ITMI962182A1 - COMPOSITION BASED ON QUAIL EGGS AND ITS PHARMACEUTICAL OR COSMETIC USE - Google Patents
COMPOSITION BASED ON QUAIL EGGS AND ITS PHARMACEUTICAL OR COSMETIC USE Download PDFInfo
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- ITMI962182A1 ITMI962182A1 IT96MI002182A ITMI962182A ITMI962182A1 IT MI962182 A1 ITMI962182 A1 IT MI962182A1 IT 96MI002182 A IT96MI002182 A IT 96MI002182A IT MI962182 A ITMI962182 A IT MI962182A IT MI962182 A1 ITMI962182 A1 IT MI962182A1
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- composition according
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- quail egg
- egg extract
- quail
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
DESCRIZIONE dell'invenzione industriale DESCRIPTION of the industrial invention
La presente invenzione riguarda le composizioni impiegate sia nel settore medico o nel settore veterinario, che nel settore cosmetico, oppure per la cura di parti superficiali del corpo umano e che sono costitute da un estratto di uova di quaglia. The present invention relates to compositions used both in the medical or veterinary sector, and in the cosmetic sector, or for the treatment of superficial parts of the human body and which consist of an extract of quail eggs.
Con il termine "uova di quaglia" si intendono le uova della specie animale Coturnix, domestica oppure selvaggia, e in particolare del ceppo B Mina. The term "quail eggs" refers to the eggs of the Coturnix animal species, domestic or wild, and in particular of the B Mina strain.
Con il termine "estratto", si intende qualsiasi frazione o parte biologicamente attiva nei confronti dell' uomo o dell'animale, delle uova di quaglia considerata come prodotto naturale, ottenuta dopo apertura ed eventualmente differenti trattamenti meccanici, fisici, chimici che consentono di separare oppure di arricchire qualsiasi costituente di -dette uova, sia che si tratti dell'albume di uovo e/o del tuorlo di uovo, oppure di qualsiasi altro costituente attivo o utile di detto uovo. Tali estratti, in generale, vengono ottenuti sotto forma omogenea, allo stato secco, per esempio mediante liofilizzazione, oppure allo stato umido, per esempio sotto forma di fluidi . The term "extract" means any fraction or part that is biologically active towards man or animal, of quail eggs considered as a natural product, obtained after opening and possibly different mechanical, physical, chemical treatments that allow to separate or to enrich any constituent of said eggs, whether it is egg white and / or egg yolk, or any other active or useful constituent of said egg. These extracts are generally obtained in a homogeneous form, in the dry state, for example by lyophilization, or in the wet state, for example in the form of fluids.
L'effetto biologicamente benefico dell'uovo di quaglia, in particolare nel trattamento di differenti disturbi, è noto da lungo tempo. Per esempio, ciò è stato stabilito e discusso nel seguente documento francese: "La Clinique", N° 22, 15 marzo 1978, pag. 2 fino a 4, JC Truffier. The biologically beneficial effect of quail egg, particularly in the treatment of different ailments, has been known for a long time. For example, this has been established and discussed in the following French document: "La Clinique", N ° 22, March 15, 1978, p. 2 to 4, JC Truffier.
Secondo il documento EP-A-0 032 344, è stato descritto e proposto un farmaco per via orale, costituito soltanto da un estratto di uova di quaglia, sotto forma di liofilizzato. According to the document EP-A-0 032 344, an oral drug has been described and proposed, consisting only of an extract of quail eggs, in the form of a lyophilisate.
Secondo il documento FR-A-2 477 017, è stata descritta e proposta una composizione ingeribile, costituita, in proporzione di 90-97% in peso, da un estratto di uova di quaglia, un idrolizzato oppure un autolisato^ di proteine animali ed un amminoacido avente un'azione epatoprotettiva. According to document FR-A-2 477 017, an ingestible composition has been described and proposed, consisting, in the proportion of 90-97% by weight, of an extract of quail eggs, a hydrolyzate or an autolysate of animal proteins and an amino acid having a hepatoprotective action.
