IT201700104587A1 - Usi terapeutici di lembi di cellule geneticamente modificate - Google Patents

Usi terapeutici di lembi di cellule geneticamente modificate

Info

Publication number
IT201700104587A1
IT201700104587A1 IT102017000104587A IT201700104587A IT201700104587A1 IT 201700104587 A1 IT201700104587 A1 IT 201700104587A1 IT 102017000104587 A IT102017000104587 A IT 102017000104587A IT 201700104587 A IT201700104587 A IT 201700104587A IT 201700104587 A1 IT201700104587 A1 IT 201700104587A1
Authority
IT
Italy
Prior art keywords
lembas
genetically modified
therapeutic uses
modified cells
cells
Prior art date
Application number
IT102017000104587A
Other languages
English (en)
Inventor
Luca Michele De
Graziella Pellegrini
Original Assignee
Holostem Terapie Avanzate S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holostem Terapie Avanzate S R L filed Critical Holostem Terapie Avanzate S R L
Priority to IT102017000104587A priority Critical patent/IT201700104587A1/it
Priority to US16/647,565 priority patent/US20200276246A1/en
Priority to EP18766291.1A priority patent/EP3684384A1/en
Priority to PCT/EP2018/075186 priority patent/WO2019057704A1/en
Publication of IT201700104587A1 publication Critical patent/IT201700104587A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/56—Fibrin; Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT102017000104587A 2017-09-19 2017-09-19 Usi terapeutici di lembi di cellule geneticamente modificate IT201700104587A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102017000104587A IT201700104587A1 (it) 2017-09-19 2017-09-19 Usi terapeutici di lembi di cellule geneticamente modificate
US16/647,565 US20200276246A1 (en) 2017-09-19 2018-09-18 Therapeutic uses of flap of genetically modified cells
EP18766291.1A EP3684384A1 (en) 2017-09-19 2018-09-18 Therapeutic uses of flap of genetically modified cells
PCT/EP2018/075186 WO2019057704A1 (en) 2017-09-19 2018-09-18 THERAPEUTIC USES OF THE RANGE OF GENETICALLY MODIFIED CELLS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000104587A IT201700104587A1 (it) 2017-09-19 2017-09-19 Usi terapeutici di lembi di cellule geneticamente modificate

Publications (1)

Publication Number Publication Date
IT201700104587A1 true IT201700104587A1 (it) 2019-03-19

Family

ID=61006171

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000104587A IT201700104587A1 (it) 2017-09-19 2017-09-19 Usi terapeutici di lembi di cellule geneticamente modificate

Country Status (4)

Country Link
US (1) US20200276246A1 (it)
EP (1) EP3684384A1 (it)
IT (1) IT201700104587A1 (it)
WO (1) WO2019057704A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110845603B (zh) * 2019-10-31 2021-07-02 山西锦波生物医药股份有限公司 人胶原蛋白17型多肽、其生产方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151248A1 (en) * 2008-07-30 2010-02-10 Johann Bauer Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
WO2017120147A1 (en) * 2016-01-04 2017-07-13 The Board Of Trustees Of The Leland Stanford Junior University Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE450601T1 (de) 2003-09-19 2009-12-15 Univ Keio Zusammensetzung für die beschichtung eines trägers zur herstellung einer zellage, träger zur herstellung einer zellage und verfahren zur herstellung einer zellage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151248A1 (en) * 2008-07-30 2010-02-10 Johann Bauer Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
WO2017120147A1 (en) * 2016-01-04 2017-07-13 The Board Of Trustees Of The Leland Stanford Junior University Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEL RIO M ET AL: "A preclinical model for the analysis of genetically modified human skin in vivo", HUMAN GENE THERAPY, & CONFERENCE ON CHANGING THE FACE OF MODERN MEDICINE - STEM CELLS AND GENE THERAPY; FLORENCE, ITALY; OCTOBER 18 -21, 2016, vol. 13, no. 8, 20 May 2002 (2002-05-20), pages 959 - 968, XP002973213, ISSN: 1043-0342, DOI: 10.1089/10430340252939069 *
ELENA DELLAMBRA ET AL: "Corrective Transduction of Human Epidermal Stem Cells in Laminin-5-Dependent Junctional Epidermolysis Bullosa", HUMAN GENE THERAPY, vol. 9, no. 9, 10 June 1998 (1998-06-10), & CONFERENCE ON CHANGING THE FACE OF MODERN MEDICINE - STEM CELLS AND GENE THERAPY; FLORENCE, ITALY; OCTOBER 18 -21, 2016, pages 1359 - 1370, XP055462504, ISSN: 1043-0342, DOI: 10.1089/hum.1998.9.9-1359 *
FULVIO MAVILIO ET AL: "Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells", NATURE MEDICINE, vol. 12, no. 12, 1 January 2007 (2007-01-01), pages 1397 - 1402, XP055355723, ISSN: 1078-8956, DOI: 10.1038/nm1504 *
YANNICK GACHE ET AL: "Construction of Skin Equivalents for Gene Therapy of Recessive Dystrophic Epidermolysis Bullosa", HUMAN GENE THERAPY, vol. 15, no. 10, 1 October 2004 (2004-10-01), & CONFERENCE ON CHANGING THE FACE OF MODERN MEDICINE - STEM CELLS AND GENE THERAPY; FLORENCE, ITALY; OCTOBER 18 -21, 2016, pages 921 - 933, XP055460324, ISSN: 1043-0342, DOI: 10.1089/hum.2004.15.921 *

Also Published As

Publication number Publication date
WO2019057704A1 (en) 2019-03-28
EP3684384A1 (en) 2020-07-29
US20200276246A1 (en) 2020-09-03

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