RU94046220A - N(hetero)-aryl-n(hetero)-tetralin piperazine having serotoninergic, dopaminoergic and adrenergic, process for preparation thereof, therapeutic composition, and use thereof - Google Patents

N(hetero)-aryl-n(hetero)-tetralin piperazine having serotoninergic, dopaminoergic and adrenergic, process for preparation thereof, therapeutic composition, and use thereof

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Publication number
RU94046220A
RU94046220A RU94046220/04A RU94046220A RU94046220A RU 94046220 A RU94046220 A RU 94046220A RU 94046220/04 A RU94046220/04 A RU 94046220/04A RU 94046220 A RU94046220 A RU 94046220A RU 94046220 A RU94046220 A RU 94046220A
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RU
Russia
Prior art keywords
hetero
aryl
preparation
treatment
dopaminoergic
Prior art date
Application number
RU94046220/04A
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Russian (ru)
Other versions
RU2115651C1 (en
Inventor
Перроне Роберто
It]
Берарди Франческо
Фиорентини Франческо
Говони Стефано
Олджиати Винченцо
Ванотти Эрмес
Гобетти Марино
Тонон Джанкарло
Original Assignee
Фармиталиа Карло Эрба С.р.л. (IT)
Фармиталиа Карло Эрба С.Р.Л.
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Application filed by Фармиталиа Карло Эрба С.р.л. (IT), Фармиталиа Карло Эрба С.Р.Л. filed Critical Фармиталиа Карло Эрба С.р.л. (IT)
Publication of RU94046220A publication Critical patent/RU94046220A/en
Application granted granted Critical
Publication of RU2115651C1 publication Critical patent/RU2115651C1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FIELD: medicine. SUBSTANCE: claimed invention describes N(hetero)-aryl-N(hetero)tetrline-alkyl piperazine having serotoninergic, dopaminoergic and adrenergic activity, processes for preparation thereof and suitable therapeutic compositions for treatment of fear caused by depression, treatment of schizophrenia, cerebral' ischemia, opium drug addiction syndromes, toxiconia, consciousness disorders such as senile feeble mindedness, disorders associated with insomnia and memory, Parkinson's and Alzeimer's disease and for treatment of arterial hypertension. EFFECT: improved properties of the therapeutic composition.

Claims (1)

N(гетеро)-арил-N(гетеро)-тетралин-алкил пиперазин, обладающий серотонинергической, допаминергической и адренергической активностью, способы его получения и соответствующие терапевтические композиции для лечения страха, вызываемого депрессией, для лечения шизофрении, церебральной ишемии синдромов опийной наркомании, токсикомании, нарушений сознания, таких как старческое слабоумие, нарушений, связанных с бессонницей и памятью, болезней Паркинсона и Альцгеймера и для лечения артериальной гипертензии.N (hetero) -aryl-N (hetero) -tetralin-alkyl piperazine having serotonergic, dopaminergic and adrenergic activity, methods for its preparation and corresponding therapeutic compositions for treating fear caused by depression, for treating schizophrenia, cerebral ischemia of opium addiction syndromes, substance abuse disorders of consciousness such as senile dementia, disorders associated with insomnia and memory, Parkinson's and Alzheimer's diseases and for the treatment of arterial hypertension.
RU94046220A 1992-06-26 1993-06-22 N-(hetero)aryl -n-(hetero)tetralinealkyl piperazines and method of preparing thereof RU2115651C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITM192A001569 1992-06-26
ITMI92A001569 1992-06-26
ITMI921569A IT1255178B (en) 1992-06-26 1992-06-26 N (ETER0) -ARIL-N (ETERO) -TETRALINALCHIL PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITIES

Publications (2)

Publication Number Publication Date
RU94046220A true RU94046220A (en) 1996-09-27
RU2115651C1 RU2115651C1 (en) 1998-07-20

Family

ID=11363580

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046220A RU2115651C1 (en) 1992-06-26 1993-06-22 N-(hetero)aryl -n-(hetero)tetralinealkyl piperazines and method of preparing thereof

Country Status (13)

Country Link
EP (1) EP0647222A1 (en)
JP (1) JPH07508514A (en)
KR (1) KR950702195A (en)
AU (1) AU670444B2 (en)
CA (1) CA2137685A1 (en)
FI (1) FI945997A (en)
HU (1) HUT71405A (en)
IL (1) IL106124A (en)
IT (1) IT1255178B (en)
NZ (1) NZ253689A (en)
RU (1) RU2115651C1 (en)
WO (1) WO1994000441A1 (en)
ZA (1) ZA934472B (en)

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NZ277373A (en) * 1993-12-28 1998-07-28 Upjohn Co Iso(thio)chroman-1-ylethylpiperazine and -piperidine derivatives (analogues)
FR2716193B1 (en) * 1994-02-16 1996-04-05 Synthelabo 1 [2- (1h-inden-3-yl) ethyl] -4- (naphthalen-1-yl) piperazine derivatives, their preparation and their therapeutic use.
US5472966A (en) * 1995-03-29 1995-12-05 Bristol-Myers Squibb Company Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines
FR2737723B1 (en) * 1995-08-09 1997-09-05 Synthelabo DERIVATIVES OF 1- (2- (1H-INDEN-3-YL) ETHYL) -4- (NAPHTALEN-1-YL) - PIPERAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
PT1464641E (en) * 1999-12-30 2008-07-01 Lundbeck & Co As H 4-phenyl-piperazinyl, -piperidinyl and tetrahydropyridyl derivatives as dopamine d4 antagonists
KR100496874B1 (en) * 2003-07-03 2005-06-22 주식회사 엘지화학 Method for Preparing Polymethylmethacrylate Using Supercritical Carbon Dioxide
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1829869A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
NZ600008A (en) 2009-12-04 2014-10-31 Sunovion Pharmaceuticals Inc Multicyclic compounds and methods of use thereof
KR20190065246A (en) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 Compounds and compositions and uses thereof
MX2019000980A (en) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof.
JP7146782B2 (en) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク Methods of treating schizophrenia
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
EA202091945A1 (en) 2018-02-16 2021-01-18 Суновион Фармасьютикалз Инк. SALTS, CRYSTALLINE FORMS AND METHODS OF THEIR PRODUCTION
MX2021010880A (en) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof.
EP4135690A1 (en) 2020-04-14 2023-02-22 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders

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DE3506117A1 (en) * 1985-02-22 1986-08-28 Basf Ag, 6700 Ludwigshafen AMINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES

Also Published As

Publication number Publication date
EP0647222A1 (en) 1995-04-12
WO1994000441A1 (en) 1994-01-06
RU2115651C1 (en) 1998-07-20
JPH07508514A (en) 1995-09-21
ITMI921569A0 (en) 1992-06-26
IT1255178B (en) 1995-10-20
CA2137685A1 (en) 1994-01-06
AU4419593A (en) 1994-01-24
FI945997A0 (en) 1994-12-21
ITMI921569A1 (en) 1993-12-26
HU9403768D0 (en) 1995-02-28
AU670444B2 (en) 1996-07-18
NZ253689A (en) 1996-11-26
ZA934472B (en) 1994-01-18
FI945997A (en) 1994-12-21
IL106124A (en) 1998-02-22
KR950702195A (en) 1995-06-19
HUT71405A (en) 1995-11-28

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