Secondo il documento FR-A-2 538 248, come prodotto cosmetico, è già stata proposta una composizione costituita in miscela omogenea, da un estratto omogeneo di uova, nella proporzione in peso di 5-75% riferita al peso totale di detta composizione, un supporto adatto per un'applicazione sotto forma di strato oppure di pellicola sulle parti superficiali del corpo umano nella proporzione in peso di 20-80% e differenti additivi usuali in cosmetica . According to document FR-A-2 538 248, as a cosmetic product, a composition has already been proposed consisting of a homogeneous mixture, from a homogeneous egg extract, in the proportion by weight of 5-75% referred to the total weight of said composition, a support suitable for application in the form of a layer or film on the superficial parts of the human body in the proportion by weight of 20-80% and different additives usual in cosmetics.
Per una composizione per uso esterno e a base di un estratto di uova di quaglia, si è scoperto che, limitando detto estratto ad una quantità biologicamente efficace, efficacemente dosabile, ma, al massimo, uguale a 1 per mille in peso del totale della composizione, da un lato, si diminuiva il ritardo di azione biologica di detta composizione, e, d'altro canto si limitavano in modo notevole gli effetti secondari dell'estratto di uova di quaglia. For a composition for external use and based on an extract of quail eggs, it has been discovered that, by limiting said extract to a biologically effective, effectively measurable quantity, but, at the most, equal to 1 per thousand by weight of the total composition, on the one hand, the biological action delay of said composition was reduced, and, on the other hand, the secondary effects of the quail egg extract were considerably limited.
Per altro, la limitazione della quantità di estratto di uova di quaglia nella proporzione precedentemente indicata, consente di far aumentare la stabilità nel tempo delle composizioni per uso esterno prese in considerazione dalla presente invenzione. On the other hand, the limitation of the quantity of quail egg extract in the previously indicated proportion allows to increase the stability over time of the compositions for external use taken into consideration by the present invention.
L'estratto di uova di quaglia presente in una composizione secondo la presente invenzione può venire dosato secondo qualsiasi tecnica opportuna, partendo da una proprietà, da una caratteristica oppure da un'attività specifica di detto estratto, per esempio, un'attività antiproteasi, in particolare anti-tripsina di detto estratto.. The quail egg extract present in a composition according to the present invention can be dosed according to any suitable technique, starting from a property, a characteristic or a specific activity of said extract, for example, an antiprotease activity, in particular anti-trypsin of said extract ..
Preferibilmente, la quantità di estratto di uova di quaglia è compresa tra 0,01 e 0,053⁄4 e per esempio tra 0,02 e 0,043⁄4 del peso totale della composizione. Preferably, the quantity of quail egg extract is comprised between 0.01 and 0.053⁄4 and for example between 0.02 and 0.043⁄4 of the total weight of the composition.
Secondo un modo preferito di realizzazione della presente invenzione, l'estratto di uova di quaglia viene ottenuto mediante liofilizzazione di tutti i fluidi oppure di una parte dei fluidi, tra i quali il tuorlo d'uovo e l'albume di uovo, contenuti nell'uovo di quaglia. According to a preferred embodiment of the present invention, the quail egg extract is obtained by lyophilizing all the fluids or part of the fluids, including egg yolk and egg white, contained in the quail egg.
In modo tradizionale, una composizione secondo la presente invenzione è costituita da differenti additivi usuali per le composizioni farmaceutiche per uso topico, oppure per le composizioni cosmetiche. A titolo esemplificativo, si scelgono additivi tra: - i prodotti anti-ossidanti, come il tocoferolo, gli agenti di conservazione come l'acido sorbico, In a traditional way, a composition according to the present invention consists of different additives which are usual for pharmaceutical compositions for topical use, or for cosmetic compositions. By way of example, additives are chosen from: - anti-oxidant products, such as tocopherol, preservation agents such as sorbic acid,
- i coloranti, - dyes,
- i profumi naturali oppure sintetici, - natural or synthetic fragrances,
- i battericidi oppure gli agenti antimicrobici, in particolare gli antibiotici, - bactericides or antimicrobial agents, in particular antibiotics,
- le sostanze che conferiscono consistenza, - e i tensioattivi. - substances that give consistency, - and surfactants.
