EA202191431A1 - Композиция для доставки лекарственных средств в толстую кишку - Google Patents

Композиция для доставки лекарственных средств в толстую кишку

Info

Publication number
EA202191431A1
EA202191431A1 EA202191431A EA202191431A EA202191431A1 EA 202191431 A1 EA202191431 A1 EA 202191431A1 EA 202191431 A EA202191431 A EA 202191431A EA 202191431 A EA202191431 A EA 202191431A EA 202191431 A1 EA202191431 A1 EA 202191431A1
Authority
EA
Eurasian Patent Office
Prior art keywords
colon
sustained release
coating
drug
release
Prior art date
Application number
EA202191431A
Other languages
English (en)
Inventor
Фелипе Варум
Роберто Карлос Браво Гонсалес
Original Assignee
Тиллоттс Фарма АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тиллоттс Фарма АГ filed Critical Тиллоттс Фарма АГ
Publication of EA202191431A1 publication Critical patent/EA202191431A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

В композиции лекарственного средства с замедленным высвобождением, содержащей лекарственное средство и, необязательно, покрытие с замедленным высвобождением для кишечного высвобождения, не является затрудненным высвобождение лекарственного средства в толстой кишке из-за отсутствия щелочного среднего слоя между сердцевиной и внешним слоем. Покрытие с замедленным высвобождением содержит внутреннее покрытие и, необязательно, изолирующий слой. Внешнее покрытие содержит смесь ферментативно разлагаемого полисахарида, который подвержен атаке ферментами толстой кишки, выбранным из группы, состоящей из крахмала, амилозы, амилопектина, хитозана, хондроитинсульфата, циклодекстрина, декстрана, пуллулана, каррагенана, склероглюкана, хитина, курдулана и левана; и пленкообразующего кишечнорастворимого полимера, имеющего пороговый рН около 6 или выше, причем ферментативно разлагаемый полисахарид и кишечнорастворимый полимер присутствуют во внешнем покрытии в соотношении более 60:40.
EA202191431A 2018-12-07 2019-12-05 Композиция для доставки лекарственных средств в толстую кишку EA202191431A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18211141.9A EP3662900A1 (en) 2018-12-07 2018-12-07 Colonic drug delivery formulation
PCT/EP2019/083912 WO2020115257A1 (en) 2018-12-07 2019-12-05 Colonic drug delivery formulation

Publications (1)

Publication Number Publication Date
EA202191431A1 true EA202191431A1 (ru) 2021-09-13

Family

ID=64661226

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191431A EA202191431A1 (ru) 2018-12-07 2019-12-05 Композиция для доставки лекарственных средств в толстую кишку

Country Status (13)

Country Link
US (1) US20220016037A1 (ru)
EP (2) EP3662900A1 (ru)
JP (1) JP7423629B2 (ru)
KR (1) KR20210100666A (ru)
CN (1) CN113164400A (ru)
AR (1) AR117281A1 (ru)
AU (1) AU2019394740A1 (ru)
BR (1) BR112021010913A2 (ru)
CA (1) CA3122033A1 (ru)
EA (1) EA202191431A1 (ru)
IL (1) IL283719A (ru)
MA (1) MA54376A (ru)
WO (1) WO2020115257A1 (ru)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812490D0 (en) 1988-05-26 1988-06-29 Agricultural & Food Res Delayed release formulations
GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
US5422121A (en) 1990-11-14 1995-06-06 Rohm Gmbh Oral dosage unit form
US5656290A (en) 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
GB9722426D0 (en) 1997-10-23 1997-12-24 Univ London Pharmacy Controlled release formulations
GB9724186D0 (en) 1997-11-14 1998-01-14 British Tech Group Low temperature coatings
FI20000780A (fi) 2000-04-03 2001-10-04 Novasso Oy Peroraalinen lääkemuoto lääkeaineen hallituksi vapauttamiseksi
GB2367002A (en) 2000-09-25 2002-03-27 British Sugar Plc Coating composition
GB0203421D0 (en) 2002-02-13 2002-04-03 Alizyme Therapeutics Ltd Composition
US7670627B2 (en) 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
DE102005032806A1 (de) 2005-07-12 2007-01-18 Röhm Gmbh Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
SI2152250T1 (sl) 2007-05-07 2020-06-30 Evonik Operations Gmbh Trdne dozirne oblike, ki vsebujejo enterično oplaščenje s pospešenim sproščanjem zdravila
EP2688557B1 (en) * 2011-03-23 2017-08-23 Ironshore Pharmaceuticals & Development, Inc. Methods and compositions for treatment of attention deficit disorder
CU24343B1 (es) * 2012-04-30 2018-05-08 Tillotts Pharma Ag Formulación de fármaco de liberación retardada
NO2659881T3 (ru) 2012-04-30 2018-04-28
AU2013404367B2 (en) * 2013-10-29 2020-02-27 Tillotts Pharma Ag A delayed release drug formulation
ES2874669T3 (es) * 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma

