ITUA20161967A1 - Sensibilizzazione di cellule cancerose a inibitori di NAMPT mediante neutralizzazione di acido nicotinico fosforibosiltransferasi - Google Patents
Sensibilizzazione di cellule cancerose a inibitori di NAMPT mediante neutralizzazione di acido nicotinico fosforibosiltransferasiInfo
- Publication number
- ITUA20161967A1 ITUA20161967A1 ITUA2016A001967A ITUA20161967A ITUA20161967A1 IT UA20161967 A1 ITUA20161967 A1 IT UA20161967A1 IT UA2016A001967 A ITUA2016A001967 A IT UA2016A001967A IT UA20161967 A ITUA20161967 A IT UA20161967A IT UA20161967 A1 ITUA20161967 A1 IT UA20161967A1
- Authority
- IT
- Italy
- Prior art keywords
- sensitization
- neutralization
- cancer cells
- nicotinic acid
- nampt inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUA2016A001967A ITUA20161967A1 (it) | 2016-03-24 | 2016-03-24 | Sensibilizzazione di cellule cancerose a inibitori di NAMPT mediante neutralizzazione di acido nicotinico fosforibosiltransferasi |
PCT/EP2017/057021 WO2017162840A1 (en) | 2016-03-24 | 2017-03-23 | Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUA2016A001967A ITUA20161967A1 (it) | 2016-03-24 | 2016-03-24 | Sensibilizzazione di cellule cancerose a inibitori di NAMPT mediante neutralizzazione di acido nicotinico fosforibosiltransferasi |
Publications (1)
Publication Number | Publication Date |
---|---|
ITUA20161967A1 true ITUA20161967A1 (it) | 2017-09-24 |
Family
ID=56235880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITUA2016A001967A ITUA20161967A1 (it) | 2016-03-24 | 2016-03-24 | Sensibilizzazione di cellule cancerose a inibitori di NAMPT mediante neutralizzazione di acido nicotinico fosforibosiltransferasi |
Country Status (2)
Country | Link |
---|---|
IT (1) | ITUA20161967A1 (it) |
WO (1) | WO2017162840A1 (it) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019087199A1 (en) * | 2017-11-06 | 2019-05-09 | Curewize Health Ltd. | Methods for prognosis and treatment of solid tumors |
JP2019137638A (ja) * | 2018-02-09 | 2019-08-22 | アピオン・ジャパン有限会社 | 新規nampt阻害剤およびそれを含有する抗腫瘍剤、新規nampt阻害剤のスクリーニング方法、新規naprt阻害剤およびそれを含有する抗腫瘍剤、新規naprt阻害剤のスクリーニング方法、腫瘍細胞に対して正常細胞の割合を増やすための方法、並びに抗腫瘍剤の処方を補助する方法 |
CN116010663B (zh) * | 2023-03-21 | 2023-06-30 | 上海美吉生物医药科技有限公司 | 一种tmt项目图谱解析和数据分析的方法及系统 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011006988A1 (en) * | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
-
2016
- 2016-03-24 IT ITUA2016A001967A patent/ITUA20161967A1/it unknown
-
2017
- 2017-03-23 WO PCT/EP2017/057021 patent/WO2017162840A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011006988A1 (en) * | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
Non-Patent Citations (4)
Title |
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ANNE ROULSTON ET AL: "New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology", MOLECULAR & CELLULAR ONCOLOGY, vol. 3, no. 1, 10 June 2015 (2015-06-10), pages e1052180, XP055327016, DOI: 10.1080/23723556.2015.1052180 * |
D. S. SHAMES ET AL: "Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors", CLINICAL CANCER RESEARCH, vol. 19, no. 24, 4 October 2013 (2013-10-04), US, pages 6912 - 6923, XP055326877, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-13-1186 * |
GAUT Z N ET AL: "Inhibition of 7-<14>C nicotinic acid metabolism in the human blood platelet by anti inflammatory drugs", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, PJD PUBLICATIONS LTD., WESTBURY, NY, US, vol. 1, no. 4, 1 July 1970 (1970-07-01), pages 547 (22) - 552 (29), XP008182522, ISSN: 0034-5164 * |
GAUT Z N ET AL: "Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 20, no. 10, 1 October 1971 (1971-10-01), pages 2903 - 2906, XP025541799, ISSN: 0006-2952, [retrieved on 19711001], DOI: 10.1016/0006-2952(71)90202-4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017162840A1 (en) | 2017-09-28 |
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