Il supporto di una composizione secondo la presente invenzione è costituito, preferibilmente, da un'emulsione omogenea oppure da un sistema che contiene almeno due fasi, per esempio, un'emulsione del tipo olio in acqua oppure acqua in olio. The support of a composition according to the present invention is preferably constituted by a homogeneous emulsion or by a system containing at least two phases, for example, an emulsion of the oil-in-water or water-in-oil type.
Questo supporto, a titolo esemplificativo, è adatto ad un'applicazione sulla pelle e/o sul cuoio capelluto del corpo umano e, a questo fine ha una forma di presentazione scelta nel gruppo che comprende creme, unguenti, pomate, oli, shampoo, schiume e saponi. This support, by way of example, is suitable for application on the skin and / or scalp of the human body and, for this purpose, has a form of presentation chosen from the group which includes creams, ointments, ointments, oils, shampoos, foams. and soaps.
Come già indicato, una composizione secondo la presente invenzione può venire impiegata come farmaco, in particolare per uso topico, e, per esempio, come composizione dermatologica. In quest'ultimo caso, e preferibilmente, la composizione dermatologica contiene una quantità terapeuticamente efficace dell'estratto di uova di quaglia per il trattamento di una malattia cutanea non infettiva, scelta nel gruppo che comprende eczema, in particolare eczema atopico, prurito in tutto il corpo umano oppure in sue parti, psoriasi e allergie. As already indicated, a composition according to the present invention can be used as a drug, in particular for topical use, and, for example, as a dermatological composition. In the latter case, and preferably, the dermatological composition contains a therapeutically effective amount of the quail egg extract for the treatment of a non-infectious skin disease, chosen from the group including eczema, in particular atopic eczema, pruritus all over the human body or parts of it, psoriasis and allergies.
Una composizione secondo la presente invenzione può anche venire impiegata come composizione cosmetica oppure per l'igiene di parti esterne del corpo umano. A composition according to the present invention can also be used as a cosmetic composition or for the hygiene of external parts of the human body.
Qui di seguito, a titolo esemplificativo, si descrive un procedimento completo di ottenimento di una composizione secondo la presente invenzione partendo da uova di quaglia. Hereinafter, by way of example, a complete process for obtaining a composition according to the present invention is described starting from quail eggs.
1/ Ottenimento di un estratto di uova di quaglia intero, ossia che contiene il tuorlo d'uovo e l'albume di uovo sotto forma omogenea e allo stato secco. 1 / Obtaining a whole quail egg extract, ie containing egg yolk and egg white in a homogeneous and dry state.
Si impiegano uova di quaglia di qualsiasi specie e provenienza, 'per esempio, della specie B Mina, prodotte da allevamenti posti sotto controllo sanitario e veterinario. Le uova fresche impiegate possono contenere embrioni oppure no. Quail eggs of any species and origin are used, for example, of the B Mina species, produced by farms under sanitary and veterinary control. The fresh eggs used may or may not contain embryos.
Le uova di quaglia vengono preventivamente trattate in modo da escludere, dai loro gusci, qualsiasi germe patogeno, per esempio, mediante immersione in uno o più bagni di soluzioni asettiche. Quail eggs are previously treated in order to exclude any pathogenic germs from their shells, for example, by immersion in one or more baths of aseptic solutions.
Le' uova vengono quindi rotte meccanicamente e vengono versate in una bacinella mantenuta sotto agitazione. Dopo avere separati i gusci, si procede ad una filtrazione in modo da ottenere, sotto forma fluida, una miscela di albume di uovo e di tuorlo di uovo di quaglia. Questa miscela viene sterilizzata mediante qualsiasi mezzo opportuno, che conservi le proprietà biologiche essenziali dei suoi costituenti. The eggs are then mechanically broken and poured into a bowl kept under stirring. After having separated the shells, a filtration is carried out in order to obtain, in fluid form, a mixture of egg white and quail egg yolk. This mixture is sterilized by any suitable means, which preserves the essential biological properties of its constituents.