Also Published As

Publication number Publication date
WO2020115257A1 (en) 2020-06-11
BR112021010913A2 (pt) 2021-08-24
US20220016037A1 (en) 2022-01-20
EP3890711A1 (en) 2021-10-13
MA54376A (fr) 2022-03-16
TW202038916A (zh) 2020-11-01
JP7423629B2 (ja) 2024-01-29
JP2022515340A (ja) 2022-02-18
AR117281A1 (es) 2021-07-28
CN113164400A (zh) 2021-07-23
IL283719A (en) 2021-07-29
AU2019394740A1 (en) 2021-06-17
EP3662900A1 (en) 2020-06-10
KR20210100666A (ko) 2021-08-17
CA3122033A1 (en) 2020-06-11

Similar Documents

Publication Publication Date Title
NO20084292L (no) Formulering for legemiddellevering til kolon
MA55365A (fr) Procédés de production de bioconjugués de polysaccharides o-antigènes d' e. coli, compositions de ceux-ci et leurs procédés d'utilisation
DK1409708T3 (da) Anvendelser af en glucan afledt af mælkesyrebakterier som anti-korrosionsmiddel
MX2012014849A (es) Acetato succinato de hidroxipropil metil celulosa con substitucion de acetato de y succinato intensificada.
SE542193C2 (en) A method for producing a film having good barrier properties and a film having good barrier properties
MX2012008919A (es) Polimeros solubles ramificados de glucosa para dialisis peritoneal.
PL2197417T3 (pl) Kompozycja farmaceutyczna zawierająca S-nitrozoglutation i polisacharyd
WO2009031039A3 (en) Tablet coatings made from modified carboxymethylcellulose materials
MX2020008643A (es) Mejoras en o con relacion a compuestos organicos.
EA202191431A1 (ru) Композиция для доставки лекарственных средств в толстую кишку
CR20210405A (es) Formulación pesticida que comprende mfc como modificador de reología
PH12020551041A1 (en) Carrageenan-based compositions for films and capsules
UA99137C2 (ru) Термостабильная композиция для животных, содержащая смесь ферментов
MX2016016336A (es) Composiciones y metodos para producir almidon con funcionalidad novedosa.
MX2017014982A (es) Almidon gelificante termicamente reversible.
CN104082639A (zh) 一种组合物增稠剂
GEP20247608B (en) Delayed release drug formulation comprising an outerlayer with an enzymaticyally degradable polymer, its composition and its method of manufacturing
WO2018020516A3 (en) A polymer network, method for production, and uses thereof
BR112013001945A2 (pt) método para produzir um glicosídeo etilenicamente insaturado
PH12019550296A1 (en) High-strength sheet material
WO2009078438A1 (ja) 微生物複合体
JP2007535583A5 (ru)
RU2015145095A (ru) Способ получения полисахаридов антибактериального действия
PH22018050327Y1 (en) Capsule film for colon-targeted drug delivery
MX2019014813A (es) Suspension de biopolimero hinchable y dispersable.