيميًا، وتركيبته وطريقة تصنيعه JOP20210136A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18211152.6A EP3662901A1 (en) 2018-12-07 2018-12-07 Delayed release drug formulation comprising an outerlayer with an enzymaticyaaly degradable polymer, its composition and its method of manufacturing
PCT/EP2019/083910 WO2020115255A1 (en) 2018-12-07 2019-12-05 Delayed release drug formulation comprising an outerlayer with an enzymaticyally degradable polymer, its composition and its method of manufacturing

Publications (1)

Publication Number Publication Date
JOP20210136A1 true JOP20210136A1 (ar) 2023-01-30

Family

ID=64661233

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0136A JOP20210136A1 (ar) 2018-12-07 2019-12-05 صيغة عقار ذات إطلاق متأخر تشتمل على طبقة خارجية مزودة ببوليمر قابل للتحلل إنزيميًا، وتركيبته وطريقة تصنيعه

Country Status (22)

Country Link
US (1) US20220023222A1 (ar)
EP (2) EP3662901A1 (ar)
JP (1) JP7391966B2 (ar)
KR (1) KR20210100663A (ar)
CN (1) CN113226292A (ar)
AR (1) AR117681A1 (ar)
AU (1) AU2019392854A1 (ar)
BR (1) BR112021010914A2 (ar)
CA (1) CA3122013A1 (ar)
CL (1) CL2021001472A1 (ar)
CO (1) CO2021008683A2 (ar)
CR (1) CR20210366A (ar)
EA (1) EA202191597A1 (ar)
GE (1) GEP20247608B (ar)
IL (1) IL283718A (ar)
JO (1) JOP20210136A1 (ar)
MA (1) MA54374A (ar)
MX (1) MX2021006603A (ar)
SG (1) SG11202105691RA (ar)
TW (1) TW202038968A (ar)
WO (1) WO2020115255A1 (ar)
ZA (1) ZA202103676B (ar)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024006539A1 (en) * 2022-07-01 2024-01-04 Vitakey Inc. Nutraceutical particles

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* Cited by examiner, † Cited by third party
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GB8812490D0 (en) 1988-05-26 1988-06-29 Agricultural & Food Res Delayed release formulations
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GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
AU2012247013B2 (en) * 2006-04-13 2016-01-14 University College London Colonic drug delivery formulation
SI2152250T1 (sl) 2007-05-07 2020-06-30 Evonik Operations Gmbh Trdne dozirne oblike, ki vsebujejo enterično oplaščenje s pospešenim sproščanjem zdravila
RU2486917C2 (ru) * 2008-02-19 2013-07-10 МакНЕЙЛ-ППС, ИНК. Композиции для нанесения покрытия способом погружения, включающие крахмал с высоким содержанием амилозы
EP2659881B1 (en) 2012-04-30 2017-11-29 Tillotts Pharma Ag A delayed release drug formulation
MA38847B2 (fr) * 2013-10-29 2021-02-26 Tillotts Pharma Ag Formulation médicamenteuse à libération retardée
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Also Published As

Publication number Publication date
CN113226292A (zh) 2021-08-06
IL283718A (en) 2021-07-29
TW202038968A (zh) 2020-11-01
MX2021006603A (es) 2021-08-24
AR117681A1 (es) 2021-08-25
BR112021010914A2 (pt) 2021-08-24
KR20210100663A (ko) 2021-08-17
SG11202105691RA (en) 2021-06-29
WO2020115255A1 (en) 2020-06-11
EP3662901A1 (en) 2020-06-10
JP7391966B2 (ja) 2023-12-05
CA3122013A1 (en) 2020-06-11
EA202191597A1 (ru) 2021-08-30
CR20210366A (es) 2021-11-23
GEP20247608B (en) 2024-03-11
JP2022511119A (ja) 2022-01-28
CO2021008683A2 (es) 2021-08-19
CL2021001472A1 (es) 2021-12-24
US20220023222A1 (en) 2022-01-27
EP3890710A1 (en) 2021-10-13
ZA202103676B (en) 2022-10-26
AU2019392854A1 (en) 2021-07-08
MA54374A (fr) 2022-03-16

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