La miscela sterilizzata, sotto forma di un fluido, viene quindi liofilizzata con qualsiasi prodotto opportuno, per ottenere una polvere omogenea di uova di quaglia intere. The sterilized mixture, in the form of a fluid, is then lyophilized with any suitable product, to obtain a homogeneous powder of whole quail eggs.
2/ Preparazione di una forma acquosa intermedia dell'estratto di uova di quaglia 2 / Preparation of an intermediate aqueous form of quail egg extract
Allo scopo di favorire l'incorporazione omogenea dell'estratto di uova di quaglia nel supporto definito qui di seguito, si prepara una sospensione omogenea in mezzo acquoso della polvere precedentemente ottenuta, nel modo seguente: In order to favor the homogeneous incorporation of the quail egg extract into the support defined below, a homogeneous suspension of the previously obtained powder is prepared in the aqueous medium, as follows:
si prelevano 18,65 mg della polvere precedentemente citata, 18.65 mg of the previously mentioned powder are taken,
- si impiega un eccipiente solubile in fase acquosa, costituito da 37,5 mg di stearato di magnesio, 973,5 mg di cellulosa microcristallina, 187,5 mg di croscarmellosio sodico e 6318,75 mg di lattosio, - an aqueous phase soluble excipient is used, consisting of 37.5 mg of magnesium stearate, 973.5 mg of microcrystalline cellulose, 187.5 mg of croscarmellose sodium and 6318.75 mg of lactose,
- e si miscelano in 100 mi di acqua pura sterile, la quantità di estratto di uova di quaglia precedentemente citata e 7,5 g dell'eccipiente avente la composizione precedentemente definita, ottenendo così 107,5 g di un liquido lattescente (A). - and the previously mentioned quantity of quail egg extract and 7.5 g of the excipient having the previously defined composition are mixed in 100 ml of sterile pure water, thus obtaining 107.5 g of a milky liquid (A).
3/ Preparazione del supporto adatto ad una applicazione in strato o in pellicola sulle parti superficiali del corpo umano 3 / Preparation of the substrate suitable for a layer or film application on the superficial parts of the human body
Questo supporto (B) è costituito da una fase acquosa (b) e da una fase oleosa (b'). This support (B) consists of an aqueous phase (b) and an oily phase (b ').
La fase acquosa (b) è un'acqua sterile sottoposta ad osmosi. Essa, in generale, costituisce tra il 43 e il 70% in peso del supporto (B) e, nel presente esempio, è 215,875 g. The aqueous phase (b) is sterile water subjected to osmosis. In general, it constitutes between 43 and 70% by weight of the support (B) and, in the present example, is 215.875 g.
La fase oleosa o grassa (b') è costituita dai seguenti prodotti nelle seguenti quantità: The oily or fat phase (b ') consists of the following products in the following quantities:
olio di jojoba: 2-4% in peso del supporto (B) e, nell'esempio presente 7,85 g; jojoba oil: 2-4% by weight of the support (B) and, in the present example, 7.85 g;
- un complesso di olii vegetali estratti da albicocca e da avocado: 2-3% del supporto (B) e, nel presente esempio 11,775 g, - a complex of vegetable oils extracted from apricot and avocado: 2-3% of the support (B) and, in the present example 11.775 g,
- burro di karité: 2-6% del supporto (B), e nel presente esempio 11,775 g, - shea butter: 2-6% of the carrier (B), and in the present example 11.775 g,
- esteri di acidi grassi estratti di soia: 8-10% del supporto (B), e nel presente esempio 35,325 g, - emulsionanti estratti di cereali e di soia che contengono lecitine e proteine: 16-34% del supporto (B), e nel presente esempio 109,8 g. - esters of fatty acids extracted from soy: 8-10% of the support (B), and in the present example 35.325 g, - emulsifiers extracted from cereals and soy containing lecithins and proteins: 16-34% of the support (B), and in the present example 109.8 g.
