ITMI921569A1 - N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica, dopaminergica e adrenergica - Google Patents

N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica, dopaminergica e adrenergica

Info

Publication number
ITMI921569A1
ITMI921569A1 IT001569A ITMI921569A ITMI921569A1 IT MI921569 A1 ITMI921569 A1 IT MI921569A1 IT 001569 A IT001569 A IT 001569A IT MI921569 A ITMI921569 A IT MI921569A IT MI921569 A1 ITMI921569 A1 IT MI921569A1
Authority
IT
Italy
Prior art keywords
tetralinalchil
eter0
etero
serotoninergic
aril
Prior art date
Application number
IT001569A
Other languages
English (en)
Inventor
Francesco Berardi
Gabriele Binda
Marino Gobetti
Stefano Govoni
Vincenzo Olgiati
Roberto Perrone
Giancarlo Tonon
Ermes Vanotti
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of ITMI921569A0 publication Critical patent/ITMI921569A0/it
Priority to ITMI921569A priority Critical patent/IT1255178B/it
Priority to JP6502035A priority patent/JPH07508514A/ja
Priority to HU9403768A priority patent/HUT71405A/hu
Priority to CA002137685A priority patent/CA2137685A1/en
Priority to RU94046220A priority patent/RU2115651C1/ru
Priority to PCT/EP1993/001589 priority patent/WO1994000441A1/en
Priority to NZ253689A priority patent/NZ253689A/en
Priority to AU44195/93A priority patent/AU670444B2/en
Priority to EP93914690A priority patent/EP0647222A1/en
Priority to ZA934472A priority patent/ZA934472B/xx
Priority to IL106124A priority patent/IL106124A/en
Publication of ITMI921569A1 publication Critical patent/ITMI921569A1/it
Priority to FI945997A priority patent/FI945997A0/fi
Priority to KR1019940704767A priority patent/KR950702195A/ko
Application granted granted Critical
Publication of IT1255178B publication Critical patent/IT1255178B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI921569A 1992-06-26 1992-06-26 N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica IT1255178B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITMI921569A IT1255178B (it) 1992-06-26 1992-06-26 N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica
NZ253689A NZ253689A (en) 1992-06-26 1993-06-22 N-(hetero)aryl-n'(hetero)-tetralinalkyl piperazine derivatives and pharmaceutical compositions
EP93914690A EP0647222A1 (en) 1992-06-26 1993-06-22 N(hetero)-aryl-n(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
CA002137685A CA2137685A1 (en) 1992-06-26 1993-06-22 N(hetero)-aryl-n-(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
RU94046220A RU2115651C1 (ru) 1992-06-26 1993-06-22 N(гетеро)-арил-n(гетеро)-тетралин-алкил-пиперазины, способ их получения
PCT/EP1993/001589 WO1994000441A1 (en) 1992-06-26 1993-06-22 N(hetero)-aryl-n(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
JP6502035A JPH07508514A (ja) 1992-06-26 1993-06-22 セレトニン性，ドーパミン性およびアドレナリン性の活性を有するｎ（ヘテロ）−アリール−ｎ（ヘテロ）−テトラリン−アルキル−ピペラジン
AU44195/93A AU670444B2 (en) 1992-06-26 1993-06-22 N(hetero)-aryl-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
HU9403768A HUT71405A (en) 1992-06-26 1993-06-22 N(hetero-aryl-n(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
ZA934472A ZA934472B (en) 1992-06-26 1993-06-22 N(hetero)-aryl-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity.
IL106124A IL106124A (en) 1992-06-26 1993-06-24 N) Hetero (-aryl-N) Hetero (-terlin-alkyl-piperazines, having serotonergic, dopaminergic and adrenergic activity
FI945997A FI945997A0 (fi) 1992-06-26 1994-12-21 Serotoniiniergisen, dopamiiniergisen ja adrenergisen aktiivisuuden omaava N(hetero)- aryyli-N(hetero)-tetralinialkyylipiperatsiini
KR1019940704767A KR950702195A (ko) 1992-06-26 1994-12-26 세로토닌, 도파민 및 아드레날린 활성을 갖는 N-아릴-N-테트랄린-알킬-피페라진[N(hetero)-ary-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity]

