ZA934472B - N(hetero)-aryl-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity. - Google Patents
N(hetero)-aryl-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity.Info
- Publication number
- ZA934472B ZA934472B ZA934472A ZA934472A ZA934472B ZA 934472 B ZA934472 B ZA 934472B ZA 934472 A ZA934472 A ZA 934472A ZA 934472 A ZA934472 A ZA 934472A ZA 934472 B ZA934472 B ZA 934472B
- Authority
- ZA
- South Africa
- Prior art keywords
- hetero
- serotoninergic
- dopaminergic
- tetralin
- piperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921569A IT1255178B (en) | 1992-06-26 | 1992-06-26 | N (ETER0) -ARIL-N (ETERO) -TETRALINALCHIL PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITIES |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA934472B true ZA934472B (en) | 1994-01-18 |
Family
ID=11363580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA934472A ZA934472B (en) | 1992-06-26 | 1993-06-22 | N(hetero)-aryl-N(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0647222A1 (en) |
JP (1) | JPH07508514A (en) |
KR (1) | KR950702195A (en) |
AU (1) | AU670444B2 (en) |
CA (1) | CA2137685A1 (en) |
FI (1) | FI945997A0 (en) |
HU (1) | HUT71405A (en) |
IL (1) | IL106124A (en) |
IT (1) | IT1255178B (en) |
NZ (1) | NZ253689A (en) |
RU (1) | RU2115651C1 (en) |
WO (1) | WO1994000441A1 (en) |
ZA (1) | ZA934472B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU684874B2 (en) * | 1993-12-28 | 1998-01-08 | Pharmacia & Upjohn Company | Heterocyclic compounds for the treatment of cns and cardiovascular disorders |
FR2716193B1 (en) * | 1994-02-16 | 1996-04-05 | Synthelabo | 1 [2- (1h-inden-3-yl) ethyl] -4- (naphthalen-1-yl) piperazine derivatives, their preparation and their therapeutic use. |
US5472966A (en) * | 1995-03-29 | 1995-12-05 | Bristol-Myers Squibb Company | Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines |
FR2737723B1 (en) * | 1995-08-09 | 1997-09-05 | Synthelabo | DERIVATIVES OF 1- (2- (1H-INDEN-3-YL) ETHYL) -4- (NAPHTALEN-1-YL) - PIPERAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
TW407153B (en) * | 1997-10-27 | 2000-10-01 | Nippon Kayaku Kk | Imidazole compounds and their use |
SK11072002A3 (en) * | 1999-12-30 | 2003-03-04 | H. Lundbeck A/S | Halo-substituted 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives, pharmaceutical composition containing the same and use thereof |
KR100496874B1 (en) * | 2003-07-03 | 2005-06-22 | 주식회사 엘지화학 | Method for Preparing Polymethylmethacrylate Using Supercritical Carbon Dioxide |
US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
EP1829869A1 (en) * | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands |
KR102074089B1 (en) | 2009-12-04 | 2020-02-05 | 선오비온 파마슈티컬스 인코포레이티드 | Multicyclic compounds and methods of use thereof |
EA201990400A1 (en) | 2016-07-29 | 2019-07-31 | Суновион Фармасьютикалз, Инк. | COMPOUNDS AND COMPOSITIONS AND THEIR APPLICATION |
MA45795A (en) | 2016-07-29 | 2019-06-05 | Sunovion Pharmaceuticals Inc | COMPOUNDS AND COMPOSITIONS, AND ASSOCIATED USES |
KR102605854B1 (en) | 2017-02-16 | 2023-11-23 | 선오비온 파마슈티컬스 인코포레이티드 | Treatment methods for schizophrenia |
EP3661929B1 (en) | 2017-08-02 | 2021-07-14 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
MX2020008537A (en) | 2018-02-16 | 2021-01-08 | Sunovion Pharmaceuticals Inc | Salts, crystal forms, and production methods thereof. |
US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
CN115734785A (en) | 2020-04-14 | 2023-03-03 | 桑诺维恩药品公司 | (S) - (4, 5-dihydro-7H-thieno [2,3-c ] pyran-7-yl) -N-methylmethanamine for the treatment of neurological and psychiatric disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2235597A1 (en) * | 1972-07-20 | 1974-01-31 | Boehringer Mannheim Gmbh | SINGLE SQUARE CLIP ON 3- (5,6,7,8TETRAHYDRONAPHTH-1-YL-OXY) -PROPYL SQUARE CLIP FOR -PIPERAZINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
GB2093837B (en) * | 1981-03-02 | 1985-04-24 | Abbott Lab | Aminoalkyl subsituted 1,2,3,4-tetrahydronaphtalenes |
US4473586A (en) * | 1982-05-03 | 1984-09-25 | Abbott Laboratories | Aminoalkyl dihydronaphthalenes |
DE3506117A1 (en) * | 1985-02-22 | 1986-08-28 | Basf Ag, 6700 Ludwigshafen | AMINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES |
-
1992
- 1992-06-26 IT ITMI921569A patent/IT1255178B/en active IP Right Grant
-
1993
- 1993-06-22 JP JP6502035A patent/JPH07508514A/en active Pending
- 1993-06-22 WO PCT/EP1993/001589 patent/WO1994000441A1/en not_active Application Discontinuation
- 1993-06-22 AU AU44195/93A patent/AU670444B2/en not_active Ceased
- 1993-06-22 EP EP93914690A patent/EP0647222A1/en not_active Withdrawn
- 1993-06-22 CA CA002137685A patent/CA2137685A1/en not_active Abandoned
- 1993-06-22 NZ NZ253689A patent/NZ253689A/en unknown
- 1993-06-22 HU HU9403768A patent/HUT71405A/en unknown
- 1993-06-22 ZA ZA934472A patent/ZA934472B/en unknown
- 1993-06-22 RU RU94046220A patent/RU2115651C1/en active
- 1993-06-24 IL IL106124A patent/IL106124A/en not_active IP Right Cessation
-
1994
- 1994-12-21 FI FI945997A patent/FI945997A0/en unknown
- 1994-12-26 KR KR1019940704767A patent/KR950702195A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL106124A (en) | 1998-02-22 |
EP0647222A1 (en) | 1995-04-12 |
WO1994000441A1 (en) | 1994-01-06 |
FI945997A (en) | 1994-12-21 |
KR950702195A (en) | 1995-06-19 |
IT1255178B (en) | 1995-10-20 |
FI945997A0 (en) | 1994-12-21 |
AU670444B2 (en) | 1996-07-18 |
RU2115651C1 (en) | 1998-07-20 |
HUT71405A (en) | 1995-11-28 |
ITMI921569A0 (en) | 1992-06-26 |
JPH07508514A (en) | 1995-09-21 |
ITMI921569A1 (en) | 1993-12-26 |
RU94046220A (en) | 1996-09-27 |
NZ253689A (en) | 1996-11-26 |
CA2137685A1 (en) | 1994-01-06 |
HU9403768D0 (en) | 1995-02-28 |
AU4419593A (en) | 1994-01-24 |
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