In queste condizioni, la fase oleosa (b') rappresenta 30-57% in peso del supporto (B) e nel presente esempio è 176,5g. Under these conditions, the oily phase (b ') represents 30-57% by weight of the support (B) and in the present example it is 176.5g.
Con mezzi tradizionali, si associano le fasi (b) e (b') sotto forma di un'emulsione olio in acqua che costituisce il supporto (B). Il rapporto in peso tra le fasi (b) e (b'), che si ottiene dalle proporzioni precedentemente definite, consente una buona idratazione della pelle. With traditional means, phases (b) and (b ') are associated in the form of an oil-in-water emulsion which constitutes the support (B). The weight ratio between phases (b) and (b '), which is obtained from the previously defined proportions, allows a good hydration of the skin.
Questa emulsione viene stabilizzata aggiungendo una sostanza naturale, contemporaneamente antibatterica e antiossidante, costituita da uno estratto di rosmarino, dosato allo 0,02% della composizione ottenuta al termine dello stadio che segue, ossia 0,1 g nel presente esempio. This emulsion is stabilized by adding a natural substance, at the same time antibacterial and antioxidant, consisting of a rosemary extract, dosed at 0.02% of the composition obtained at the end of the following step, i.e. 0.1 g in the present example.
4/ Ottenimento della composizione finale 4 / Obtaining the final composition
Il liquido lattescente (A), che costituisce la forma acquosa intermedia dell'estratto di uova di quaglia, viene introdotto, adottando qualsiasi mezzo tradizionale, nel supporto (B) e si ottengono 500 g di un prodotto finito stabile, di colore bianco e di aspetto fluido, il cui stendimento viene effettuato facilmente senza ungere la pelle. The milky liquid (A), which constitutes the intermediate aqueous form of the quail egg extract, is introduced, using any traditional means, into the support (B) and 500 g of a stable finished product, white in color and of fluid appearance, the spreading of which is carried out easily without greasing the skin.
Dalle quantità e dalle composizioni precedentemente esemplificate risulta che questo prodotto finito contiene 0,0375 % in peso dell'estratto di uova di quaglia. From the quantities and compositions previously exemplified it results that this finished product contains 0.0375% by weight of the quail egg extract.
La composizione del prodotto ottenuto alla fine può venire completata con .vitamine, come vitamina A e vitamina E, oligo-elementi, per esempio zinco, selenio . The composition of the product obtained at the end can be completed with vitamins, such as vitamin A and vitamin E, trace elements, for example zinc, selenium.
Questo prodotto può venire confezionato in modo opportuno, per esempio, in vasi, flaconi oppure in altri sistemi che consentono la sua distribuzione, che sono costituiti per esempio da pompe e da tubi. This product can be suitably packaged, for example, in jars, bottles or in other systems that allow its distribution, which are constituted for example by pumps and pipes.
La composizione ottenuta, come precedentemente descritto, è stata oggetto di prove cliniche su 21 persone affette da differenti malattie cutanee, non infettive, con risultati positivi e favorevoli ottenuti nel caso di 16 di dette persone. Alcuni casi sono descritti qui di seguito: The composition obtained, as previously described, was the subject of clinical trials on 21 people suffering from different non-infectious skin diseases, with positive and favorable results obtained in the case of 16 of said people. Some cases are described below:
Caso N° 1: una donna di 87 anni soffriva di un eczema di vecchia data sulla parte anteriore di una gamba. L'applicazione della composizione secondo la presente invenzione, due volte al giorno, ha comportato una scomparsa delle lesioni in corrispondenza del terzo giorno di applicazione. L'applicazione della composizione è stata proseguita fino ad oggi e non si è notata alcuna recidiva. Case # 1: An 87-year-old woman suffered from longstanding eczema on the front of one leg. The application of the composition according to the present invention, twice a day, resulted in a disappearance of the lesions on the third day of application. The application of the composition has continued to date and no recurrence has been noted.