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921569A IT1255178B (it) 1992-06-26 1992-06-26 N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica

Publications (3)

Publication Number Publication Date
ITMI921569A0 ITMI921569A0 (it) 1992-06-26
ITMI921569A1 true ITMI921569A1 (it) 1993-12-26
IT1255178B IT1255178B (it) 1995-10-20

Family

ID=11363580

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921569A IT1255178B (it) 1992-06-26 1992-06-26 N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica

Country Status (13)

Country Link
EP (1) EP0647222A1 (it)
JP (1) JPH07508514A (it)
KR (1) KR950702195A (it)
AU (1) AU670444B2 (it)
CA (1) CA2137685A1 (it)
FI (1) FI945997A0 (it)
HU (1) HUT71405A (it)
IL (1) IL106124A (it)
IT (1) IT1255178B (it)
NZ (1) NZ253689A (it)
RU (1) RU2115651C1 (it)
WO (1) WO1994000441A1 (it)
ZA (1) ZA934472B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0737189B1 (en) * 1993-12-28 1999-07-28 PHARMACIA & UPJOHN COMPANY Heterocyclic compounds for the treatment of cns and cardiovascular disorders
FR2716193B1 (fr) * 1994-02-16 1996-04-05 Synthelabo Dérivés de 1[2-(1h-inden-3-yl)ethyl]-4-(naphtalen-1-yl)piperazine, leur préparation et leur application en thérapeutique.
US5472966A (en) * 1995-03-29 1995-12-05 Bristol-Myers Squibb Company Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines
FR2737723B1 (fr) * 1995-08-09 1997-09-05 Synthelabo Derives de 1-(2-(1h-inden-3-yl)ethyl)-4-(naphtalen-1-yl)- piperazine, leur preparation et leur application en therapeutique
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
WO2001049679A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
KR100496874B1 (ko) * 2003-07-03 2005-06-22 주식회사 엘지화학 초임계 이산화탄소를 이용한 폴리메틸메타크릴레이트제조방법
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1829869A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
AU2010325925B2 (en) 2009-12-04 2016-02-25 Pgi Drug Discovery Llc. Multicyclic compounds and methods of use thereof
JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
MA45857A (fr) 2016-07-29 2021-05-19 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
AU2018220509B2 (en) 2017-02-16 2022-04-28 Sunovion Pharmaceuticials Inc. Methods of treating schizophrenia
CA3070993A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
KR20200122345A (ko) 2018-02-16 2020-10-27 선오비온 파마슈티컬스 인코포레이티드 염, 결정 형태 및 이들의 제조 방법
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders

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DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung
US4130646A (en) * 1975-07-25 1978-12-19 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
GB2093837B (en) * 1981-03-02 1985-04-24 Abbott Lab Aminoalkyl subsituted 1,2,3,4-tetrahydronaphtalenes
US4473586A (en) * 1982-05-03 1984-09-25 Abbott Laboratories Aminoalkyl dihydronaphthalenes
DE3506117A1 (de) * 1985-02-22 1986-08-28 Basf Ag, 6700 Ludwigshafen Amine, verfahren zu ihrer herstellung und ihre verwendung als fungizide

Also Published As

Publication number Publication date
HUT71405A (en) 1995-11-28
IT1255178B (it) 1995-10-20
AU4419593A (en) 1994-01-24
EP0647222A1 (en) 1995-04-12
KR950702195A (ko) 1995-06-19
RU2115651C1 (ru) 1998-07-20
FI945997A (fi) 1994-12-21
AU670444B2 (en) 1996-07-18
JPH07508514A (ja) 1995-09-21
IL106124A (en) 1998-02-22
HU9403768D0 (en) 1995-02-28
CA2137685A1 (en) 1994-01-06
NZ253689A (en) 1996-11-26
ITMI921569A0 (it) 1992-06-26
FI945997A0 (fi) 1994-12-21
WO1994000441A1 (en) 1994-01-06
RU94046220A (ru) 1996-09-27
ZA934472B (en) 1994-01-18

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Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960613