Caso N° 2: una donna di 25 anni presentava problemi cutanei che comparivano durante i periodi di stress, con lesioni eritematose, calde e pruriginose. L'applicazione di una composizione secondo la presente invenzione sulle lesioni ha comportato una scomparsa dei sintomi in meno di 30 minuti. Case No. 2: A 25-year-old woman presented with skin problems that appeared during periods of stress, with erythematous, hot and itchy lesions. The application of a composition according to the present invention on the lesions resulted in a disappearance of the symptoms in less than 30 minutes.
Caso N° 3: un uomo di 66 anni soffriva di lesioni cutanee con pelle secca e con fenomeni di desquamazione e soprattutto con prurito che compariva in modo spontaneo e che veniva aggravato nel corso della manipolazione di oggetti polverosi oppure di erbe, con arrossamenti cutanei. Case N ° 3: a 66-year-old man suffered from skin lesions with dry skin and peeling phenomena and above all with itching that appeared spontaneously and was aggravated during the handling of dusty objects or herbs, with skin redness.
L'applicazione di una composizione secondo l'invenzione ha comportato una scomparsa del prurito entro qualche minuto, con una scomparsa degli arrossamenti in meno di 15 minuti. Il prurito, che compariva parecchie volte durante la giornata, è diventato sempre meno frequente e è stato calmato in modo sistematico da una nuova applicazione. The application of a composition according to the invention resulted in a disappearance of the itch within a few minutes, with a disappearance of the redness in less than 15 minutes. The itch, which appeared several times during the day, became less and less frequent and was systematically calmed by a new application.
Caso N° 4: un uomo di 25 anni soffriva di una psoriasi relativamente di vecchia data, localizzata sui fianchi e sulla parte laterale della parte superiore delle cosce e che resisteva nei confronti di terapie tradizionali. L'applicazione della composizione secondo l'invenzione ha comportato una diminuzione delle lesioni in corrispondenza del secondo giorno e una scomparsa del prurito. Dopo parecchi giorni di applicazione, il miglioramento è diventato progressivo e persistente sopprimendo la desquamazione. Alla fine di 3 settimane, si è notata una stabilizzazione del risultato. Case No. 4: A 25-year-old man suffered from relatively long-standing psoriasis, localized on the hips and sides of the upper thighs and resisting traditional therapies. The application of the composition according to the invention led to a decrease in lesions on the second day and a disappearance of the itch. After several days of application, the improvement became progressive and persistent by suppressing the desquamation. At the end of 3 weeks, a stabilization of the result was noted.
Caso N° 5: Un bambino di 12 anni soffriva di una lesione cutanea con uno strato rosso, pelle simile a cartone, infiammazione, a livello del cavo popliteo e della parte interna del ginocchio destro. L'origine di questa lesione era indeterminata. In corrispondenza del primo giorno di applicazione di una composizione secondo l'invenzione, si è osservata una regressione dei segni di infiammazione locale, con una persistenza di una zona eritematosa localizzata. In corrispondenza del secondo giorno e del terzo giorno, la lesione iniziale era quasi scomparsa, ma differenti segni cutanei, che ricordano un poco una allergia solare, sono comparsi sulla superficie interna della coscia. In corrispondenza del quarto giorno, questi segni sono quasi scomparsi. In corrispondenza del quinto giorno, la pelle ha ripreso il suo carattere normale. Case No. 5: A 12-year-old boy suffered from a skin lesion with a red layer, cardboard-like skin, inflammation, at the level of the popliteal fossa and the inner part of the right knee. The origin of this injury was undetermined. On the first day of application of a composition according to the invention, a regression of the signs of local inflammation was observed, with a persistence of a localized erythematous area. By day two and day three, the initial lesion had almost disappeared, but different skin signs, somewhat reminiscent of a sun allergy, appeared on the inner surface of the thigh. By the fourth day, these signs have almost disappeared. By the fifth day, the skin returned to its normal character.
Claims (10)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9512670A FR2740041B3 (en) | 1995-10-23 | 1995-10-23 | QUAIL EGG COMPOSITION, AND ITS PHARMACEUTICAL OR COSMETIC USE |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI962182A1 true ITMI962182A1 (en) | 1998-04-22 |
IT1285544B1 IT1285544B1 (en) | 1998-06-08 |
Family
ID=9483970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI002182A IT1285544B1 (en) | 1995-10-23 | 1996-10-22 | COMPOSITION BASED ON QUAIL EGGS AND ITS PHARMACEUTICAL OR COSMETIC USE |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH690540A5 (en) |
FR (1) | FR2740041B3 (en) |
IT (1) | IT1285544B1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2810550B1 (en) * | 2000-06-27 | 2004-10-08 | Medibrevex | NOVEL SOLUBLE GALEIC FORMS OF QUAIL EGGS FOR MEDICINAL USE FOR EYE AND NASAL WASHING AND METHODS OF MAKING SAME |
FR2811898B1 (en) * | 2000-07-18 | 2003-12-12 | Medibrevex | GALENIC MEDICINAL FORMS HOMEOPATHIC OF ALLERGENS IMPREGNATED ON A BIOLOGICALLY ACTIVE SUPPORT FOR SPECIFIC DESENSITIZATION BY SUBLINGUAL WAY AND THEIR MANUFACTURING PROCESS |
FR2813531B1 (en) * | 2000-09-06 | 2003-02-14 | Medibrevex | GALENIC FORMS OF OLIGOELEMENTS INCORPORATED IN A BIOLOGICALLY ACTIVE EXCIPIENT OF HOMOGENATE OF QUAIL EGGS AND THEIR MANUFACTURING METHOD |
FR2939044B1 (en) * | 2008-11-28 | 2010-12-31 | Dit Bon Michel Betend | NOVEL FORMULATIONS BASED ON ANTISED MILK LYOPHILISATES AND HUMAN PROTEAS INHIBITORS, INDICATED IN MILK INTOLERANCE, ALLERGIC AND INFECTIOUS INFLAMMATION |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2472391A1 (en) * | 1979-12-28 | 1981-07-03 | Truffier Jean Claude | QUAY EGG LYOPHILIZATION FOR THE TREATMENT OF ALLERGIC DISEASES |
HU194740B (en) * | 1984-07-24 | 1988-03-28 | Egal Vegyipari Koezoes Vallala | Process for preparing roborating composition of quail egg base |
JPS61280413A (en) * | 1985-06-05 | 1986-12-11 | Res Inst For Prod Dev | Hair cosmetic |
JPS62283907A (en) * | 1986-05-30 | 1987-12-09 | Res Inst For Prod Dev | Skin cosmetic |
FR2624013B2 (en) * | 1987-10-08 | 1991-07-12 | Medibrevex | APPLICATION AS MEDICINES USEFUL FOR THE ALLOPATHIC TREATMENT OF ALLERGIC DISEASES OF GALENIC FORMS OF QUAIL EGGS |
JPH02149525A (en) * | 1988-11-30 | 1990-06-08 | Taiyo Kagaku Co Ltd | Anti-carcinogenic promoter composition, drink composition and external preparation composition containing the same composition |
-
1995
- 1995-10-23 FR FR9512670A patent/FR2740041B3/en not_active Expired - Lifetime
-
1996
- 1996-10-22 CH CH02584/96A patent/CH690540A5/en not_active IP Right Cessation
- 1996-10-22 IT IT96MI002182A patent/IT1285544B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CH690540A5 (en) | 2000-10-13 |
FR2740041B3 (en) | 1997-09-12 |
IT1285544B1 (en) | 1998-06-08 |
FR2740041A3 (en) | 1997-04-25 |
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